| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Sazzad Hassan, Fiona Williams, Niranjan Awasthi, Margaret A Schwarz, Roderich E Schwarz, Jun Li, Urs von Holze. Combination effect of lapatinib with foretinib in HER2 and MET co-activated experimental esophageal adenocarcinoma. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31772236. |
the co-administration of foretinib and lapatinib effectively inhibited both met and her2 phosphorylation, enhanced inhibition of cell proliferation and xenograft tumor growth by inducing apoptosis, and significantly enhanced mouse overall survival, overcoming single agent resistance. |
2020-11-09 |
2023-08-13 |
mouse |
| Md Sazzad Hassan, Fiona Williams, Niranjan Awasthi, Margaret A Schwarz, Roderich E Schwarz, Jun Li, Urs von Holze. Combination effect of lapatinib with foretinib in HER2 and MET co-activated experimental esophageal adenocarcinoma. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31772236. |
in the oe19 eac cell line with mainly her2 phosphorylation, and the eso51 eac cell line with mainly met phosphorylation, profound cell growth inhibition with induction of apoptosis was observed in response to single agent with lack of enhanced growth inhibition when the two agents were combined. |
2020-11-09 |
2023-08-13 |
mouse |
| Nehal Gupta, Parul Gupta, Sanjay K Srivastav. Penfluridol overcomes paclitaxel resistance in metastatic breast cancer. Scientific reports. vol 9. issue 1. 2020-10-05. PMID:30911062. |
in addition, tumors from paclitaxel and pfl-treated mice showed reduced her2 and β-catenin expression, along with increased apoptosis. |
2020-10-05 |
2023-08-13 |
mouse |
| Richard L Carpenter, Hui-Wen L. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of carcinogenesis & mutagenesis. vol 2013. issue Suppl 7. 2020-10-01. PMID:27088047. |
regulation of apoptosis by her2 in breast cancer. |
2020-10-01 |
2023-08-13 |
Not clear |
| Richard L Carpenter, Hui-Wen L. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of carcinogenesis & mutagenesis. vol 2013. issue Suppl 7. 2020-10-01. PMID:27088047. |
a primary function of her2 is suppressing apoptosis to enhance cell survival giving rise to uncontrolled proliferation and tumor growth. |
2020-10-01 |
2023-08-13 |
Not clear |
| Richard L Carpenter, Hui-Wen L. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of carcinogenesis & mutagenesis. vol 2013. issue Suppl 7. 2020-10-01. PMID:27088047. |
there has been much investigation into the mechanisms by which apoptosis is suppressed by her2 in hopes of finding clinical targets for her2-positive breast cancers as these cancers often become resistant to therapies that directly target her2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Richard L Carpenter, Hui-Wen L. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of carcinogenesis & mutagenesis. vol 2013. issue Suppl 7. 2020-10-01. PMID:27088047. |
her2-mediated activation of pi3k-akt signaling is required for many of the mechanisms her2 uses to suppress apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Richard L Carpenter, Hui-Wen L. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of carcinogenesis & mutagenesis. vol 2013. issue Suppl 7. 2020-10-01. PMID:27088047. |
her2 also suppresses p53-mediated apoptosis by upregulation of mdm2 by activation of akt. |
2020-10-01 |
2023-08-13 |
Not clear |
| Richard L Carpenter, Hui-Wen L. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of carcinogenesis & mutagenesis. vol 2013. issue Suppl 7. 2020-10-01. PMID:27088047. |
there is also recent evidence to suggest her2 can directly influence apoptosis by translocation to the mitochondria to inhibit cytochrome |
2020-10-01 |
2023-08-13 |
Not clear |
| Babak Nami, Hamid Maadi, Zhixiang Wan. The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation. Cancers. vol 11. issue 3. 2020-10-01. PMID:30884851. |
our results also showed that pertuzumab, but not trastuzumab, abrogated the effect of her2 overexpression on cell cycle in particular g1/s transition, g2/m transition, and m phase, whereas trastuzumab abolished the inhibitory effect of her2 on apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Abdulfattah Salah Fararjeh, Li-Ching Chen, Yuan-Soon Ho, Tzu-Chun Cheng, Yun-Ru Liu, Hang-Lung Chang, Hui-Wen Chang, Chih-Hsiung Wu, Shih-Hsin T. Proteasome 26S Subunit, non-ATPase 3 (PSMD3) Regulates Breast Cancer by Stabilizing HER2 from Degradation. Cancers. vol 11. issue 4. 2020-10-01. PMID:31013812. |
knockdown of psmd3 significantly impaired the stability of her2, inhibited bc cell proliferation and colony formation, and induced cell apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Michael E Grossmann, Da-Qing Yang, Zhijun Guo, David A Potter, Margot P Clear. Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis. Current pharmacology reports. vol 1. issue 5. 2020-09-30. PMID:26405648. |
in addition to the anticancer effect of metformin mediated through the ampk pathway, additional mechanisms of action that directly target tissues have been identified including effects on stem cells, apoptosis, stat3 and her2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yun Yang, Feng Ren, Ziyin Tian, Wei Song, Binfeng Cheng, Zhiwei Fen. Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30538636. |
osthole synergizes with her2 inhibitor, trastuzumab in her2-overexpressed n87 gastric cancer by inducing apoptosis and inhibition of akt-mapk pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Praful R Nai. Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems. Polymers. vol 11. issue 4. 2020-09-30. PMID:30959799. |
these include inhibition of oncogenic pathways (including those involving her2, egfr, mapk, pi3k/akt, stat3, and hif-1α), augmentation of apoptosis by inhibiting anti-apoptosis proteins (bcl-2, bcl-xl, and survivin), and targeting dysregulated pathways such as wnt/β-catenin and hedgehog. |
2020-09-30 |
2023-08-13 |
Not clear |
| Liang Xia, Yang Wang, Yuhua Hu, Chunye Zhang, Ting Gu, Lizhen Wang, Jiang Li, Wenwen Yu, Zhen Tia. Human epithelial growth factor receptor 2 in human salivary carcinoma ex pleomorphic adenoma: a potential therapeutic target. Cancer management and research. vol 10. 2020-09-29. PMID:30555262. |
to inhibit human epithelial growth factor receptor 2 (her2) in salivary carcinoma ex pleomorphic adenoma (cxpa) and investigate the effects on tumor cell proliferation, cell cycle, and apoptosis. |
2020-09-29 |
2023-08-13 |
human |
| Sara Alkhezayem, Tanveer A Wani, Salma Wakil, Ashwaq Aljuraysi, Seema Zarga. Transcriptome analysis of neratinib treated HER2 positive cancer model vs untreated cancer unravels the molecular mechanism of action of neratinib. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 28. issue 8. 2020-09-28. PMID:32792841. |
neratinib targets her2 and blocks its signal transduction resulting in inhibition of cell proliferation and induction of apoptosis without any information about the molecular mechanism involved. |
2020-09-28 |
2023-08-13 |
mouse |
| Sasha E Stanton, Ekram Gad, Lauren R Corulli, Hailing Lu, Mary L Disi. Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets. Vaccine. vol 37. issue 27. 2020-07-23. PMID:31126858. |
silencing protein expression of the early antigens increased apoptosis (p < 0.0001 for all antigens in mouse and p < 0.05 for all antigens in human triple negative breast cancer) and decreased survival (p < 0.0001 for all antigens in mouse and human triple negative and her2 positive breast cancer). |
2020-07-23 |
2023-08-13 |
mouse |
| Gulcan Bulut, Harika Atmaca, Burcak Karac. Trastuzumab in combination with AT-101 induces cytotoxicity and apoptosis in Her2 positive breast cancer cells. Future oncology (London, England). vol 16. issue 3. 2020-07-15. PMID:31829029. |
trastuzumab in combination with at-101 induces cytotoxicity and apoptosis in her2 positive breast cancer cells. |
2020-07-15 |
2023-08-13 |
Not clear |
| Mehri Abedi, Reza Ahangari Cohan, Fereidoun Mahboudi, Mohammad Ali Faramarzi, Ramin Fazel, Narges Damavandi, Mehdi Shafiee Ardestani, Fatemeh Davam. Novel trastuzumab-DM1 conjugate: Synthesis and bio-evaluation. Journal of cellular physiology. vol 234. issue 10. 2020-05-28. PMID:30854662. |
in vitro biological activity of trastuzumab-dm1 conjugates was assessed on breast cancer cell lines expressing different levels of her2 using binding affinity, antiproliferative, apoptosis, and antibody-dependent cell-mediated cytotoxicity (adcc) assays. |
2020-05-28 |
2023-08-13 |
Not clear |
| Wenjuan Ma, Yuxi Zhan, Yuxin Zhang, Xiaoru Shao, Xueping Xie, Chenchen Mao, Weitong Cui, Qian Li, Jiye Shi, Jiang Li, Chunhai Fan, Yunfeng Li. An Intelligent DNA Nanorobot with Nano letters. vol 19. issue 7. 2020-04-07. PMID:31185573. |
an increased her2 digestion through hapt-tfna further induced cell apoptosis and arrested cell growth. |
2020-04-07 |
2023-08-13 |
mouse |