| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Da-Guang Wang, Ya-Bin Sun, Fei Ye, Wei Li, Punyaram Kharbuja, Ling Gao, David Y Zhang, Jian Su. Anti-tumor activity of the X-linked inhibitor of apoptosis (XIAP) inhibitor embelin in gastric cancer cells. Molecular and cellular biochemistry. vol 386. issue 1-2. 2014-08-21. PMID:24136460. |
molecularly, embelin downregulated expression of x-linked inhibitor of apoptosis and cell cycle-regulatory proteins, such as cdk1, cdc25b, cdc25c, cyclinb1, and cdk2. |
2014-08-21 |
2023-08-12 |
human |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 3. 2014-08-19. PMID:24242917. |
in this study, we report that inhibition of cdk1, 2, and 9 (with the broad range cdk inhibitor, azd5438) in proliferating iec-6 cells triggered dna damage, activated p53 signaling, inhibited proliferation, and induced apoptosis. |
2014-08-19 |
2023-08-12 |
Not clear |
| Duane H Hamilton, Bruce Huang, Romaine I Fernando, Kwong-Yok Tsang, Claudia Palen. WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition. Cancer research. vol 74. issue 9. 2014-07-06. PMID:24626094. |
in support of a causal connection, pretreatment of tumor cells with a specific inhibitor of wee1, a negative regulator kinase of cdk1, could counter the defective apoptosis of tumor cells expressing high levels of brachyury. |
2014-07-06 |
2023-08-12 |
human |
| Janet E Holt, Victoria Pye, Evan Boon, Jessica L Stewart, Irene García-Higuera, Sergio Moreno, Rubén Rodríguez, Keith T Jones, Eileen A McLaughli. The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development (Cambridge, England). vol 141. issue 6. 2014-05-01. PMID:24553289. |
loss of apc/c(fzr1) activity was associated with raised cyclin b1 levels, suggesting that cdk1 may trigger apoptosis. |
2014-05-01 |
2023-08-12 |
mouse |
| Jing Zhao, Su-Xia Han, Jin-Lu Ma, Xia Ying, Peijun Liu, Juan Li, Lijuan Wang, Ying Zhang, Jiguang Ma, Li Zhang, Qing Zh. The role of CDK1 in apoptin-induced apoptosis in hepatocellular carcinoma cells. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23619525. |
the role of cdk1 in apoptin-induced apoptosis in hepatocellular carcinoma cells. |
2014-01-17 |
2023-08-12 |
human |
| Jing Zhao, Su-Xia Han, Jin-Lu Ma, Xia Ying, Peijun Liu, Juan Li, Lijuan Wang, Ying Zhang, Jiguang Ma, Li Zhang, Qing Zh. The role of CDK1 in apoptin-induced apoptosis in hepatocellular carcinoma cells. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23619525. |
shrna knockdown of cdk1 significantly reduced the tumor-specific killing effects of apoptin, suggesting that cdk1 plays an important role in the regulation of apoptin-induced apoptosis. |
2014-01-17 |
2023-08-12 |
human |
| Jing Zhao, Su-Xia Han, Jin-Lu Ma, Xia Ying, Peijun Liu, Juan Li, Lijuan Wang, Ying Zhang, Jiguang Ma, Li Zhang, Qing Zh. The role of CDK1 in apoptin-induced apoptosis in hepatocellular carcinoma cells. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23619525. |
the link between cdk1 and apoptin may be a novel cellular signaling pathway to modulate apoptosis in cancer; therefore, apoptin may have pharmacological potential to be directly employed for cancer therapy. |
2014-01-17 |
2023-08-12 |
human |
| Ahmed Kamal, Jaki R Tamboli, V Lakshma Nayak, S F Adil, M V P S Vishnuvardhan, S Ramakrishn. Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents. Bioorganic & medicinal chemistry letters. vol 23. issue 11. 2013-12-09. PMID:23623491. |
moreover, cell cycle arrest in g2/m and reduction in cdk1 expression level were observed upon treatment of these compounds and they also induced caspase-3 dependent apoptosis. |
2013-12-09 |
2023-08-12 |
human |
| Yongfeng Zhou, Yanying Bi, Chunhui Yang, Jingbo Yang, Yu Jiang, Fanmin Meng, Bo Yu, Muhammad Khan, Tonghui Ma, Hong Yan. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Die Pharmazie. vol 68. issue 9. 2013-12-03. PMID:24147344. |
further mechanistic studies revealed that induction of apoptosis is associated with cell cycle arrest at g2/m phase, increased generation of reactive oxygen species (ros), reduced mitochondrial membrane potential (mmp), release of cytochrome c (cyto c) and apoptosis inducing factor (aif) from mitochondria to cytosol, upregulation of bax, p21 and p53, and down-regulation of bcl-2, cyclin b1 and cyclin-dependent kinase 1 (cdk1). |
2013-12-03 |
2023-08-12 |
human |
| Ricardo Parrondo, Alicia de Las Pozas, Teresita Reiner, Carlos Perez-Stabl. ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells. PeerJ. vol 1. 2013-09-23. PMID:24058878. |
furthermore, we find that the ability of docetaxel to increase cyclin b1/cdk1-mediated phosphorylation of bcl-2/bcl-xl and decrease mcl-1 is required for abt-737 to enhance apoptosis in pc3 cells, as determined by addition of cdk1 inhibitor purvalanol a and expression of shrna specific for cyclin b1. |
2013-09-23 |
2023-08-12 |
human |
| Wenshuang Wu, Haoyu Ye, Li Wan, Xiaolei Han, Guangcheng Wang, Jia Hu, Minhai Tang, Xingmei Duan, Yi Fan, Shichao He, Li Huang, Heying Pei, Xuewei Wang, Xiuxia Li, Caifeng Xie, Ronghong Zhang, Zhu Yuan, Yongqiu Mao, Yuquan Wei, Lijuan Che. Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo. Carcinogenesis. vol 34. issue 7. 2013-09-06. PMID:23471882. |
millepachine, a novel chalcone, induces g2/m arrest by inhibiting cdk1 activity and causing apoptosis via ros-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo. |
2013-09-06 |
2023-08-12 |
mouse |
| Na Zhang, Li-Yan Zhang, Yan Zhang, Qing Ji, Jin-Hong Wang, Rui-Zhe Qi, Jing Xu, Wei-Ping Yuan, Tao Cheng, Ying-Dai Ga. [Effects of DAPT on biological activity of hematopoietic stem cells in mice]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 3. 2013-05-16. PMID:22739182. |
the results indicated that the mrna expression of the cell cycle related-genes cdk1, cdk2, cdk4, cdk6, p27 in lin(-) c-kit(+)sca-1(+) marked cells increased (p < 0.05), the expression of p18, p21 decreased (p < 0.05), the expression of the apoptosis related-genes bcl-2, bcl-xl, bax, p53, puma in lin(-) c-kit(+)sca-1(+) marked cells increased (p < 0.05), the expression of bim decreased (p < 0.05), the expression of mcl-1 had not changed (p > 0.05) after treatment with dapt 1 µmol/l for 5 d. the changes of cell cycle of lin(-)c-kit(+)sca-1(+) marked cells in bone marrow had no statistical significance after treatment with dapt 1 µmol/l for 5 d, cd34(-)lin(-)c-kit(+)sca-1(+) marked cells in bone marrow at g(0) phase decreased and at g(1) phase increased after treatment with dapt 1 µmol/l for 5 d (p < 0.05); the apoptotic fractions of lin(-) c-kit(+) sca-1(+) marked cells and cd34(-)lin(-)c-kit(+)sca-1(+) marked cells in bone marrow increased after treatment with dapt 1 µmol/l for 5 d (p < 0.05). |
2013-05-16 |
2023-08-12 |
mouse |
| Qin Wang, Peter C Wu, David Z Dong, Iana Ivanova, Elizabeth Chu, Steven Zeliadt, Hubert Vesselle, Daniel Y W. Polyploidy road to therapy-induced cellular senescence and escape. International journal of cancer. vol 132. issue 7. 2013-04-04. PMID:22945332. |
we now report that aberrant expression of cdk1 interferes with apoptosis and promotes the formation of polyploid senescent cells during tcs. |
2013-04-04 |
2023-08-12 |
human |
| Junfang Wu, Giorgi Kharebava, Chunshu Piao, Bogdan A Stoica, Michael Dinizo, Boris Sabirzhanov, Marie Hanscom, Kelsey Guanciale, Alan I Fade. Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo. PloS one. vol 7. issue 7. 2013-01-10. PMID:22848730. |
cr8, a novel and potent cdk1 inhibitor, blocked apoptosis of primary cortical neurons at low-micromolar concentrations. |
2013-01-10 |
2023-08-12 |
rat |
| Martina Cozzi, Francesca Giorgi, Eleonora Marcelli, Francesca Pentimalli, Iris Maria Forte, Silvia Schenone, Vittorio D'Urso, Giulia De Falco, Maurizio Botta, Antonio Giordano, Paola Indovin. Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. Cell cycle (Georgetown, Tex.). vol 11. issue 5. 2013-01-04. PMID:22333592. |
by using a small-molecule inhibitor of wee1, a crucial cdk1 negative regulator, we were able to shift the balance toward apoptosis rather than growth arrest and enhance the efficacy of the src inhibitors, suggesting a possible use of these selective drugs in combination for a safe and efficient treatment of bl. |
2013-01-04 |
2023-08-12 |
Not clear |
| Xiangrui Liu, Frankie Lam, Shenhua Shi, Peter M Fischer, Shudong Wan. In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83. Investigational new drugs. vol 30. issue 3. 2012-09-20. PMID:21331744. |
these results suggest that combined inhibition of cdk9 and cdk1 may result in the effective induction of apoptosis and cdki-83 has the potential to be developed as an anti-cancer agent. |
2012-09-20 |
2023-08-12 |
human |
| Wen-Wen Huang, Jai-Sing Yang, Meng-Wei Lin, Po-Yuan Chen, Shang-Ming Chiou, Fu-Shin Chueh, Yu-Hsuan Lan, Shu-Jen Pai, Minoru Tsuzuki, Wai-Jane Ho, Jing-Gung Chun. Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22272214. |
our results demonstrated that cucurbitacin e-induced g(2)/m arrest was associated with a marked increase in the levels of p53, p21 and a decrease in phospho-signal transducer and activator of transcription 3 (stat3), cyclin-dependent kinase 1 (cdk1) and cyclin b. cucurbitacin e-triggered apoptosis was accompanied with up-regulation of fas/cd95, truncated bid (t-bid) and a loss of ΔΨ(m), resulting in the releases of cytochrome c, apoptotic protease activating factor 1 (apaf-1) and apoptosis-inducing factor (aif), and sequential activation of caspase-8, caspase-9, and caspase-3. |
2012-08-23 |
2023-08-12 |
human |
| Su-Hua Huang, Liu-Wei Wu, An-Cheng Huang, Chien-Chih Yu, Jin-Cherng Lien, Yi-Ping Huang, Jai-Sing Yang, Jen-Hung Yang, Yu-Ping Hsiao, W Gibson Wood, Chun-Shu Yu, Jing-Gung Chun. Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways. Journal of agricultural and food chemistry. vol 60. issue 2. 2012-08-20. PMID:22148415. |
results indicated that (1) bitc significantly reduced cell number and induced cell morphological changes in a dose-dependent manner in a375.s2 cells; (2) bitc induced arrest in cell cycle progression at g(2)/m phase through cyclin a, cdk1, cdc25c/wee1-mediated pathways; (3) bitc induced apoptosis and increased sub-g(1) population; and (4) bitc promoted the production of ros and ca(2+) and loss of ΔΨ(m) and caspase-3 activity. |
2012-08-20 |
2023-08-12 |
human |
| Xudong Li, Shijia Chen, Ren Su. Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus. Journal of virology. vol 86. issue 12. 2012-08-09. PMID:22496227. |
cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of kaposi's sarcoma-associated herpesvirus. |
2012-08-09 |
2023-08-12 |
Not clear |
| Xudong Li, Shijia Chen, Ren Su. Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus. Journal of virology. vol 86. issue 12. 2012-08-09. PMID:22496227. |
here we report that cyclin-dependent kinase 1 (cdk1) inhibition can induce both apoptosis and kshv reactivation in a population of pel cells. |
2012-08-09 |
2023-08-12 |
Not clear |