| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W H Hu, H Johnson, H B Sh. Activation of NF-kappaB by FADD, Casper, and caspase-8. The Journal of biological chemistry. vol 275. issue 15. 2000-05-05. PMID:10753878. |
fas-associated death domain protein (fadd), caspase-8-related protein (casper), and caspase-8 are components of the tumor necrosis factor receptor type 1 (tnf-r1) and fas signaling complexes that are involved in tnf-r1- and fas-induced apoptosis. |
2000-05-05 |
2023-08-12 |
Not clear |
| M Chisiki, A Kawada, M Akiyama, Y Itoh, S Tajima, A Ishibashi, F Yudat. Bowen's disease showing spontaneous complete regression associated with apoptosis. The British journal of dermatology. vol 140. issue 5. 2000-05-04. PMID:10354038. |
strong expression of fas (apo-1/cd95) antigen, an apoptosis-related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of fas-mediated apoptosis in the spontaneous complete regression of our patient's bowen's disease. |
2000-05-04 |
2023-08-12 |
Not clear |
| R Roy, S M Singh, A Shanker, A Sodh. Mechanism of thymocyte apoptosis induced by serum of tumor-bearing host: the molecular events involved and their inhibition by thymosin alpha-1. International journal of immunopharmacology. vol 22. issue 4. 2000-05-04. PMID:10689104. |
elucidation of the signal transduction mechanism revealed involvement of protein tyrosine kinase, protein kinase c and ser/thr phosphatases with concomitant increase in the level of protein products of apoptosis associated genes p53, bax, bad, fas and fas ligand and cleavage of n-terminal 23 kda fragment of bcl-2 that exhibited bax-like death effector properties. |
2000-05-04 |
2023-08-12 |
mouse |
| R S Chapkin, Y Fan, J R Lupto. Effect of diet on colonic-programmed cell death: molecular mechanism of action. Toxicology letters. vol 112-113. 2000-05-04. PMID:10720760. |
antagonism of fas signaling using a soluble fas:fc chimera blocked butyrate induction of apoptosis. |
2000-05-04 |
2023-08-12 |
mouse |
| R S Chapkin, Y Fan, J R Lupto. Effect of diet on colonic-programmed cell death: molecular mechanism of action. Toxicology letters. vol 112-113. 2000-05-04. PMID:10720760. |
therefore, fas receptor dependent signal transduction is required for butyrate induction of apoptosis in colonic cells. |
2000-05-04 |
2023-08-12 |
mouse |
| W A Chow, J J Fang, J K Ye. The IFN regulatory factor family participates in regulation of Fas ligand gene expression in T cells. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 7. 2000-05-04. PMID:10725705. |
activated t cells undergo apoptosis upon expression and ligation of fas ligand (fasl) to fas/apo-1 (cd95) receptor. |
2000-05-04 |
2023-08-12 |
Not clear |
| R S Hotchkiss, K W Tinsley, J J Hui, K C Chang, P E Swanson, A M Drewry, T G Buchman, I E Kar. p53-dependent and -independent pathways of apoptotic cell death in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 7. 2000-05-04. PMID:10725725. |
two potential pathways of sepsis-induced lymphocyte apoptosis, fas and p53, were investigated. |
2000-05-04 |
2023-08-12 |
mouse |
| R S Hotchkiss, K W Tinsley, J J Hui, K C Chang, P E Swanson, A M Drewry, T G Buchman, I E Kar. p53-dependent and -independent pathways of apoptotic cell death in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 7. 2000-05-04. PMID:10725725. |
fas receptor-deficient mice had no protection against sepsis-induced apoptosis in thymocytes or splenocytes. |
2000-05-04 |
2023-08-12 |
mouse |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
rho family proteins modulate rapid apoptosis induced by cytotoxic t lymphocytes and fas. |
2000-05-04 |
2023-08-12 |
Not clear |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
little is known about the role of rho proteins in apoptosis produced by stimuli evolved specifically to produce apoptosis, such as granzymes from cytotoxic t lymphocytes (ctls) and fas. |
2000-05-04 |
2023-08-12 |
Not clear |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
activated mutants of each gtpase increased susceptibility to apoptosis, and activation of cdc42 increased within 5 min of fas stimulation. |
2000-05-04 |
2023-08-12 |
Not clear |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
in contrast, during the time required for ctl and fas killing, no apoptosis was produced by dominant-negative or activated mutants or by c. difficile toxin alone. |
2000-05-04 |
2023-08-12 |
Not clear |
| H Shinohara, H Yagita, Y Ikawa, N Oyaiz. Fas drives cell cycle progression in glioma cells via extracellular signal-regulated kinase activation. Cancer research. vol 60. issue 6. 2000-05-04. PMID:10749152. |
we report here that: (a) in gliomas, [3h]tdr incorporation was enhanced by anti-fas igm monoclonal antibody ch-11 and conversely inhibited by anti-fasl monoclonal antibody nok-2; (b) cross-linking of fas with ch-11 drove both cell cycle progression and apoptosis as demonstrated by the induction of the s-g2 phase of dna and rna and fragmented nuclei; (c) phosphorylation of extracellular signal-regulated kinase (erk), but not of c-jun nh2-terminal kinase or p38, was induced by cross-linking of fas; (d) a mitogen-activated protein kinase/erk kinase 1 (mek1) inhibitor pd98059 completely blocked ch-11-induced erk phosphorylation as well as cell cycle progression without affecting induction of apoptosis; and (e) a broad-spectrum caspase inhibitor z-asp-ch2-dcb inhibited ch-11-induced erk phosphorylation, cell cycle progression, and apoptosis. |
2000-05-04 |
2023-08-12 |
Not clear |
| K Fukuzuka, C K Edwards, M Clare-Salzler, E M Copeland, L L Moldawer, D W Mozing. Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 4. 2000-05-04. PMID:10749790. |
however, little is known about the underlying mechanisms responsible for the increased apoptosis of lymphoid and parenchymal cells in solid organs and the role played by inflammatory mediators, such as tumor necrosis factor-alpha (tnf-alpha) and fas ligand (fasl), as well as by glucocorticoids. |
2000-05-04 |
2023-08-12 |
mouse |
| M S Iordanov, O P Ryabinina, J Wong, T H Dinh, D L Newton, S M Rybak, B E Magu. Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis. Cancer research. vol 60. issue 7. 2000-05-04. PMID:10766189. |
the caspase inhibitor benzyloxycarbonyl-val-ala-asp(ome) fluoromethyl ketone (zvadfmk), at concentrations that completely prevent apoptosis and caspase activation induced by ligation of the death receptor fas, had only a partial protective effect on onconase-induced cell death. |
2000-05-04 |
2023-08-12 |
Not clear |
| M S Iordanov, O P Ryabinina, J Wong, T H Dinh, D L Newton, S M Rybak, B E Magu. Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis. Cancer research. vol 60. issue 7. 2000-05-04. PMID:10766189. |
the proapoptotic activity of the p53 tumor suppressor protein and the fas ligand/fas/fas-associating protein with death domain (fadd)/caspase-8 proapoptotic cascade were not required for onconase-induced apoptosis. |
2000-05-04 |
2023-08-12 |
Not clear |
| T Yasuda, Y Zhang, H Nagase, T Kaneko, K Sayama, H Hashimoto, A Matsuzaw. Immunological characterization of C3H mice congenic for Fas(lprcg), C3h/HeJ-Fas(lprcg)/Fas(lprcg). Laboratory animals. vol 34. issue 1. 2000-05-03. PMID:10759366. |
fas(lpr) (lpr) and fas(lprcg) (lpr(cg)) are allelic mutations of the fas gene that is involved in apoptosis or programmed cell death. |
2000-05-03 |
2023-08-12 |
mouse |
| T Yasuda, Y Zhang, H Nagase, T Kaneko, K Sayama, H Hashimoto, A Matsuzaw. Immunological characterization of C3H mice congenic for Fas(lprcg), C3h/HeJ-Fas(lprcg)/Fas(lprcg). Laboratory animals. vol 34. issue 1. 2000-05-03. PMID:10759366. |
the newly-developed congenic c3h-lpr(cg) mice will provide a powerful tool for research into the function of fas apart from apoptosis. |
2000-05-03 |
2023-08-12 |
mouse |
| J Kleeff, M Kornmann, H Sawhney, M Kor. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. International journal of cancer. vol 86. issue 3. 2000-05-02. PMID:10760829. |
pancreatic cancer cells are usually resistant to apoptosis induced by cytotoxic drugs, by activation of surface receptors such as fas and tnf receptor or by serum or growth factor withdrawal. |
2000-05-02 |
2023-08-12 |
Not clear |
| H Matsubara, K Ikuta, Y Ozaki, Y Suzuki, N Suzuki, T Sato, K Suzumor. Gonadotropins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells. The Journal of clinical endocrinology and metabolism. vol 85. issue 4. 2000-05-01. PMID:10770207. |
our results also suggest that fas, fas ligand, p53, and bax may play roles in this apoptosis controlled by hcg, tgfbeta1, and m-csf. |
2000-05-01 |
2023-08-12 |
human |