| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kin-Mei Leung, Sarah Batey, Robert Rowlands, Samine J Isaac, Phil Jones, Victoria Drewett, Joana Carvalho, Miguel Gaspar, Sarah Weller, Melanie Medcalf, Mateusz M Wydro, Robert Pegram, Geert C Mudde, Anton Bauer, Kevin Moulder, Max Woisetschläger, Mihriban Tuna, John S Haurum, Haijun Su. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 11. 2016-09-20. PMID:26234505. |
in tumor cells that express high levels of her2, fs102 caused profound her2 internalization and degradation leading to tumor cell apoptosis. |
2016-09-20 |
2023-08-13 |
Not clear |
| Kin-Mei Leung, Sarah Batey, Robert Rowlands, Samine J Isaac, Phil Jones, Victoria Drewett, Joana Carvalho, Miguel Gaspar, Sarah Weller, Melanie Medcalf, Mateusz M Wydro, Robert Pegram, Geert C Mudde, Anton Bauer, Kevin Moulder, Max Woisetschläger, Mihriban Tuna, John S Haurum, Haijun Su. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 11. 2016-09-20. PMID:26234505. |
in turn, increased depletion of her2 commits the cells to apoptosis as a result of oncogene shock. |
2016-09-20 |
2023-08-13 |
Not clear |
| Laura H Rosenberg, Marie Lafitte, Victor Quereda, Wayne Grant, Weimin Chen, Mathieu Bibian, Yoshihiko Noguchi, Mohammad Fallahi, Chunying Yang, Jenny C Chang, William R Roush, John L Cleveland, Derek R Ducket. Therapeutic targeting of casein kinase 1δ in breast cancer. Science translational medicine. vol 7. issue 318. 2016-09-20. PMID:26676609. |
specifically, selective knockdown of ck1δ, or treatment with a highly selective and potent ck1δ inhibitor, triggers apoptosis of ck1δ-expressing breast tumor cells ex vivo, tumor regression in orthotopic models of triple-negative breast cancer, including patient-derived xenografts, and tumor growth inhibition in human epidermal growth factor receptor 2-positive (her2(+)) breast cancer models. |
2016-09-20 |
2023-08-13 |
human |
| Hyojin Lee, Duncan Hieu M Dam, Ji Won Ha, Jun Yue, Teri W Odo. Enhanced Human Epidermal Growth Factor Receptor 2 Degradation in Breast Cancer Cells by Lysosome-Targeting Gold Nanoconstructs. ACS nano. vol 9. issue 10. 2016-08-04. PMID:26335372. |
within the target organelle, lysosomes, her2 was degraded by enzymes at low ph, which resulted in apoptosis. |
2016-08-04 |
2023-08-13 |
human |
| E D Bazhanova, Yu O Kozlova, V N Anisimov, D S Sukhanov, D L Tepl. [PHARMACOLOGICAL CORRECTION OF APOPTOSIS LEVEL OF CORTICAL NEURONS IN AGED HER2/NEU TRANSGENIC MICE]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 52. issue 1. 2016-06-22. PMID:27220241. |
previously we have shown that in this strain of mice the apoptosis level is low, without any age-related changes, due to the suppression, first of all, of the p53-dependent pathway by her2 (tyrosine kinase receptor) overexpression. |
2016-06-22 |
2023-08-13 |
mouse |
| Onat Kadioglu, Jingming Cao, Mohamed E M Saeed, Henry Johannes Greten, Thomas Effert. Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals. Targeted oncology. vol 10. issue 3. 2016-06-21. PMID:25410594. |
epidermal growth factor receptors (egfr, her2, her3) activate signal transduction pathways involved in cancer proliferation, apoptosis, differentiation, metastasis, and angiogenesis. |
2016-06-21 |
2023-08-13 |
Not clear |
| Adela Madrid-Paredes, Marisa Cañadas-Garre, Antonio Sánchez-Pozo, Miguel Ángel Calleja-Hernánde. De novo resistance biomarkers to anti-HER2 therapies in HER2-positive breast cancer. Pharmacogenomics. vol 16. issue 12. 2016-06-16. PMID:26257318. |
molecular mechanisms proposed to be responsible for this de novo resistance include her2 modifications, defects in the antibody dependent cellular cytotoxicity or in cell arrest and apoptosis or alterations in her2 signaling components. |
2016-06-16 |
2023-08-13 |
Not clear |
| Kaifee Arman, Sercan Ergün, Ebru Temiz, Serdar Öztuzc. The interrelationship between HER2 and CASP3/8 with apoptosis in different cancer cell lines. Molecular biology reports. vol 41. issue 12. 2016-06-07. PMID:25189649. |
the interrelationship between her2 and casp3/8 with apoptosis in different cancer cell lines. |
2016-06-07 |
2023-08-13 |
human |
| Kaifee Arman, Sercan Ergün, Ebru Temiz, Serdar Öztuzc. The interrelationship between HER2 and CASP3/8 with apoptosis in different cancer cell lines. Molecular biology reports. vol 41. issue 12. 2016-06-07. PMID:25189649. |
the primary function of her2 is suppressing apoptosis to enhance cell survival and eventually giving rise to uncontrolled proliferation and tumor growth. |
2016-06-07 |
2023-08-13 |
human |
| Kaifee Arman, Sercan Ergün, Ebru Temiz, Serdar Öztuzc. The interrelationship between HER2 and CASP3/8 with apoptosis in different cancer cell lines. Molecular biology reports. vol 41. issue 12. 2016-06-07. PMID:25189649. |
the objective of this work was to study the expression levels of her2 and apoptosis related factors casp-3 and casp-8 in several breast and other cancer cell lines and finally to find a meaningful correlation between all these. |
2016-06-07 |
2023-08-13 |
human |
| Kaifee Arman, Sercan Ergün, Ebru Temiz, Serdar Öztuzc. The interrelationship between HER2 and CASP3/8 with apoptosis in different cancer cell lines. Molecular biology reports. vol 41. issue 12. 2016-06-07. PMID:25189649. |
in summary we conclude that her2 promotes cell survival by inhibiting apoptosis i.e. |
2016-06-07 |
2023-08-13 |
human |
| Angelika Kaczyńska, Joanna Świerczyńska, Anna Herman-Antosiewic. Sensitization of HER2 Positive Breast Cancer Cells to Lapatinib Using Plants-Derived Isothiocyanates. Nutrition and cancer. vol 67. issue 6. 2016-06-07. PMID:26134366. |
nearly 25% of all breast cancer is characterized by overexpression of her2 (human epidermal growth factor receptor 2) which leads to overactivation of prosurvival signal transduction pathways, especially through akt-mtor-s6k kinases, and results in enhanced proliferation, migration, induction of angiogenesis, and apoptosis inhibition. |
2016-06-07 |
2023-08-13 |
human |
| Takuro Mizukami, Yosuke Togashi, Shunsuke Sogabe, Eri Banno, Masato Terashima, Marco A De Velasco, Kazuko Sakai, Yoshihiko Fujita, Shuta Tomida, Takako Eguchi Nakajima, Narikazu Boku, Kazuto Nishi. EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26081723. |
the combination of trametinib and lapatinib synergistically inhibited the cell growth of the ocum-1 cell line and strongly induced apoptosis by inhibiting the activated egfr and her2 signals. |
2016-05-24 |
2023-08-13 |
Not clear |
| Christian D Young, Carlos L Arteaga, Rebecca S Coo. Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers. Breast cancer research : BCR. vol 17. 2016-04-21. PMID:26637440. |
consequently, inhibitors of her2 and type i pi3k block growth and increase apoptosis in her2+ breast cancers, especially when used in combination. |
2016-04-21 |
2023-08-13 |
human |
| Mohammad E Khosroshahi, Zahra Hassannejad, Masoumeh Firouzi, Ahmad R Arsh. Nanoshell-mediated targeted photothermal therapy of HER2 human breast cancer cells using pulsed and continuous wave lasers: an in vitro study. Lasers in medical science. vol 30. issue 7. 2016-04-20. PMID:26137934. |
in this study, we report the apoptosis induction in her2 overexpressed breast cancer cells using pulsed, continuous wave lasers and polyvinylpyrrolidone (pvp)-stabilized magneto-plasmonic nanoshells (pvp-mpns) delivered by immunoliposomes. |
2016-04-20 |
2023-08-13 |
human |
| Sun Hee Park, Koichi Ito, William Olcott, Igor Katsyv, Gwyneth Halstead-Nussloch, Hanna Y Iri. PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim. Breast cancer research : BCR. vol 17. 2016-04-18. PMID:26084280. |
ptk6 inhibition promotes apoptosis of lapatinib-resistant her2(+) breast cancer cells by inducing bim. |
2016-04-18 |
2023-08-13 |
human |
| Amanda L Rinkenbaugh, Albert S Baldwi. The NF-κB Pathway and Cancer Stem Cells. Cells. vol 5. issue 2. 2016-04-09. PMID:27058560. |
downstream of key oncogenic pathways, such as ras, bcr-abl, and her2, nf-κb regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. |
2016-04-09 |
2023-08-13 |
Not clear |
| Xin Li, Baozhong Wang, Weiwei Liu, Mingming Gui, Zheng Peng, Songdong Men. Blockage of conformational changes of heat shock protein gp96 on cell membrane by a α-helix peptide inhibits HER2 dimerization and signaling in breast cancer. PloS one. vol 10. issue 4. 2016-03-30. PMID:25898135. |
targeting cell membrane gp96 promoted her2 ubiquitination and subsequent lysosomal degradation, which led to decreased cell growth and increased apoptosis, and inhibited tumor growth in vivo. |
2016-03-30 |
2023-08-13 |
Not clear |
| Binbing Ling, Bosong Gao, Jian Yan. Evaluating the Effects of Tetrachloro-1,4-benzoquinone, an Active Metabolite of Pentachlorophenol, on the Growth of Human Breast Cancer Cells. Journal of toxicology. vol 2016. 2016-03-16. PMID:26981120. |
luminal a subtype mcf7 (er(+), pr(+), her2(-)) cells maintained the highest intracellular ros level and were subjected to tcbq-induced ros reduction, apoptosis, and cytotoxicity. |
2016-03-16 |
2023-08-13 |
human |
| Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Jong-Kyu Woo, Bo-Hyoung Jang, Hoyeon Go, Yong Cheol Shin, Seong-Gyu K. Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25936427. |
the present study aimed to investigate the effects of a phytoestrogen, apigenin, on proliferation and apoptosis of the human epidermal growth factor receptor 2 (her2)-expressing breast cancer cell line skbr3. |
2016-03-10 |
2023-08-13 |
human |