| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chae Eun Kim, Do Youn Jun, Jong-Sik Kim, Young Ho Ki. Cis-trimethoxy resveratrol induces intrinsic apoptosis via prometaphase arrest and prolonged CDK1 activation pathway in human Jurkat T cells. Oncotarget. vol 9. issue 4. 2019-11-20. PMID:29435156. |
cis-trimethoxy resveratrol induces intrinsic apoptosis via prometaphase arrest and prolonged cdk1 activation pathway in human jurkat t cells. |
2019-11-20 |
2023-08-13 |
human |
| Ying Shen, Wenling Tu, Yunqiang Liu, Xiling Yang, Qiang Dong, Bo Yang, Jinyan Xu, Yuanlong Yan, Xue Pei, Mohan Liu, Wenming Xu, Yuan Yan. TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29748603. |
we demonstrated that the promotion of p53 degradation by tspy1 influenced the activity of p53 target molecules (cdk1, p21, and bax) to expedite the g2/m phase transition and decrease cell apoptosis, accelerating cell proliferation. |
2019-11-07 |
2023-08-13 |
mouse |
| Hui Zou, Runying Zou, Keke Chen, Chengguang Zhu, Xin Tian, Yalan You, Xiangling H. miR-129 targets CDK1 and iASPP to modulate Burkitt lymphoma cell proliferation in a TAp63-dependent manner. Journal of cellular biochemistry. vol 119. issue 11. 2019-10-10. PMID:30105797. |
cyclin b/cyclin-dependent kinase 1 (cdk1) phosphorylates inhibitor of apoptosis stimulating protein of p53 (iaspp) to promote iaspp nucleus localization and its inhibitory effect on p53. |
2019-10-10 |
2023-08-13 |
Not clear |
| Xinjian Yu, Ri-Qing Yu, Xiyang Zhang, Fengping Zhan, Xian Sun, Yuping W. DDT exposure induces cell cycle arrest and apoptosis of skin fibroblasts from Indo-Pacific humpback dolphin via mitochondria dysfunction. Aquatic toxicology (Amsterdam, Netherlands). vol 213. 2019-09-25. PMID:31255889. |
the dna damage and mitochondria dysfunction were likely triggered by an increase of cellular reactive oxygen species (ros), alteration in mitochondrial membrane potential, reduction in the cellular atp levels, decreased expression of the genes cdk1, cdk4, cyclin b1, cyclin d1 and apoptosis regulator bcl-2, release of cytochrome c, and activation of caspase-3, caspase-8 and caspase-9. |
2019-09-25 |
2023-08-13 |
Not clear |
| Li Zhang, Wenquan Kang, Xiaolan Lu, Shiyang Ma, Lei Dong, Baicang Zo. LncRNA CASC11 promoted gastric cancer cell proliferation, migration and invasion in vitro by regulating cell cycle pathway. Cell cycle (Georgetown, Tex.). vol 17. issue 15. 2019-09-20. PMID:30200804. |
meanwhile, mir-340-5p overexpression promoted gc cell apoptosis and induced cell cycle arrest, while cdk1 overexpression inhibited cell apoptosis and accelerated cell cycle. |
2019-09-20 |
2023-08-13 |
Not clear |
| Guangyu Zhou, Xiaofei Zhang, Wanning Wang, Wenlong Zhang, Huaying Wang, Guangda Xi. Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-07-01. PMID:30865617. |
results a total of 1246 degs were identified from pbmcs samples, among them upregulated ccl5 was found to be involved in the chemokine signaling pathway, and bax was found to be apoptosis related; while downregulated ppm1a and cdk1 were associated with the mapk signaling pathway and the p53 signaling pathway, respectively. |
2019-07-01 |
2023-08-13 |
Not clear |
| Yi Zhang, Li Zhang, Qiyu Zhang, Weilong Hong, Xiaohua Li. [microRNA-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 46. issue 6. 2019-05-20. PMID:29658663. |
overexpression of mir-222 enhanced the cell viability of hs fibroblasts; increased mrna and protein expressions of proliferating cell nuclear antigen (pcna), collagen alpha-1 (Ⅰ) chain (col1a1) and collagen alpha-1 (Ⅲ) chain (col3a1); increased cell population in s phase and protein expressions of cyclin d1, cyclin e1 and cyclin-dependent kinases 1 (cdk1); inhibited cell apoptosis and reduced protein expressions of caspase-3/9. |
2019-05-20 |
2023-08-13 |
Not clear |
| Rui Tao Zhang, Hui Rong Shi, Fang Ren, Zhe Ying Liu, Peng Cheng J. [Effects of Diallyl Disulfide on the Proliferation and Apoptosis of Epithelial Ovarian Cancer Cells by Inducing G2/M Arrest]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 41. issue 1. 2019-05-14. PMID:30837041. |
after 30 mg/l dads was applied to sk-ov-3 and ovcar-3 cells for 24 h,the expressions of p-chk1(ser345)(f=108.89,p=0.013;f=97.58,p=0.018),p-cdc25c(ser216)(f=87.25,p=0.025;f=114.25,p=0.009),p-p53(ser15)(f=112.41,p=0.011;f=255.87,p=0.000),p21waf1(f=246.38,p=0.001;f=141.36,p=0.005)and p-cdk1(thr14/tyr15)protein(f=298.12,p=0.000;f=233.15,p=0.000)were significantly increased,whereas the expressions of cdk1(f=308.24,p=0.000;f=257.55,p=0.000)and cyclinb1 protein(f=223.15,p=0.001;f=241.28,p=0.000)were significantly reduced.the expressions of proliferation and apoptosis-related proteins pcna(f=77.36,p=0.031;f=157.28,p=0.001),ki-67(f=205.64,p=0.007;f=315.22,p=0.000)and survivin(f=122.13,p=0.013;f=188.24,p=0.000)were significantly decreased and cleaved-caspase3 protein was significantly increased(f=86.46,p=0.023;f=99.11,p=0.009).conclusion dads can inhibit the proliferation of ovarian cancer cells and induce their apoptosis,which may be related to the activation of chk1-cdc25c and p53-p21waf1 signaling pathways in g2/m checkpoint,decreased kinase activity of cdk1,down-regulated expressions of cdk1 and cyclinb1 proteins,and ultimately cell cycle arrest at g2/m phase. |
2019-05-14 |
2023-08-13 |
mouse |
| María Galindo-Moreno, Servando Giráldez, Carmen Sáez, Miguel Á Japón, Maria Tortolero, Francisco Romer. Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer. Scientific reports. vol 7. issue 1. 2019-04-23. PMID:28855742. |
in fact, cdk1 inhibition downregulates survival and induces apoptosis. |
2019-04-23 |
2023-08-13 |
human |
| Dong-Jun Fu, Ping Li, Bo-Wen Wu, Xin-Xin Cui, Cheng-Bin Zhao, Sai-Yang Zhan. Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors. European journal of medicinal chemistry. vol 165. 2019-03-21. PMID:30690300. |
compound 19c could inhibit mgc803 cell growth and colony formation, induce g2/m phase arrest by down expression of cdk1, and promote apoptosis by regulating dr5 and bcl-2 family. |
2019-03-21 |
2023-08-13 |
Not clear |
| Xiaozhe Qi, Liye Zhu, Bo Yang, Haoshu Luo, Wentao Xu, Xiaoyun He, Kunlun Huan. Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 121. 2019-02-13. PMID:30120945. |
oct2 knockout alleviated the increase of caspase 3 and cdk1 induced by ota, leading to a reduction of apoptosis. |
2019-02-13 |
2023-08-13 |
rat |
| Xiaozhe Qi, Liye Zhu, Bo Yang, Haoshu Luo, Wentao Xu, Xiaoyun He, Kunlun Huan. Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 121. 2019-02-13. PMID:30120945. |
in short, our findings indicate that oct2 knockout possibly mitigate ota-induced apoptosis by preventing the increase of caspase 3 and cdk1. |
2019-02-13 |
2023-08-13 |
rat |
| Cinzia Giagulli, Pasqualina D'Ursi, Wangxiao He, Simone Zorzan, Francesca Caccuri, Kristen Varney, Alessandro Orro, Stefania Marsico, Benoît Otjacques, Carlo Laudanna, Luciano Milanesi, Riccardo Dolcetti, Simona Fiorentini, Wuyuan Lu, Arnaldo Carus. A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747658. |
here, we show that a single arginine (r) to glycine (g) mutation at position 76 in the refp17 backbone (p17r76g), as in the s75x variant, is per se sufficient to confer a b-cell clonogenic potential to the viral protein and modulate, through activation of the pten/pi3k/akt signaling pathway, different molecules involved in apoptosis inhibition (casp-9, casp-7, dff-45, npm, ywhaz, src, pax2, mapk8), cell cycle promotion and cancer progression (cdk1, cdk2, cdk8, chek1, chek2, gsk-3 beta, npm, pak1, pp2c-alpha). |
2019-02-04 |
2023-08-13 |
Not clear |
| Lauren Anton, Ann DeVine, Luz-Jeannette Sierra, Amy G Brown, Michal A Elovit. miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28596604. |
apoptosis genes, bcl2 and birc5, and proliferation genes, cdk1 and ccnd2, were repressed by mir-143 and mir-145. |
2018-12-31 |
2023-08-13 |
Not clear |
| Gabriela Vera-Lozada, Priscilla Segges, Claudio Gustavo Stefanoff, Mário Henrique M Barros, Gerald Niedobitek, Rocio Hassa. Pathway-focused gene expression profiles and immunohistochemistry detection identify contrasting association of caspase 3 (CASP3) expression with prognosis in pediatric classical Hodgkin lymphoma. Hematological oncology. vol 36. issue 4. 2018-11-07. PMID:29901224. |
selected genes were associated with cell cycle (cenpf, cdk1, ccna2, ccne2, and hmmr), apoptosis (bcl2, bcl2l1, and casp3), and monocytes/macrophages (lyz and stat1). |
2018-11-07 |
2023-08-13 |
Not clear |
| L Li, Y-W Qu, Y-P L. Over-expression of miR-1271 inhibits endometrial cancer cells proliferation and induces cell apoptosis by targeting CDK1. European review for medical and pharmacological sciences. vol 21. issue 12. 2018-07-23. PMID:28682437. |
over-expression of mir-1271 inhibits endometrial cancer cells proliferation and induces cell apoptosis by targeting cdk1. |
2018-07-23 |
2023-08-13 |
Not clear |
| Xia Xiao, Huaiqin Liu, Xiaodong L. Orlistat treatment induces apoptosis and arrests cell cycle in HSC-3 oral cancer cells. Microbial pathogenesis. vol 112. 2018-07-09. PMID:28882785. |
thus, orlistat induces apoptosis and cell cycle arrest in g2/m phase in hsc-3 cells through decrease in expression of cyclin d1 and e and increase in phosphorylation of cdk1. |
2018-07-09 |
2023-08-13 |
Not clear |
| Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang, Chuanna Li. The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells. Journal of ovarian research. vol 10. issue 1. 2018-06-04. PMID:28899430. |
the aberrant upstream pathway regulations of cdk1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells. |
2018-06-04 |
2023-08-13 |
Not clear |
| Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang, Chuanna Li. The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells. Journal of ovarian research. vol 10. issue 1. 2018-06-04. PMID:28899430. |
the present study aimed to analyze the relationship between cdk1 and the proliferation and apoptosis of ovarian cancer cells, investigate its molecular mechanism preliminarily. |
2018-06-04 |
2023-08-13 |
Not clear |
| Li-Juan Wei, Jun-An Li, Dong-Mei Bai, Ying Son. miR-223-RhoB signaling pathway regulates the proliferation and apoptosis of colon adenocarcinoma. Chemico-biological interactions. vol 289. 2018-06-04. PMID:29660302. |
we further used western blot to determine levels of cell cycle regulators cdk1 and cyclin b1 with anti-mir-223 or apoptosis with overexpression of rhob. |
2018-06-04 |
2023-08-13 |
human |