| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard L Carpenter, Woody Han, Ivy Paw, Hui-Wen L. HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells. PloS one. vol 8. issue 11. 2014-09-02. PMID:24236056. |
to elucidate the mechanisms for her2-mediated survival, we investigated the relationship between her2 and p53 upregulated modulator of apoptosis (puma), a potent apoptosis inducer. |
2014-09-02 |
2023-08-12 |
Not clear |
| Kun Liu, Honglin Chen, Qingsheng You, Hai Shi, Zhiwei Wan. The siRNA cocktail targeting VEGF and HER2 inhibition on the proliferation and induced apoptosis of gastric cancer cell. Molecular and cellular biochemistry. vol 386. issue 1-2. 2014-08-21. PMID:24158524. |
the sirna cocktail targeting vegf and her2 inhibition on the proliferation and induced apoptosis of gastric cancer cell. |
2014-08-21 |
2023-08-12 |
human |
| Kun Liu, Honglin Chen, Qingsheng You, Hai Shi, Zhiwei Wan. The siRNA cocktail targeting VEGF and HER2 inhibition on the proliferation and induced apoptosis of gastric cancer cell. Molecular and cellular biochemistry. vol 386. issue 1-2. 2014-08-21. PMID:24158524. |
the aim of this study was to investigate the inhibitory effect of a sirna cocktail targeting vascular endothelial growth factor (vegf) and human epidermal growth factor receptor 2 (her2) on cell proliferation, induced apoptosis and the expression of vegf and her2 in human gastric carcinoma cell. |
2014-08-21 |
2023-08-12 |
human |
| Kun Liu, Honglin Chen, Qingsheng You, Hai Shi, Zhiwei Wan. The siRNA cocktail targeting VEGF and HER2 inhibition on the proliferation and induced apoptosis of gastric cancer cell. Molecular and cellular biochemistry. vol 386. issue 1-2. 2014-08-21. PMID:24158524. |
the inhibition of vegf and her2 expressions can induce apoptosis of sgc-7901 cells. |
2014-08-21 |
2023-08-12 |
human |
| Tao Deng, Jeff C Liu, Philip E D Chung, David Uehling, Ahmed Aman, Babu Joseph, Troy Ketela, Zhe Jiang, Nathan F Schachter, Robert Rottapel, Sean E Egan, Rima Al-Awar, Jason Moffat, Eldad Zacksenhau. shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer research. vol 74. issue 7. 2014-06-07. PMID:24487029. |
in addition, tbk1/ikkε inhibition cooperated with lapatinib, a her2/egfr1-targeted drug, to accelerate apoptosis and kill her2(+) breast cancer cells both in culture and in xenografts. |
2014-06-07 |
2023-08-12 |
mouse |
| Jang-Chang Lee, Li-Chen Chou, Jin-Chemg Lien, Jia-Chiun Wu, Chi-Hung Huang, Chao-Ho Chung, Fang-Yu Lee, Li-Jiau Huang, Sheng-Chu Kuo, Tzong-Der Wa. CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23900492. |
among the test compounds, (1-benzyl-3-(p-hydroxymethylphenyl)-5-methylfuro[3,2-c]pyrazol) (clc604), an isosteric analogue of yc-1, significantly suppressed the expression of her2, and preferentially inhibited cell proliferation and induced apoptosis in her2-overexpressing cancer cells. |
2014-04-29 |
2023-08-12 |
Not clear |
| Ming Shi, Mingzhen Zhao, Meiru Hu, Dan Liu, Hong Cao, Lu Qian, Zhengyan Yang, Yabin Hu, Ming Yu, Shuo Yang, Yuanfang Ma, Ning Gu. β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes. International journal of cardiology. vol 167. issue 4. 2014-04-11. PMID:22564389. |
β2-ar-induced her2 transactivation mediated by erbin confers protection from apoptosis in cardiomyocytes. |
2014-04-11 |
2023-08-12 |
Not clear |
| Cheng Huang, Suz-Yi Lee, Chih-Li Lin, Tzu-Huei Tu, Ling Hsuan Chen, Yi Jing Chen, Hsiu-Chen Huan. Co-treatment with quercetin and 1,2,3,4,6-penta-O-galloyl-β-D-glucose causes cell cycle arrest and apoptosis in human breast cancer MDA-MB-231 and AU565 cells. Journal of agricultural and food chemistry. vol 61. issue 26. 2013-12-31. PMID:23731217. |
after treatment of each cell line with these compounds, we found that que combined with 5gg induced s-phase arrest and apoptosis in mda-bm-231 cells through downregulation of s-phase kinase protein 2 expression, but induced g2/m-phase arrest and apoptosis in au565 cells through downregulation of her2 expression. |
2013-12-31 |
2023-08-12 |
human |
| Kristine Kleivi Sahlberg, Vesa Hongisto, Henrik Edgren, Rami Mäkelä, Kirsi Hellström, Eldri U Due, Hans Kristian Moen Vollan, Niko Sahlberg, Maija Wolf, Anne-Lise Børresen-Dale, Merja Perälä, Olli Kallioniem. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23253899. |
silencing of her2 caused a greater growth arrest and apoptosis in the responding compared to the non-responding cell lines, indicating that the resistant cells are inherently less dependent on the her2 pathway. |
2013-12-23 |
2023-08-12 |
Not clear |
| Kristine Kleivi Sahlberg, Vesa Hongisto, Henrik Edgren, Rami Mäkelä, Kirsi Hellström, Eldri U Due, Hans Kristian Moen Vollan, Niko Sahlberg, Maija Wolf, Anne-Lise Børresen-Dale, Merja Perälä, Olli Kallioniem. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23253899. |
importantly, co-silencing of stard3, grb7, psmd3 and perld1 together with her2 led to an additive inhibition of cell viability as well as induced apoptosis. |
2013-12-23 |
2023-08-12 |
Not clear |
| F M Berglund, N R Weerasinghe, L Davidson, J C Lim, B J Eickholt, N R Lesli. Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1. Oncogene. vol 32. issue 37. 2013-11-08. PMID:23085752. |
changes in her2, pten, pik3ca and akt have all been reported to lead to both enhanced proliferation and failures in hollow lumen formation in three dimensional epithelial culture models, but it is not clear whether these failures in lumen formation are caused by any failure in the spatial coordination of lumen formation (hollowing) or purely a failure in the apoptosis and clearance of luminal cells (cavitation). |
2013-11-08 |
2023-08-12 |
Not clear |
| Zev A Wainberg, Adrian Anghel, Amy M Rogers, Amrita J Desai, Ondrej Kalous, Dylan Conklin, Raul Ayala, Neil A O'Brien, Cornelia Quadt, Mikhail Akimov, Dennis J Slamon, Richard S Fin. Inhibition of HSP90 with AUY922 induces synergy in HER2-amplified trastuzumab-resistant breast and gastric cancer. Molecular cancer therapeutics. vol 12. issue 4. 2013-10-22. PMID:23395886. |
in vitro, the combination induced greater decreases in her2, a g2 cell-cycle arrest, and increased apoptosis. |
2013-10-22 |
2023-08-12 |
human |
| Marc Y Fink, Jerry E Chipu. Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers. Genes & cancer. vol 4. issue 5-6. 2013-09-26. PMID:24069506. |
in particular, the mitochondrial pathway for apoptosis is important for death induced by inhibitors of her2. |
2013-09-26 |
2023-08-12 |
Not clear |
| Tian-wen Chen, Ya-nan Liang, Duo Feng, Lin-yu Tao, Ke Qi, Hao-yun Zhang, Hong-xian Wang, Qiu-sheng Lin, Heng Kon. Metformin inhibits proliferation and promotes apoptosis of HER2 positive breast cancer cells by downregulating HSP90. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 18. issue 1. 2013-06-26. PMID:23613388. |
metformin inhibits proliferation and promotes apoptosis of her2 positive breast cancer cells by downregulating hsp90. |
2013-06-26 |
2023-08-12 |
Not clear |
| D Kostyal, R S Welt, J Danko, T Shay, C Lanning, K Horton, S Wel. Trastuzumab and lapatinib modulation of HER2 tyrosine/threonine phosphorylation and cell signaling. Medical oncology (Northwood, London, England). vol 29. issue 3. 2013-06-14. PMID:21769502. |
taken together, these results demonstrate that inhibition of her2 phosphorylation by lapatinib is sufficient to induce apoptosis while trastuzumab binding to the extracellular her2 domain may function by sterically modulating the detection of phosphate moieties by cytoplasmic signal transducers. |
2013-06-14 |
2023-08-12 |
Not clear |
| Joep P J de Hoon, Jürgen Veeck, Birgit E P J Vriens, Tim G A Calon, Manon van Engeland, Vivianne C G Tjan-Heijne. Taxane resistance in breast cancer: a closed HER2 circuit? Biochimica et biophysica acta. vol 1825. issue 2. 2013-03-12. PMID:22280939. |
interestingly, besides altered microtubule physiology we identified the her2 signaling cascade as a major dominator influencing several routes of cytotoxicity escape, such as cell survival, apoptosis, drug efflux, and drug metabolism. |
2013-03-12 |
2023-08-12 |
Not clear |
| Javier A Menendez, Cristina Oliveras-Ferraros, Sílvia Cufí, Bruna Corominas-Faja, Jorge Joven, Begoña Martin-Castillo, Alejandro Vazquez-Marti. Metformin is synthetically lethal with glucose withdrawal in cancer cells. Cell cycle (Georgetown, Tex.). vol 11. issue 15. 2013-02-01. PMID:22809961. |
under glucose withdrawal stress, metformin supplementation circumvented the ability of oncogenes (e.g., her2) to protect breast cancer cells from glucose-deprivation apoptosis. |
2013-02-01 |
2023-08-12 |
Not clear |
| Xiao-Feng Le, Maria I Almeida, Weiqun Mao, Riccardo Spizzo, Simona Rossi, Milena S Nicoloso, Shu Zhang, Yun Wu, George A Calin, Robert C Bas. Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer. PloS one. vol 7. issue 7. 2012-12-07. PMID:22829924. |
forced expression of mir-194 in breast cancer cells that overexpress her2 produced no effect on apoptosis, modest inhibition of proliferation, significant inhibition of cell migration/invasion in vitro and significant inhibition of xenograft growth in vivo. |
2012-12-07 |
2023-08-12 |
human |
| Anthony C Faber, Ryan B Corcoran, Hiromichi Ebi, Lecia V Sequist, Belinda A Waltman, Euiheon Chung, Joao Incio, Subba R Digumarthy, Sarah F Pollack, Youngchul Song, Alona Muzikansky, Eugene Lifshits, Sylvie Roberge, Erik J Coffman, Cyril H Benes, Henry L Gómez, José Baselga, Carlos L Arteaga, Miguel N Rivera, Dora Dias-Santagata, Rakesh K Jain, Jeffrey A Engelma. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer discovery. vol 1. issue 4. 2012-11-21. PMID:22145099. |
surprisingly, pretreatment rna levels of the bh3-only pro-apoptotic bim strongly predicted the capacity of egfr, her2, and pi3k inhibitors to induce apoptosis in egfr-mutant, her2-amplified, and pik3ca-mutant cancers, respectively, but bim levels did not predict responsiveness to standard chemotherapies. |
2012-11-21 |
2023-08-12 |
Not clear |
| Hideo Tomioka, Toru Mukohara, Yu Kataoka, Roudy Chiminch Ekyalongo, Yohei Funakoshi, Yasuo Imai, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minam. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. International journal of oncology. vol 41. issue 2. 2012-10-19. PMID:22614071. |
inhibition of the mtor/s6k signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with her2 amplification. |
2012-10-19 |
2023-08-12 |
Not clear |