| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
an unscheduled cdk1 activation may contribute to neuronal apoptosis occurring in neurodegenerative diseases. |
2003-07-30 |
2023-08-12 |
Not clear |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
thus, a cell type-specific modulation of cdk1 might be taken advantage of for the therapeutic correction of pathogenic imbalances in apoptosis control. |
2003-07-30 |
2023-08-12 |
Not clear |
| Leanne Cartee, Heidi Sankala, Christine Davis, Rebecca Smith, Sonia Maggio, Peck-Sun Lin, Paul Dent, Steven Gran. 7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism. International journal of oncology. vol 21. issue 2. 2003-01-27. PMID:12118331. |
despite failing to enhance apoptosis, ucn-01 treatment abrogated ir-induced g2/m arrest in both cell lines, an event associated with enhanced activation of cyclin-dependent kinase 1 (cdk1), promotion of g0/g1 arrest, and dephosphorylation of the retinoblastoma protein (prb). |
2003-01-27 |
2023-08-12 |
Not clear |
| Karen Higginbottom, Michele Cummings, Adrian C Newland, Paul D Alle. Etoposide-mediated deregulation of the G2M checkpoint in myeloid leukaemic cell lines results in loss of cell survival. British journal of haematology. vol 119. issue 4. 2003-01-23. PMID:12472573. |
only hl60 cells that subsequently underwent apoptosis elicited the same effect of increased cdk1 tyrosine phosphorylation. |
2003-01-23 |
2023-08-12 |
Not clear |
| Yun Dai, Paul Dent, Steven Gran. Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A. Cell cycle (Georgetown, Tex.). vol 1. issue 2. 2003-01-07. PMID:12429924. |
induction of apoptosis in human leukemia cells by the cdk1 inhibitor cgp74514a. |
2003-01-07 |
2023-08-12 |
human |
| Yun Dai, Paul Dent, Steven Gran. Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A. Cell cycle (Georgetown, Tex.). vol 1. issue 2. 2003-01-07. PMID:12429924. |
these findings indicate that the selective cdk1 inhibitor, cgp74514a, induces complex changes in cell cycle-related proteins in human leukemia cells accompanied by extensive mitochondrial damage, caspase activation, and apoptosis. |
2003-01-07 |
2023-08-12 |
human |
| Maria Castedo, Thomas Roumier, Julià Blanco, Karine F Ferri, Jordi Barretina, Lionel A Tintignac, Karine Andreau, Jean-Luc Perfettini, Alessandra Amendola, Roberta Nardacci, Philip Leduc, Donald E Ingber, Sabine Druillennec, Bernard Roques, Serge A Leibovitch, Montserrat Vilella-Bach, Jie Chen, José A Este, Nazanine Modjtahedi, Mauro Piacentini, Guido Kroeme. Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. The EMBO journal. vol 21. issue 15. 2002-09-16. PMID:12145207. |
sequential involvement of cdk1, mtor and p53 in apoptosis induced by the hiv-1 envelope. |
2002-09-16 |
2023-08-12 |
Not clear |
| Maria Castedo, Thomas Roumier, Julià Blanco, Karine F Ferri, Jordi Barretina, Lionel A Tintignac, Karine Andreau, Jean-Luc Perfettini, Alessandra Amendola, Roberta Nardacci, Philip Leduc, Donald E Ingber, Sabine Druillennec, Bernard Roques, Serge A Leibovitch, Montserrat Vilella-Bach, Jie Chen, José A Este, Nazanine Modjtahedi, Mauro Piacentini, Guido Kroeme. Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. The EMBO journal. vol 21. issue 15. 2002-09-16. PMID:12145207. |
inhibition of cyclin-dependent kinase-1 (cdk1) prevents karyogamy, mtor activation, p53(s15) phosphorylation and apoptosis. |
2002-09-16 |
2023-08-12 |
Not clear |
| Tone Sandal, Camilla Stapnes, Hans Kleivdal, Lars Hedin, Stein Ove Døskelan. A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells. The Journal of biological chemistry. vol 277. issue 23. 2002-07-12. PMID:11909854. |
a near perfect proportionality was observed between inhibitor potency to protect against camp-induced apoptosis and to antagonize cdk5, and to a lesser extent, cdk2 and cdk1. |
2002-07-12 |
2023-08-12 |
rat |
| W M Liu, A J Lawrence, S P Joe. The importance of drug scheduling and recovery phases in determining drug activity. Improving etoposide efficacy in BCR-ABL-positive CML cells. European journal of cancer (Oxford, England : 1990). vol 38. issue 6. 2002-06-27. PMID:11937320. |
we have investigated the effect of etoposide schedule on cell cycle distribution, apoptosis and p21(waf1) and cdk1(p34) status in two bcr-abl-positive chronic myeloid leukaemia (cml) cell lines (k562 and ku812) and two small cell lung cancer (sclc) cell lines (h69 and glc4). |
2002-06-27 |
2023-08-12 |
Not clear |
| C P Diggle, E Pitt, P Roberts, L K Trejdosiewicz, J Southgat. N;-3 and n;-6 polyunsaturated fatty acids induce cytostasis in human urothelial cells independent of p53 gene function. Journal of lipid research. vol 41. issue 9. 2000-11-24. PMID:10974058. |
cytostatic concentrations of n;-3 and n;-6 pufa did not induce apoptosis, but caused permanent growth arrest ("interphase" or "reproductive" cell death) and mrna levels for genes involved in cell cycle control (p21, p16, p27, cdk1, cdk2, and cdk4) were not altered. |
2000-11-24 |
2023-08-12 |
human |
| S A Alhasan, J F Ensley, F H Sarka. Genistein induced molecular changes in a squamous cell carcinoma of the head and neck cell line. International journal of oncology. vol 16. issue 2. 2000-03-07. PMID:10639578. |
in this report we show that these changes are accompanied by the down-regulation of cdk1, and cyclinb1, and up-regulation of the cyclin dependent kinase (cdk) inhibitor p21waf1, which may be responsible for the induction of cell cycle arrest and apoptosis. |
2000-03-07 |
2023-08-12 |
Not clear |
| M Hajdúch, L Havlíèek, J Veselý, R Novotný, V Mihál, M Strna. Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs. Advances in experimental medicine and biology. vol 457. 1999-11-04. PMID:10500810. |
we originally discovered oc and its inhibitory activity toward cdk1 family of cdks, and recently reported the induction of apoptosis and tumor regression following oc application. |
1999-11-04 |
2023-08-12 |
Not clear |
| S Wang, Z Wang, L H Boise, P Dent, S Gran. Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL. Leukemia. vol 13. issue 10. 1999-11-03. PMID:10516758. |
potentiation of paclitaxel-induced apoptosis by bryostatin 1 in u937/bcl-xl cells occurred primarily in the g2m cell population, and was associated with alterations in bcl-xl gel mobility and a reduction in paclitaxel-mediated stimulation of cdk1 activity. |
1999-11-03 |
2023-08-12 |
human |
| A M Ibrado, C N Kim, K Bhall. Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells. Leukemia. vol 12. issue 12. 1998-12-10. PMID:9844922. |
temporal relationship of cdk1 activation and mitotic arrest to cytosolic accumulation of cytochrome c and caspase-3 activity during taxol-induced apoptosis of human aml hl-60 cells. |
1998-12-10 |
2023-08-12 |
human |
| A M Ibrado, C N Kim, K Bhall. Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells. Leukemia. vol 12. issue 12. 1998-12-10. PMID:9844922. |
taxol-induced g2/m transition is mediated by p34(cdc-2) (cdk1) which, if prematurely activated, may also trigger apoptosis. |
1998-12-10 |
2023-08-12 |
human |
| A M Ibrado, C N Kim, K Bhall. Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells. Leukemia. vol 12. issue 12. 1998-12-10. PMID:9844922. |
these findings indicate that bcl-xl overexpression does not affect taxol-induced cdk1 activity leading to g2/m transition, which temporally precedes the cytosolic cyt c-mediated cleavage and activity of caspase-3 and apoptosis. |
1998-12-10 |
2023-08-12 |
human |
| B W Parker, G Kaur, W Nieves-Neira, M Taimi, G Kohlhagen, T Shimizu, M D Losiewicz, Y Pommier, E A Sausville, A M Senderowic. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood. vol 91. issue 2. 1998-02-11. PMID:9427698. |
while flavopiridol caused cell cycle arrest with decline in cdk1 activity in pc3 cells, apoptosis of sudhl4 cells occurred without evidence of cell cycle arrest. |
1998-02-11 |
2023-08-12 |
Not clear |
| B Schutte, L Nieland, M van Engeland, M E Henfling, L Meijer, F C Ramaeker. The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics. Experimental cell research. vol 236. issue 1. 1997-11-25. PMID:9344580. |
bivariate cdk1/dna analysis confirmed these observations and showed that a subpopulation of cells with characteristics of apoptosis became cdk1 negative. |
1997-11-25 |
2023-08-12 |
Not clear |
| J H Trembley, J O Ebbert, B T Kren, C J Stee. Differential regulation of cyclin B1 RNA and protein expression during hepatocyte growth in vivo. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 7. issue 7. 1997-04-29. PMID:8809408. |
in a peroxisome proliferation model of hepatocyte growth and apoptosis, cyclin b1 and cdk1 proteins were induced in the absence of transcript up-regulation. |
1997-04-29 |
2023-08-12 |
human |