| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine E Schaberg, Venktesh S Shirure, Elizabeth A Worley, Steven C George, Kristen M Naegl. Ensemble clustering of phosphoproteomic data identifies differences in protein interactions and cell-cell junction integrity of HER2-overexpressing cells. Integrative biology : quantitative biosciences from nano to macro. vol 9. issue 6. 2018-04-02. PMID:28492659. |
our cell and molecular biology experiments demonstrate that shc and ctnnd1 interact in an egf- and her2-dependent manner and that the cell junctions are phenotypically affected by her2, breaking down in response to egf and yet avoiding apoptosis as a result of cell junction loss. |
2018-04-02 |
2023-08-13 |
Not clear |
| Marco Silipo, Hannah Gautrey, Swapna Satam, Thomas Lennard, Alison Tyson-Cappe. How is Herstatin, a tumor suppressor splice variant of the oncogene HER2, regulated? RNA biology. vol 14. issue 5. 2018-03-12. PMID:27935425. |
herstatin acts as a tumor suppressor by effectively blocking her2 activity and cell proliferation, while promoting apoptosis. |
2018-03-12 |
2023-08-13 |
human |
| Bruna Corominas-Faja, Luciano Vellon, Elisabet Cuyàs, Maria Buxó, Begoña Martin-Castillo, Dolors Serra, Jordi García, Ruth Lupu, Javier A Menende. Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer. Histology and histopathology. vol 32. issue 7. 2018-03-07. PMID:27714708. |
furthermore, in the presence of high concentrations of c75, her2-negative mcf-7 breast cancer cells overexpressing her2 (mcf-7/her2) had significantly higher levels of apoptosis than her2-negative cells. |
2018-03-07 |
2023-08-13 |
human |
| Yuan Lu, Yuan Wang, Mi Zhang, Li Liu, Fakai Li, Jian Zhang, Mingxiang Ye, Hu Zhao, Jing Zhao, Bo Yan, Angang Yang, Rui Zhang, Xia Li, Xinling Re. HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth. Oncotarget. vol 7. issue 17. 2018-02-07. PMID:26988752. |
importantly, intravenous injection of scfv-9r/her2-sirna complex markedly suppressed growth of egfr-positive nsclc xenograft in nude mice, resulting from downregulated her2 expression, reduced cell proliferation and enhanced cell apoptosis. |
2018-02-07 |
2023-08-13 |
mouse |
| Debora de Melo Gagliato, Denis Leonardo Fontes Jardim, Mario Sergio Pereira Marchesi, Gabriel N Hortobagy. Mechanisms of resistance and sensitivity to anti-HER2 therapies in HER2+ breast cancer. Oncotarget. vol 7. issue 39. 2018-02-06. PMID:26824988. |
phosphorylation of tyrosine residues within the cytoplasmic domain is the result of receptor dimerization and culminates into initiation of a variety of signalling pathways involved in cellular proliferation, transcription, motility and apoptosis inhibition [5].in addition to being an important prognostic factor in women diagnosed with bc, her2 overexpression also identifies those patients who benefit from treatment with agents that target her2, such as trastuzumab, pertuzumab, trastuzumab emtansine (t-dm1) and small molecules tyrosine kinase inhibitors of her2 [6, 11, 127].in fact, trastuzumab altered the natural history of patients diagnosed with her2+ bc, both in early and metastatic disease setting, in a major way [8-10]. |
2018-02-06 |
2023-08-13 |
human |
| Mossa Gardaneh, Sahar Shojaei, Ahmad Kaviani, Babak Behna. GDNF induces RET-SRC-HER2-dependent growth in trastuzumab-sensitive but SRC-independent growth in resistant breast tumor cells. Breast cancer research and treatment. vol 162. issue 2. 2017-12-07. PMID:28116540. |
we investigated the role of glial cell line-derived neurotrophic factor (gdnf) in compensating trastuzumab (tzmb)-induced apoptosis in her2 |
2017-12-07 |
2023-08-13 |
Not clear |
| Pilar Diz Taín, Ana López González, Andrés García-Palom. [Mechanism of action and preclinical development of afatinib]. Medicina clinica. vol 146 Suppl 1. 2017-11-09. PMID:27426242. |
covalent attachment to cysteine residues in the catalytic domain of egfr, her2 and erbb4 inhibits the tyrosine kinase activity (tkis) of these receptors, decreasing auto- and transphosphorylation between erbb dimers, and thus blocking the activity of downstream signalling pathways related to growth and apoptosis suppression. |
2017-11-09 |
2023-08-13 |
Not clear |
| Min Ma, Yi Ma, Gui-Juan Zhang, Rui Liao, Xue-Feng Jiang, Xian-Xin Yan, Feng-Jie Bie, Xiao-Bo Li, Yan-Hong L. Eugenol alleviated breast precancerous lesions through HER2/PI3K-AKT pathway-induced cell apoptosis and S-phase arrest. Oncotarget. vol 8. issue 34. 2017-09-25. PMID:28915591. |
eugenol also significantly induced human breast precancerous lesion mcf-10at cell apoptosis and cell cycle s-phase arrest, but the biological effects nearly disappeared after her2 over-expression through transfecting pcdna3.1-her2. |
2017-09-25 |
2023-08-13 |
human |
| Ji Young Kim, Youngkwan Cho, Eunhye Oh, Nahyun Lee, Hyunsook An, Daeil Sung, Tae-Min Cho, Jae Hong Se. Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27238567. |
dsf/cu treatment induced apoptosis, associated with a marked decrease in her2, truncated p95her2, phospho-her2, her3, phospho-her3 and phospho-akt levels, and p27 nuclear accumulation. |
2017-07-26 |
2023-08-13 |
Not clear |
| Ji Young Kim, Youngkwan Cho, Eunhye Oh, Nahyun Lee, Hyunsook An, Daeil Sung, Tae-Min Cho, Jae Hong Se. Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27238567. |
dsf administration resulted in a significant reduction in tumor growth and an enhancement of apoptosis, as well as her2 intracellular domain (icd) and aldh1a1 downregulation. |
2017-07-26 |
2023-08-13 |
Not clear |
| Longqiang Cheng, Bingxiang Zhan, Peng Luo, Baolong Wan. miRNA‑375 regulates the cell survival and apoptosis of human non‑small cell carcinoma by targeting HER2. Molecular medicine reports. vol 15. issue 3. 2017-07-13. PMID:28098887. |
mirna‑375 regulates the cell survival and apoptosis of human non‑small cell carcinoma by targeting her2. |
2017-07-13 |
2023-08-13 |
mouse |
| Leiming Zhang, Junlin Ren, Hangyu Zhang, Gang Cheng, Yanming Xu, Shuangwu Yang, Chao Dong, Dandong Fang, Jianning Zhang, Angang Yan. HER2-targeted recombinant protein immuno-caspase-6 effectively induces apoptosis in HER2-overexpressing GBM cells in vitro and in vivo. Oncology reports. vol 36. issue 5. 2017-03-13. PMID:27633091. |
following specific binding to and internalization into her2-overexpressing tumor cells, the e23sfv-fdt-casp6 protein induced tumor cell apoptosis and inhibited the proliferation of her2-overexpressing a172 and u251mg cells in vitro, but not in u87mg cells with undetectable her2. |
2017-03-13 |
2023-08-13 |
mouse |
| Xin Li, Jinmei Xu, Xi Tang, Yilun Liu, Xiaoping Yu, Zhi Wang, Weihua Li. Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo. Molecular medicine reports. vol 13. issue 5. 2017-02-16. PMID:26985659. |
cyanidin-3-glucoside and peonidin-3-glucoside were able to inhibit phosphorylation of her2, induce apoptosis, suppress migration and invasion, and inhibit tumor cell growth. |
2017-02-16 |
2023-08-13 |
human |
| Neda Esfandiari, Mohsen Karimi Arzanani, Masoud Soleimani, Mina Kohi-Habibi, Winnie E Svendse. A new application of plant virus nanoparticles as drug delivery in breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-07. PMID:26286831. |
we investigated the efficiency of pvx-herceptin to induce sk-ov-3 and sk-br-3 cells (her2 positive cell lines) apoptosis. |
2017-02-07 |
2023-08-13 |
Not clear |
| Kavisha Patidar, Aruna Deshmukh, Srinivas Bandaru, Chandana Lakkaraju, Amandeep Girdhar, Gutlapalli Vr, Tushar Banerjee, Anuraj Nayarisseri, Sanjeev Kumar Sing. Virtual Screening Approaches in Identification of Bioactive Compounds Akin to Delphinidin as Potential HER2 Inhibitors for the Treatment of Breast Cancer. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 4. 2017-01-26. PMID:27221932. |
recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting her2 receptors. |
2017-01-26 |
2023-08-13 |
Not clear |
| Somchai Kritsanawong, Sukanda Innajak, Masaya Imoto, Ramida Watanapokasi. Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. International journal of oncology. vol 48. issue 5. 2016-12-26. PMID:26892433. |
human epidermal growth factor receptor 2 (her2) and mitogen-activated protein kinase (mapk) signaling have been shown to play important roles in apoptosis. |
2016-12-26 |
2023-08-13 |
human |
| Raju Vivek, Ramar Thangam, Selvaraj Rajesh Kumar, Chandrababu Rejeeth, Gopal Senthil Kumar, Srinivasan Sivasubramanian, Savariar Vincent, Dhanaraj Gopi, Soundarapandian Kanna. HER2 Targeted Breast Cancer Therapy with Switchable "Off/On" Multifunctional "Smart" Magnetic Polymer Core-Shell Nanocomposites. ACS applied materials & interfaces. vol 8. issue 3. 2016-10-31. PMID:26771508. |
the prepared her-fe3o4@plga-pvp nanocomposites facilitate packing of anticancer drug (tamoxifen) without premature release in the bloodstream, recognizing the target cells through binding of herceptin antibody to her2, a cell surface receptor expressed by breast cancer cells to promote her2 receptor mediated endocytosis and finally releasing the drug at the intracellular site of tumor cells ("on" state) to induce apoptosis. |
2016-10-31 |
2023-08-13 |
Not clear |
| Dongli Zhao, Yanxia Sui, Xiaoqiang Zhen. MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. Oncology reports. vol 35. issue 2. 2016-10-17. PMID:26718987. |
mir-331-3p inhibits proliferation and promotes apoptosis by targeting her2 through the pi3k/akt and erk1/2 pathways in colorectal cancer. |
2016-10-17 |
2023-08-13 |
Not clear |
| Xu Wan, Xiaoyao Zheng, Xiaoying Pang, Zheming Zhang, Qizhi Zhan. Incorporation of lapatinib into human serum albumin nanoparticles with enhanced anti-tumor effects in HER2-positive breast cancer. Colloids and surfaces. B, Biointerfaces. vol 136. 2016-09-26. PMID:26539808. |
furthermore, in vitro and in vivo data indicated that lhnps presented the strong ability to induce apoptosis and superior anti-tumor efficacy in tumor-bearing mice to the commercial tablet tykerb through the inhibition of her2 phosphorylation. |
2016-09-26 |
2023-08-13 |
mouse |
| Kin-Mei Leung, Sarah Batey, Robert Rowlands, Samine J Isaac, Phil Jones, Victoria Drewett, Joana Carvalho, Miguel Gaspar, Sarah Weller, Melanie Medcalf, Mateusz M Wydro, Robert Pegram, Geert C Mudde, Anton Bauer, Kevin Moulder, Max Woisetschläger, Mihriban Tuna, John S Haurum, Haijun Su. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 11. 2016-09-20. PMID:26234505. |
a her2-specific modified fc fragment (fcab) induces antitumor effects through degradation of her2 and apoptosis. |
2016-09-20 |
2023-08-13 |
Not clear |