| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Zhang, Wei-Long Hong, Zhi-Ming Li, Qi-Yu Zhang, Kang Zen. The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars. Aesthetic plastic surgery. vol 45. issue 2. 2021-04-19. PMID:32350561. |
the overexpression of mir-222 enhanced the hs fibroblast proliferation, increased the cell population in the s phase, inhibited the cell apoptosis, enhanced the expression levels of col1a1, col3a1 mrna/protein, proliferating cell nuclear antigen (pcna), cyclin d1, cyclin e1 and cdk1 and reduced the expression levels of cleaved caspase-3/9. |
2021-04-19 |
2023-08-13 |
Not clear |
| Ashraf A Aly, Stefan Bräse, Alaa A Hassan, Nasr K Mohamed, Lamiaa E Abd El-Haleem, Martin Nieger, Nesrin M Morsy, Mohammed B Alshammari, Mahmoud A A Ibrahim, Elshimaa M N Abdelhafe. Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents. Molecules (Basel, Switzerland). vol 25. issue 23. 2021-04-07. PMID:33260954. |
design, synthesis, and molecular docking of paracyclophanyl-thiazole hybrids as novel cdk1 inhibitors and apoptosis inducing anti-melanoma agents. |
2021-04-07 |
2023-08-13 |
Not clear |
| Wei Zhu, Jing-Zi Wang, Ji-Fu Wei, Chen L. Role of m6A methyltransferase component VIRMA in multiple human cancers (Review). Cancer cell international. vol 21. issue 1. 2021-03-21. PMID:33731118. |
in an m6a-dependent or -independent manner, virma can play an oncogenic role by regulating cancer cell proliferation, migration and invasion, metastasis, apoptosis resistance and tumor growth in different pathways by targeting stem factors, ccat1/2, id2, gata3, cdk1, c-jun, etc. |
2021-03-21 |
2023-08-13 |
human |
| Ying Wang, Xiaomin Du, Jun Wan. Transfer of miR-15a-5p by placental exosomes promotes pre-eclampsia progression by regulating PI3K/AKT signaling pathway via CDK1. Molecular immunology. vol 128. 2021-01-25. PMID:33197745. |
further investigation showed that exosomal mir-15a-5p inhibited the activation of the pi3k/akt pathway by down-regulating cdk1, thus suppressing htr-8/svneo cell proliferation, invasion, and apoptosis. |
2021-01-25 |
2023-08-13 |
mouse |
| Yao Liu, Li-Li Wang, Shuo Chen, Zhi-Hong Zong, Xue Guan, Yang Zha. LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1. Journal of cellular and molecular medicine. 2021-01-09. PMID:29799152. |
overexpression of lncrna abhd11-as1 promoted the proliferation, g1-s progression, invasion and migration of endometrial cancer cells; inhibited apoptosis; up-regulated cyclin d1, cdk1, cdk2, cdk4, bcl-xl and vegfa; and down-regulated p16, while abhd11-as1 down-regulation has the opposite effect. |
2021-01-09 |
2023-08-13 |
mouse |
| Gege Chen, Ke Hu, Haiguo Sun, Jinfeng Zhou, Dongliang Song, Zhijian Xu, Lu Gao, Ye Lu, Yao Cheng, Qilin Feng, Hui Zhang, Yingcong Wang, Liangning Hu, Kang Lu, Xiaosong Wu, Bo Li, Weiliang Zhu, Jumei Sh. A novel phosphoramide compound, DCZ0847, displays in vitro and in vivo anti-myeloma activity, alone or in combination with bortezomib. Cancer letters. vol 478. 2020-12-10. PMID:32160976. |
the anti-myeloma activity of dcz0847 was associated with inhibition of cell proliferation; promotion of cell apoptosis via mitochondrial transmembrane potential collapse and caspase-mediated extrinsic or intrinsic apoptotic pathways; and the induction of g2/m phase arrest via downregulation of cdc25c, cdk1, and cyclin b1. |
2020-12-10 |
2023-08-13 |
Not clear |
| Ying Wang, Cheng-Zhen Chen, Xu-Huang Fu, Jian-Bo Liu, Yan-Xia Peng, Yi-Jie Wang, Dong-Xu Han, Zhe Zhang, Bao Yuan, Yan Gao, Hao Jiang, Jia-Bao Zhan. CPEB3 regulates the proliferation and apoptosis of bovine cumulus cells. Animal science journal = Nihon chikusan Gakkaiho. vol 91. issue 1. 2020-10-30. PMID:32648330. |
these effects were likely due cpeb3 inhibition-induced decreases in intracellular reactive oxygen species levels; increases in mitochondrial membrane potential; decreases in apoptosis; downregulation of ccna, ccnd, ccne, cdk2, cdk4, cdk6, p21, and p27 mrna expression; and upregulation of ccnb, cdk1, has2, ptgs2, ptx3, and cebpb mrna expression. |
2020-10-30 |
2023-08-13 |
cattle |
| Qing Tang, Hongmei Zhang, Man Kong, Xiaoli Mao, Xiaocui Ca. Hub genes and key pathways of non-small lung cancer identified using bioinformatics. Oncology letters. vol 16. issue 2. 2020-10-01. PMID:30008938. |
the top 9 hub genes were cyclin-dependent kinase 9 (cdk1), polo-like kinase 1, aurora kinase b, cell division cycle 20, baculoviral initiator of apoptosis repeat containing 5, mitotic checkpoint serine/threonine kinase b, proliferating cell nuclear antigen (pcna), centromere protein a and mad2 mitotic arrest deficient-like 1, and the kmplot results revealed that the high expression levels of these genes resulted in significantly low survival rates, compared with low expression samples (p<0.05), with the exception of pcna and cdk1. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhenhua Song, Yunyun Pan, Gengqiang Ling, Shiyong Wang, Min Huang, Xiaodan Jiang, Yiquan K. Escape of U251 glioma cells from temozolomide-induced senescence was modulated by CDK1/survivin signaling. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559969. |
the levels of survivin and cdk1 expression in a human glioma cell line (u251) were monitored, and cell apoptosis, cell cycle distribution, anchorage-independent growth, and senescence were studied in u251 cells in different degrees of senescence. |
2020-09-29 |
2023-08-13 |
human |
| Jinglan Jin, Hongqin Xu, Wanyu Li, Xiaotong Xu, Huan Liu, Feng We. LINC00346 Acts as a Competing Endogenous RNA Regulating Development of Hepatocellular Carcinoma via Modulating CDK1/CCNB1 Axis. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32133348. |
overexpressing linc00460 and silencing mir-199a-3p promoted cell invasion, inhibited apoptosis of hcc, and arrested the cell cycle in s phase while opposite results were obtained when silencing linc00346, cdk1, and ccnb1. |
2020-09-28 |
2023-08-13 |
Not clear |
| Mykola Zdioruk, Andrew Want, Anna Mietelska-Porowska, Katarzyna Laskowska-Kaszub, Joanna Wojsiat, Agata Klejman, Ewelina Użarowska, Paulina Koza, Sylwia Olejniczak, Stanislaw Pikul, Witold Konopka, Jakub Golab, Urszula Wojd. A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe. Cancers. vol 12. issue 8. 2020-09-28. PMID:32759730. |
in ht-29 cells, both agents altered phosphorylation status of cdk1 and of spindle assembly checkpoint proteins numa and aurora b, while g2/m arrest and apoptosis blocking was consistent with p53-independent accumulation in the nucleus and largely in the cytoplasm of p21/waf1/cip1, a key determinant of cell fate programs. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lindsay J Bailey-Steinitz, Ying-Hsuan Shih, Monte J Radeke, Pete J Coffe. An in vitro model of chronic wounding and its implication for age-related macular degeneration. PloS one. vol 15. issue 7. 2020-09-22. PMID:32701996. |
genes associated with the major rpe cell functions (lrat, mitf, rdh11) significantly downregulate after wounding, in addition to differential expression of genes associated with the cell cycle (cdk1, cdc6, cdc20), inflammation (il-18, ccl2), and apoptosis (fas). |
2020-09-22 |
2023-08-13 |
human |
| Bingjie Cai, Xinxin Wang, Hongtao Liu, Shanshan Ma, Kun Zhang, Yanting Zhang, Qinghua Li, Junmin Wang, Minghao Yao, Fangxia Guan, Guangwen Yi. Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p. Cell cycle (Georgetown, Tex.). vol 18. issue 14. 2020-08-17. PMID:31203719. |
over-expressed lncrna5322 was found to promote proliferation, colony formation ability but inhibit apoptosis of hfscs, in addition to up-regulation of the expression of cdk1 and cdk2. |
2020-08-17 |
2023-08-13 |
mouse |
| Christopher Fitzpatrick, Maximiliano F Bendek, Macarena Briones, Nicole Farfán, Valeria A Silva, Gino Nardocci, Martín Montecino, Anne Boland, Jean-François Deleuze, Jaime Villegas, Claudio Villota, Verónica Silva, Lorena Lobos-Gonzalez, Vincenzo Borgna, Eric Barrey, Luis O Burzio, Verónica A Burzi. Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors. Cell death & disease. vol 10. issue 6. 2020-06-25. PMID:31142736. |
this effect is mediated by downregulation of the key cell cycle progression factors cyclin b1, cyclin d1, cdk1, cdk4, and survivin, the latter also constituting an essential inhibitor of apoptosis, underlying additionally the onset of apoptosis. |
2020-06-25 |
2023-08-13 |
human |
| Yue Sun, Yanhui Han, Mingyue Song, Noppawat Charoensinphon, Jinkai Zheng, Peiju Qiu, Xian Wu, Hang Xia. Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis. Food & function. vol 10. issue 11. 2020-04-16. PMID:31664275. |
flow cytometry and western blotting analysis revealed that m2 and m3 caused significant cell cycle arrest and cellular apoptosis and profoundly modulated multiple proteins associated with cell proliferation and cell death, including p21, cyclin b1, cdk1, cyclin d1, cdk6, cdk4, bax, cleaved caspase-1, and cleaved parp. |
2020-04-16 |
2023-08-13 |
mouse |
| Debottam Sinha, Pascal H G Duijf, Kum Kum Khann. Mitotic slippage: an old tale with a new twist. Cell cycle (Georgetown, Tex.). vol 18. issue 1. 2020-02-17. PMID:30601084. |
abbreviations: apc/c: anaphase-promoting complex/cyclosome; bad: bcl2-associated agonist of cell death; bak1: bcl2 antagonist kinase1; bax: bcl2-associated x; bcl2: b-cell chronic lymphocytic leukaemia (cll)/lymphoma 2; bh: bcl2 homology domain; bid: bh3-interacting domain death agonist; bim: bcl2-interacting mediator of cell death; bub: budding uninhibited by benzimidazoles; cdc: cell division cycle; cdh1: cadherin-1; cdk1: cyclin-dependent kinase 1; cep55: centrosomal protein (55 kda): cin: chromosomal instability; cta: cancer testis antigen; egr1: early growth response protein 1; erk: extracellular signal-regulated kinase; escrt: endosomal sorting complexes required for transport; gin: genomic instability; mad2: mitotic arrest deficient 2; mcl1: myeloid cell leukemia sequence 1; mps1: monopolar spindle 1 kinase; myt1: myelin transcription factor 1; plk1: polo like kinase 1; puma: p53-upregulated mediator of apoptosis; sac: spindle assembly checkpoint; taa: tumor-associated antigen. |
2020-02-17 |
2023-08-13 |
Not clear |
| Qiying Yi, Yang Liu, Min Cao, Jianing Liu, Qin Xiang, Guo Tan, Huatang Zhang, Guoqi Lai, Yajun Xi. Transcriptional analysis and differentially expressed gene screening of spontaneous liver tumors in CBA/CaJ mice. Gene. vol 725. 2020-01-06. PMID:31629818. |
we further validated the functions of upregulated genes, such as cyclin-dependent kinase 1 (cdk1) and polo-like kinase 1 (plk1), with regards to cell cycle regulation, apoptosis, and proliferation in normal human liver or liver tumor-derived cell lines. |
2020-01-06 |
2023-08-13 |
mouse |
| Wei Gan, Hua Zhao, Tiegang Li, Kuijie Liu, Jiangsheng Huan. CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069733. |
in crc cell lines, cdk1 interacted with iaspp to affect crc cell proliferation and apoptosis; moreover, the p53 apoptosis pathway was involved in this progression. |
2019-11-20 |
2023-08-13 |
Not clear |
| Wei Gan, Hua Zhao, Tiegang Li, Kuijie Liu, Jiangsheng Huan. CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069733. |
taken together, we revealed that cdk1 and iaspp was up-regulated in crc tissues and cell lines; cdk1 protein interacted with iaspp protein to affect crc cell proliferation and apoptosis through the p53 apoptosis pathway. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mi Ran Byun, Jin Woo Cho. Phosphorylation of caspase-9 at Thr125 directs paclitaxel resistance in ovarian cancer. Oncotarget. vol 9. issue 1. 2019-11-20. PMID:29416675. |
however, a subsequent research showed that the expression level of cdk1 failed to show significant correlation with delayed apoptosis and patient survival. |
2019-11-20 |
2023-08-13 |
Not clear |