| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven E Canfield, Keyi Zhu, Simon A Williams, David J McConke. Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells. Molecular cancer therapeutics. vol 5. issue 8. 2006-12-04. PMID:16928825. |
together, our data show that bortezomib interferes with docetaxel-induced apoptosis via a p21-dependent mechanism that is associated with cdk1 inhibition. |
2006-12-04 |
2023-08-12 |
human |
| Dongpo Cai, Vaughan M Latham, Xinxin Zhang, Geoffrey I Shapir. Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. Cancer research. vol 66. issue 18. 2006-11-28. PMID:16982772. |
these events do not occur after individual depletion of cdk2 and cdk1, suggesting that reduction of cdk2, cdk1, and rna polymerase ii activities all contribute to apoptosis in u2os cells. |
2006-11-28 |
2023-08-12 |
Not clear |
| Lyubomir T Vassilev, Christian Tovar, Shaoqing Chen, Dejan Knezevic, Xiaolan Zhao, Hongmao Sun, David C Heimbrook, Li Che. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 28. 2006-08-31. PMID:16818887. |
although cdk1 inhibition for up to 24 h is well tolerated, longer exposure to the inhibitor induces apoptosis in tumor cells, suggesting that selective cdk1 inhibitors may have utility in cancer therapy. |
2006-08-31 |
2023-08-12 |
human |
| A Rivera, A Mavila, K J Bayless, G E Davis, S A Maxwel. Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells. Cellular and molecular life sciences : CMLS. vol 63. issue 12. 2006-08-09. PMID:16799873. |
thus, cyclin a1 might mediate apoptosis and mitotic catastrophe through an unscheduled or inappropriate activation of cdk1. |
2006-08-09 |
2023-08-12 |
Not clear |
| Viveka Mayya, Karim Rezual, Linfeng Wu, Michael B Fong, David K Ha. Absolute quantification of multisite phosphorylation by selective reaction monitoring mass spectrometry: determination of inhibitory phosphorylation status of cyclin-dependent kinases. Molecular & cellular proteomics : MCP. vol 5. issue 6. 2006-07-14. PMID:16546994. |
as a test case, we chose the conserved inhibitory site of the cyclin-dependent kinases (cdks), cdk1, cdk2, and cdk3, which are important regulators of cell cycle transitions and apoptosis. |
2006-07-14 |
2023-08-12 |
Not clear |
| J-L Perfettini, M Castedo, T Roumier, K Andreau, R Nardacci, M Piacentini, G Kroeme. Mechanisms of apoptosis induction by the HIV-1 envelope. Cell death and differentiation. vol 12 Suppl 1. 2006-05-23. PMID:15719026. |
second, fusion of the interacting cells may lead to the formation of syncytia which then succumb to apoptosis in a complex pathway involving the activation of several kinases (cyclin-dependent kinase-1, cdk1; checkpoint kinase-2, chk2; mammalian target of rapamycin, mtor; p38 mitogen-activated protein kinase, p38 mapk; inhibitor of nf-kappab kinase, ikk), as well as the activation of several transcription factors (nf-kappab, p53), finally resulting in the activation of the mitochondrial pathway of apoptosis. |
2006-05-23 |
2023-08-12 |
human |
| J-L Perfettini, M Castedo, T Roumier, K Andreau, R Nardacci, M Piacentini, G Kroeme. Mechanisms of apoptosis induction by the HIV-1 envelope. Cell death and differentiation. vol 12 Suppl 1. 2006-05-23. PMID:15719026. |
third, if the env-expressing cell is at an early stage of imminent apoptosis, its fusion with a cd4-expressing target cell can precipitate the death of both cells, through a process that may be considered as contagious apoptosis and which does not involve cdk1, mtor, p38 nor p53, yet does involve mitochondria. |
2006-05-23 |
2023-08-12 |
human |
| Dongpo Cai, Kate F Byth, Geoffrey I Shapir. AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9. Cancer research. vol 66. issue 1. 2006-02-23. PMID:16397259. |
az703-induced apoptosis in nci-h1299 cells was enhanced by small interfering rna-mediated depletion of cdk9, which caused reduced levels of mcl-1 and xiap, suggesting that cdk2, cdk1, and cdk9 represent a rational subset of family members for drug targeting. |
2006-02-23 |
2023-08-12 |
Not clear |
| Mariko Tomita, Hirochika Kawakami, Jun-nosuke Uchihara, Taeko Okudaira, Masato Masuda, Nobuyuki Takasu, Takehiro Matsuda, Takao Ohta, Yuetsu Tanaka, Kazuiku Ohshiro, Naoki Mor. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. International journal of cancer. vol 118. issue 3. 2006-02-07. PMID:16106398. |
curcumin induced cell cycle arrest by reducing the expression of cyclin d1, cdk1 and cdc25c and apoptosis by reducing the expression of xiap and survivin. |
2006-02-07 |
2023-08-12 |
mouse |
| Hai Jiang, Shouqing Luo, Honglin L. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. The Journal of biological chemistry. vol 280. issue 21. 2005-08-15. PMID:15790566. |
furthermore, we found that cdk1 activity was required for etoposide-induced apoptosis of hela cells. |
2005-08-15 |
2023-08-12 |
Not clear |
| Maria Bai, Alexandra Papoudou-Bai, Panagiotis Kitsoulis, Nikolaos Horianopoulos, Sevasti Kamina, Niki John Agnantis, Panagiotis Kanavaro. Cell cycle and apoptosis deregulation in classical Hodgkin lymphomas. In vivo (Athens, Greece). vol 19. issue 2. 2005-07-12. PMID:15796209. |
moreover, substantial evidence that h/rs cells have defective cell cycle and apoptosis regulation has been provided by studies showing that these cells are characterized, in a large proportion of cases, by alterations of the p53, rb and p27 tumor suppressor pathways, overexpression of cyclins involved in the g1/s and g2/m transition such as cyclins e, d2, d3, a and b1, overexpression of cyclin-dependent kinases such as cdk1, 2 and 6 and overexpression of anti-apoptotic proteins such as c-flip, bcl-xl, c-iap2, x-linked i4p and survivin. |
2005-07-12 |
2023-08-12 |
Not clear |
| Roy M Golstey. Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle. Cancer letters. vol 217. issue 2. 2005-03-03. PMID:15617830. |
cdk1 and cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle. |
2005-03-03 |
2023-08-12 |
human |
| Uma Kamasani, Minzhou Huang, James B Duhadaway, Edward V Prochownik, P Scott Donover, George C Prendergas. Cyclin B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition. Cancer research. vol 64. issue 22. 2005-02-24. PMID:15548709. |
steady-state levels of cyclin b1 and its associated kinase cdk1 were suppressed in a rhob-dependent manner in cells fated to undergo fti-induced apoptosis. |
2005-02-24 |
2023-08-12 |
mouse |
| Dong Xiao, Candace S Johnson, Donald L Trump, Shivendra V Sing. Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells. Molecular cancer therapeutics. vol 3. issue 5. 2005-01-11. PMID:15141014. |
in conclusion, our data indicate that peitc-induced cell cycle arrest in pc-3 cells is likely due to proteasome-mediated degradation of cdc25c and cdk1, and ectopic expression of bcl-2 fails to confer resistance to peitc-induced apoptosis. |
2005-01-11 |
2023-08-12 |
human |
| Anna Maria Canudas, Elvira G Jordà, Ester Verdaguer, Andrés Jiménez, Francesc Xavier Sureda, Víctor Rimbau, Antoni Camins, Mercè Pallà. Cyclosporin A enhances colchicine-induced apoptosis in rat cerebellar granule neurons. British journal of pharmacology. vol 141. issue 4. 2004-10-14. PMID:14976124. |
roscovitine (25-50 microm), a selective cdk1, 2 and 5 inhibitor, showed an antiapoptotic effect against colchicine- and colchicine plus csa-induced apoptosis. |
2004-10-14 |
2023-08-12 |
rat |
| Maria Castedo, Jean-Luc Perfettini, Thomas Roumier, Kenichi Yakushijin, David Horne, René Medema, Guido Kroeme. The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. Oncogene. vol 23. issue 25. 2004-07-01. PMID:15048074. |
fusion between nonsynchronized cells leads to the formation of heterokarya which transiently activate cyclin-dependent kinase 1 (cdk1)/cyclin b1 and enter the prophase of the cell cycle, where they arrest due to a loss of cdk1/cyclin b1 activity, activate p53, disorganize centrosomes, and undergo apoptosis. |
2004-07-01 |
2023-08-12 |
Not clear |
| E K Han, S C Ng, N Arber, M Begemann, I B Weinstei. Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis. Apoptosis : an international journal on programmed cell death. vol 4. issue 3. 2004-01-05. PMID:14634283. |
during the g2 and m phases, premature activation of cdk1 can cause cells to enter mitotic catastrophe, which results in apoptosis. |
2004-01-05 |
2023-08-12 |
Not clear |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
moreover, the activation of cdk1 may be required for apoptosis induction in some particular pathways of cell killing. |
2003-07-30 |
2023-08-12 |
Not clear |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
this applies to several clinically important settings, for instance to paclitaxel-induced killing of breast cancer cells, in which the erbb2 receptor kinase can mediate apoptosis inhibition through inactivation of cdk1. |
2003-07-30 |
2023-08-12 |
Not clear |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
the activation of cdk1 participates also in hiv-1-induced apoptosis, upstream of the p53-dependent mitochondrial permeabilization step. |
2003-07-30 |
2023-08-12 |
Not clear |