| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xian Chen, Ying Liao, Dan Long, Ting Yu, Fang Shen, Xuechi Li. The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro. International journal of molecular medicine. vol 40. issue 1. 2018-03-16. PMID:28534969. |
in this study, the cdk1 inhibitor, purvalanol a was applied to explore the relevance of cdc2 signaling and taxol sensitivity through analyses, such as cellular proliferation and apoptosis assays, elisa, western blot analysis and immunoprecipitation. |
2018-03-16 |
2023-08-13 |
Not clear |
| Shi-Bin Wang, Zhenzhou Tao, Ping L. Lawsone suppresses azoxymethane mediated colon cancer in rats and reduces proliferation of DLD-1 cells via NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-27. PMID:28222396. |
results on human dld-1 cells showed ls delayed progression of cell cycle by decreasing expression of cyclin b1 as well as cdk1 by inactivating nf-κb without inducing apoptosis. |
2018-02-27 |
2023-08-13 |
human |
| Shi-Bin Wang, Zhenzhou Tao, Ping L. Lawsone suppresses azoxymethane mediated colon cancer in rats and reduces proliferation of DLD-1 cells via NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-27. PMID:28222396. |
the suppressive activity on dld-1 cells was not by apoptosis but by decreased nf-κb activity resulting in suppression of expression levels of cyclin b1 and cdk1. |
2018-02-27 |
2023-08-13 |
human |
| Mei-Chi Chang, Yi-Jane Chen, Eric Jein-Wein Liou, Wan-Yu Tseng, Chiu-Po Chan, Hseuh-Jen Lin, Wan-Chuen Liao, Ya-Ching Chang, Po-Yuan Jeng, Jiiang-Huei Jen. 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. Oncotarget. vol 7. issue 46. 2018-02-08. PMID:27740938. |
7-kc also induced g0/g1 cell cycle arrest and apoptosis with an inhibition of cyclin dependent kinase 1 (cdk1) and cyclin b1 expression. |
2018-02-08 |
2023-08-13 |
Not clear |
| Lumin Wang, Hongfei Sun, Xiaofei Wang, Ni Hou, Lingyu Zhao, Dongdong Tong, Kang He, Yang Yang, Tusheng Song, Jun Yang, Chen Huan. EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. Oncotarget. vol 7. issue 29. 2018-02-06. PMID:27244890. |
silencing hoxd3 could block transition of the g2/m phase, increase cell apoptosis, decrease the expression of cell cycle and apoptosis-related proteins, egfr, p-akt, p-erk, ccnb1, cdk1 and bcl2 by targeting egfr through egfr/akt and erk cell signaling pathways. |
2018-02-06 |
2023-08-13 |
Not clear |
| Bruna Isabela Biazi, Thalita Alves Zanetti, Adrivanio Baranoski, Amanda Cristina Corveloni, Mário Sérgio Mantovan. Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation. Basic & clinical pharmacology & toxicology. vol 121. issue 4. 2018-01-30. PMID:28256105. |
rt-qpcr showed that c-ner down-regulated genes related to apoptosis (bak1, bax, capn1, casp8, casp9, parp1 and tp53), cell cycle (ccnd1, ccne1, cdk1 and cdk2), xenobiotic metabolism (cyp2d6 and cyp3a4) and paraptosis (igf1r receptor). |
2018-01-30 |
2023-08-13 |
human |
| Zhongming Huang, Junhua Li, Shaohua Du, Yanghua Tang, Ligang Huang, Luwei Xiao, Peijian Ton. FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome. Oncotarget. vol 7. issue 26. 2018-01-12. PMID:27223089. |
fkbp14 knockdown decreased the protein levels of pcna, cdk1 and ccnb1 that promotes cell cycle, increased bax, caspase-3 and caspase-7 protein involved in promoting cell apoptosis, and increased kif4a expression as well as decreased smc4 and tmem33 proteins that contribute to cell invasion and adhesion. |
2018-01-12 |
2023-08-13 |
Not clear |
| Zongliang Lu, Rui Zhou, Ya Kong, Jiajia Wang, Wanyuan Xia, Jing Guo, Jie Liu, Hailan Sun, Kai Liu, Jian Yang, Mantian Mi, Hongxia X. S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Current cancer drug targets. vol 16. issue 5. 2017-10-03. PMID:26638886. |
additional studies revealed that s-equol caused cell cycle arrest in the g2/m phase in pc3 cells by downregulating cyclin b1 and cdk1 and upregulating cdk inhibitors (p21 and p27), as well as inducing apoptosis by upregulating fas ligand (fasl) and the expression of proapoptotic bim. |
2017-10-03 |
2023-08-13 |
mouse |
| Chuangyu Wen, Junxiong Chen, Di Zhang, Huihui Wang, Jia Che, Qiyuan Qin, Lu He, Zerong Cai, Mengmeng Lin, Qiong Lou, Lanlan Huang, Daici Chen, Aikichi Iwamoto, Donglin Ren, Lei Wang, Ping Lan, Jianping Wang, Huanliang Liu, Xiangling Yan. Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells. Cancer letters. vol 383. issue 2. 2017-08-08. PMID:27713084. |
finally, cdk1 activity was involved in pab-induced mitotic arrest and apoptosis in crc cells. |
2017-08-08 |
2023-08-13 |
Not clear |
| Rebecca S Lescarbeau, Liang Lei, Katrina K Bakken, Peter A Sims, Jann N Sarkaria, Peter Canoll, Forest M Whit. Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma. Molecular cancer therapeutics. vol 15. issue 6. 2017-06-27. PMID:27196784. |
although the response was more heterogeneous, on-target wee1 inhibition led to decreased cdk1 y15 phosphorylation and increased dna damage and apoptosis in each line. |
2017-06-27 |
2023-08-13 |
mouse |
| Alexey V Danilov, Shanhu Hu, Bernardo Orr, Kristina Godek, Lisa Maria Mustachio, David Sekula, Xi Liu, Masanori Kawakami, Faye M Johnson, Duane A Compton, Sarah J Freemantle, Ethan Dmitrovsk. Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2. Molecular cancer therapeutics. vol 15. issue 11. 2017-06-15. PMID:27550941. |
overexpression of cp110, which is a mediator of cdk2 inhibitor-induced anaphase catastrophe (and a cdk1 and 2 phosphorylation substrate), antagonized anaphase catastrophe and apoptosis following dinaciclib treatment. |
2017-06-15 |
2023-08-13 |
Not clear |
| Scott E Counts, Elliott J Mufso. Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease. Cell transplantation. vol 26. issue 4. 2017-04-28. PMID:27938491. |
in this regard, the multifunctional protein regulator of cell cycle (rgcc) has been implicated in driving g1/s and g2/m phase transitions through its interactions with cdc/cyclin-dependent kinase 1 (cdk1) and is induced by p53, which mediates apoptosis in neurons. |
2017-04-28 |
2023-08-13 |
human |
| Xiu-Wu Pan, Lu Chen, Yi Hong, Dan-Feng Xu, Xi Liu, Lin Li, Yi Huang, Li-Ming Cui, Si-Shun Gan, Qi-Wei Yang, Hai Huang, Fa-Jun Qu, Jian-Qing Ye, Lin-Hui Wang, Xin-Gang Cu. EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling. International journal of oncology. vol 48. issue 6. 2017-03-10. PMID:27035563. |
eif3d silencing in human 786-o and achn ccrcc cell lines by rna interference demonstrated that eif3d knockdown obviously inhibited cell proliferation and colony formation, caused g2/m arrest through downregulation of cyclin b1 and cdk1 and upregulation of p21, and induced apoptosis shown by sub-g1 accumulation and rarp cleavage. |
2017-03-10 |
2023-08-13 |
human |
| Chao Cheng, Jian-Tong Jiao, Yu Qian, Xiao-Yi Guo, Jin Huang, Min-Chao Dai, Lei Zhang, Xiao-Peng Ding, Da Zong, Jun-Fei Sha. Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells. Molecular medicine reports. vol 13. issue 5. 2017-02-16. PMID:27035875. |
by immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce g2/m cell cycle arrest and apoptosis by increasing the expression levels of cyclin g2, cleaved caspase‑3 and fas ligand (fasl), and decreasing the expression of cyclin‑dependent kinase 1 (cdk1). |
2017-02-16 |
2023-08-13 |
human |
| S Anbumani, Mary N Mohankuma. Gene expression in Catla catla (Hamilton) subjected to acute and protracted doses of gamma radiation. Aquatic toxicology (Amsterdam, Netherlands). vol 178. 2017-01-17. PMID:27497304. |
from day 12 onwards, gadd45α, cdk1 and bcl-2 genes were up-regulated following protracted exposure, indicating dna repair, cell-cycle arrest and apoptosis. |
2017-01-17 |
2023-08-13 |
Not clear |
| Sebastian Czaplinski, Manuela Hugle, Valerie Stiehl, Simone Fuld. Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis. Oncotarget. vol 7. issue 8. 2017-01-09. PMID:26046302. |
mechanistically, bi 2536/vcr co-treatment triggers prolonged mitotic arrest, which is necessary for bi 2536/vcr-mediated apoptosis, since pharmacological inhibition of mitotic arrest by the cdk1 inhibitor ro-3306 significantly reduces cell death. |
2017-01-09 |
2023-08-13 |
Not clear |
| Kuei-Li Lin, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells. Integrative cancer therapies. vol 13. issue 3. 2016-12-13. PMID:22505597. |
the combined treatment of fnq with pp2 enhanced the cell cycle arrest and apoptosis and also led to the downregulation of bcl-xl, mcl-1, xiap, cyclin a, cyclin b, cdk1, and cdk2 and upregulation of p27, bax, and bad. |
2016-12-13 |
2023-08-12 |
human |
| Mike I Walton, Paul D Eve, Angela Hayes, Alan T Henley, Melanie R Valenti, Alexis K De Haven Brandon, Gary Box, Kathy J Boxall, Matthew Tall, Karen Swales, Thomas P Matthews, Tatiana McHardy, Michael Lainchbury, James Osborne, Jill E Hunter, Neil D Perkins, G Wynne Aherne, John C Reader, Florence I Raynaud, Suzanne A Eccles, Ian Collins, Michelle D Garret. The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma. Oncotarget. vol 7. issue 3. 2016-12-13. PMID:26295308. |
genotoxic-induced chk1 activity (ps296 chk1) and cell cycle arrest (py15 cdk1) were inhibited both in vitro and in human tumor xenografts by cct245737, causing increased dna damage and apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |
| Nithyananda Thorenoor, Petra Faltejskova-Vychytilova, Sonja Hombach, Jitka Mlcochova, Markus Kretz, Marek Svoboda, Ondrej Slab. Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget. vol 7. issue 1. 2016-11-07. PMID:26506418. |
long non-coding rna zfas1 interacts with cdk1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. |
2016-11-07 |
2023-08-13 |
Not clear |
| Shixuan Zhang, Yongming Bao, Xiulan Ju, Kangjian Li, Haiyan Shang, Lisha Ha, Yuan Qian, Liang Zou, Xiaodan Sun, Jing Li, Qianru Wang, Qingyu Fa. BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS. Scientific reports. vol 5. 2016-09-12. PMID:26330167. |
ba-j as a novel cdk1 inhibitor selectively induces apoptosis in cancer cells by regulating ros. |
2016-09-12 |
2023-08-13 |
Not clear |