| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baskaran Stephen Inbaraj, Leng-Huei Hua, Bing-Huei Che. Comparative Study on Inhibition of Pancreatic Cancer Cells by Resveratrol Gold Nanoparticles and a Resveratrol Nanoemulsion Prepared from Grape Skin. Pharmaceutics. vol 13. issue 11. 2021-11-30. PMID:34834286. |
western blot analysis implied that both can down-regulate expressions of cyclin a, cyclin b, cdk1, and cdk2 and up-regulate expressions of p53 and p21, accompanied by enhancing cytochrome c expression, decreasing bcl-2 expression, increasing bax expression, and leading to the elevation of caspase-8, caspase-9, and caspase-3 activities for cell apoptosis execution. |
2021-11-30 |
2023-08-13 |
Not clear |
| Shuxin Kong, Jianyang Liu, Bin Zhang, Feng Lv, Yang Yu, Tao Qi. MicroRNA-337-3p impedes breast cancer progression by targeting cyclin-dependent kinase 1. Oncology letters. vol 23. issue 1. 2021-11-26. PMID:34820014. |
cdk1 expression was upregulated in bc cells and tissues, which was associated with increased cell proliferation and adhesion, as well as decreased apoptosis in bc. |
2021-11-26 |
2023-08-13 |
Not clear |
| Fuchuan Xie, Wei Xiao, Yunming Tian, Yuhong Lan, Chi Zhang, Li Ba. MicroRNA-195-3p inhibits cyclin dependent kinase 1 to induce radiosensitivity in nasopharyngeal carcinoma. Bioengineered. vol 12. issue 1. 2021-11-23. PMID:34585634. |
cdk1 was a target gene of mir-195-3p, and cdk1 overexpression counteracted the effects of mir-195-3p on npc cell growth, apoptosis, cell cycle progression and radiosensitivity. |
2021-11-23 |
2023-08-13 |
human |
| A K M Nawshad Hossian, Gerardo G Mackenzie, George Mattheolabaki. Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649787. |
following transfection with mir‑143 and mir‑506, we analyzed the differential gene expression of cdk4 and cdk1, using qpcr or western blot analysis, and evaluated cell cycle inhibition, apoptosis and cytotoxicity. |
2021-10-28 |
2023-08-13 |
Not clear |
| A K M Nawshad Hossian, Gerardo G Mackenzie, George Mattheolabaki. Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649787. |
the combinatorial mir‑143/506 treatment downregulated cdk4 and cdk1 levels, and induced apoptosis in lc cells, while sparing normal lung fibroblasts. |
2021-10-28 |
2023-08-13 |
Not clear |
| Xiaofeng Zhou, Yingting He, Nian Li, Guofeng Bai, Xiangchun Pan, Zhe Zhang, Hao Zhang, Jiaqi Li, Xiaolong Yua. DNA methylation mediated RSPO2 to promote follicular development in mammals. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34175894. |
moreover, rspo2 promoted the proliferation of gcs with increasing the expression level of pcna, cdk1, and ccnd1 and promoted the e2 secretion of gcs with increasing the expression level of cyp19a1 and hsd17b1 and inhibited the apoptosis of gcs with decreasing the expression level of caspase3, cleaved caspase3, cleaved caspase8, cleaved caspase9, cleaved parp, and bax. |
2021-09-20 |
2023-08-13 |
Not clear |
| Rosa Wijnen, Camilla Pecoraro, Daniela Carbone, Hamid Fiuji, Amir Avan, Godefridus J Peters, Elisa Giovannetti, Patrizia Dian. Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC). Cancers. vol 13. issue 17. 2021-09-13. PMID:34503199. |
targeting cdk1 showed promising results for pdac treatment in different preclinical models, where cdk1 inhibition induced cell cycle arrest in the g2/m phase and led to induction of apoptosis. |
2021-09-13 |
2023-08-13 |
Not clear |
| Rosa Wijnen, Camilla Pecoraro, Daniela Carbone, Hamid Fiuji, Amir Avan, Godefridus J Peters, Elisa Giovannetti, Patrizia Dian. Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC). Cancers. vol 13. issue 17. 2021-09-13. PMID:34503199. |
to conclude, cdk1 inhibition induces g2/m cell cycle arrest, stimulates apoptosis, and specifically targets cscs, which makes it a promising treatment for pdac. |
2021-09-13 |
2023-08-13 |
Not clear |
| Hamid Cheshomi, Ahmad Reza Bahrami, Maryam M Mati. Ellagic acid and human cancers: a systems pharmacology and docking study to identify principal hub genes and main mechanisms of action. Molecular diversity. vol 25. issue 1. 2021-09-02. PMID:32410114. |
generally, it turned out that ea probably exerts most of its anticancer activities, through induction of apoptosis, as well as p53 and wnt signaling pathways, and also by affecting the expression of several hub genes such as cdkn1a, cdk4, cdk2, cdk6, tp53, jun, ccna2, mapk14, cdk1, and ccnb1 and especially interactions with some related proteins including p53, cdk6, and mapk14. |
2021-09-02 |
2023-08-13 |
human |
| Ling Wang, Yan Chen, Hui Li, Qiqi Xu, Rong Li. The cyclin-dependent kinase inhibitor AT7519 augments cisplatin's efficacy in ovarian cancer via multiple oncogenic signaling pathways. Fundamental & clinical pharmacology. 2021-07-29. PMID:34212421. |
mechanistic studies suggest that at7519 (i) inhibits proliferation via decreasing activities of cdk1 and 2, and via inhibiting rna transcription; (ii) inhibits migration via suppressing epithelial-mesenchymal transition (emt); and (iii) induces apoptosis via decreasing mcl-1 and increasing bim in ovarian cancer cells. |
2021-07-29 |
2023-08-13 |
mouse |
| Xiaowei Zhang, Yu Dong, Miao Gao, Minfeng Hao, Hui Ren, Ling Guo, Hua Gu. Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-13. PMID:33196942. |
the expression of genes related to apoptosis and drug resistance as well as the cell cycle regulators, including mdm2, cyclinb1, and cdk1, were detected by western blot. |
2021-07-13 |
2023-08-13 |
Not clear |
| Omeed Darweesh, Eman Al-Shehri, Hugo Falquez, Joachim Lauterwasser, Frank Edlich, Rajnikant Pate. Identification of a novel Bax-Cdk1 signalling complex that links activation of the mitotic checkpoint to apoptosis. Journal of cell science. vol 134. issue 8. 2021-07-12. PMID:33722980. |
we show here that activated cdk1 forms a complex with the pro-apoptotic proteins bax and bak (also known as bak1) during sac-induced apoptosis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Min Ren, Lihui Yang, Dongxia Li, Ling Yang, Yila Su, Xiulan S. Cell Cycle Regulation by Berberine in Human Melanoma A375 Cells. Bulletin of experimental biology and medicine. vol 169. issue 4. 2021-07-09. PMID:32915362. |
we studied the effects of berberine on the proliferation, apoptosis, and migration of skin melanoma a375 cells, as well as cell cycle-related mirnas and their target genes, cdk1, cdk2, and cyclins d1 and a. |
2021-07-09 |
2023-08-13 |
human |
| Liansheng Gao, Chun Wang, Bing Qin, Tao Li, Weilin Xu, Cameron Lenahan, Guangyu Ying, Jianru Li, Tengfei Zhao, Yongjian Zhu, Gao Che. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and "cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats. Cell transplantation. vol 29. 2021-06-24. PMID:32841050. |
the pfkfb3 agonist, meclizine, activated cyclin-dependent kinase 1 (cdk1) and promoted the phosphorylation of p27, ultimately suppressing neuronal apoptosis. |
2021-06-24 |
2023-08-13 |
rat |
| Xun Yin, Yingjie Wang, Yingfei Sun, Yun Han, Huanling Sun, Mengyun Zou, Ronglong Luo, Xiuli Pen. Down-regulated gga-miR-223 inhibits proliferation and induces apoptosis of MG-infected DF-1 cells by targeting FOXO3. Microbial pathogenesis. vol 155. 2021-06-17. PMID:33932542. |
further studies showed that overexpressed gga-mir-223 could promote cell proliferation, cell cycle, and inhibit cell apoptosis by notably promoting the expression of cell cycle marker genes cyclin-dependent kinase 1 (cdk1), cyclin-dependent kinase 6 (cdk6) and cyclin d1 (ccnd1) and inhibiting the expression of apoptosis markers bcl-2-like 11(bim), fas ligand (faslg) and tnf-related apoptosis-inducing ligand (trail). |
2021-06-17 |
2023-08-13 |
chicken |
| Chao Yang, Feng Li, Jianbin Ma, Hai-Bao Zhang, Jing Jia, Jin Zeng, Xinyang Wang, Dalin He, Peng Gu. Evaluation of anti-cancer potency of silibinin on murine renal carcinoma RenCa cells in an animal model with an intact immune system. Anti-cancer drugs. vol 31. issue 8. 2021-06-15. PMID:32209841. |
silibinin slightly triggered apoptosis and significantly induced g2-m cell cycle arrest by downregulating cyclin b1 and cdk1 and increasing expression of p21. |
2021-06-15 |
2023-08-13 |
mouse |
| Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Sh. Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells. Frontiers in pharmacology. vol 12. 2021-06-08. PMID:34093198. |
glucocappasalin induces g2/m-phase arrest, apoptosis, and autophagy pathways by targeting cdk1 and plk1 in cervical carcinoma cells. |
2021-06-08 |
2023-08-13 |
Not clear |
| Hong-Yong Zhang, Ying-Chun Ouyang, Jian Li, Chun-Hui Zhang, Wei Yue, Tie-Gang Meng, Heide Schatten, Qing-Yuan Sun, Wei-Ping Qia. Gefitinib reduces oocyte quality by disturbing meiotic progression. Toxicology. vol 452. 2021-05-12. PMID:33548356. |
we further showed that gefitinib treatment increased phosphorylation of cdk1 at the site of try15, inhibited cyclin b1 entry into the nucleus, and disrupted normal spindle assembly, chromosome alignment and mitochondria dynamics, finally leading to the generation of aneuploidy and early apoptosis of oocytes. |
2021-05-12 |
2023-08-13 |
Not clear |
| Chunhua Lin, Hejia Yuan, Wenting Wang, Zhe Zhu, Youyi Lu, Jiahui Wang, Fan Feng, Jitao W. Importance of PNO1 for growth and survival of urinary bladder carcinoma: Role in core-regulatory circuitry. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-04-23. PMID:31800162. |
cd44, ptgs2, cyclin d1, cdk1, il-8, fra1, as well as mtor, p70 s6 kinase, p38 and caspase-3 proteins were all down-regulated in pno1 kd cells, suggesting the involvement of pno1 in inflammatory responses, cell cycle regulation, chemotaxis, cell growth and proliferation, apoptosis, cell migration and invasiveness. |
2021-04-23 |
2023-08-13 |
mouse |
| Xuan Che, Jianzhang Wang, Jiayi He, Qin Yu, Wenting Sun, Shuyi Chen, Gen Zou, Tiantian Li, Xinyue Guo, Xinmei Zhan. A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-04-22. PMID:31814282. |
we found that mifepristone causes cell cycle arrest through inhibiting cdk1 and cdk2 expressions and induces cell apoptosis via the mitochondria-dependent signalling pathway in endometrial epithelial cells and stromal cells of adenomyosis. |
2021-04-22 |
2023-08-13 |
human |