| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cong Zhang, Jia Lin, Jing Ge, Li-Li Wang, Nan Li, Xue-Tong Sun, Hua-Bin Cao, Jin-Long L. Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 44. 2018-05-09. PMID:28765097. |
in summary, cd is a hepatotoxin that causes hepatocytes damage by inducing oxidative stress, excessive autophagy and apoptosis as a mechanism of toxicity. |
2018-05-09 |
2023-08-13 |
chicken |
| Tianshu Wei, Jin Jia, Youichiro Wada, Carolyn M Kapron, Ju Li. Dose dependent effects of cadmium on tumor angiogenesis. Oncotarget. vol 8. issue 27. 2018-03-29. PMID:28388546. |
furthermore, cd in high concentrations (>10 μm) induces ec apoptosis via the activation of caspase-3, resulting in destruction of tumor vasculature. |
2018-03-29 |
2023-08-13 |
Not clear |
| Han Wu, Liang Wang, Dongmei Zhang, Ji Qian, Lijun Yan, Qiyun Tang, Runzhou Ni, Xiaoping Zo. PRDM5 promotes the apoptosis of epithelial cells induced by IFN-γ during Crohn's disease. Pathology, research and practice. vol 213. issue 6. 2018-03-26. PMID:28476379. |
elevated apoptosis of intestinal epithelial cells (iecs) greatly impairs the epithelial barrier integrity and contributes to the pathogenesis of crohn's disease (cd). |
2018-03-26 |
2023-08-13 |
mouse |
| Han Wu, Liang Wang, Dongmei Zhang, Ji Qian, Lijun Yan, Qiyun Tang, Runzhou Ni, Xiaoping Zo. PRDM5 promotes the apoptosis of epithelial cells induced by IFN-γ during Crohn's disease. Pathology, research and practice. vol 213. issue 6. 2018-03-26. PMID:28476379. |
overproduction of pro-inflammatory cytokine interferon-γ (ifn-γ) induces the excessive apoptosis of iecs and is involved in cd development. |
2018-03-26 |
2023-08-13 |
mouse |
| Han Wu, Liang Wang, Dongmei Zhang, Ji Qian, Lijun Yan, Qiyun Tang, Runzhou Ni, Xiaoping Zo. PRDM5 promotes the apoptosis of epithelial cells induced by IFN-γ during Crohn's disease. Pathology, research and practice. vol 213. issue 6. 2018-03-26. PMID:28476379. |
taken together, these data suggest that highly expressed prdm5 may promote the ifn-γ-induced iec apoptosis in the progression of cd. |
2018-03-26 |
2023-08-13 |
mouse |
| Xueyan Dai, Chenghong Xing, Huabin Cao, Junrong Luo, Tiancheng Wang, Ping Liu, Xiaoquan Guo, Guoliang Hu, Caiying Zhan. Alterations of mitochondrial antioxidant indexes and apoptosis in duck livers caused by Molybdenum or/and cadmium. Chemosphere. vol 193. 2018-03-22. PMID:29169133. |
to investigate the co-induced toxic effects of mo combined with cd on mitochondrial oxidative stress and apoptosis in duck livers. |
2018-03-22 |
2023-08-13 |
cat |
| Xueyan Dai, Chenghong Xing, Huabin Cao, Junrong Luo, Tiancheng Wang, Ping Liu, Xiaoquan Guo, Guoliang Hu, Caiying Zhan. Alterations of mitochondrial antioxidant indexes and apoptosis in duck livers caused by Molybdenum or/and cadmium. Chemosphere. vol 193. 2018-03-22. PMID:29169133. |
taken together, it was suggested that dietary mo and cd might lead to mitochondrial oxidative stress and apoptosis in duck livers, and it showed a possible synergistic relationship between the two elements. |
2018-03-22 |
2023-08-13 |
cat |
| Z Ou, Y Chen, X Niu, W He, B Song, D Fan, X Su. High-mobility group box 1 regulates cytoprotective autophagy in a mouse spermatocyte cell line (GC-2spd) exposed to cadmium. Irish journal of medical science. vol 186. issue 4. 2018-03-21. PMID:28389990. |
increasing evidence demonstrates that cd induces testicular germ cell apoptosis in rodent animals. |
2018-03-21 |
2023-08-13 |
mouse |
| Huilin Yang, Yuande Peng, Yixue Shi, Jianxiang Tian, Juan Wang, Xianjin Peng, Chunliang Xie, Xiang Xu, Qisheng Song, Zhi Wang, Zhiyue L. Transcriptome assembly and expression profiling of the molecular responses to cadmium toxicity in cerebral ganglia of wolf spider Pardosa pseudoannulata (Araneae: Lycosidae). Ecotoxicology (London, England). vol 27. issue 2. 2018-03-15. PMID:29299797. |
cd exposure leads to strong damage in the nervous system, such as apoptosis and necrosis of nerve cells, therefore we conducted a transcriptomic analysis of pardosa pseudoannulata cerebral ganglia under cd stress to profile differential gene expression (dge). |
2018-03-15 |
2023-08-13 |
spider |
| Daiana G Alvarez-Olmedo, Veronica S Biaggio, Geremy A Koumbadinga, Nidia N Gómez, Chunhua Shi, Daniel R Ciocca, Zarah Batulan, Mariel A Fanelli, Edward R O'Brie. Recombinant heat shock protein 27 (HSP27/HSPB1) protects against cadmium-induced oxidative stress and toxicity in human cervical cancer cells. Cell stress & chaperones. vol 22. issue 3. 2018-02-21. PMID:28337643. |
overexpression of heat shock protein 27 (hsp27/hspb1)-a multifunctional protein chaperone-has been shown to protect cells from oxidative damage and apoptosis triggered by cd exposure. |
2018-02-21 |
2023-08-13 |
human |
| Daiana G Alvarez-Olmedo, Veronica S Biaggio, Geremy A Koumbadinga, Nidia N Gómez, Chunhua Shi, Daniel R Ciocca, Zarah Batulan, Mariel A Fanelli, Edward R O'Brie. Recombinant heat shock protein 27 (HSP27/HSPB1) protects against cadmium-induced oxidative stress and toxicity in human cervical cancer cells. Cell stress & chaperones. vol 22. issue 3. 2018-02-21. PMID:28337643. |
cd induced necrotic cell death pathways, although apoptosis was also activated; pre-treatment with l-name or rhsp27 mitigated cell death. |
2018-02-21 |
2023-08-13 |
human |
| Soumaya Ben Jannet, Nolwenn Hymery, Soumaya Bourgou, Ahmed Jdey, Mokhtar Lachaal, Christian Magné, Riadh Ksour. Antioxidant and selective anticancer activities of two Euphorbia species in human acute myeloid leukemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-21. PMID:28380413. |
cytotoxicity of plant methanol and chloroform fractions was examined towards human acute myeloid leukemia (thp1) and human colon epithelial (caco2) cancer cell lines, as well as cd 14 and iec-6 normal cells by targeting various modulators of apoptosis or inflammation. |
2018-02-21 |
2023-08-13 |
human |
| Jian-An Bai, Hua Jie, Sun Wei, Shidong Wang, Huarui Guo, Qiyun Tan. GART mediates the renewal of intestinal epithelial barrier via p38/p53/PUMA cascade in colitis. Apoptosis : an international journal on programmed cell death. vol 21. issue 12. 2018-01-29. PMID:27718035. |
taken together, gart plays a critical role in the protection of cellular apoptosis and migration of intestinal epithelial cells to maintain the integrity of the epithelial barrier, thus providing a new potential approach in designing a novel therapy for cd. |
2018-01-29 |
2023-08-13 |
Not clear |
| Runxiang Zhang, Ran Yi, Yanju Bi, Lu Xing, Jun Bao, Jianhong L. The Effect of Selenium on the Cd-Induced Apoptosis via NO-Mediated Mitochondrial Apoptosis Pathway in Chicken Liver. Biological trace element research. vol 178. issue 2. 2018-01-25. PMID:28062951. |
however, little is known regarding the effects of cd-induced apoptosis in hepatic cells and the antagonistic effects of se on cd in poultry. |
2018-01-25 |
2023-08-13 |
chicken |
| Mengmeng Zhang, Junrong Luo, Caiying Zhang, Huabin Cao, Bing Xia, Guoliang H. Alterations in antioxidant function and cell apoptosis in duck spleen exposed to molybdenum and/or cadmium. Journal of veterinary science. vol 18. issue 2. 2018-01-04. PMID:27297413. |
the results suggest that mo and/or cd can induce oxidative stress and apoptosis of spleen via effects on the mitochondrial intrinsic pathway. |
2018-01-04 |
2023-08-13 |
Not clear |
| Ming-Hsiu Wu, Chung-Ching Chio, Kuen-Jer Tsai, Ching-Ping Chang, Nan-Kai Lin, Chao-Ching Huang, Mao-Tsun Li. Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis. Molecular neurobiology. vol 53. issue 6. 2017-12-29. PMID:26126515. |
compared with cd rats, wd rats exhibited higher levels of brain infarct, neurologic deficits, brain edema, and apoptosis of apn-containing neurons; upregulation of both adr-1 and p38 mitogen-activated protein kinase (p38mapk); and downregulation of adr-2 in ischemic brain tissues including frontal cortex, striatum, and hippocampus. |
2017-12-29 |
2023-08-13 |
rat |
| Ming-Hsiu Wu, Chung-Ching Chio, Kuen-Jer Tsai, Ching-Ping Chang, Nan-Kai Lin, Chao-Ching Huang, Mao-Tsun Li. Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis. Molecular neurobiology. vol 53. issue 6. 2017-12-29. PMID:26126515. |
increasing percentages of apn-containing neurons by baculovirus-mediated administration of apn, in addition to reducing apoptosis of apn-containing neurons in ischemic brain tissues, significantly attenuated brain infarct and edema, neurologic deficits, and altered expression of adr-1, p38mapk, and adr-2 in both wd and cd group rats. |
2017-12-29 |
2023-08-13 |
rat |
| Keum-Young So, Byung-Hoon Lee, Seon-Hee O. The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes. Toxicology. vol 393. 2017-12-19. PMID:29111403. |
cd decreased cell viability in a dose-dependent manner; cleaved caspase-8, caspase-3, and poly (adp-ribose) polymerase (parp)-1; increased dna laddering; induced ccaat-enhancer-binding protein homologous protein (chop); and reduced tumor necrosis factor (tnf)-α expression; indicating that caspase-dependent and endoplasmic reticulum (er)-mediated apoptosis are involved in cd-induced immunotoxicity. |
2017-12-19 |
2023-08-13 |
mouse |
| Keum-Young So, Byung-Hoon Lee, Seon-Hee O. The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes. Toxicology. vol 393. 2017-12-19. PMID:29111403. |
calpain inhibitors blocked cd-induced apoptosis and autophagy, indicating that calpain plays a critical role in cd cytotoxicity. |
2017-12-19 |
2023-08-13 |
mouse |
| Lele Shi, Huabin Cao, Junrong Luo, Ping Liu, Tiancheng Wang, Guoliang Hu, Caiying Zhan. Effects of molybdenum and cadmium on the oxidative damage and kidney apoptosis in Duck. Ecotoxicology and environmental safety. vol 145. 2017-12-01. PMID:28692912. |
to investigate the co-induced toxic effects of mo and cd on oxidative damage and kidney apoptosis in duck, 120 ducks were randomly divided into control group and 5 treatment groups which were treated with a commercial diet containing different dosages of mo and cd. |
2017-12-01 |
2023-08-13 |
human |