| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Man Zhu, Xiaoyu Tang, Zhengyan Gong, Wenjuan Tang, Yanmin Zhan. TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner. Life sciences. vol 285. 2021-11-15. PMID:34520770. |
inhibition of her2 or ephb4 is discovered to induce ros-dependent apoptosis by decreasing e-cadherin expression in skbr3 and mda-mb-453 cells. |
2021-11-15 |
2023-08-13 |
Not clear |
| Man Zhu, Xiaoyu Tang, Zhengyan Gong, Wenjuan Tang, Yanmin Zhan. TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner. Life sciences. vol 285. 2021-11-15. PMID:34520770. |
mechanistic investigation revealed that tad blockades both ephb4 positive signal transduction and activation of her2 signal transduction, thereby suppressing e-cadherin/tgf-β/p-smad2/3 signaling axis to elicit ros-dependent endogenous mitochondrial apoptosis. |
2021-11-15 |
2023-08-13 |
Not clear |
| Man Zhu, Xiaoyu Tang, Zhengyan Gong, Wenjuan Tang, Yanmin Zhan. TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner. Life sciences. vol 285. 2021-11-15. PMID:34520770. |
together, these findings not only provide a new approach for her2-bc therapy but also increase our understanding of the regulating effect of e-cadherin by her2 and ephb4 in ros-mediated apoptosis. |
2021-11-15 |
2023-08-13 |
Not clear |
| Min-Gu Lee, Kyu-Shik Lee, Kyung-Soo Na. Arctigenin-mediated cell death of SK-BR-3 cells is caused by HER2 inhibition and autophagy-linked apoptosis. Pharmacological reports : PR. vol 73. issue 2. 2021-11-02. PMID:33677703. |
arctigenin-mediated cell death of sk-br-3 cells is caused by her2 inhibition and autophagy-linked apoptosis. |
2021-11-02 |
2023-08-13 |
human |
| Meetu Kaushik Tiwari, Daniel A Colon-Rios, Hemanta C Rao Tumu, Yanfeng Liu, Elias Quijano, Adam Krysztofiak, Cynthia Chan, Eric Song, Demetrios T Braddock, Hee-Won Suh, W Mark Saltzman, Faye A Roger. Direct targeting of amplified gene loci for proapoptotic anticancer therapy. Nature biotechnology. 2021-10-29. PMID:34711990. |
focusing on cancers driven by her2 amplification, we find that tfos targeting her2 induce copy number-dependent dna double-strand breaks (dsbs) and activate p53-independent apoptosis in her2-positive cancer cells and human tumor xenografts via a mechanism that is independent of her2 cellular function. |
2021-10-29 |
2023-08-13 |
human |
| Yuan-Wan Sun, Ting-Kuang Niu, Jin-Ming Yang, Chul-Hoon Kwon, Kuen-Yuan Chen, Kun-Ming Che. Potentiation of the growth inhibition activity of 2-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(2-hydroxyethyl)amino)ethan-1-ol (CK0402) by Herceptin in SKBR-3 human breast cancer cells. Experimental and therapeutic medicine. vol 1. issue 3. 2021-10-21. PMID:22993569. |
in addition, ck0402 also induced stronger g(2)/m arrest, apoptosis and autophagy in skbr-3 cells than in er(+) and her2(-) mcf-7 cells. |
2021-10-21 |
2023-08-12 |
human |
| Chien-Chang Kao, Yi-Ching Cheng, Ming-Hsin Yang, Tai-Lung Cha, Guang-Huan Sun, Chi-Tang Ho, Ying-Chao Lin, Hao-Kuang Wang, Sheng-Tang Wu, Tzong-Der Wa. Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway. Environmental toxicology. vol 36. issue 11. 2021-10-05. PMID:34291863. |
demethoxycurcumin induces apoptosis in her2 overexpressing bladder cancer cells through degradation of her2 and inhibiting the pi3k/akt pathway. |
2021-10-05 |
2023-08-13 |
human |
| Chien-Chang Kao, Yi-Ching Cheng, Ming-Hsin Yang, Tai-Lung Cha, Guang-Huan Sun, Chi-Tang Ho, Ying-Chao Lin, Hao-Kuang Wang, Sheng-Tang Wu, Tzong-Der Wa. Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway. Environmental toxicology. vol 36. issue 11. 2021-10-05. PMID:34291863. |
among the test compounds, dmc significantly suppressed the expression of her2, and preferentially inhibited cell proliferation and induced apoptosis in her2-overexpressing bladder cancer cells. |
2021-10-05 |
2023-08-13 |
human |
| Bo Luo, Xin-Hong Wu, Yao-Jun Feng, Hong-Mei Zheng, Qu Zhang, Xin-Jun Liang, Ding-Feng Huang, Juan X. Nuclear Her2 contributes to paclitaxel resistance in breast cancer cells. Anti-cancer drugs. vol 32. issue 7. 2021-09-07. PMID:33587352. |
her2 nuclear expression decreases paclitaxel-induced apoptosis. |
2021-09-07 |
2023-08-13 |
Not clear |
| Junbiao Wang, Romilde Iannarelli, Stefania Pucciarelli, Emiliano Laudadio, Roberta Galeazzi, Mara Giangrossi, Maurizio Falconi, Lishan Cui, Aleix Marti Navia, Michela Buccioni, Gabriella Marucci, Daniele Tomassoni, Laura Serini, Stefania Sut, Filippo Maggi, Stefano Dall'Acqua, Cristina Marchini, Augusto Amic. Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice. Pharmacological research. vol 161. 2021-09-01. PMID:32822867. |
acetylshikonin anticancer effect depends on its ability to act as a potent inhibitor of dihydrofolate reductase (dhfr), to down-regulate key mediators governing cancer growth and progression, such as her2, src and stat3, and to induce apoptosis by caspase-3 activation. |
2021-09-01 |
2023-08-13 |
mouse |
| Rohit Sharma, Mythili Kameswaran, Usha Pandey, Ashutosh Das. Dose-dependent cell cycle arrest and apoptosis in HER2 breast cancer cells by Journal of cancer research and therapeutics. vol 16. issue 6. 2021-08-23. PMID:33342808. |
dose-dependent cell cycle arrest and apoptosis in her2 breast cancer cells by trastuzumab is a food and drug administration-approved humanized monoclonal antibody which targets the extracellular domain of human epidermal growth factor receptor 2 (her2) receptor overexpressed on her2-positive breast cancer cells. |
2021-08-23 |
2023-08-13 |
human |
| Nandini Dey, Jennifer Aske, Xiaoqian Lin, Yuliang Sun, Brian Leyland-Jones, Lori Friedman, Pradip D. A tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy. American journal of cancer research. vol 11. issue 6. 2021-07-13. PMID:34249433. |
a tipping-point for apoptosis following dual inhibition of her2 signaling network by t-dm1 plus gdc-0980 maximizes anti-tumor efficacy. |
2021-07-13 |
2023-08-13 |
Not clear |
| Zizhong Xu, Yating Hu, Zhaohui Y. Effect of the ACY-1 gene on HER2 and TRAIL expression in rectal carcinoma. Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-17. PMID:34131440. |
furthermore, the human epidermal growth factor receptor-2 (her2) gene is involved in tumor metastasis and invasion, while tumor necrosis factor-related apoptosis-inducing ligand (trail) induces tumor cell apoptosis. |
2021-06-17 |
2023-08-13 |
human |
| Maria Maddalena Laterza, Vincenza Ciaramella, Bianca Arianna Facchini, Elisena Franzese, Carmela Liguori, Stefano De Falco, Paola Coppola, Luca Pompella, Giuseppe Tirino, Massimiliano Berretta, Liliana Montella, Gaetano Facchini, Fortunato Ciardiello, Ferdinando de Vit. Enhanced Antitumor Effect of Trastuzumab and Duligotuzumab or Ipatasertib Combination in HER-2 Positive Gastric Cancer Cells. Cancers. vol 13. issue 10. 2021-06-05. PMID:34066144. |
we have assessed the efficacy of duligotuzumab or ipatasertib and trastuzumab in combination, analyzing proliferation, migration and apoptosis and downstream intracellular signaling in vitro on human her2-positive gcc (nci-n87, oe33, oe19) and in negative her2 gcc (mkn28). |
2021-06-05 |
2023-08-13 |
human |
| Cinzia Antognelli, Isabella Palumbo, Simonetta Piattoni, Monica Calzuola, Beatrice Del Papa, Vincenzo N Talesa, Cynthia Ariste. Exploring the radiosensitizing potential of AZD8931: a pilot study on the human LoVo colorectal cancer cell line. International journal of radiation biology. vol 96. issue 11. 2021-05-24. PMID:32910714. |
to explore the radiosensitizing effect of azd8931, a novel equipotent and reversible inhibitor of signaling by egfr (her1), her2 and her3 receptors, focusing on cell cycle progression, apoptosis and clonogenic capacity in the human lovo colorectal cancer (crc) cell line, also in comparison with the egfr-blocking monoclonal antibody cetuximab or the egfr tyrosine kinase selective small molecular inhibitor gefitinib. |
2021-05-24 |
2023-08-13 |
human |
| Andreia Gameiro, Catarina Nascimento, Jorge Correia, Fernando Ferreir. HER2-Targeted Immunotherapy and Combined Protocols Showed Promising Antiproliferative Effects in Feline Mammary Carcinoma Cell-Based Models. Cancers. vol 13. issue 9. 2021-05-18. PMID:33919468. |
while, in human breast cancer, the use of anti-her2 monoclonal antibodies (mabs) is common, acting by blocking the extracellular domain (ecd) of the her2 protein and by inducing cell apoptosis, scarce information is available on use these immunoagents in fmc. |
2021-05-18 |
2023-08-13 |
human |
| Sven Roßwag, Cristina L Cotarelo, Klaus Pantel, Sabine Riethdorf, Jonathan P Sleeman, Marcus Schmidt, Sonja Thale. Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2- Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2- Breast Cancer. Cancers. vol 13. issue 8. 2021-05-02. PMID:33920089. |
inhibition of nfkb signaling blocked expression of her2 and foxm1 in the ctcs, and induced apoptosis. |
2021-05-02 |
2023-08-13 |
Not clear |
| Parvaneh Maleki, Hamid Gourabi, Mohammad Tahmaseb, Afsaneh Golkar-Narenji, Masood Bazrga. Lapatinib Decreases the Preimplantation Aneuploidy Rate of in vitro Fertilized Mouse Embryos without Affecting Completion of Preimplantation Development. Cytogenetic and genome research. vol 160. issue 11-12. 2021-04-16. PMID:33176309. |
lapatinib simultaneously inhibits egfr and her2, leading to apoptosis. |
2021-04-16 |
2023-08-13 |
mouse |
| A A Daks, O A Fedorova, O Y Shuvalov, S E Parfenev, N A Barle. The Role of ERBB2/HER2 Tyrosine Kinase Receptor in the Regulation of Cell Death. Biochemistry. Biokhimiia. vol 85. issue 10. 2021-03-17. PMID:33202212. |
here, we review the studies focused on the involvement of her2 in various signaling pathways and its role in the regulation of apoptosis. |
2021-03-17 |
2023-08-13 |
human |
| Alberto Cedro-Tanda, Magdalena Ríos-Romero, Sandra Romero-Córdoba, Mireya Cisneros-Villanueva, Rosa Gloria Rebollar-Vega, Luis Alberto Alfaro-Ruiz, Silvia Jiménez-Morales, Carlos Domínguez-Reyes, Felipe Villegas-Carlos, Alberto Tenorio-Torres, Veronica Bautista-Piña, Fredy Omar Beltrán-Anaya, Alfredo Hidalgo-Mirand. A lncRNA landscape in breast cancer reveals a potential role for AC009283.1 in proliferation and apoptosis in HER2-enriched subtype. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32753692. |
these studies revealed that ac009283.1 regulates genes involved in proliferation, cell cycle and apoptosis in a her2 cellular model. |
2020-12-08 |
2023-08-13 |
human |