| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Pandolfi, V Montagnani, A Lapucci, B Stecc. HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth. Cell death and differentiation. vol 22. issue 12. 2016-08-29. PMID:26024388. |
our data show that activation of hh signaling enhances proliferation in presence of e2f1 and promotes apoptosis in its absence or upon cdk1 inhibition, suggesting that e2f1/iaspp dictates the outcome of hh signaling in melanoma. |
2016-08-29 |
2023-08-13 |
human |
| Yu-ying Liu, Guo-peng Wang, Zhe Peng, Jing-ying Guo, Qian Wu, Jing Xie, Shu-sheng Gon. E2F1-CDK1 pathway activation in kanamycin-induced spiral ganglion cell apoptosis and the protective effect of CR8. Neuroscience letters. vol 617. 2016-08-08. PMID:26905670. |
in this study, we deafened guinea pigs with a subcutaneous injection of kanamycin followed by an intravenous infusion of furosemide and then assayed the expression levels of cleaved caspase-3, e2f1, cdk1 and cleaved caspase-9 during the induced sgc apoptosis. |
2016-08-08 |
2023-08-13 |
Not clear |
| Shuit-Mun Wong, Fu-Hwa Liu, Yueh-Lun Lee, Huei-Mei Huan. MPT0B169, a New Antitubulin Agent, Inhibits Bcr-Abl Expression and Induces Mitochondrion-Mediated Apoptosis in Nonresistant and Imatinib-Resistant Chronic Myeloid Leukemia Cells. PloS one. vol 11. issue 1. 2016-07-20. PMID:26815740. |
it triggered cell cycle arrest at the g2/m phase before apoptosis, which was related to the upregulation of the mitotic marker mpm2 and the cyclin b1 level, and a change in the phosphorylation of cdk1. |
2016-07-20 |
2023-08-13 |
Not clear |
| Weihua Zhou, Jie Xu, Elise Gelston, Xing Wu, Zhengzhi Zou, Bin Wang, Yunxin Zeng, Hua Wang, Anwen Liu, Lingzhi Xu, Quentin Li. Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26188358. |
indeed, ox-1 decreases the kinase activity of cdk1 (cdc2)/cyclin b1, leading to inhibition of bcl-xl phosphorylation and subsequent resistance to apoptosis. |
2016-06-10 |
2023-08-13 |
Not clear |
| Ling-Chu Chang, Yung-Luen Yu, Min-Tsang Hsieh, Sheng-Hung Wang, Ruey-Hwang Chou, Wei-Chien Huang, Hui-Yi Lin, Hsin-Yi Hung, Li-Jiau Huang, Sheng-Chu Ku. A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics. American journal of cancer research. vol 6. issue 4. 2016-05-17. PMID:27186428. |
the activation of c-jun n-terminal kinase (jnk) was associated with mt3-037-induced cdk1 and aurora a/b activation and apoptosis. |
2016-05-17 |
2023-08-13 |
mouse |
| Hussein Basma, Sandra E Ghayad, Ghina Rammal, Angelo Mancinelli, Mohammad Harajly, Farah Ghamloush, Loai Dweik, Rabab El-Eit, Hassan Zalzali, Wissam Rabeh, Claudio Pisano, Nadine Darwiche, Raya Saa. The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26453552. |
st1926 induced an early dna damage response (ddr), which led to increase in apoptosis, in addition to s-phase cell cycle arrest and a reduction in protein levels of the cell cycle kinase cdk1. |
2016-05-13 |
2023-08-13 |
mouse |
| Anima Tripathi, Shail K Chaub. Reduction of phosphorylated Thr-161 Cdk1 level participates in roscovitine-induced Fas ligand-mediated apoptosis in rat eggs cultured in vitro. In vitro cellular & developmental biology. Animal. vol 51. issue 2. 2016-05-03. PMID:25148827. |
reduction of phosphorylated thr-161 cdk1 level participates in roscovitine-induced fas ligand-mediated apoptosis in rat eggs cultured in vitro. |
2016-05-03 |
2023-08-13 |
rat |
| Anima Tripathi, Shail K Chaub. Reduction of phosphorylated Thr-161 Cdk1 level participates in roscovitine-induced Fas ligand-mediated apoptosis in rat eggs cultured in vitro. In vitro cellular & developmental biology. Animal. vol 51. issue 2. 2016-05-03. PMID:25148827. |
the present study was aimed to find out whether roscovitine reduces phosphorylated thr-161 of cyclin-dependent kinase 1 (cdk1) level and induces egg apoptosis through fas ligand (fasl)-mediated pathway. |
2016-05-03 |
2023-08-13 |
rat |
| Anima Tripathi, Shail K Chaub. Reduction of phosphorylated Thr-161 Cdk1 level participates in roscovitine-induced Fas ligand-mediated apoptosis in rat eggs cultured in vitro. In vitro cellular & developmental biology. Animal. vol 51. issue 2. 2016-05-03. PMID:25148827. |
taken together, these results suggest that roscovitine reduced phosphorylated thr-161 of cdk1 level and induces apoptosis through fasl-mediated pathway in rat eggs cultured in vitro. |
2016-05-03 |
2023-08-13 |
rat |
| Melanie Schwermer, Sangkyun Lee, Johannes Köster, Tom van Maerken, Harald Stephan, Angelika Eggert, Katharina Morik, Johannes H Schulte, Alexander Schram. Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors. Oncotarget. vol 6. issue 17. 2016-04-29. PMID:26029996. |
apoptosis induced by cdk1 inhibition was dependent on caspase activation and was concomitant with upregulation of transcriptional targets of tp53. |
2016-04-29 |
2023-08-13 |
Not clear |
| Rosaria Chilà, Alessandra Basana, Monica Lupi, Federica Guffanti, Eugenio Gaudio, Andrea Rinaldi, Luciano Cascione, Valentina Restelli, Chiara Tarantelli, Francesco Bertoni, Giovanna Damia, Laura Carrass. Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma. Oncotarget. vol 6. issue 5. 2016-03-28. PMID:25428911. |
the combined inhibition of chk1 and wee1 was strongly synergistic in mcl cells, leading to deregulation of the cell cycle, with increased activity of cdk2 and cdk1, and activation of apoptosis. |
2016-03-28 |
2023-08-13 |
mouse |
| Xiao-Qiang Wang, Yu-Chuan Wang, Ya-Tu Guo, Xin Tan. Effect of piperlongumine on drug resistance reversal in human retinoblastoma HXO-RB44/VCR and SO-Rb50/CBP cell lines. International journal of clinical and experimental pathology. vol 8. issue 3. 2016-03-22. PMID:26045758. |
we found that after treatment with plgm, drug sensitivity and apoptosis rate of these drug resistance cancer cells were improved, cell cycle was arrested, the expressions of p-gp, mdr1, mrp1, top-ii, gst-π, survivin, bcl-2, cdk1, abcb1 and abcg1 was decreased, while the activities of caspase-3/8 and intracellular content of rh-123 was increased. |
2016-03-22 |
2023-08-13 |
human |
| Victoria C Silva, Melissa Plooster, Jessica C Leung, Lynne Cassimeri. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell cycle (Georgetown, Tex.). vol 14. issue 7. 2015-12-28. PMID:25602147. |
synchronized cells treated with a 4 hour pulse of inhibitors to cdk1 or both aurora a and plk1 delayed mitotic entry and apoptosis was triggered only in p53-deficient cells. |
2015-12-28 |
2023-08-13 |
Not clear |
| Victoria C Silva, Melissa Plooster, Jessica C Leung, Lynne Cassimeri. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell cycle (Georgetown, Tex.). vol 14. issue 7. 2015-12-28. PMID:25602147. |
expression of flag-tagged cflipl in p53-deficient cells rescues them from apoptosis triggered by stathmin depletion or cdk1 inhibition during g2. |
2015-12-28 |
2023-08-13 |
Not clear |
| Hiroshi Jikihara, Guangying Qi, Koichiro Nozoe, Mayumi Hirokawa, Hiromi Sato, Yuka Sugihara, Fumio Shimamot. Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. Oncology reports. vol 33. issue 3. 2015-11-03. PMID:25573280. |
moreover, we demonstrated that age delayed cell cycle progression by downregulating cyclin b1 and cdk1 expression via inactivation of nf-κb in the human colorectal cancer cells but did not induce apoptosis. |
2015-11-03 |
2023-08-13 |
human |
| Qinghua Xi, Menghui Huang, Yingying Wang, Jianxin Zhong, Rong Liu, Guiqin Xu, Lifei Jiang, Juan Wang, Zheng Fang, Shuyun Yan. The expression of CDK1 is associated with proliferation and can be a prognostic factor in epithelial ovarian cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 7. 2015-10-26. PMID:25910705. |
meanwhile, we found that knockdown cdk1 by shcdk1 promoted the apoptosis rate and increased the sensitivity to chemotherapy drugs. |
2015-10-26 |
2023-08-13 |
human |
| J O Ayeni, S D Campbel. "Ready, set, go": checkpoint regulation by Cdk1 inhibitory phosphorylation. Fly. vol 8. issue 3. 2015-10-05. PMID:25483135. |
these unexpected complexities in cdk1 inhibitory phosphorylation demonstrate that the checkpoint mechanism is not a simple binary "off/on" switch, but has at least three distinct states: "ready", to prevent chromosome damage and apoptosis, "set", for developmentally regulated g2 phase arrest, and "go", when cdc25 phosphatases remove inhibitory phosphates to trigger cdk1 activation at the g2/m transition. |
2015-10-05 |
2023-08-13 |
Not clear |
| J Bargiela-Iparraguirre, L Prado-Marchal, N Pajuelo-Lozano, B Jiménez, R Perona, I Sánchez-Pére. Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells. Cell cycle (Georgetown, Tex.). vol 13. issue 22. 2015-09-16. PMID:25483095. |
however, apoptosis (assessed by caspase-3 activation, parp proteolysis and levels of antiapoptotic bcl 2-family members), the dna damage response (assessed by h2ax phosphorylation) and exit from mitosis (assessed by cyclin b degradation and cdk1 regulation) were activated equally between cells, independently of mad2 or bubr1-protein levels. |
2015-09-16 |
2023-08-13 |
Not clear |
| Joyce P Y Mak, Wing Yu Man, Hoi Tang Ma, Randy Y C Poo. Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25301733. |
small-molecule inhibitors of chk1 (azd7762) or wee1 (mk-1775) induced mitotic catastrophe, as characterized by dephosphorylation of cdk1(tyr15), phosphorylation of histone h39(ser10), and apoptosis. |
2015-08-31 |
2023-08-13 |
Not clear |
| Angelika Stehle, Manuela Hugle, Simone Fuld. Eribulin synergizes with Polo-like kinase 1 inhibitors to induce apoptosis in rhabdomyosarcoma. Cancer letters. vol 365. issue 1. 2015-08-24. PMID:25917079. |
on molecular grounds, eribulin/bi 2536 co-treatment causes profound mitotic arrest, which is critically required for synergism, since inhibition of mitotic arrest by cdk1 inhibitor ro-3306 abolishes eribulin/bi 2536-mediated apoptosis. |
2015-08-24 |
2023-08-13 |
Not clear |