| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Schwill, Rastislav Tamaskovic, Aaron S Gajadhar, Florian Kast, Forest M White, Andreas Plückthu. Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer. Science signaling. vol 12. issue 565. 2020-03-16. PMID:30670633. |
here, we sought to analyze the adaptive kinase response in cancer cells after distinct treatment with agents targeting human epidermal growth factor receptor 2 (her2), specifically those that induce either only temporary cell cycle arrest or, alternatively, apoptosis in her2-overexpressing cancers. |
2020-03-16 |
2023-08-13 |
human |
| Hongmei Xiao, Peter E Jensen, Xinjian Che. Elimination of Osteosarcoma by Necroptosis with Graphene Oxide-Associated Anti-HER2 Antibodies. International journal of molecular sciences. vol 20. issue 18. 2020-01-28. PMID:31491952. |
tra/go induces oxidative stress and strong her2 signaling to elicit immediate degradation of both ciap (cellular inhibitor of apoptosis protein) and caspase 8, leading to activation of necroptosis. |
2020-01-28 |
2023-08-13 |
Not clear |
| Teresa Puig, Carlos Turrado, Bellinda Benhamú, Helena Aguilar, Joana Relat, Silvia Ortega-Gutiérrez, Gemma Casals, Pedro F Marrero, Ander Urruticoechea, Diego Haro, María Luz López-Rodríguez, Ramon Colome. Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 15. issue 24. 2019-11-20. PMID:20008854. |
experimental design: we evaluated the in vitro effects of the compounds on breast cancer cell growth (sk-br3, mcf-7, and mda-mb-231), apoptosis [as assessed by cleavage of poly(adp-ribose) polymerase], cell signaling (her2, erk1/2, and akt), and fatty acid metabolism enzymes (fasn and cpt-1). |
2019-11-20 |
2023-08-12 |
mouse |
| Teresa Puig, Carlos Turrado, Bellinda Benhamú, Helena Aguilar, Joana Relat, Silvia Ortega-Gutiérrez, Gemma Casals, Pedro F Marrero, Ander Urruticoechea, Diego Haro, María Luz López-Rodríguez, Ramon Colome. Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 15. issue 24. 2019-11-20. PMID:20008854. |
moreover, the compounds induced apoptosis and caused a marked decrease in the active forms of her2, akt, and erk1/2 proteins. |
2019-11-20 |
2023-08-12 |
mouse |
| Shiying Wu, Qian Zhang, Fei Zhang, Fansen Meng, Shengduo Liu, Ruyuan Zhou, Qingzhe Wu, Xinran Li, Li Shen, Jun Huang, Jun Qin, Songying Ouyang, Zongping Xia, Hai Song, Xin-Hua Feng, Jian Zou, Pinglong X. HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity. Nature cell biology. vol 21. issue 8. 2019-11-19. PMID:31332347. |
here, we show that the receptor tyrosine kinase her2 (also known as erbb-2 or neu) potently inhibits cgas-sting signalling and prevents cancer cells from producing cytokines, entering senescence and undergoing apoptosis. |
2019-11-19 |
2023-08-13 |
Not clear |
| Sri HariKrishna Vellanki, Rodrigo G B Cruz, Hanne Jahns, Lance Hudson, Giovanni Sette, Adriana Eramo, Ann M Hopkin. Natural compound Tetrocarcin-A downregulates Junctional Adhesion Molecule-A in conjunction with HER2 and inhibitor of apoptosis proteins and inhibits tumor cell growth. Cancer letters. vol 440-441. 2019-10-11. PMID:30312728. |
natural compound tetrocarcin-a downregulates junctional adhesion molecule-a in conjunction with her2 and inhibitor of apoptosis proteins and inhibits tumor cell growth. |
2019-10-11 |
2023-08-13 |
human |
| Sadia Afrin, Francesca Giampieri, Tamara Y Forbes-Hernández, Massimiliano Gasparrini, Adolfo Amici, Danila Cianciosi, Josè L Quiles, Maurizio Battin. Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. Free radical biology & medicine. vol 126. 2019-09-19. PMID:30056083. |
compared to 5-fu alone, mh synergistically enhanced the chemotherapeutic effects of 5-fu, by reducing cell proliferation through the suppression of egfr, her2, p-akt and p-mtor expression, and promoting apoptosis by the modulation pro-apoptotic (p53, bax, cyto c, fasl caspase-3, -8, -9 and cleave-parp) and anti-apoptotic (bcl-2) markers. |
2019-09-19 |
2023-08-13 |
human |
| Lu Xue, Nita J Maihle, Xiaolin Yu, Shou-Ching Tang, Hong Yan Li. Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth. Molecular pharmaceutics. vol 15. issue 11. 2019-08-26. PMID:30222359. |
in breast cancer xenograft models, heh is capable of triggering cell apoptosis, decreasing her2 and egfr expression, and suppressing tumor growth. |
2019-08-26 |
2023-08-13 |
Not clear |
| J Cong, R Liu, J Hou, X Wang, H Jiang, J Wan. Effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells. Neoplasma. vol 66. issue 2. 2019-08-15. PMID:30509111. |
in conclusion, her2 protein is over-expressed in epithelial ovarian cancer tissues, and trastuzumab exerts anti-tumor effect by inhibiting cell proliferation and inducing apoptosis, suggesting it might be a novel approach for the treatment of ovarian cancer. |
2019-08-15 |
2023-08-13 |
human |
| Yan-Yan Yan, Hong Bi, Wei Zhang, Qing Wen, Hong Liu, Jin-Xia Li, Hui-Zhi Zhang, Yan-Xia Zhang, Jia-Shan L. Downregulation and subcellular distribution of HER2 involved in MDA-MB-453 breast cancer cell apoptosis induced by lapatinib/celastrol combination. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 22. issue 3. 2019-07-12. PMID:28730769. |
downregulation and subcellular distribution of her2 involved in mda-mb-453 breast cancer cell apoptosis induced by lapatinib/celastrol combination. |
2019-07-12 |
2023-08-13 |
Not clear |
| Siao-Syun Guan, Cheng-Tien Wu, Chen-Yuan Chiu, Tsai-Yueh Luo, Jeng-Yih Wu, Tse-Zung Liao, Shing-Hwa Li. Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo. Journal of translational medicine. vol 16. issue 1. 2019-06-14. PMID:29921305. |
the human epidermal growth factor receptor 2 (her2) involved proliferation, angiogenesis, and reduced apoptosis in gastric cancer (gc), which is a common target for tumor therapy. |
2019-06-14 |
2023-08-13 |
human |
| YingHui Wang, Louise Pinet, Nadine Assrir, Latifa Elantak, Françoise Guerlesquin, Ali Badache, Ewen Lescop, Carine van Heijenoor. Biomolecular NMR assignments. vol 12. issue 1. 2019-05-31. PMID:28905237. |
erbb2 (or her2) is a receptor tyrosine kinase that is involved in signaling pathways controlling cell division, motility and apoptosis. |
2019-05-31 |
2023-08-13 |
Not clear |
| Leticia Vicosa Pires, Yuyin Yi, Jung-Chien Cheng, Lolita Schneider Pizzolato, Elvira Cordero, Peter C K Leung, Ilma Simoni Bru. Lapatinib Inhibits Amphiregulin-induced BeWo Choriocarcinoma Cell Proliferation by Reducing ERK1/2 and AKT Signaling Pathways. Anticancer research. vol 39. issue 5. 2019-05-23. PMID:31092430. |
lapatinib is a potent egfr and human epidermal growth factor receptor 2 (her2) inhibitor that inhibits cell proliferation and induces apoptosis in various human cancer cells. |
2019-05-23 |
2023-08-13 |
human |
| Pouria Samadi, Sahar Saki, Fatemeh Karimi Dermani, Mona Pourjafar, Massoud Saidija. Emerging ways to treat breast cancer: will promises be met? Cellular oncology (Dordrecht). vol 41. issue 6. 2018-12-24. PMID:30259416. |
these components include erbb family members (her1, her2, her3 and her4), ras/mapk pathway components (ras, raf, mek and erk), vegf family members (vegfa, vegfb, vegfc, vegf and pgf), apoptosis and cell cycle regulators (bak, bax, bcl-2, bcl-x, mcl-1 and bcl-w, p53 and pi3k/akt/mtor pathway components) and dna repair pathway components such as brca1. |
2018-12-24 |
2023-08-13 |
Not clear |
| Naihua Liu, Menglu Zhu, Yingjie Linhai, Yuwei Song, Xiujuan Gui, Guoqiang Tan, Jinyuan Li, Yan Liu, Zhendong Deng, Xiaoting Chen, Jing Wang, Lili Jia, Xiuzhen He, Xiaoyu Wang, Shaoqiang Li. Increasing HER2 α2,6 sialylation facilitates gastric cancer progression and resistance via the Akt and ERK pathways. Oncology reports. vol 40. issue 5. 2018-12-18. PMID:30226606. |
herein, we identified her2 as an st6gal‑i substrate and showed that her2 α2,6 sialylation confers protection against trastuzumab‑mediated apoptosis. |
2018-12-18 |
2023-08-13 |
human |
| Lan Li, Chengke Luo, Zhenwei Song, Eduardo Reyes-Vargas, Fred Clayton, Jufang Huang, Peter Jensen, Xinjian Che. Association of anti-HER2 antibody with graphene oxide for curative treatment of osteosarcoma. Nanomedicine : nanotechnology, biology, and medicine. vol 14. issue 2. 2018-12-17. PMID:29170110. |
tra/go simultaneously induced oxidative stress and her2 signaling in the target cells, leading to rapid depletion of the cellular inhibitors of apoptosis protein (ciap) and caspase-8, formation of rip1/ripk3/mlkl necroptosome and necroptosis of the os cells. |
2018-12-17 |
2023-08-13 |
mouse |
| Cristina E Rodríguez, Damian E Berardi, Marianela Abrigo, Laura B Todaro, Elisa D Bal de Kier Joffé, Gabriel L Fiszma. Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28722778. |
breast cancer human cells culture as spheroids develop autophagy and apoptosis, which promotes trastuzumab resistance in her2 overexpressing cells. |
2018-10-15 |
2023-08-13 |
human |
| Abbas Pirpour Tazehkand, Maryam Akbarzadeh, Kobra Velaie, Mohammad Reza Sadeghi, Nasser Samad. The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-10. PMID:29684854. |
inhibition of either nrf2 or her2 alone and in combination caused a significant increase in oxaliplatin-induced cytotoxicity and apoptosis with maximum effects in sw480/res cells with low her2 and nrf2 expression levels. |
2018-10-10 |
2023-08-13 |
Not clear |
| Kazutoshi Isobe, Atsushi Kakimoto, Tetuo Mikami, Kyohei Kaburaki, Hiroshi Kobayashi, Takahiro Yoshizawa, Yuta Nakano, Takashi Makino, Hajime Otsuka, Go Sano, Keishi Sugino, Susumu Sakamoto, Yujiro Takai, Naobumi Tochigi, Akira Iyoda, Sakae Homm. PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma. Oncology reports. vol 40. issue 1. 2018-09-27. PMID:29767258. |
correlations of pd-l1 mrna expression with bim, p53 upregulated modular of apoptosis (puma), human epidermal growth factor receptor 2 (her2), mesenchymal-epithelial transition (met), egfr, and vascular endothelial growth factor a (vegfa) were determined. |
2018-09-27 |
2023-08-13 |
human |
| Chin-Cheng S. Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway. International journal of molecular medicine. vol 41. issue 4. 2018-08-23. PMID:29393362. |
these findings demonstrated that tan-iia inhibited human gastric cancer ags cells; one of the molecular mechanisms may be through decreasing the protein expression of vegfr and her2, then blocking the ras/raf/mek/erk pathway to induce the activation of parp and caspase-3 to induce apoptosis. |
2018-08-23 |
2023-08-13 |
human |