| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu-Fang Duan, Ying-Li Wu, Han-Zhang Xu, Meng Zhao, Han-Yi Zhuang, Xiao-Dong Wang, Hua Yan, Guo-Qiang Che. Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes. Chemico-biological interactions. vol 183. issue 1. 2010-01-28. PMID:19781537. |
we also found that the combination of ato and ptx at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (cdk1) on thr(161) and promoted the dysregulated activation of cdk1. |
2010-01-28 |
2023-08-12 |
human |
| Li-Chen Chou, Jai-Sing Yang, Li-Jiau Huang, Hsi-Chin Wu, Chi-Cheng Lu, Jo-Hua Chiang, Kuan-Tin Chen, Sheng-Chu Kuo, Jing-Gung Chun. The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells. Journal of gastroenterology. vol 44. issue 10. 2009-12-01. PMID:19688288. |
the synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (chm-1) promoted g2/m arrest through inhibition of cdk1 and induced apoptosis through the mitochondrial-dependent pathway in ct-26 murine colorectal adenocarcinoma cells. |
2009-12-01 |
2023-08-12 |
Not clear |
| Ting-Ching Chen, Kuang-Chi Lai, Jai-Sing Yang, Ching-Lung Liao, Te-Chun Hsia, Guang-Wei Chen, Jen-Jyh Lin, Hui-Ju Lin, Tsan-Hung Chiu, Yih-Jing Tang, Jing-Gung Chun. Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. International journal of oncology. vol 34. issue 6. 2009-08-18. PMID:19424587. |
while undergoing apoptosis, there was a remarkable accumulation of g2/m cells with the upregulatoin of wee1 but it also inhibited cyclin b, cdk1 and cdc25c that led to g2/m arrest. |
2009-08-18 |
2023-08-12 |
rat |
| Eun Jeong Choi, Gun-Hee Ki. Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells. The Journal of nutritional biochemistry. vol 20. issue 4. 2009-07-24. PMID:18656338. |
based on our findings, the mechanism by which apigenin causes cell cycle arrest via the regulation of cdk1 and p21(cip1) and induction of apoptosis seems to be involved in the p53-dependent pathway. |
2009-07-24 |
2023-08-12 |
human |
| Kensuke Kojima, Masaya Shimanuki, Masato Shikami, Michael Andreeff, Hideki Nakakum. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer science. vol 100. issue 6. 2009-07-08. PMID:19385969. |
we suggest that ro-3306 actively enhances downstream p53 signaling to promote apoptosis and that a combination strategy aimed at both inhibiting cdk1 and activating p53 signaling is potentially effective in aml, where tp53 mutations are rare and downstream p53 signaling is intact. |
2009-07-08 |
2023-08-12 |
Not clear |
| Haripriya Vittal Rao, Lakshmi Thirumangalakudi, Paula Gramma. Cyclin C and cyclin dependent kinases 1, 2 and 3 in thrombin-induced neuronal cell cycle progression and apoptosis. Neuroscience letters. vol 450. issue 3. 2009-04-20. PMID:19103257. |
these results suggest that decreases in g1-s regulators cyclin c and cdks 3, cdk2 and cdk1 in response to thrombin could make conditions unfavorable for s phase entry and favor neuronal apoptosis. |
2009-04-20 |
2023-08-12 |
rat |
| Eun Jeong Choi, Woong Shick Ah. Antiproliferative effects of dehydrocostuslactone through cell cycle arrest and apoptosis in human ovarian cancer SK-OV-3 cells. International journal of molecular medicine. vol 23. issue 2. 2009-04-20. PMID:19148545. |
following exposure to dehydrocostuslactone, there was a marked increase in the expression of the apoptotic protein bax and the downstream target p53, a tumor suppressor transcription factor protein, causing the release of cytochrome c. based on our findings, the mechanism by which dehydrocostuslactone causes cell cycle arrest is via cdk1 down-regulation, and its induction of apoptosis appears to be related to the activation of p53 and the release of cytochrome c. |
2009-04-20 |
2023-08-12 |
human |
| Alvaro Glavic, Cristina Molnar, Darko Cotoras, José F de Celi. Drosophila Axud1 is involved in the control of proliferation and displays pro-apoptotic activity. Mechanisms of development. vol 126. issue 3-4. 2009-04-10. PMID:19084594. |
conversely, the increase in daxud1 expression impedes cell cycle progression at mitosis through disturbance of cdk1 activity, and induces the apoptosis of these cells in a jnk-dependent manner. |
2009-04-10 |
2023-08-12 |
human |
| Rachel M A Barrett, Toby P Osborne, Sally P Wheatle. Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity. Cell cycle (Georgetown, Tex.). vol 8. issue 2. 2009-04-08. PMID:19158485. |
interestingly, survivin is phosphorylated by the mitotic kinase, cdk1, and a nonphosphorylatable form, survivin(t34a), cannot inhibit apoptosis. |
2009-04-08 |
2023-08-12 |
Not clear |
| Albert H Kim, Azad Bonn. Cdk1-FOXO1: a mitotic signal takes center stage in post-mitotic neurons. Cell cycle (Georgetown, Tex.). vol 7. issue 24. 2009-03-16. PMID:19124971. |
however, the mechanisms by which cdk1 promotes neuronal apoptosis are incompletely understood. |
2009-03-16 |
2023-08-12 |
Not clear |
| Zakir Ullah, Matthew J Kohn, Rieko Yagi, Lyubomir T Vassilev, Melvin L DePamphili. Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity. Genes & development. vol 22. issue 21. 2009-02-26. PMID:18981479. |
in contrast, ro3306 induced abortive endoreduplication and apoptosis in embryonic stem cells, revealing that inactivation of cdk1 triggers endoreduplication only in cells programmed to differentiate into polyploid cells. |
2009-02-26 |
2023-08-12 |
Not clear |
| Zakir Ullah, Matthew J Kohn, Rieko Yagi, Lyubomir T Vassilev, Melvin L DePamphili. Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity. Genes & development. vol 22. issue 21. 2009-02-26. PMID:18981479. |
ts cell mutants revealed that p57 was required to trigger endoreduplication by inhibiting cdk1, while p21 suppressed expression of the checkpoint protein kinase chk1, thereby preventing induction of apoptosis. |
2009-02-26 |
2023-08-12 |
Not clear |
| P G Hemmati, G Normand, B Gillissen, J Wendt, B Dörken, P T Danie. Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF. Oncogene. vol 27. issue 53. 2008-12-10. PMID:18806827. |
notably, p14(arf)-induced apoptosis was preceded by an arrest in the g2 phase of cell cycle, which coincided with downregulation of cdc2 (cdk1) protein expression and lack of its nuclear localization. |
2008-12-10 |
2023-08-12 |
mouse |
| Samuel C McNeely, B Frazier Taylor, J Christopher State. Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent. Toxicology and applied pharmacology. vol 231. issue 1. 2008-09-19. PMID:18501396. |
roscovitine also reduced bcl-2 ser70 phosphorylation and protected against apoptosis, suggesting mitotic arrest caused by hyperactivation of cdk1 directly or indirectly leads to bcl-2 phosphorylation and apoptosis. |
2008-09-19 |
2023-08-12 |
human |
| P Liu, T P Kao, H Huan. CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor. Oncogene. vol 27. issue 34. 2008-09-16. PMID:18408765. |
ectopic expression of constitutively active cdk1 also inhibits foxo1-induced apoptosis in pca cells. |
2008-09-16 |
2023-08-12 |
human |
| Ying Wai Chan, Hoi Tang Ma, Winnie Wong, Chui Chui Ho, Kin Fan On, Randy Y C Poo. CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis. Cell cycle (Georgetown, Tex.). vol 7. issue 10. 2008-09-15. PMID:18418077. |
cdk1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis. |
2008-09-15 |
2023-08-12 |
Not clear |
| Ying Wai Chan, Hoi Tang Ma, Winnie Wong, Chui Chui Ho, Kin Fan On, Randy Y C Poo. CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis. Cell cycle (Georgetown, Tex.). vol 7. issue 10. 2008-09-15. PMID:18418077. |
using live cell imaging and various approaches that uncoupled mitotic events, we show that apoptosis was induced by both prolonged nocodazole treatment as well as by inhibition of cdk1 activity after a transient nocodazole block. |
2008-09-15 |
2023-08-12 |
Not clear |
| Wen Xu, Jianwen Liu, Changlong Li, He-Zhen Wu, Yan-Wen Li. Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer letters. vol 264. issue 2. 2008-07-22. PMID:18343026. |
the results showed that kg induced g2/m phase growth arrest correlated with cyclin b1 and cdk1 decrease in a p53-independent manner, and also caused an increase in apoptosis, which was confirmed by characteristic morphological changes, evident dna fragmentation, increased apoptotic sub-g1 population. |
2008-07-22 |
2023-08-12 |
human |
| Weijun Liu, Wenqi Li, Takeo Fujita, Qi Yang, Yong Wa. Proteolysis of CDH1 enhances susceptibility to UV radiation-induced apoptosis. Carcinogenesis. vol 29. issue 2. 2008-03-25. PMID:18174259. |
in addition, uv-induced degradation of cdh1 results in the accumulation of cyclin b1 and therefore to increased cdk1 activity, which is believed to enhance uv-induced apoptosis. |
2008-03-25 |
2023-08-12 |
human |
| Rüdiger Schweigreiter, Taras Stasyk, Igea Contarini, Silke Frauscher, Thomas Oertle, Lars Klimaschewski, Lukas A Huber, Christine E Bandtlo. Phosphorylation-regulated cleavage of the reticulon protein Nogo-B by caspase-7 at a noncanonical recognition site. Proteomics. vol 7. issue 24. 2008-02-28. PMID:18072206. |
taken together, we identified an rtn protein as one out of a selected number of caspase targets during apoptosis and as a novel substrate for cdk1 and 2. |
2008-02-28 |
2023-08-12 |
rat |