| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideo Tomioka, Toru Mukohara, Yu Kataoka, Roudy Chiminch Ekyalongo, Yohei Funakoshi, Yasuo Imai, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minam. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. International journal of oncology. vol 41. issue 2. 2012-10-19. PMID:22614071. |
while the mtor inhibitor everolimus enhanced fluorouracil-induced apoptosis in both her2-amplified cell lines, this was not the case in the gastric cancer cell lines without her2 amplification. |
2012-10-19 |
2023-08-12 |
Not clear |
| Hideo Tomioka, Toru Mukohara, Yu Kataoka, Roudy Chiminch Ekyalongo, Yohei Funakoshi, Yasuo Imai, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minam. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. International journal of oncology. vol 41. issue 2. 2012-10-19. PMID:22614071. |
in summary, inhibition of the mtor/s6k signal may be a key molecular event in enhancing fluorouracil-induced apoptosis specifically in gastric cancer cells with her2 amplification. |
2012-10-19 |
2023-08-12 |
Not clear |
| Hitomi Kurose, Masa-Aki Shibata, Munekazu Iinuma, Yoshinori Otsuk. Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp. Journal of biomedicine & biotechnology. vol 2012. 2012-10-02. PMID:22577295. |
in this study, we investigated the influence of α-mangostin on apoptosis and cell cycle in the human breast cancer cell line mda-mb231 (carrying a p53 mutation, and her2, er, and pgr negative) in order to elucidate its anticancer mechanisms. |
2012-10-02 |
2023-08-12 |
mouse |
| Carlos Turrado, Teresa Puig, Javier García-Cárceles, Marta Artola, Bellinda Benhamú, Silvia Ortega-Gutiérrez, Joana Relat, Gloria Oliveras, Adriana Blancafort, Diego Haro, Pedro F Marrero, Ramón Colomer, María L López-Rodrígue. New synthetic inhibitors of fatty acid synthase with anticancer activity. Journal of medicinal chemistry. vol 55. issue 11. 2012-10-01. PMID:22559865. |
among them, derivative 30 blocks the 90% of fasn activity at low concentration (4 μm), is highly cytotoxic in a broad panel of tumor cells, induces apoptosis, and blocks the activation of her2, akt, and erk pathways. |
2012-10-01 |
2023-08-12 |
mouse |
| Yan-dan Yao, Tian-meng Sun, Song-yin Huang, Shuang Dou, Ling Lin, Jia-ning Chen, Jian-bin Ruan, Cheng-qiong Mao, Feng-yan Yu, Mu-sheng Zeng, Jian-ye Zang, Qiang Liu, Feng-xi Su, Peter Zhang, Judy Lieberman, Jun Wang, Erwei Son. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Science translational medicine. vol 4. issue 130. 2012-08-09. PMID:22517885. |
plk1-sirnas transferred by f5-p inhibited target gene expression, reduced proliferation, and induced apoptosis of her2(+) breast cancer cell lines and primary human cancer cells in vitro without triggering an interferon response. |
2012-08-09 |
2023-08-12 |
human |
| Yan-dan Yao, Tian-meng Sun, Song-yin Huang, Shuang Dou, Ling Lin, Jia-ning Chen, Jian-bin Ruan, Cheng-qiong Mao, Feng-yan Yu, Mu-sheng Zeng, Jian-ye Zang, Qiang Liu, Feng-xi Su, Peter Zhang, Judy Lieberman, Jun Wang, Erwei Son. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Science translational medicine. vol 4. issue 130. 2012-08-09. PMID:22517885. |
intravenously injected f5-p/plk1-sirna complexes concentrated in orthotopic her2(+) breast cancer xenografts and persisted for at least 72 hours, leading to suppressed plk1 gene expression and tumor cell apoptosis. |
2012-08-09 |
2023-08-12 |
human |
| Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huan. The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells. Lipids. vol 47. issue 4. 2012-07-20. PMID:22218925. |
proliferation decreased after downregulation of her2, which was consistent with increased apoptosis. |
2012-07-20 |
2023-08-12 |
Not clear |
| Teresa Puig, Helena Aguilar, Sílvia Cufí, Glòria Oliveras, Carlos Turrado, Sílvia Ortega-Gutiérrez, Bellinda Benhamú, María Luz López-Rodríguez, Ander Urruticoechea, Ramon Colome. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast cancer research : BCR. vol 13. issue 6. 2012-06-25. PMID:22177475. |
inhibiting the enzyme fatty acid synthase (fasn) leads to apoptosis of breast carcinoma cells, and this is linked to human epidermal growth factor receptor 2 (her2) signaling pathways in models of simultaneous expression of fasn and her2. |
2012-06-25 |
2023-08-12 |
human |
| Brent N Rexer, Carlos L Arteag. Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications. Critical reviews in oncogenesis. vol 17. issue 1. 2012-05-29. PMID:22471661. |
these mechanisms involve alterations to her2 itself, coexpression or acquisition of bypass signaling through other receptor or intracellular signaling pathways, defects in mechanisms of cell cycle regulation or apoptosis, and host factors that may modulate drug response. |
2012-05-29 |
2023-08-12 |
human |
| Tuanlao Wang, Ming Zhang, Zexu Ma, Ke Guo, Vinay Tergaonkar, Qi Zeng, Wanjin Hon. A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal. Journal of cellular physiology. vol 227. issue 6. 2012-04-19. PMID:21928319. |
low concentration of ga (50-100 nm)-induced apoptosis of the rab7 knocked-down cells but not control cells, suggesting that rab7 and hsp90 together contribute to the optimal stability of egfr and her2 as well as to protect cancer cells from apoptosis. |
2012-04-19 |
2023-08-12 |
Not clear |
| Jasgit C Sachdev, Mohammad Jahanze. Blockade of the HER family of receptors in the treatment of HER2-positive metastatic breast cancer. Clinical breast cancer. vol 12. issue 1. 2012-03-09. PMID:21903480. |
her2 is a member of the human epidermal growth factor receptor family of receptor tyrosine kinases, also known as the her family, which activates signaling that promotes tumorigenic cellular processes such as proliferation and evasion of apoptosis. |
2012-03-09 |
2023-08-12 |
human |
| Yan-yan Yan, Li-sheng Zheng, Xu Zhang, Li-kun Chen, Satyakam Singh, Fang Wang, Jian-ye Zhang, Yong-ju Liang, Chun-ling Dai, Lian-quan Gu, Mu-sheng Zeng, Tanaji T Talele, Zhe-sheng Chen, Li-Wu F. Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu. Molecular pharmaceutics. vol 8. issue 5. 2012-02-24. PMID:21812426. |
in addition, combination of emodin amad treatment and sirna against her2 synergistically inhibited proliferation and induced apoptosis. |
2012-02-24 |
2023-08-12 |
Not clear |
| A Bergamaschi, B S Katzenellenboge. Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance. Oncogene. vol 31. issue 1. 2012-02-21. PMID:21666713. |
increasing the level of mir-451 by overexpression, which decreased 14-3-3ζ, suppressed cell proliferation and colony formation, markedly reduced activation of her2, egfr and mapk signaling, increased apoptosis, and, importantly, restored the growth-inhibitory effectiveness of serms in endocrine-resistant cells. |
2012-02-21 |
2023-08-12 |
Not clear |
| Jixia Li, Yeon-Yong Cho, Alyssa Langfald, Andria Carper, Ronald A Lubet, Clinton J Grubbs, Marna E Ericson, Ann M Bod. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21791570. |
these results combined with immunoreactivity data indicated that, in addition to egfr and her2, lapatinib treatment was associated with changes in a number of other signaling molecules, including igf-1r, akt, and downstream targets such as gsk3, p27, p53, and cyclin d1 presumably leading to impaired proliferation, apoptosis, or cell-cycle arrest. |
2012-01-05 |
2023-08-12 |
human |
| Bo Zhong, Rati Lama, Kerri M Smith, Yan Xu, Bin S. Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76. Bioorganic & medicinal chemistry letters. vol 21. issue 18. 2011-12-19. PMID:21807508. |
it selectively induces apoptosis of her2 positive breast cancer cells. |
2011-12-19 |
2023-08-12 |
Not clear |
| J Tanizaki, I Okamoto, S Fumita, W Okamoto, K Nishio, K Nakagaw. Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification. Oncogene. vol 30. issue 39. 2011-12-07. PMID:21499301. |
roles of bim induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with her2 amplification. |
2011-12-07 |
2023-08-12 |
human |
| J Tanizaki, I Okamoto, S Fumita, W Okamoto, K Nishio, K Nakagaw. Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification. Oncogene. vol 30. issue 39. 2011-12-07. PMID:21499301. |
lapatinib induced apoptosis in association with upregulation of the pro-apoptotic protein bcl-2 interacting mediator of cell death (bim) through inhibition of the mek-erk signaling pathway in breast cancer cells with her2 amplification. |
2011-12-07 |
2023-08-12 |
human |
| J Tanizaki, I Okamoto, S Fumita, W Okamoto, K Nishio, K Nakagaw. Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification. Oncogene. vol 30. issue 39. 2011-12-07. PMID:21499301. |
our results thus suggest that inhibition of both pi3k-survivin and mek-erk-bim pathways is required for effective induction of apoptosis in breast cancer cells with her2 amplification. |
2011-12-07 |
2023-08-12 |
human |
| Vassilis Papanikolaou, Dimitrios Iliopoulos, Ioannis Dimou, Stephanie Dubos, Constantine Kappas, Sofia Kitsiou-Tzeli, Aspasia Tsezo. Survivin regulation by HER2 through NF-κB and c-myc in irradiated breast cancer cells. Journal of cellular and molecular medicine. vol 15. issue 7. 2011-11-15. PMID:20716114. |
this study revealed the significance of her2 in the radio-resistance of her2(+) breast cancer cells through induction of transcription factors nf-κb and c-myc, leading to activation of survivin, a downstream target oncogene preventing apoptosis. |
2011-11-15 |
2023-08-12 |
human |
| Tuba Ozbay, Rita Naht. Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines. Breast cancer : basic and clinical research. vol 5. 2011-11-10. PMID:21792311. |
in addition, delphinidin induced a significant level of apoptosis in her2-overexpressing cells in association with reduced her2 and mapk signaling. |
2011-11-10 |
2023-08-12 |
Not clear |