| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Kotchetkov, A A Krivtchik, J Cinatl, B Kornhuber, J Cinat. Selective cytotoxic activity of a novel ribonucleoside diphosphate reductase inhibitor MDL-101,731 against thyroid cancer in vitro. Folia biologica. vol 45. issue 5. 2000-04-14. PMID:10730887. |
these results demonstrated that mdl-101,731 is a potent antitumor agent against cultured thyroid cancer cells due to its ability to induce apoptosis in association with increased fas expression. |
2000-04-14 |
2023-08-12 |
human |
| B Bader-Meunier, F Rieux-Laucat, L Croisille, J Yvart, F Mielot, J P Dommergues, F Ledeist, G Tcherni. Dyserythropoiesis associated with a fas-deficient condition in childhood. British journal of haematology. vol 108. issue 2. 2000-04-13. PMID:10691859. |
defective lymphocyte apoptosis caused by mutations of the fas gene can result in an autoimmune lymphoproliferative syndrome (alps) in humans. |
2000-04-13 |
2023-08-12 |
Not clear |
| B Bader-Meunier, F Rieux-Laucat, L Croisille, J Yvart, F Mielot, J P Dommergues, F Ledeist, G Tcherni. Dyserythropoiesis associated with a fas-deficient condition in childhood. British journal of haematology. vol 108. issue 2. 2000-04-13. PMID:10691859. |
the regression of dyserythropoiesis under steroid therapy suggested that it resulted from an autoimmune mechanism, itself secondary to the lymphocyte fas apoptosis deficiency. |
2000-04-13 |
2023-08-12 |
Not clear |
| C Benz, S Angermüller, G Otto, P Sauer, W Stremmel, A Stieh. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. European journal of clinical investigation. vol 30. issue 3. 2000-04-13. PMID:10691996. |
because the fas receptor-ligand system may mediate apoptosis in human liver cells, the effect of toxic bile acids on hepatocellular fas receptor expression was evaluated. |
2000-04-13 |
2023-08-12 |
human |
| Q Chen, L P Samaranayake, X Zhen, G Luo, M Nie, B L. Up-regulation of Fas ligand and down-regulation of Fas expression in oral carcinogenesis. Oral oncology. vol 35. issue 6. 2000-04-13. PMID:10705088. |
an important molecule involved in delivering the death signal that initiates apoptosis is called fas, or apo-1, which sits on the cell surface. |
2000-04-13 |
2023-08-12 |
Not clear |
| Q Chen, L P Samaranayake, X Zhen, G Luo, M Nie, B L. Up-regulation of Fas ligand and down-regulation of Fas expression in oral carcinogenesis. Oral oncology. vol 35. issue 6. 2000-04-13. PMID:10705088. |
when another molecule called the fas ligand (fasl) binds to it, fas triggers a series of events inside the cell that leads to apoptosis. |
2000-04-13 |
2023-08-12 |
Not clear |
| A L Dunican, S J Leuenroth, A Ayala, H H Simm. CXC chemokine suppression of polymorphonuclear leukocytes apoptosis and preservation of function is oxidative stress independent. Shock (Augusta, Ga.). vol 13. issue 3. 2000-04-13. PMID:10718383. |
the addition of neutralizing antibodies to fas, tnfr55, or r75 caused no change in il-8 suppression of apoptosis. |
2000-04-13 |
2023-08-12 |
Not clear |
| C Lamboley, A F Bringuier, G Feldman. Apoptotic behaviour of hepatic and extra-hepatic tumor cell lines differs after Fas stimulation. Cellular and molecular biology (Noisy-le-Grand, France). vol 46. issue 1. 2000-04-13. PMID:10726968. |
it has been shown that some hepatoma cell lines may escape apoptosis because of abnormal fas localization correlated with non-functionality of the fas protein or dysfunctionality in the fas pathway cascade. |
2000-04-13 |
2023-08-12 |
Not clear |
| C Lamboley, A F Bringuier, G Feldman. Apoptotic behaviour of hepatic and extra-hepatic tumor cell lines differs after Fas stimulation. Cellular and molecular biology (Noisy-le-Grand, France). vol 46. issue 1. 2000-04-13. PMID:10726968. |
these results show that each tumor cell line is characterized by different apoptotic behaviour in relation to fas and/or ifngamma-induced apoptosis. |
2000-04-13 |
2023-08-12 |
Not clear |
| F Romeo, D Li, M Shi, J L Meht. Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovascular research. vol 45. issue 3. 2000-04-13. PMID:10728402. |
since there is evidence for elevation of catecholamine levels in plasma and coronary artery endothelial cell injury in chf, the present study was designed to test the hypothesis that carvedilol inhibits epinephrine-induced apoptosis, and the inhibitory effect is mediated by modulation of fas, fas ligand (fasl) and caspase-3 pathway, in cultured human coronary artery endothelial cells (hcaecs). |
2000-04-13 |
2023-08-12 |
human |
| A M Murshedul, M Nagase, T Yoshizawa, N Sakat. Thymocyte apoptosis by T-2 toxin in vivo in mice is independent of Fas/Fas ligand system. Bioscience, biotechnology, and biochemistry. vol 64. issue 1. 2000-04-13. PMID:10766511. |
to find whether fas/fas ligand (fasl) pathway is involved in t-2 toxin (t-2)-mediated thymocyte apoptosis, we used lpr/lpr (lpr) and gld/gld (gld) mice, whose fas and fasl proteins, respectively, are functionally deficient. |
2000-04-13 |
2023-08-12 |
mouse |
| A Y Ng, W Bales, R W Veltr. Phenylbutyrate-induced apoptosis and differential expression of Bcl-2, Bax, p53 and Fas in human prostate cancer cell lines. Analytical and quantitative cytology and histology. vol 22. issue 1. 2000-04-12. PMID:10696460. |
phenylbutyrate-induced apoptosis and differential expression of bcl-2, bax, p53 and fas in human prostate cancer cell lines. |
2000-04-12 |
2023-08-12 |
human |
| M Jenkins, M Keir, J M McCun. A membrane-bound Fas decoy receptor expressed by human thymocytes. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713117. |
human thymocytes at several stages of maturation express fas, yet resist apoptosis induction through its ligation. |
2000-04-12 |
2023-08-12 |
human |
| M Jenkins, M Keir, J M McCun. A membrane-bound Fas decoy receptor expressed by human thymocytes. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713117. |
a proximal step in apoptotic signaling through fas is implicated in this resistance, as these cells undergo normal levels of apoptosis induction after exposure to tumor necrosis factor-alpha. |
2000-04-12 |
2023-08-12 |
human |
| M Jenkins, M Keir, J M McCun. A membrane-bound Fas decoy receptor expressed by human thymocytes. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713117. |
unlike soluble forms of fas receptor, fdr dominantly inhibited apoptosis induction by fas ligand in transfected human embryonic kidney cells. |
2000-04-12 |
2023-08-12 |
human |
| M Jenkins, M Keir, J M McCun. A membrane-bound Fas decoy receptor expressed by human thymocytes. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713117. |
the data suggest that fas signal pathways in primary human cells may be regulated by expression of a membrane-bound decoy receptor, analogous to the regulation of tumor necrosis factor-related apoptosis inducing ligand (trail)-induced apoptosis by decoy receptors. |
2000-04-12 |
2023-08-12 |
human |
| B C Yang, Y S Wang, C H Wang, H H Lin, M J Tang, T L Yan. Transient apoptosis elicited by insulin in serum-starved glioma cells involves Fas/Fas-L and Bcl-2. Cell biology international. vol 23. issue 8. 2000-04-11. PMID:10704237. |
when insulin-elicited transient apoptosis of glioma cells was in progress, the expression of fas gene increased at both transcriptional and translational levels. |
2000-04-11 |
2023-08-12 |
Not clear |
| B C Yang, Y S Wang, C H Wang, H H Lin, M J Tang, T L Yan. Transient apoptosis elicited by insulin in serum-starved glioma cells involves Fas/Fas-L and Bcl-2. Cell biology international. vol 23. issue 8. 2000-04-11. PMID:10704237. |
apoptosis occurred in the cells having high level of surface fas protein. |
2000-04-11 |
2023-08-12 |
Not clear |
| L O'Connor, A W Harris, A Strasse. CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types. Cancer research. vol 60. issue 5. 2000-04-11. PMID:10728678. |
we report that thymocytes from mice lacking functional fas ligand (gld) show normal sensitivity to apoptosis transduced by p53, and that hepatocytes fromp53-/- mice have normal sensitivity to apoptosis triggered through ligation of cd95. |
2000-04-11 |
2023-08-12 |
mouse |
| T Otsuki, O Yamada, J Kurebayashi, T Moriya, H Sakaguchi, H Kunisue, K Yata, M Uno, Y Yawata, A Uek. Estrogen receptors in human myeloma cells. Cancer research. vol 60. issue 5. 2000-04-11. PMID:10728710. |
in addition, effects on membrane fas expression, appearance of apoptosis, and cell cycle perturbation were analyzed. |
2000-04-11 |
2023-08-12 |
human |