| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony C Faber, Danan Li, Youngchul Song, Mei-Chih Liang, Beow Y Yeap, Roderick T Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, Jeffrey A Engelma. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19850869. |
differential induction of apoptosis in her2 and egfr addicted cancers following pi3k inhibition. |
2009-12-15 |
2023-08-12 |
Not clear |
| Ji-Young Song, Sang-Wook Lee, Joon Pio Hong, Sung Eun Chang, Han Choe, Jene Cho. Epidermal growth factor competes with EGF receptor inhibitors to induce cell death in EGFR-overexpressing tumor cells. Cancer letters. vol 283. issue 2. 2009-09-04. PMID:19380191. |
by contrast, egf may also stimulate apoptosis in tumor cells, depending on egfr and her2 (erbb-2) expression levels. |
2009-09-04 |
2023-08-12 |
Not clear |
| Margaret Flowers, Patricia A Thompso. t10c12 conjugated linoleic acid suppresses HER2 protein and enhances apoptosis in SKBr3 breast cancer cells: possible role of COX2. PloS one. vol 4. issue 4. 2009-07-13. PMID:19399184. |
t10c12 conjugated linoleic acid suppresses her2 protein and enhances apoptosis in skbr3 breast cancer cells: possible role of cox2. |
2009-07-13 |
2023-08-12 |
Not clear |
| Bin Chen, Bin Su, Shiuan Che. A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms. Biochemical pharmacology. vol 77. issue 12. 2009-06-02. PMID:19428334. |
a cox-2 inhibitor nimesulide analog selectively induces apoptosis in her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms. |
2009-06-02 |
2023-08-12 |
Not clear |
| Bin Chen, Bin Su, Shiuan Che. A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms. Biochemical pharmacology. vol 77. issue 12. 2009-06-02. PMID:19428334. |
these results suggest that compound 76 selectively induce apoptosis in her2 overexpressing breast cancer cells through the mitochondria, and could be used as a lead to design more potent derivatives. |
2009-06-02 |
2023-08-12 |
Not clear |
| Jing Wan, Peter Sazani, Ryszard Kol. Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells. International journal of cancer. vol 124. issue 4. 2009-01-14. PMID:19035464. |
sso111 treatment of sk-br-3 cells, which highly overexpress her2, led to inhibition of cell proliferation and induction of apoptosis. |
2009-01-14 |
2023-08-12 |
human |
| Jin Won Kim, Hwang-Phill Kim, Seock-Ah Im, Soyeong Kang, Hyung Seok Hur, Young-Kwang Yoon, Do-Youn Oh, Jee Hyun Kim, Dong Soon Lee, Tae-You Kim, Yung-Jue Ban. The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. Cancer letters. vol 272. issue 2. 2008-12-29. PMID:18774637. |
lapatinib also induced apoptosis in nci-n87 which has high her2 amplification ratio. |
2008-12-29 |
2023-08-12 |
Not clear |
| John W Park, Richard M Neve, Janos Szollosi, Christopher C Ben. Unraveling the biologic and clinical complexities of HER2. Clinical breast cancer. vol 8. issue 5. 2008-12-23. PMID:18952552. |
her2 plays a critical role in normal development, forming homodimers or heterodimers with other her family members and triggering downstream signaling cascades controlling proliferation, cell survival, and apoptosis. |
2008-12-23 |
2023-08-12 |
human |
| Eugenia Ortega, Rosa M Marti, Andree Yeramian, Anabel Sorolla, Xavier Dolcet, David Llobet, Leandro Abal, Maria Santacana, Judit Pallares, Antonio Llombart-Cussac, Xavier Matias-Gui. Targeted therapies in gynecologic cancers and melanoma. Seminars in diagnostic pathology. vol 25. issue 4. 2008-12-23. PMID:19013892. |
the most promising signaling pathways to be targeted for therapies in these tumors are the tyrosine kinase receptor (egfr, her2, c-kit), the ras/b-raf/mapk, the pi3k-mtor, and apoptosis signaling pathways. |
2008-12-23 |
2023-08-12 |
Not clear |
| Teresa Puig, Alejandro Vázquez-Martín, Joana Relat, Jordi Pétriz, Javier A Menéndez, Rut Porta, Gemma Casals, Pedro F Marrero, Diego Haro, Joan Brunet, Ramon Colome. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. Breast cancer research and treatment. vol 109. issue 3. 2008-07-24. PMID:17902053. |
treating cancer cells with egcg or c75 induced apoptosis and caused a decrease in the active forms of oncoprotein her2, akt and erk1/2 to a similar degree. |
2008-07-24 |
2023-08-12 |
human |
| Chia-Hua Liang, Li-Yen Shiu, Li-Ching Chang, Hamm-Ming Sheu, Eing-Mei Tsai, Kou-Wha Ku. Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin. Chemical research in toxicology. vol 21. issue 2. 2008-04-08. PMID:18078328. |
we have previously demonstrated that solamargine (sm), the major steroidal glycoalkaloid extracted from chinese herb solanum plants, reveals down-regulation of her2 and up-regulation of fas and tumor necrosis factor receptor (tnfr) expressions, triggers the mitochondria-mediated cell apoptosis pathway, and sensitizes human nonsmall cell lung cancer (nsclc) h441 and a549 adenocarcinoma cells to chemotherapy. |
2008-04-08 |
2023-08-12 |
human |
| Chia-Hua Liang, Li-Yen Shiu, Li-Ching Chang, Hamm-Ming Sheu, Eing-Mei Tsai, Kou-Wha Ku. Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin. Chemical research in toxicology. vol 21. issue 2. 2008-04-08. PMID:18078328. |
relevant studies have shown that her2 overexpressing cancer cells are more resistant than her2 low-expressing cells to the chemotherapeutic agent and tumor necrosis factor-induced apoptosis. |
2008-04-08 |
2023-08-12 |
human |
| Chia-Hua Liang, Li-Yen Shiu, Li-Ching Chang, Hamm-Ming Sheu, Eing-Mei Tsai, Kou-Wha Ku. Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin. Chemical research in toxicology. vol 21. issue 2. 2008-04-08. PMID:18078328. |
the data presented herein suggest that the expression of her2 did not influence the sm-induced apoptosis of different types of lung cancer cells and that the sm up-regulation of her2 and top2a expressions simultaneously augmented trastuzumab and epirubicin-induced deaths of lung cancer h661 and h69 cells. |
2008-04-08 |
2023-08-12 |
human |
| Ashok K Chakraborty, Ke Liang, Michael P DiGiovann. Co-targeting insulin-like growth factor I receptor and HER2: dramatic effects of HER2 inhibitors on nonoverexpressing breast cancer. Cancer research. vol 68. issue 5. 2008-04-08. PMID:18316619. |
induction of apoptosis was most striking in mcf7 cells using a herceptin/igfir antagonist combination despite these cells being her2 nonoverexpressing. |
2008-04-08 |
2023-08-12 |
human |
| Seung Jin Kim, Shinzaburo Noguch. [Prediction of response to docetaxel in breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 35. issue 2. 2008-04-04. PMID:18281755. |
recent studies in this area have demonstrated various mechanisms involved in the anti-tumor activity of docetaxel: (1) efflux (p-glycoprotein), (2) metabolism (cyp3a4), (3) beta-tubulin (isotype class i and iii), (4) cell cycle (her2, brca1), (5) apoptosis (p53, bcl-2, thioredoxin), and (6) cell proliferation (mib-1, nuclear grade). |
2008-04-04 |
2023-08-12 |
Not clear |
| Jean-François Mineo, Anne Bordron, Marc Baroncini, Claude-Alain Maurage, Carole Ramirez, Rose-Mary Siminski, Christian Berthou, Phong Dam Hie. Low HER2-expressing glioblastomas are more often secondary to anaplastic transformation of low-grade glioma. Journal of neuro-oncology. vol 85. issue 3. 2008-02-11. PMID:17571214. |
anti-human epithelial receptor type 2 (her2) antibodies have the ability to induce in vitro apoptosis of glioblastoma (gbm) cells. |
2008-02-11 |
2023-08-12 |
Not clear |
| Rita Nahta, Linda X H Yuan, Yi Du, Francisco J Estev. Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308062. |
in the current study, we show that the dual epidermal growth factor receptor (egfr)/human egfr-2 (her2) kinase inhibitor lapatinib induces apoptosis in trastuzumab-resistant cells derived from the her2-overexpressing skbr3 breast cancer line. |
2007-11-09 |
2023-08-12 |
Not clear |
| Chia-Hua Liang, Li-Yen Shiu, Li-Ching Chang, Hamm-Ming Sheu, Kou-Wha Ku. Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular nutrition & food research. vol 51. issue 8. 2007-11-09. PMID:17639997. |
interestingly, this investigation reveals that sm up-regulated fas expression and down-regulated the expression of her2, whose overexpression is associated with resistance to drugs, and promotes chemotherapy-induced apoptosis in nsclc a549 and h441 cells. |
2007-11-09 |
2023-08-12 |
human |
| Chia-Hua Liang, Li-Yen Shiu, Li-Ching Chang, Hamm-Ming Sheu, Kou-Wha Ku. Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular nutrition & food research. vol 51. issue 8. 2007-11-09. PMID:17639997. |
results of this study suggest that sm induces fas and tnfr-induced nsclc cell apoptosis and reduces her2 expression. |
2007-11-09 |
2023-08-12 |
human |
| David Y Zhang, Yong Li, Syed M Abbas Rizvi, Changfa Qu, John Kearsley, Barry J Alle. Cytotoxicity of breast cancer cells overexpressing HER2/neu by 213Bi-Herceptin radioimmunoconjugate. Cancer letters. vol 218. issue 2. 2007-10-30. PMID:15670895. |
we used western blot and flow cytometry analysis to examine the expression of her2 in a panel of established human metastatic breast cancer cell lines (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2h-tetrazolium, inner salt) mts assay to evaluate the cytotoxicity and the tunel assay to analyze cellular apoptosis. |
2007-10-30 |
2023-08-12 |
human |