| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Pan, S M Vickers, A Pickens, J O Phillips, W Ying, J A Thompson, G P Siegal, J M McDonal. Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin. The American journal of pathology. vol 155. issue 1. 1999-07-26. PMID:10393851. |
here we demonstrate that tamoxifen and trifluoperazine, both potent calmodulin antagonists, induce apoptosis in vitro, probably acting via the fas system, in human cholangiocarcinoma cells. |
1999-07-26 |
2023-08-12 |
mouse |
| G Pan, S M Vickers, A Pickens, J O Phillips, W Ying, J A Thompson, G P Siegal, J M McDonal. Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin. The American journal of pathology. vol 155. issue 1. 1999-07-26. PMID:10393851. |
fas antibody, tamoxifen, and trifluoperazine induced dose-dependent apoptosis only in fas-positive cells; fas-negative cells were unaffected. |
1999-07-26 |
2023-08-12 |
mouse |
| G Pan, S M Vickers, A Pickens, J O Phillips, W Ying, J A Thompson, G P Siegal, J M McDonal. Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin. The American journal of pathology. vol 155. issue 1. 1999-07-26. PMID:10393851. |
furthermore, apoptosis induced by tamoxifen in fas-positive cells was blocked by an inhibitory fas antibody. |
1999-07-26 |
2023-08-12 |
mouse |
| L R Feldenberg, S Thevananther, M del Rio, M de Leon, P Devaraja. Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells. The American journal of physiology. vol 276. issue 6. 1999-07-22. PMID:10362772. |
exogenous application of stimulatory fas monoclonal antibodies also induces apoptosis in nonischemic mdck cells, indicating that they retain fas-dependent pathways of programmed cell death. |
1999-07-22 |
2023-08-12 |
Not clear |
| S H Lee, M S Shin, W S Park, S Y Kim, H S Kim, J Y Han, G S Park, S M Dong, J H Pi, C S Kim, S H Kim, J Y Lee, N J Yo. Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer. Oncogene. vol 18. issue 25. 1999-07-22. PMID:10391683. |
however, many non-lymphoid tumor cells have been found to be resistant to fas-mediated apoptosis, which suggests that fas mutations, one of the possible mechanisms for fas-resistance, may be involved in the pathogenesis of non-lymphoid malignancies as well. |
1999-07-22 |
2023-08-12 |
human |
| P Ströbel, R Nanan, S Gattenlöhner, S Müller-Deubert, H K Müller-Hermelink, H W Kreth, A Mar. Reversible monoclonal lymphadenopathy in autoimmune lymphoproliferative syndrome with functional FAS (CD95/APO-1) deficiency. The American journal of surgical pathology. vol 23. issue 7. 1999-07-21. PMID:10403307. |
the fas (cd95/apo-1) receptor and its ligand play an important role in the initiation of apoptosis under many physiologic conditions. |
1999-07-21 |
2023-08-12 |
mouse |
| A R Chaudhuri, S St Jeor, J P Maciejewsk. Apoptosis induced by human cytomegalovirus infection can be enhanced by cytokines to limit the spread of virus. Experimental hematology. vol 27. issue 7. 1999-07-16. PMID:10390195. |
we have hypothesized that hcmv infection might directly or indirectly result in upregulation of fas receptor and in the presence of fas ligand, lead to apoptosis of infected cells. |
1999-07-16 |
2023-08-12 |
human |
| A R Chaudhuri, S St Jeor, J P Maciejewsk. Apoptosis induced by human cytomegalovirus infection can be enhanced by cytokines to limit the spread of virus. Experimental hematology. vol 27. issue 7. 1999-07-16. PMID:10390195. |
ifn-gamma, in addition to its intrinsic antiviral activity, primes hcmv infected cells to the action of fas ligand and fas-mediated apoptosis. |
1999-07-16 |
2023-08-12 |
human |
| D J Wilson, A Alessandrini, R C Bud. MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis. Cellular immunology. vol 194. issue 1. 1999-07-15. PMID:10357882. |
although the protease cascade initiated by fas (cd95, apo-1) is well characterized, there remains little known about how kinase pathways may impact on fas-mediated apoptosis. |
1999-07-15 |
2023-08-12 |
Not clear |
| D J Wilson, A Alessandrini, R C Bud. MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis. Cellular immunology. vol 194. issue 1. 1999-07-15. PMID:10357882. |
this was confirmed in the current study by showing that activation of mek1, the upstream regulator of erk, reduces fas-mediated apoptosis, whereas inhibition of mek1 augments apoptosis by fas. |
1999-07-15 |
2023-08-12 |
Not clear |
| D J Wilson, A Alessandrini, R C Bud. MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis. Cellular immunology. vol 194. issue 1. 1999-07-15. PMID:10357882. |
this is supported by the ability of the caspase blocker zvad to inhibit both apoptosis and jnk activation by fas. |
1999-07-15 |
2023-08-12 |
Not clear |
| E Bossy-Wetzel, D R Gree. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. The Journal of biological chemistry. vol 274. issue 25. 1999-07-15. PMID:10364179. |
when jurkat cells were induced to undergo apoptosis by fas receptor ligation, cytochrome c was released from mitochondria, an event that was prevented by the caspase inhibitor, zvad-fmk (zval-ala-asp-ch2f). |
1999-07-15 |
2023-08-12 |
Not clear |
| K A Young, B R Zirkin, R J Nelso. Short photoperiods evoke testicular apoptosis in white-footed mice (Peromyscus leucopus). Endocrinology. vol 140. issue 7. 1999-07-15. PMID:10385406. |
in the present study, the possible role of apoptosis was assessed during naturally occurring, short day-induced gonadal regression in white-footed mice by in situ terminal transferase-mediated end labeling (tunel), quantitative dna 3'-end-labeling autoradiography (laddering) of dna fragments, and quantification of fas protein expression, an early initiator of apoptosis. |
1999-07-15 |
2023-08-12 |
mouse |
| K A Young, B R Zirkin, R J Nelso. Short photoperiods evoke testicular apoptosis in white-footed mice (Peromyscus leucopus). Endocrinology. vol 140. issue 7. 1999-07-15. PMID:10385406. |
the increase in tunel positive-labeled germ cells, testicular dna fragmentation, and up-regulation of the fas protein before short day reductions of testis mass and function suggest that apoptosis is important for the mediation of photoperiod-induced testicular regression in white-footed mice. |
1999-07-15 |
2023-08-12 |
mouse |
| M S Shin, W S Park, S Y Kim, H S Kim, S J Kang, K Y Song, J Y Park, S M Dong, J H Pi, R R Oh, J Y Lee, N J Yoo, S H Le. Alterations of Fas (Apo-1/CD95) gene in cutaneous malignant melanoma. The American journal of pathology. vol 154. issue 6. 1999-07-14. PMID:10362803. |
however, many nonlymphoid tumor cells have been found to be resistant to fas-mediated apoptosis, which suggests that fas mutations, one of the possible mechanisms for fas resistance, may be involved in the pathogenesis of nonlymphoid malignancies as well. |
1999-07-14 |
2023-08-12 |
human |
| P Terheyden, C Siedel, A Merkel, E Kämpgen, E B Bröcker, J C Becke. Predominant expression of Fas (CD95) ligand in metastatic melanoma revealed by longitudinal analysis. The Journal of investigative dermatology. vol 112. issue 6. 1999-07-13. PMID:10383736. |
as fas ligand positive melanoma cells are capable of inducing apoptosis in susceptible cells, e.g., fas positive tumor infiltrating lymphocytes, we tested for the presence of apoptotic cells in situ by terminal deoxynucleotidyl transferase-mediated dutp nick end labeling. |
1999-07-13 |
2023-08-12 |
Not clear |
| P Terheyden, C Siedel, A Merkel, E Kämpgen, E B Bröcker, J C Becke. Predominant expression of Fas (CD95) ligand in metastatic melanoma revealed by longitudinal analysis. The Journal of investigative dermatology. vol 112. issue 6. 1999-07-13. PMID:10383736. |
thus, fas ligand mediated apoptosis does not seem to be a major immune escape mechanism for melanoma but its expression correlates with the stage of melanoma. |
1999-07-13 |
2023-08-12 |
Not clear |
| S S Metkar, K N Naresh, A A Redkar, C S Soman, S H Advani, J J Nadkarn. Expression of Fas and Fas ligand in Hodgkin's disease. Leukemia & lymphoma. vol 33. issue 5-6. 1999-07-12. PMID:10342579. |
these six cases with expression of both fas and fas ligand were investigated for the incidence of apoptosis. |
1999-07-12 |
2023-08-12 |
Not clear |
| S S Metkar, K N Naresh, A A Redkar, C S Soman, S H Advani, J J Nadkarn. Expression of Fas and Fas ligand in Hodgkin's disease. Leukemia & lymphoma. vol 33. issue 5-6. 1999-07-12. PMID:10342579. |
thus fas - fasl interactions may not lead to apoptosis of the rs cells. |
1999-07-12 |
2023-08-12 |
Not clear |
| V R Lombardi, M García, L Rey, R Cacabelo. Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals. Journal of neuroimmunology. vol 97. issue 1-2. 1999-07-12. PMID:10408971. |
in addition there was a significant difference in the extent of apoptosis in lymphocyte culture, as measured by mean fluorescence intensity (mfi) of fas antigen (cd95) expression on cd4+ t cells in 6 ad patients (mfi = 36% and 43%, by anti-cd3 and hyperthermia mediated-apoptosis, respectively) with respect to 6 healthy individuals (mfi = 24% and 31%, by anti-cd3 and hyperthermia mediated-apoptosis, respectively), as well as in t-cell proliferation assay. |
1999-07-12 |
2023-08-12 |
human |