| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K H Chang, J M Kim, H Y Kim, Y G Song, Y H Choi, Y S Park, J H Cho, S K Hon. Spontaneous programmed cell death of peripheral blood mononuclear cells from HIV-infected persons is decreased with interleukin-15. Yonsei medical journal. vol 41. issue 1. 2000-04-11. PMID:10731928. |
we evaluated the effect of il-15 on the survival of peripheral blood mononuclear cells of hiv patients by examining in vitro lymphocyte apoptosis, and correlated the process with bcl-2 and fas gene regulation. |
2000-04-11 |
2023-08-12 |
human |
| K H Chang, J M Kim, H Y Kim, Y G Song, Y H Choi, Y S Park, J H Cho, S K Hon. Spontaneous programmed cell death of peripheral blood mononuclear cells from HIV-infected persons is decreased with interleukin-15. Yonsei medical journal. vol 41. issue 1. 2000-04-11. PMID:10731928. |
the results were as follows: 1) il-15 reduced culture induced lymphocyte apoptosis in hiv patients in a dose dependent manner, and reached a plateau level at a concentration of 100 ng/ml; 2) il-15 significantly reduced the level of apoptosis after 3 days (14%) and 5 days (15%) of culture in hiv patients, while no difference was observed in hiv (-) donors; 3) the percentage of viable cells among the total number of lymphocytes was significantly enhanced by 25% in hiv patients with il-15; 4) bcl-2 expression was decreased in hiv patients (53.9 +/- 12.3%) compared to hiv (-) donors (93.0 +/- 3.7%), and il-15 increased bcl-2 expression by 21.2 +/- 5.2% in hiv patients; 5) fas expression was increased in hiv patients (70.2 +/- 4.6%) compared to hiv (-) donors (32.4 +/- 4.3%), and il-15 increased fas expression by 8.4 +/- 1.2% in hiv (-) donors. |
2000-04-11 |
2023-08-12 |
human |
| H Kazama, S Yonehar. Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase. The Journal of cell biology. vol 148. issue 3. 2000-04-07. PMID:10662780. |
transient expression of k-ras mutants revealed that oncogenic mutant k-ras (rasv12) strongly inhibited, whereas dominant-inhibitory mutant k-ras (rasn17) enhanced, fas-mediated apoptosis by inhibiting fas-triggered activation of caspases without affecting an expression level of fas. |
2000-04-07 |
2023-08-12 |
Not clear |
| A Zeytun, M Nagarkatti, P S Nagarkatt. Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs. Blood. vol 95. issue 6. 2000-04-07. PMID:10706882. |
growth of fasl-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in fas(+) organs. |
2000-04-07 |
2023-08-12 |
mouse |
| A Zeytun, M Nagarkatti, P S Nagarkatt. Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs. Blood. vol 95. issue 6. 2000-04-07. PMID:10706882. |
in the current study, we investigated whether the growth of fasl-bearing tumor cells would induce apoptosis and toxicity in organs that express high level of fas. |
2000-04-07 |
2023-08-12 |
mouse |
| A Zeytun, M Nagarkatti, P S Nagarkatt. Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs. Blood. vol 95. issue 6. 2000-04-07. PMID:10706882. |
furthermore, the soluble fasl was functional inasmuch as the sera from tumor-bearing mice were able to induce apoptosis in fas(+) but not fas(-) targets. |
2000-04-07 |
2023-08-12 |
mouse |
| A Zeytun, M Nagarkatti, P S Nagarkatt. Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs. Blood. vol 95. issue 6. 2000-04-07. PMID:10706882. |
histopathologic studies and in situ tunel assay to detect apoptosis were carried out in c57bl/6 +/+ (fas(+)) or c57bl/6 lpr/lpr (fas(-)) mice injected with syngeneic lsa and el-4 tumor cells. |
2000-04-07 |
2023-08-12 |
mouse |
| A Zeytun, M Nagarkatti, P S Nagarkatt. Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs. Blood. vol 95. issue 6. 2000-04-07. PMID:10706882. |
together, these data suggested that the in vivo growth of fasl-bearing tumor cells can induce significant apoptosis and toxicity in fas(+) tissues of the host. |
2000-04-07 |
2023-08-12 |
mouse |
| C E Jackson, R E Fischer, A P Hsu, S M Anderson, Y Choi, J Wang, J K Dale, T A Fleisher, L A Middelton, M C Sneller, M J Lenardo, S E Straus, J M Puc. Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. American journal of human genetics. vol 64. issue 4. 2000-04-05. PMID:10090885. |
in cotransfection experiments, fas constructs with either intra- or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type fas. |
2000-04-05 |
2023-08-12 |
Not clear |
| C E Jackson, R E Fischer, A P Hsu, S M Anderson, Y Choi, J Wang, J K Dale, T A Fleisher, L A Middelton, M C Sneller, M J Lenardo, S E Straus, J M Puc. Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. American journal of human genetics. vol 64. issue 4. 2000-04-05. PMID:10090885. |
variant a(-1)t at the fas signal-sequence cleavage site, which mediates apoptosis less well than wild-type fas and is partially inhibitory, was present in 13% of african american alleles. |
2000-04-05 |
2023-08-12 |
Not clear |
| C E Jackson, R E Fischer, A P Hsu, S M Anderson, Y Choi, J Wang, J K Dale, T A Fleisher, L A Middelton, M C Sneller, M J Lenardo, S E Straus, J M Puc. Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. American journal of human genetics. vol 64. issue 4. 2000-04-05. PMID:10090885. |
among the alps-associated fas mutants, dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular, versus extracellular, portion of the fas receptor. |
2000-04-05 |
2023-08-12 |
Not clear |
| M Ohashi, M Iwase, M Nagum. Changes in susceptibility to Fas-mediated apoptosis during differentiation of HL-60 cells. Journal of leukocyte biology. vol 67. issue 3. 2000-04-05. PMID:10733098. |
these results suggest that the difference of susceptibility to fas-mediated apoptosis among cell populations depends on the expression of fas ag, bcl-2, and caspases. |
2000-04-05 |
2023-08-12 |
Not clear |
| L Zhu, X Yu, Y Akatsuka, J A Cooper, C Anasett. Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells. Immunology. vol 97. issue 1. 2000-04-04. PMID:10447711. |
in addition, apoptosis induced by direct ligation of the fas receptor by anti-fas antibody is not associated with erk activation and is not inhibited by pd 098059. |
2000-04-04 |
2023-08-12 |
Not clear |
| A Ayala, C S Chung, Y X Xu, T A Evans, K M Redmond, I H Chaudr. Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin. Immunology. vol 97. issue 1. 2000-04-04. PMID:10447713. |
increased inducible apoptosis in cd4+ t lymphocytes during polymicrobial sepsis is mediated by fas ligand and not endotoxin. |
2000-04-04 |
2023-08-12 |
mouse |
| N Urushihara, H Iwagaki, T Yagi, H Kohka, K Kobashi, Y Morimoto, T Yoshino, T Tanimoto, M Kurimoto, N Tanak. Elevation of serum interleukin-18 levels and activation of Kupffer cells in biliary atresia. Journal of pediatric surgery. vol 35. issue 3. 2000-04-04. PMID:10726686. |
in addition, il-18 enhances intracellular adhesion molecule-1 (icam-1) expression as well as fas ligand (fasl) expression, and induces apoptosis in hepatic injury. |
2000-04-04 |
2023-08-12 |
Not clear |
| T Jayaraman, A R Mark. Calcineurin is downstream of the inositol 1,4,5-trisphosphate receptor in the apoptotic and cell growth pathways. The Journal of biological chemistry. vol 275. issue 9. 2000-04-03. PMID:10692444. |
human t lymphocytes (jurkat) that are made deficient in ip(3)r do not generate ca(2+) signals in response to t cell receptor stimulation, fail to translocate the nuclear factor for activated t cells to the nucleus, and are remarkably resistant to induction of apoptosis with cd95 (fas), dexamethasone, gamma irradiation, and t cell receptor stimulation using anti-cd3 antibody. |
2000-04-03 |
2023-08-12 |
human |
| F Kühnel, L Zender, Y Paul, M K Tietze, C Trautwein, M Manns, S Kubick. NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. The Journal of biological chemistry. vol 275. issue 9. 2000-04-03. PMID:10692445. |
nfkappab mediates apoptosis through transcriptional activation of fas (cd95) in adenoviral hepatitis. |
2000-04-03 |
2023-08-12 |
mouse |
| F Kühnel, L Zender, Y Paul, M K Tietze, C Trautwein, M Manns, S Kubick. NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. The Journal of biological chemistry. vol 275. issue 9. 2000-04-03. PMID:10692445. |
therefore our study demonstrates a new pro-apoptotic function of nfkappab in fas (cd95)-mediated apoptosis of hepatocytes. |
2000-04-03 |
2023-08-12 |
mouse |
| M Irmler, V Steiner, C Ruegg, H Wajant, J Tschop. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. FEBS letters. vol 468. issue 2-3. 2000-04-03. PMID:10692572. |
caspase-induced inactivation of the anti-apoptotic traf1 during fas ligand-mediated apoptosis. |
2000-04-03 |
2023-08-12 |
Not clear |
| M Irmler, V Steiner, C Ruegg, H Wajant, J Tschop. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. FEBS letters. vol 468. issue 2-3. 2000-04-03. PMID:10692572. |
here we show that traf1 is cleaved after asp-163 when cells are induced to undergo apoptosis by fas ligand (fasl). |
2000-04-03 |
2023-08-12 |
Not clear |