| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joaquín Herrero-Ruiz, Mar Mora-Santos, Servando Giráldez, Carmen Sáez, Miguel A Japón, Maria Tortolero, Francisco Romer. βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25149538. |
specifically, treatment with the chemotherapeutic agent doxorubicin in certain cell lines provokes cdk1 degradation and induces apoptosis, whereas in others it inhibits destruction of the protein. |
2015-08-06 |
2023-08-13 |
Not clear |
| Ling-Chu Chang, Yung-Luen Yu, Chin-Yu Liu, Yung-Yi Cheng, Ruey-Hwang Chou, Min-Tsang Hsieh, Hui-Yi Lin, Hsin-Yi Hung, Li-Jiau Huang, Yang-Chang Wu, Sheng-Chu Ku. The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1. Cancer chemotherapy and pharmacology. vol 75. issue 6. 2015-07-29. PMID:25947085. |
the newly synthesized 2-arylnaphthyridin-4-one, csc-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating cdk1. |
2015-07-29 |
2023-08-13 |
Not clear |
| Yang Liu, Yan-Hua Zhu, Cheng-Qiong Mao, Shuang Dou, Song Shen, Zi-Bin Tan, Jun Wan. Triple negative breast cancer therapy with CDK1 siRNA delivered by cationic lipid assisted PEG-PLA nanoparticles. Journal of controlled release : official journal of the Controlled Release Society. vol 192. 2015-07-20. PMID:25016158. |
it is demonstrated that only in c-myc overexpressed tnbc cells, while not in normal mammary epithelial cells, delivery of sirna targeting cyclin-dependent kinase 1 (cdk1) with the nanoparticle carrier (npsicdk1) induces cell viability decreasing and cell apoptosis through rnai-mediated cdk1 expression inhibition, indicating the synthetic lethality between c-myc with cdk1 in tnbc cells. |
2015-07-20 |
2023-08-13 |
mouse |
| I Neganova, K Tilgner, A Buskin, I Paraskevopoulou, S P Atkinson, D Peberdy, J F Passos, M Lak. CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells. Cell death & disease. vol 5. 2015-07-02. PMID:25375373. |
to investigate the impacts of cdk1 downregulation, we performed rna interference studies which in addition to expected mitotic deficiencies revealed a large range of additional phenotypes related to maintenance of pluripotency, ability to repair double strand breaks (dsbs) and commitment to apoptosis. |
2015-07-02 |
2023-08-13 |
human |
| I Neganova, K Tilgner, A Buskin, I Paraskevopoulou, S P Atkinson, D Peberdy, J F Passos, M Lak. CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells. Cell death & disease. vol 5. 2015-07-02. PMID:25375373. |
together these data suggest that cdk1 regulates multiple events in human pluripotent stem cells ranging from regulation of mitosis, g2/m checkpoint maintenance, execution of apoptosis, maintenance of pluripotency and genomic stability. |
2015-07-02 |
2023-08-13 |
human |
| Shuo Chen, Xi Chen, Yin-Ling Xiu, Kai-Xuan Sun, Yang Zha. MicroRNA-490-3P targets CDK1 and inhibits ovarian epithelial carcinoma tumorigenesis and progression. Cancer letters. vol 362. issue 1. 2015-06-18. PMID:25819031. |
mir-490-3p overexpression promoted g1/s or g2/m arrest and apoptosis; reduced cell proliferation, migration and invasion; reduced cdk1, bcl-xl, mmp2/9, ccnd1, smarcd1 mrna or protein expression; and induced p53 expression. |
2015-06-18 |
2023-08-13 |
Not clear |
| A Yalcin, B F Clem, Y Imbert-Fernandez, S C Ozcan, S Peker, J O'Neal, A C Klarer, A L Clem, S Telang, J Chesne. 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. Cell death & disease. vol 5. 2015-06-04. PMID:25032860. |
in this study, we demonstrate that sirna silencing of endogenous pfkfb3 inhibits cdk1 activity, which in turn stabilizes p27 protein levels causing cell cycle arrest at g1/s and increased apoptosis in hela cells. |
2015-06-04 |
2023-08-13 |
human |
| Ramamani Arumugam, Don Fleenor, Michael Freemar. Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression. Endocrine. vol 46. issue 3. 2015-04-02. PMID:24114406. |
conversely, prl treatment increased dna synthesis, reduced apoptosis, and enhanced expression of a, b and d2 cyclins, cdk1, irs-2, foxm1, bclxl, and pttg1; bcl6 declined. |
2015-04-02 |
2023-08-12 |
rat |
| Taryn E Dick, Jeremy A Hengst, Todd E Fox, Ashley L Colledge, Vijay P Kale, Shen-Shu Sung, Arun Sharma, Shantu Amin, Thomas P Loughran, Mark Kester, Hong-Gang Wang, Jong K Yu. The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. The Journal of pharmacology and experimental therapeutics. vol 352. issue 3. 2015-03-31. PMID:25563902. |
further examination of the mechanism of action of ski-178 implicated c-jun nh2-terminal kinase (jnk) and cyclin-dependent protein kinase 1 (cdk1) as critical factors required for ski-178-induced apoptosis. |
2015-03-31 |
2023-08-13 |
human |
| Taryn E Dick, Jeremy A Hengst, Todd E Fox, Ashley L Colledge, Vijay P Kale, Shen-Shu Sung, Arun Sharma, Shantu Amin, Thomas P Loughran, Mark Kester, Hong-Gang Wang, Jong K Yu. The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. The Journal of pharmacology and experimental therapeutics. vol 352. issue 3. 2015-03-31. PMID:25563902. |
in cell cycle synchronized human aml cell lines, we demonstrate that entry into mitosis is required for apoptotic induction by ski-178 and that cdk1, not jnk, is required for ski-178-induced apoptosis. |
2015-03-31 |
2023-08-13 |
human |
| Ellen Weisberg, Atsushi Nonami, Zhao Chen, Feiyang Liu, Jianming Zhang, Martin Sattler, Erik Nelson, Kristen Cowens, Amanda L Christie, Constantine Mitsiades, Kwok-Kin Wong, Qingsong Liu, Nathanael Gray, James D Griffi. Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. Leukemia. vol 29. issue 1. 2015-03-24. PMID:24791855. |
the specificity of wee1 as the target of mk-1775 was validated by wee1 knockdown, as well as partial reversal of drug combination-induced apoptosis by a cyclin-dependent kinase 1 (cdk1) inhibitor. |
2015-03-24 |
2023-08-13 |
human |
| Won Young Jang, Ji Young Lee, Seung Tae Lee, Do Youn Jun, Young Ho Ki. Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25218503. |
these results demonstrate that jnki-induced mitochondrial apoptosis was caused by microtubule damage-mediated prometaphase arrest, prolonged cdk1 activation, and phosphorylation of bcl-2 family proteins in jurkat t cells. |
2015-02-25 |
2023-08-13 |
human |
| Tian-En Wang, Yong-Kang Wang, Jing Jin, Bai-Ling Xu, Xiao-Guang Che. A novel derivative of quinazoline, WYK431 induces G2/M phase arrest and apoptosis in human gastric cancer BGC823 cells through the PI3K/Akt pathway. International journal of oncology. vol 45. issue 2. 2015-01-26. PMID:24859921. |
the results showed that wyk431 inhibited proliferation, arrested the cell cycle at the g(2)/m phase, which was related to cdk1 and cdc25c, and induced apoptosis associated with activation of caspase-3 and caspase-9 rather than caspase-8 in bgc823 cells. |
2015-01-26 |
2023-08-13 |
mouse |
| Lingli Zhou, Xiaoling Cai, Xueyao Han, Naihan Xu, Donald C Chan. CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents. Cell biology international. vol 38. issue 6. 2015-01-10. PMID:24677263. |
cdk1 switches mitotic arrest to apoptosis by phosphorylating bcl-2/bax family proteins during treatment with microtubule interfering agents. |
2015-01-10 |
2023-08-12 |
Not clear |
| Lingli Zhou, Xiaoling Cai, Xueyao Han, Naihan Xu, Donald C Chan. CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents. Cell biology international. vol 38. issue 6. 2015-01-10. PMID:24677263. |
we demonstrate that cell cycle-dependent kinase 1 (cdk1) is important in switching cells from mitotic arrest to apoptosis during mias treatment. |
2015-01-10 |
2023-08-12 |
Not clear |
| Lingli Zhou, Xiaoling Cai, Xueyao Han, Naihan Xu, Donald C Chan. CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents. Cell biology international. vol 38. issue 6. 2015-01-10. PMID:24677263. |
overexpression of non-degradable cyclin b1 sustained cdk1 activation and mitotic arrest, followed by caspase-3 dependent apoptosis. |
2015-01-10 |
2023-08-12 |
Not clear |
| A Carbone, M Pennati, P Barraja, A Montalbano, B Parrino, V Spanò, A Lopergolo, S Sbarra, V Doldi, N Zaffaroni, G Cirrincione, P Dian. Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)- 1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsentin analogues. Current medicinal chemistry. vol 21. issue 14. 2014-12-29. PMID:24180279. |
the most active compound of this series acts as a cdk1 inhibitor, and was found to cause cell cycle arrest at g2/m phase, to induce apoptosis by preventing the phosphorylation of survivin in thr(34) and to increase the cytotoxic activity of paclitaxel in sto cells. |
2014-12-29 |
2023-08-12 |
human |
| Yulei Zhao, Prem Khanal, Paul Savage, Yi-Min She, Terry D Cyr, Xiaolong Yan. YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway. Cancer research. vol 74. issue 16. 2014-12-15. PMID:24812269. |
mounting evidence argues that cancer cell apoptosis triggered by antitubulin drugs relies upon activation of the cell-cycle kinase cdk1; however, mechanistic connections of this event to apoptosis remain obscure. |
2014-12-15 |
2023-08-13 |
human |
| Yulei Zhao, Prem Khanal, Paul Savage, Yi-Min She, Terry D Cyr, Xiaolong Yan. YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway. Cancer research. vol 74. issue 16. 2014-12-15. PMID:24812269. |
in this study, we identified the antiapoptotic protein yap, a core component of the hippo signaling pathway implicated in tumorigenesis, as a critical linker coupling cdk1 activation to apoptosis in the antitubulin drug response. |
2014-12-15 |
2023-08-13 |
human |
| Yulei Zhao, Prem Khanal, Paul Savage, Yi-Min She, Terry D Cyr, Xiaolong Yan. YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway. Cancer research. vol 74. issue 16. 2014-12-15. PMID:24812269. |
mutations in these phosphorylation sites on yap relieved its ability to block antitubulin drug-induced apoptosis, further suggesting that yap was inactivated by cdk1 phosphorylation. |
2014-12-15 |
2023-08-13 |
human |