| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xudong Li, Shijia Chen, Ren Su. Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus. Journal of virology. vol 86. issue 12. 2012-08-09. PMID:22496227. |
caspases, but not p53, are required for pel cell apoptosis induced by cdk1 inhibition. |
2012-08-09 |
2023-08-12 |
Not clear |
| Xudong Li, Shijia Chen, Ren Su. Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus. Journal of virology. vol 86. issue 12. 2012-08-09. PMID:22496227. |
our study thus establishes a key role for cdk1 in pel cell survival and the maintenance of kshv latency and reveals a multifaceted relationship between kshv reactivation and pel cell apoptosis. |
2012-08-09 |
2023-08-12 |
Not clear |
| Chun-Han Chen, Cho-Hwa Liao, Ya-Ling Chang, Jih-Hwa Guh, Shiow-Lin Pan, Che-Ming Ten. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer letters. vol 315. issue 1. 2012-04-02. PMID:22033245. |
the data suggest that protopine increased the activity of cyclin-dependent kinase 1 (cdk1)/cyclin b1 complex and that contributed to cell apoptosis by modulating mitochondria-mediated signaling pathways, such as bcl-2 phosphorylation and mcl-1 down-regulation. |
2012-04-02 |
2023-08-12 |
human |
| David Du Pasquier, Aude Dupré, Catherine Jessu. Unfertilized Xenopus eggs die by Bad-dependent apoptosis under the control of Cdk1 and JNK. PloS one. vol 6. issue 8. 2012-02-15. PMID:21858202. |
unfertilized xenopus eggs die by bad-dependent apoptosis under the control of cdk1 and jnk. |
2012-02-15 |
2023-08-12 |
xenopus_laevis |
| Li-Hong Zhu, Wei Bi, Xiao-Dong Liu, Jie-Fen Li, Ying-Ya Wu, Biao-Yan Du, Yu-Hui Ta. Induction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippage. Oncology reports. vol 26. issue 6. 2012-01-27. PMID:21887472. |
we also demonstrated that promotion of mitotic slippage by a cdk1 inhibitor enhanced apoptosis. |
2012-01-27 |
2023-08-12 |
human |
| Pin-Hsuan Lu, Chia-Chun Yu, Po-Cheng Chiang, Yi-Cheng Chen, Yunn-Fang Ho, Fan-Lu Kung, Jih-Hwa Gu. Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer. The Journal of urology. vol 186. issue 6. 2012-01-03. PMID:22019170. |
paclitaxel induces apoptosis through activation of nuclear protein kinase c-δ and subsequent activation of golgi associated cdk1 in human hormone refractory prostate cancer. |
2012-01-03 |
2023-08-12 |
human |
| Wei Fu, Le Ma, Baoky Chu, Xue Wang, Marilyn M Bui, Jennifer Gemmer, Soner Altiok, W Jackson Pledge. The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. Molecular cancer therapeutics. vol 10. issue 6. 2011-11-09. PMID:21490307. |
we suggest that sch triggers the apoptosis of osteosarcoma cells by inactivating cdk1 and cdk2 and that sch may be useful for treatment of drug-resistant osteosarcomas. |
2011-11-09 |
2023-08-12 |
mouse |
| Wen-Wen Huang, Shih-Wei Ko, Huei-Yann Tsai, Jing-Gung Chung, Jo-Hua Chiang, Kuan-Tin Chen, Yen-Chen Chen, Hung-Yi Chen, Yuh-Fung Chen, Jai-Sing Yan. Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. International journal of oncology. vol 38. issue 4. 2011-08-23. PMID:21271215. |
cantharidin induces g2/m phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of cdk1 activity and caspase-dependent signaling pathways. |
2011-08-23 |
2023-08-12 |
human |
| Wen-Wen Huang, Shih-Wei Ko, Huei-Yann Tsai, Jing-Gung Chung, Jo-Hua Chiang, Kuan-Tin Chen, Yen-Chen Chen, Hung-Yi Chen, Yuh-Fung Chen, Jai-Sing Yan. Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. International journal of oncology. vol 38. issue 4. 2011-08-23. PMID:21271215. |
based on our observations, we suggest that ctd is able to induce g2/m phase arrest and apoptosis in colo 205 cells through inhibition of cdk1 activity and caspase-dependent signaling pathways. |
2011-08-23 |
2023-08-12 |
human |
| Christopher Abdullah, Xiaolei Wang, Dorothea Becke. Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma. Cell cycle (Georgetown, Tex.). vol 10. issue 6. 2011-08-23. PMID:21358262. |
furthermore, we present the results of in vitro and preclinical in vivo studies, which demonstrate that treatment with a small-molecule cyclin-dependent kinase inhibitor that selectively blocks the function of cdk2, cdk5, cdk1, and cdk9, leads not only to inhibition of melanoma cell proliferation and apoptosis of melanoma cells, but also impairs the growth of human melanoma xenografts. |
2011-08-23 |
2023-08-12 |
human |
| Bing Hu, Ke-Ping Shen, Hong-Mei An, Yang Wu, Qin D. Aqueous extract of Curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma LS-174-T cells independent of p53. Cancer biotherapy & radiopharmaceuticals. vol 26. issue 1. 2011-06-30. PMID:21348775. |
this study suggests that aeca might be effective as an antiproliferative herb for colon carcinoma, the antitumor activity of aeca may involve both extrinsic and intrinsic apoptosis, and aeca induces g2/m phase arrest via downregulation of cyclin b1 and cdk1 and without the participation of p53. |
2011-06-30 |
2023-08-12 |
human |
| Margarita Maurer, Oxana Komina, Andrzej Składanowski, Józefa Wesierska-Gade. Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle. Journal of experimental therapeutics & oncology. vol 9. issue 1. 2011-03-17. PMID:21275261. |
analysis of the cell cycle and apoptosis regulators revealed that c-1305 strongly elevated phosphorylation of cdk1 at the inhibitory sites (thr14/tyr15) in hl-60 cells. |
2011-03-17 |
2023-08-12 |
mouse |
| J C Su, K L Lin, C M Chien, C H Tseng, Y L Chen, L S Chang, S R Li. Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell biochemistry and function. vol 28. issue 8. 2011-02-22. PMID:21104938. |
the combined treatment of fnq with ag1478 (a specific egfr inhibitor) significantly enhanced the g(2)/m arrest and apoptosis, and also led to up-regulation in bax, p53, p21, p27, release of mitochondrial cytochrome c, and down-regulation of bcl-2, xiap, survivin, cyclin a, cyclin b, cdk1, and cdk2 in a549 cells. |
2011-02-22 |
2023-08-12 |
Not clear |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
ctx iii exerted cytotoxicity with the s-phase cell cycle arrest, correlated with a marked decrease in the expression levels of cyclin a, cyclin b, and cyclin-dependent kinase 1 (cdk1), and apoptosis, accompanied with bax and bad up-regulation, and the down-regulation of bcl-2, p-bad, and x-linked inhibitor of apoptosis (xiap) with cytochrome c release and sequential activation of caspase-9 and caspase-3 in ca9-22 cells. |
2010-12-13 |
2023-08-12 |
Not clear |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
the pp2 also caused the s-phase arrest and apoptosis, and led to down-regulation of bcl-2, p-bad, xiap, cyclin a, cyclin b, and cdk1, and up-regulation of bax and bad, similar to that observed in ctx iii treatment. |
2010-12-13 |
2023-08-12 |
Not clear |
| Danupon Nantajit, Ming Fan, Nadire Duru, Yunfei Wen, John C Reed, Jian Jian L. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808790. |
enforced translocation of cyclin b1 and cdk1 into mitochondria with a mitochondrial-targeting-peptide increased levels of ser-315 phosphorylation on mitochondrial p53, improved atp production and decreased apoptosis by sequestering p53 from binding to bcl-2 and bcl-xl. |
2010-11-04 |
2023-08-12 |
mouse |
| Yuh-Ling Lin, Yi-Ting Su, Bing-Huei Che. A study on inhibition mechanism of breast cancer cells by bis-type triaziquone. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20371239. |
western blot analysis indicated that btzq may up-regulate expression of cyclin b, p21, p53 and cytochrome c, but down-regulate cdk1 expression in a dose-dependent manner, leading to apoptosis of bc-m1 cells. |
2010-09-07 |
2023-08-12 |
Not clear |
| Samuel McNeely, Chiara Conti, Tahir Sheikh, Himali Patel, Sonya Zabludoff, Yves Pommier, Gary Schwartz, Archie Ts. Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase. Cell cycle (Georgetown, Tex.). vol 9. issue 5. 2010-06-29. PMID:20160494. |
prevention of premature mitotic entry via cdk1 sirna knockdown suppressed apoptosis. |
2010-06-29 |
2023-08-12 |
Not clear |
| David T Terrano, Meenakshi Upreti, Timothy C Chamber. Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Molecular and cellular biology. vol 30. issue 3. 2010-02-17. PMID:19917720. |
thus, phosphorylation of antiapoptotic bcl-2 proteins acts as a sensor for cdk1 signal duration and as a functional link coupling mitotic arrest to apoptosis. |
2010-02-17 |
2023-08-12 |
Not clear |
| Edward L LaGory, Leonid A Sitailo, Mitchell F Dennin. The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. The Journal of biological chemistry. vol 285. issue 3. 2010-02-08. PMID:19917613. |
wild-type mefs underwent a pronounced g(2)/m arrest, cdk1 phosphorylation, and induction of apoptosis following uv exposure, whereas pkcdelta null mefs were resistant to these effects. |
2010-02-08 |
2023-08-12 |
mouse |