| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ssu-Chia Lin, Shih-Chieh Chueh, Che-Jen Hsiao, Tsia-Kun Li, Tzu-Hsuan Chen, Cho-Hwa Liao, Ping-Chiang Lyu, Jih-Hwa Gu. Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia (New York, N.Y.). vol 9. issue 10. 2007-12-27. PMID:17971903. |
in summary, we suggest that prazosin is a potential antitumor agent that induces cell apoptosis through the induction of dna damage stress, leading to cdk1 inactivation and g2 checkpoint arrest. |
2007-12-27 |
2023-08-12 |
mouse |
| E Schmitt, M Beauchemin, R Bertran. Nuclear colocalization and interaction between bcl-xL and cdk1(cdc2) during G2/M cell-cycle checkpoint. Oncogene. vol 26. issue 40. 2007-10-11. PMID:17369848. |
here, we show that in addition to its mitochondrial effect that delays apoptosis, bcl-xl colocalizes and binds to cdk1(cdc2) during g(2)/m cell-cycle checkpoint and its overexpression stabilizes a g(2)/m-arrest senescence program in surviving cells after dna damage. |
2007-10-11 |
2023-08-12 |
Not clear |
| E Schmitt, M Beauchemin, R Bertran. Nuclear colocalization and interaction between bcl-xL and cdk1(cdc2) during G2/M cell-cycle checkpoint. Oncogene. vol 26. issue 40. 2007-10-11. PMID:17369848. |
the nuclear interaction of bcl-xl and cdk1(cdc2) suggests that bcl-xl is coupled to the stabilization of a cell-cycle checkpoint induced by dna damage, and this effect is genetically distinct from its function on apoptosis. |
2007-10-11 |
2023-08-12 |
Not clear |
| Andrei Goga, Dun Yang, Aaron D Tward, David O Morgan, J Michael Bisho. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nature medicine. vol 13. issue 7. 2007-09-05. PMID:17589519. |
cells transformed with myc, but not cells transformed by a panel of other activated oncogenes, rapidly underwent apoptosis when treated with small-molecule cdk1 inhibitors. |
2007-09-05 |
2023-08-12 |
mouse |
| Andrei Goga, Dun Yang, Aaron D Tward, David O Morgan, J Michael Bisho. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nature medicine. vol 13. issue 7. 2007-09-05. PMID:17589519. |
the inhibitor of apoptosis protein birc5 (survivin), a known cdk1 target, is required for the survival of cells overexpressing myc. |
2007-09-05 |
2023-08-12 |
mouse |
| Andrei Goga, Dun Yang, Aaron D Tward, David O Morgan, J Michael Bisho. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nature medicine. vol 13. issue 7. 2007-09-05. PMID:17589519. |
inhibition of cdk1 rapidly downregulates survivin expression and induces myc-dependent apoptosis. |
2007-09-05 |
2023-08-12 |
mouse |
| Pin-Hsuan Lu, Fan-Lu Kung, Sheng-Chu Kuo, Shih-Chieh Chueh, Jih-Hwa Gu. Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. Naunyn-Schmiedeberg's archives of pharmacology. vol 374. issue 3. 2007-07-30. PMID:17102938. |
it also induced several pathways, including cyclin b1 up-regulation, dephosphorylation on tyr(15) and phosphorylation on thr(161) of cdk1 and cdc25c phosphorylation, and roscovitine (a cdk1 inhibitor) significantly inhibited k2154-induced apoptosis, suggesting a pro-apoptotic role of cdk1. |
2007-07-30 |
2023-08-12 |
Not clear |
| K Aoki, M Aoki, M Sugai, N Harada, H Miyoshi, T Tsukamoto, T Mizoshita, M Tatematsu, H Seno, T Chiba, M Oshima, C-L Hsieh, M M Taket. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Oncogene. vol 26. issue 24. 2007-07-12. PMID:17160019. |
we also found that wnt signal activation increased phosphorylation of cdc2 (cdk1) that inhibited its activity, and suppressed apoptosis upon exposure of the cells to nocodazole or colcemid. |
2007-07-12 |
2023-08-12 |
mouse |
| Taeko Okudaira, Mitsuomi Hirashima, Chie Ishikawa, Shoko Makishi, Mariko Tomita, Takehiro Matsuda, Hirochika Kawakami, Naoya Taira, Kazuiku Ohshiro, Masato Masuda, Nobuyuki Takasu, Naoki Mor. A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines. International journal of cancer. vol 120. issue 10. 2007-06-26. PMID:17278100. |
hg9nc(null) induced cell cycle arrest by reducing the expression of cyclin d1, cyclin d2, cyclin b1, cdk1, cdk4, cdk6, cdc25c and c-myc, and apoptosis by reducing the expression of xiap, c-iap2 and survivin. |
2007-06-26 |
2023-08-12 |
mouse |
| Ayelet Erez, Asher Castiel, Luba Trakhtenbrot, Marina Perelman, Esther Rosenthal, Itamar Goldstein, Noa Stettner, Alon Harmelin, Hagit Eldar-Finkelman, Stefano Campaner, Ilan Kirsch, Shai Izrael. The SIL gene is essential for mitotic entry and survival of cancer cells. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17456584. |
inducible knockdown of sil in cancer cells in vitro delayed entrance into mitosis, decreased activation of the cdk1 (cdc2)-cyclin b complex, and induced apoptosis in a p53-independent manner. |
2007-06-18 |
2023-08-12 |
mouse |
| Michaela Merkerova, Hana Bruchova, Radim Brdick. Expression analysis of PCNA gene in chronic myelogenous leukemia--combined application of siRNA silencing and expression arrays. Leukemia research. vol 31. issue 5. 2007-06-12. PMID:17070905. |
pcna inhibition led to down-regulation of cdk1, cdk4, plk1, erk3, jnk1, stat5, and several inhibitors of apoptosis (daxx, mdm2, survivin). |
2007-06-12 |
2023-08-12 |
Not clear |
| Haojie Huang, Donald J Tindal. CDK2 and FOXO1: a fork in the road for cell fate decisions. Cell cycle (Georgetown, Tex.). vol 6. issue 8. 2007-05-23. PMID:17457058. |
it has been well established that cyclin-dependent kinases (cdks) including cdk2 and cdk1 play an essential role in mediating cell-cycle arrest, dna repair and apoptosis in cells with damaged genomes. |
2007-05-23 |
2023-08-12 |
Not clear |
| D Henley, M Isbill, R Fernando, J S Foster, J Wimalasen. Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activity. Cancer chemotherapy and pharmacology. vol 59. issue 2. 2007-04-23. PMID:16972069. |
in this paper, we have investigated whether cell cycle transit and or cdc2 (cdk1) activity is required for the apoptosis induced by ptx. |
2007-04-23 |
2023-08-12 |
Not clear |
| Xiu-Wei Hu, Ching-Ming Chien, Sheng-Huei Yang, Yi-Hsiung Lin, Chih-Ming Lu, Yeh-Long Chen, Shinne-Ren Li. A novel indoloquinoline derivative, IQDMA, induces S-phase arrest and apoptosis in promyelocytic leukemia HL-60 cells. Cell biology and toxicology. vol 22. issue 6. 2007-04-12. PMID:16906476. |
analysis of the cell cycle regulatory proteins demonstrated that iqdma did not change the steady-state levels of cyclin b1, cyclin d3, and p21, but decreased the protein levels of cdk1, cdk2, and cyclin a. iqdma also caused a marked increase in apoptosis, which was accompanied by increased levels of bax, activated caspase-3, -8, and -9, and cleaved parp. |
2007-04-12 |
2023-08-12 |
human |
| Yu-Jhang Lu, Sheng-Huei Yang, Ching-Ming Chien, Yi-Hsiung Lin, Xiu-Wei Hu, Zchong-Zcho Wu, Ming-Jung Wu, Shinne-Ren Li. Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 1. 2007-04-09. PMID:17064874. |
analysis of the cell cycle regulatory proteins demonstrated that thdb did not change the steady-state levels of cyclin b1, cyclin e, cdk1 and cdc25c, but decreased the protein levels of cdk2 and cyclin a. thdb also caused a marked increase in apoptosis, as characterized by dna fragmentation (dna ladder and sub g1 formation), and poly (adp-ribose) polymerase (parp) cleavage, which was associated with activation of caspase-3, caspase-8 and caspase-9. |
2007-04-09 |
2023-08-12 |
human |
| Zchong-Zcho Wu, Ching-Ming Chien, Sheng-Huei Yang, Yi-Hsiung Lin, Xiu-Wei Hu, Yu-Jhang Lu, Ming-Jung Wu, Shinne-Ren Li. Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDA, in chronic myeloid leukemia (K562) cells. Molecular and cellular biochemistry. vol 292. issue 1-2. 2007-01-23. PMID:16733797. |
analysis of the cell cycle regulatory proteins demonstrated that thda did not change the steady-state levels of cyclin b1, cyclin d3 and cdc25c, but decreased the protein levels of cdk1, cdk2 and cyclin a. thda also caused a marked increase in apoptosis, which was associated with activation of caspase-3 and proteolytic cleavage of poly (adp-ribose) polymerase. |
2007-01-23 |
2023-08-12 |
Not clear |
| J Wu, Y Feng, D Xie, X Li, W Xiao, D Tao, J Qin, J Hu, K Gardner, S I V Judge, Q Q Li, J Gon. Unscheduled CDK1 activity in G1 phase of the cell cycle triggers apoptosis in X-irradiated lymphocytic leukemia cells. Cellular and molecular life sciences : CMLS. vol 63. issue 21. 2006-12-13. PMID:17013563. |
unscheduled cdk1 activity in g1 phase of the cell cycle triggers apoptosis in x-irradiated lymphocytic leukemia cells. |
2006-12-13 |
2023-08-12 |
Not clear |
| J Wu, Y Feng, D Xie, X Li, W Xiao, D Tao, J Qin, J Hu, K Gardner, S I V Judge, Q Q Li, J Gon. Unscheduled CDK1 activity in G1 phase of the cell cycle triggers apoptosis in X-irradiated lymphocytic leukemia cells. Cellular and molecular life sciences : CMLS. vol 63. issue 21. 2006-12-13. PMID:17013563. |
recently, several investigations provided evidence demonstrating that unscheduled cdk1 activation may also be involved in apoptosis in cancerous cells. |
2006-12-13 |
2023-08-12 |
Not clear |
| J Wu, Y Feng, D Xie, X Li, W Xiao, D Tao, J Qin, J Hu, K Gardner, S I V Judge, Q Q Li, J Gon. Unscheduled CDK1 activity in G1 phase of the cell cycle triggers apoptosis in X-irradiated lymphocytic leukemia cells. Cellular and molecular life sciences : CMLS. vol 63. issue 21. 2006-12-13. PMID:17013563. |
in this article, we demonstrate that x-ray irradiation induced g1 arrest in molt-4 lymphocytic leukemia cells, the arrest being accompanied by reduction in the activity of cdk2, but increased cdk1 activity and cell apoptosis in the g1 phase. |
2006-12-13 |
2023-08-12 |
Not clear |
| J Wu, Y Feng, D Xie, X Li, W Xiao, D Tao, J Qin, J Hu, K Gardner, S I V Judge, Q Q Li, J Gon. Unscheduled CDK1 activity in G1 phase of the cell cycle triggers apoptosis in X-irradiated lymphocytic leukemia cells. Cellular and molecular life sciences : CMLS. vol 63. issue 21. 2006-12-13. PMID:17013563. |
interestingly, this increase in cdk1 and apoptosis by ionizing radiation was prevented by pretreatment with the cdk1 inhibitor, roscovitine, suggesting that cdk1 kinase activity is required for radiation-induced apoptotic cell death in this model system. |
2006-12-13 |
2023-08-12 |
Not clear |