| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke Liang, Yang Lu, Weidong Jin, K Kian Ang, Luka Milas, Zhen Fa. Sensitization of breast cancer cells to radiation by trastuzumab. Molecular cancer therapeutics. vol 2. issue 11. 2004-07-28. PMID:14617784. |
using six breast cancer cell lines with various levels of her2 (bt474, skbr3, mda453, mcf7, zr75b, and mda468), we found that trastuzumab (herceptin), a humanized monoclonal antibody that may inhibit breast cancer cell proliferation but does not induce apoptosis when used alone, enhanced radiation-induced apoptosis of the cells in a her2 level-dependent manner. |
2004-07-28 |
2023-08-12 |
human |
| Ke Liang, Yang Lu, Weidong Jin, K Kian Ang, Luka Milas, Zhen Fa. Sensitization of breast cancer cells to radiation by trastuzumab. Molecular cancer therapeutics. vol 2. issue 11. 2004-07-28. PMID:14617784. |
compared with parental or control vector-transfected mcf7 cells, mcf7her2 cells showed increased phosphorylation of at least two important her2 downstream molecules, protein kinase b/akt and mitogen-activated protein kinase (mapk), and increased resistance to radiotherapy, as shown by reduced induction of apoptosis and increased cell clonogenic survival after radiation. |
2004-07-28 |
2023-08-12 |
human |
| Jing Zhao, Li-Hong Zhang, Lin-Tao Jia, Li Zhang, Yan-Ming Xu, Zhi Wang, Cui-Juan Yu, Wei-Dan Peng, Wei-Hong Wen, Cheng-Ji Wang, Si-Yi Chen, An-Gang Yan. Secreted antibody/granzyme B fusion protein stimulates selective killing of HER2-overexpressing tumor cells. The Journal of biological chemistry. vol 279. issue 20. 2004-07-21. PMID:15004021. |
these results demonstrate that the chimeric immunogrb molecule, which is capable of antibody-directed targeting and granzyme b-mediated killing, has therapeutic potential against her2 tumors, especially in cases in which caspase-dependent apoptosis is inhibited. |
2004-07-21 |
2023-08-12 |
mouse |
| Pamela N Münster, Douglas C Marchion, Andrea D Basso, Neal Rose. Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway. Cancer research. vol 62. issue 11. 2002-07-16. PMID:12036925. |
degradation of her2 by ansamycins induces growth arrest and apoptosis in cells with her2 overexpression via a her3, phosphatidylinositol 3'-kinase-akt-dependent pathway. |
2002-07-16 |
2023-08-12 |
Not clear |
| Pamela N Münster, Douglas C Marchion, Andrea D Basso, Neal Rose. Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway. Cancer research. vol 62. issue 11. 2002-07-16. PMID:12036925. |
breast cancers with high expression of her2 are associated frequently with aggressive, poor prognosis disease and resistance to chemotherapy-induced apoptosis. |
2002-07-16 |
2023-08-12 |
Not clear |
| X F Le, M Marcelli, A McWatters, B Nan, G B Mills, C A O'Brian, R C Bas. Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity. Oncogene. vol 20. issue 57. 2002-01-23. PMID:11781840. |
our earlier studies have shown that recombinant heregulinbeta1 (hrg) induces apoptosis in skbr3 breast cancer cells that overexpress her2. |
2002-01-23 |
2023-08-12 |
human |
| D Frolik, R Caduff, Z Varg. Pleomorphic lobular carcinoma of the breast: its cell kinetics, expression of oncogenes and tumour suppressor genes compared with invasive ductal carcinomas and classical infiltrating lobular carcinomas. Histopathology. vol 39. issue 5. 2002-01-02. PMID:11737309. |
the study addresses whether pleomorphic lobular breast carcinomas represent a distinct entity with respect to proliferation and apoptosis as well the expression of the p53, bcl-2 and her2 protein. |
2002-01-02 |
2023-08-12 |
Not clear |
| P Casalini, L Botta, S Menar. Role of p53 in HER2-induced proliferation or apoptosis. The Journal of biological chemistry. vol 276. issue 15. 2001-05-24. PMID:11278558. |
her2 oncogene overexpression has been associated either with proliferation or differentiation and apoptosis. |
2001-05-24 |
2023-08-12 |
Not clear |
| P Casalini, L Botta, S Menar. Role of p53 in HER2-induced proliferation or apoptosis. The Journal of biological chemistry. vol 276. issue 15. 2001-05-24. PMID:11278558. |
wild type (wt) p53-igrov1 cells showed growth inhibition and apoptosis after her2 transfection, whereas no anti-proliferative effect was observed in its mutated p53 sub-line unless wt p53 was cotransfected with her2. |
2001-05-24 |
2023-08-12 |
Not clear |
| X F Le, R Vadlamudi, A McWatters, D S Bae, G B Mills, R Kumar, R C Bas. Differential signaling by an anti-p185(HER2) antibody and heregulin. Cancer research. vol 60. issue 13. 2000-08-17. PMID:10910064. |
heregulin-induced apoptosis could be blocked by inhibition of p70s6k, but not by inhibition of pi3-k. heregulin-induced differentiation could be eliminated by inhibition of pi3-k. we conclude that id5 and heregulin signal via different pathways, although both agents can inhibit the clonogenic growth of cells that overexpress her2. |
2000-08-17 |
2023-08-12 |
Not clear |
| F F Zheng, S D Kuduk, G Chiosis, P N Münster, L Sepp-Lorenzino, S J Danishefsky, N Rose. Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases. Cancer research. vol 60. issue 8. 2000-05-11. PMID:10786665. |
gmd-4c is a potent inducer of g1 block and apoptosis of breast cancer cell lines that overexpress her2, but does not appreciably inhibit the growth of 32d cells that lack her-kinases. |
2000-05-11 |
2023-08-12 |
Not clear |
| X F Le, A McWatters, J Wiener, J Y Wu, G B Mills, R C Bas. Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 1. 2000-02-28. PMID:10656457. |
in mammary cells overexpressing her2, anti-her2 mab id5 induces g1 arrest, whereas heregulin induces g2-m arrest, cell differentiation, and apoptosis. |
2000-02-28 |
2023-08-12 |
human |
| R Kumar, M Mandal, A Lipton, H Harvey, C B Thompso. Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 2. issue 7. 1999-02-09. PMID:9816290. |
overexpression of her2 modulates bcl-2, bcl-xl, and tamoxifen-induced apoptosis in human mcf-7 breast cancer cells. |
1999-02-09 |
2023-08-12 |
human |
| R Kumar, M Mandal, A Lipton, H Harvey, C B Thompso. Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 2. issue 7. 1999-02-09. PMID:9816290. |
here we investigated the effects of her2 on expression of apoptotic pathways and modulation of tamoxifen-induced apoptosis in er-positive mcf-7 breast cancer cells. |
1999-02-09 |
2023-08-12 |
human |
| R Kumar, M Mandal, A Lipton, H Harvey, C B Thompso. Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 2. issue 7. 1999-02-09. PMID:9816290. |
we report that her2 overexpression in mcf-7 cells is accompanied by up-regulation of antiapoptotic bcl-2 and bcl-xl proteins and suppression of tamoxifen-induced apoptosis. |
1999-02-09 |
2023-08-12 |
human |