| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huihui Tian, Mengxia Ding, Yujie Guo, Zhaoyan Zhu, Yange Yu, Yadong Tian, Kui Li, Guirong Sun, Ruirui Jiang, Ruili Han, Fengbin Yan, Xiangtao Kan. Effect of HSPA8 gene on the proliferation, apoptosis and immune function of HD11 cells. Developmental and comparative immunology. 2023-02-10. PMID:36764422. |
transfection of the hspa8 interference fragment significantly downregulated the level of hspa8 expression in hd11 cells; significantly inhibited the proliferation of hd11 cells and the expression of pcna, ccnd1 and cdk1; increased the number of cells in the g1 phase and decreased the number of cells in the s phase; increased the rate of apoptosis, downregulated the expression of bcl-2 and upregulated the expression levels of fas and fasl; and inhibited the expression of the lps-induced cytokines il-1β and nf-κb. |
2023-02-10 |
2023-08-14 |
chicken |
| Shuai Zhang, Ru Feng, Jiefei Bai, Shangyong Ning, Xiaodong Xu, Jie Sun, Meng Wu, Hui Li. CDK7 inhibition induces apoptosis in acute myeloid leukemia cells and exerts synergistic antileukemic effects with azacitidine Leukemia & lymphoma. 2023-01-19. PMID:36657437. |
thz1 decreased cell viability, induced apoptosis in a dose and time-dependent manner, induced g0/g1 cell cycle arrest, decreased phosphorylated cdk1 and cdk2 expression, and inhibited rna pol ii phosphorylation at multiple serine sites. |
2023-01-19 |
2023-08-14 |
mouse |
| Idir Malki, Inara Liepina, Nora Kogelnik, Hollie Watmuff, Sue Robinson, Adam Lightfoot, Oksana Gonchar, Andrew Bottrill, Andrew M Fry, Cyril Domingue. Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions. Nucleic acids research. 2022-12-20. PMID:36537190. |
we established that sam68 is specifically phosphorylated at t33 and t317 by cdk1, and demonstrated that these phosphorylation events reduce the binding of sam68 to rna, control its cellular localization and reduce its alternative splicing activity, leading to a reduction in the induction of apoptosis and an increase in the proliferation of hct116 cells. |
2022-12-20 |
2023-08-14 |
Not clear |
| Deepa Mandal, Paritosh Patel, Suresh K Verma, Bikash Ranjan Sahu, Tithi Parij. Proximal discrepancy in intrinsic atomic interaction arrests G2/M phase by inhibiting Cyclin B1/CDK1 to infer molecular and cellular biocompatibility of D-limonene. Scientific reports. vol 12. issue 1. 2022-10-28. PMID:36307489. |
the study suggested the arrest of the cell cycle at g2/m phase leading to apoptosis and other discrepancies of molecular activity mediated via significant alteration in protein expression pattern of anti-apoptotic proteins like cyclin b1 and cdk1. |
2022-10-28 |
2023-08-14 |
Not clear |
| Yuan Yuan, Xiaojing Zhang, Kaining Du, Xiaohui Zhu, Shanshan Chang, Yang Chen, Yidan Xu, Jiachun Sun, Xiaonuan Luo, Shiqi Deng, Ying Qin, Xianling Feng, Yanjie Wei, Xinmin Fan, Ziyang Liu, Baixin Zheng, Hassan Ashktorab, Duane Smoot, Song Li, Xiaoxun Xie, Zhe Jin, Yin Pen. Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer. Cell death & disease. vol 13. issue 9. 2022-09-27. PMID:36167685. |
these findings suggest that circ_cea protects gc cells from stress-induced apoptosis, via acting as a protein scaffold and interacting with p53 and cdk1 proteins. |
2022-09-27 |
2023-08-14 |
Not clear |
| Qin Zhang, Li Chen, Mengxi Gao, Shubin Wang, Lingzhen Meng, Liru Gu. Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN. Molecular and cellular biochemistry. 2022-09-09. PMID:36083512. |
molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human hepg2 cell proliferation by targeting bax, cdk1, and jun. |
2022-09-09 |
2023-08-14 |
human |
| Qin Zhang, Li Chen, Mengxi Gao, Shubin Wang, Lingzhen Meng, Liru Gu. Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN. Molecular and cellular biochemistry. 2022-09-09. PMID:36083512. |
thus, kaempferol can promote hepg2 cell apoptosis, and the regulatory mechanism may be related to the regulation of the expression levels of the apoptosis-related proteins bax, cdk1, and jun. |
2022-09-09 |
2023-08-14 |
human |
| Si Huang, Jingxian Xiao, Junyong Wu, Jiayi Liu, Xueping Feng, Chengdong Yang, Daxiong Xiang, Shilin Lu. Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity. Frontiers in pharmacology. vol 13. 2022-06-13. PMID:35694267. |
tizoxanide promotes apoptosis in glioblastoma by inhibiting cdk1 activity. |
2022-06-13 |
2023-08-14 |
Not clear |
| Libang Yang, Adam Gilbertsen, Karen Smith, Hong Xia, LeeAnn Higgins, Candace Guerrero, Craig A Henk. Proteomic analysis of the IPF mesenchymal progenitor cell nuclear proteome identifies abnormalities in key nodal proteins that underlie their fibrogenic phenotype. Proteomics. 2022-05-28. PMID:35633524. |
interactomics implicated parp1, cdk1, and bach1 as key hub proteins in the dna damage/repair, differentiation, and apoptosis signaling pathways respectively. |
2022-05-28 |
2023-08-13 |
mouse |
| Y-J Yang, S Luo, Z-L X. Effects of miR-490-5p targeting CDK1 on proliferation and apoptosis of colon cancer cells via ERK signaling pathway. European review for medical and pharmacological sciences. vol 26. issue 6. 2022-04-01. PMID:35363355. |
effects of mir-490-5p targeting cdk1 on proliferation and apoptosis of colon cancer cells via erk signaling pathway. |
2022-04-01 |
2023-08-13 |
Not clear |
| Jean Schneider, Ye Won Jeon, Young Jin Suh, Seung Taek Li. Effects of Ruxolitinib and Calcitriol Combination Treatment on Various Molecular Subtypes of Breast Cancer. International journal of molecular sciences. vol 23. issue 5. 2022-03-10. PMID:35269680. |
our results revealed the synergistic anticancer effect of ruxolitinib and calcitriol combination treatment in skbr3 and mda-mb-468 cells, but not in mcf-7 cells in vitro, via cell proliferation inhibition, apoptosis induction, cell cycle arrest, and the alteration of cell signaling protein expression, including cell cycle-related (cyclin d1, cdk1, cdk4, p21, and p27), apoptosis-related (c-caspase and c-parp), and cell proliferation-related (c-myc, p-p53, and p-jak2) proteins. |
2022-03-10 |
2023-08-13 |
mouse |
| Xiao Yang, Xingchen Li, Yuan Cheng, Jingyi Zhou, Boqiang Shen, Lijun Zhao, Jianliu Wan. Comprehensive Analysis of the Glycolysis-Related Gene Prognostic Signature and Immune Infiltration in Endometrial Cancer. Frontiers in cell and developmental biology. vol 9. 2022-02-28. PMID:35223866. |
further, the protein of cdk1, a gene in the signature, was found to be closely related to prognosis of ec and inhibition of cdk1 could inhibit migration and promote apoptosis of ec cells. |
2022-02-28 |
2023-08-13 |
Not clear |
| Huihui Tian, Mengxia Ding, Yujie Guo, Zhaoyan Zhu, Yange Yu, Yadong Tian, Kui Li, Guirong Sun, Ruirui Jiang, Ruili Han, Fengbin Yan, Xiangtao Kan. Effect of HSPA8 on the proliferation, apoptosis and immune function of chicken macrophages. The international journal of biochemistry & cell biology. 2022-02-26. PMID:35217190. |
transfection of the hspa8 interference fragment significantly downregulated the level of hspa8 expression in hd11 cells; significantly inhibited the proliferation of hd11 cells and the expression of pcna, ccnd1 and cdk1; increased the number of cells in the g1 phase and decreased the number of cells in the s phase; increased the rate of apoptosis, downregulated the expression of bcl-2 and upregulated the expression levels of fas and fasl; and inhibited the expression of the lps-induced cytokines il-1β and nf-κb. |
2022-02-26 |
2023-08-13 |
chicken |
| Xiaoyu Li, Peng Zhou, Zhen Luo, Ru Feng, Lu Wan. Hohenbuehelia serotina polysaccharides self-assembled nanoparticles for delivery of quercetin and their anti-proliferative activities during gastrointestinal digestion in vitro. International journal of biological macromolecules. 2022-01-30. PMID:35093441. |
compared with undigested ones, qc-hsp nps after gastrointestinal digestion exhibited the more significant anti-proliferative activity on hela cells through accumulation of intracellular ros, arrest of cell cycle at g2/m phase by regulation of cyclin b1, cdk1, p53 and p21 and induction of apoptosis by er apoptosis pathway. |
2022-01-30 |
2023-08-13 |
Not clear |
| Wei-Hao Li, Kai Huang, Feng-Biao Wen, Guang-Hui Cui, Hai-Zhou Guo, Song Zha. PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway. Laboratory investigation; a journal of technical methods and pathology. 2022-01-18. PMID:35039611. |
furthermore, functional experimental results suggested that loss of plod3 led to increased phosphorylation levels of cdk1 and limd1 and downregulated yap1, thereby suppressing the proliferation, colony formation, cell cycle entry, and resistance to apoptosis of nsclc cells in vitro and inhibiting tumor growth in vivo. |
2022-01-18 |
2023-08-13 |
human |
| Camilla Pecoraro, Barbara Parrino, Stella Cascioferro, Adrian Puerta, Amir Avan, Godefridus J Peters, Patrizia Diana, Elisa Giovannetti, Daniela Carbon. A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells. Molecules (Basel, Switzerland). vol 27. issue 1. 2022-01-11. PMID:35011251. |
interestingly, cyclin-dependent kinase 1 (cdk1) is overexpressed in pdac tissues and has been correlated to the aggressive nature of these tumors because of its key role in cell cycle progression and resistance to the induction of apoptosis. |
2022-01-11 |
2023-08-13 |
Not clear |
| Nadeeya Mad-Adam, Thidarath Rattanaburee, Tanotnon Tanawattanasuntorn, Potchanapond Graidis. Effects of trans-(±)-kusunokinin on chemosensitive and chemoresistant ovarian cancer cells. Oncology letters. vol 23. issue 2. 2022-01-07. PMID:34992691. |
moreover, western blot analysis was performed to determine the proteins level of topoisomerase ii, cyclin d1, cdk1, bax and p53-upregulated modulator of apoptosis (puma). |
2022-01-07 |
2023-08-13 |
Not clear |
| Bang-Xu Nie, Gang Zhao, Xiao-Feng Yuan, Lin-Xin Yu, Jin Zhang, Yong Yuan, Yao Liu, Jun Hu, En Song, Yu-Cheng Zhou, Jun Sh. Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo. Journal of chemical neuroanatomy. vol 119. 2021-12-11. PMID:34839004. |
inhibition of cdk1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo. |
2021-12-11 |
2023-08-13 |
rat |
| Bang-Xu Nie, Gang Zhao, Xiao-Feng Yuan, Lin-Xin Yu, Jin Zhang, Yong Yuan, Yao Liu, Jun Hu, En Song, Yu-Cheng Zhou, Jun Sh. Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo. Journal of chemical neuroanatomy. vol 119. 2021-12-11. PMID:34839004. |
cyclin-dependent kinase 1 (cdk1) is closely related to the apoptosis pathway, but no csci-related studies on cdk1 have been conducted. |
2021-12-11 |
2023-08-13 |
rat |
| Bang-Xu Nie, Gang Zhao, Xiao-Feng Yuan, Lin-Xin Yu, Jin Zhang, Yong Yuan, Yao Liu, Jun Hu, En Song, Yu-Cheng Zhou, Jun Sh. Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo. Journal of chemical neuroanatomy. vol 119. 2021-12-11. PMID:34839004. |
in conclusion, cdk1 downregulation suppressed the activation of anterior horn astrocytes and microglia, promoted motor neuron repair, and inhibited neurons apoptosis and autophagy to promote the recovery of motor function after spinal cord injury. |
2021-12-11 |
2023-08-13 |
rat |