| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Yuan, Yajing Zhang, Shiwen Zhao, Jie Chen, Jinlong Yang, Tao Wang, Hui Zou, Yi Wang, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Li. Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:29891925. |
studies have demonstrated that cd can induce apoptosis in neuronal cells. |
2019-10-15 |
2023-08-13 |
rat |
| Xiangqi Teng, Weiqian Zhang, Yangyang Song, Haibin Wang, Ming Ge, Ruili Zhan. Protective effects of Ganoderma lucidum triterpenoids on oxidative stress and apoptosis in the spleen of chickens induced by cadmium. Environmental science and pollution research international. vol 26. issue 23. 2019-10-03. PMID:31222655. |
in the present study, we have examined the protective effects of ganoderma lucidum triterpenoids on oxidative stress and apoptosis in the spleen of chickens induced by cd. |
2019-10-03 |
2023-08-13 |
human |
| Martha Reyes-Becerril, Carlos Angulo, Veronica Sanchez, Alberto Cuesta, Ariel Cru. Methylmercury, cadmium and arsenic(III)-induced toxicity, oxidative stress and apoptosis in Pacific red snapper leukocytes. Aquatic toxicology (Amsterdam, Netherlands). vol 213. 2019-09-25. PMID:31207538. |
our data showed that mehg, cd, and as(iii) might have been cytotoxic and induced oxidative stress and apoptosis with possible biological consequences in fish. |
2019-09-25 |
2023-08-13 |
human |
| Chenglong Ji, Zhen Lu, Lanlan Xu, Fei Li, Ming Cong, Xiujuan Shan, Huifeng W. Evaluation of mitochondrial toxicity of cadmium in clam Ruditapes philippinarum using iTRAQ-based proteomics. Environmental pollution (Barking, Essex : 1987). vol 251. 2019-09-03. PMID:31125810. |
moreover, dynamical regulations, such as reconstruction of energy homeostasis, induction of stress resistance and apoptosis, and morphological alterations, in mitochondria might play essential roles in cd tolerance. |
2019-09-03 |
2023-08-13 |
Not clear |
| Yan Yuan, Jinlong Yang, Jie Chen, Shiwen Zhao, Tao Wang, Hui Zou, Yi Wang, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Li. Alpha-lipoic acid protects against cadmium-induced neuronal injury by inhibiting the endoplasmic reticulum stress eIF2α-ATF4 pathway in rat cortical neurons in vitro and in vivo. Toxicology. vol 414. 2019-08-13. PMID:30605698. |
furthermore, the er-stress inhibitor salubrinal blocked the dephosphorylation of eukaryotic translation initiation factor 2α (eif2α) and significantly reduced the induction of er stress marker chop, the increase of the b-cell lymphoma-2 associate x protein (bax)/b-cell lymphoma-2 (bcl-2) ratio, and apoptosis induced by cd. |
2019-08-13 |
2023-08-13 |
rat |
| Yan Yuan, Jinlong Yang, Jie Chen, Shiwen Zhao, Tao Wang, Hui Zou, Yi Wang, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Li. Alpha-lipoic acid protects against cadmium-induced neuronal injury by inhibiting the endoplasmic reticulum stress eIF2α-ATF4 pathway in rat cortical neurons in vitro and in vivo. Toxicology. vol 414. 2019-08-13. PMID:30605698. |
importantly, α-la inhibited the activation of the er stress eif2α-atf4 pathway, the increase of the bax/bcl-2 ratio, the activation of caspase-12 and -3, and the apoptosis induced by cd. |
2019-08-13 |
2023-08-13 |
rat |
| Yan Yuan, Jinlong Yang, Jie Chen, Shiwen Zhao, Tao Wang, Hui Zou, Yi Wang, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Li. Alpha-lipoic acid protects against cadmium-induced neuronal injury by inhibiting the endoplasmic reticulum stress eIF2α-ATF4 pathway in rat cortical neurons in vitro and in vivo. Toxicology. vol 414. 2019-08-13. PMID:30605698. |
taken together, our results demonstrated that cd triggered protein changes in the er accompanied by apoptosis via the eif2α-atf4 signaling pathway in the neuronal cells of rats, both in vitro and in vivo. |
2019-08-13 |
2023-08-13 |
rat |
| Meinan Yu, Dunyan Su, Yuanyuan Yang, Lin Qin, Chuan Hu, Rui Liu, Yang Zhou, Chuanyao Yang, Xiaotong Yang, Guanlin Wang, Huile Ga. D-T7 Peptide-Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma. ACS applied materials & interfaces. vol 11. issue 1. 2019-07-31. PMID:30525386. |
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) and apoptosis assays showed that cd&ptx@tbrbps had the highest cytotoxicity and the median survival time of the cd&ptx@tbrnp group was 3.31-fold and 1.23-fold longer than that of the saline and cd&ptx@brnp groups, respectively. |
2019-07-31 |
2023-08-13 |
Not clear |
| Na Guo, Rui Miao, Xingchun Gao, Dong Huang, Zhifang Hu, Naichun Ji, Ying Nan, Fengliang Jiang, Xingchun Go. Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147. Molecular medicine reports. vol 19. issue 5. 2019-07-30. PMID:30942433. |
it was identified that shikonin was able to induce apoptosis in human glioma cells in a time‑ and dose‑dependent manner, and a decreased expression level of cluster of differentiation (cd)147 was observed in shikonin‑treated u251 and u87mg cells. |
2019-07-30 |
2023-08-13 |
human |
| Nazima Bashir, Kalist Shagirtha, Vaikundam Manoharan, Selvaraj Miltonprab. The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating cadmium-induced testes-toxicity in rat model: implication of PI3K/Akt/Nrf-2 signaling. Bioscience reports. vol 39. issue 1. 2019-07-29. PMID:30355647. |
the present study aims to evaluate the protective effect of grape seed proanthocyanidins (gsp) on cadmium (cd)-induced testicular apoptosis, inflammation, and oxidative stress in rats. |
2019-07-29 |
2023-08-13 |
rat |
| Jin-Yong Lee, Maki Tokumoto, Gi-Wook Hwang, Moo-Yeol Lee, Masahiko Sato. Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity. Scientific reports. vol 7. issue 1. 2019-07-24. PMID:29229987. |
microarray analysis in arnt knockdown cells revealed a decrease in the expression of a number of genes, including a known apoptosis inhibitor, birc3, whose gene and protein expression level was also decreased by cd treatment. |
2019-07-24 |
2023-08-13 |
human |
| Jin-Yong Lee, Maki Tokumoto, Gi-Wook Hwang, Moo-Yeol Lee, Masahiko Sato. Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity. Scientific reports. vol 7. issue 1. 2019-07-24. PMID:29229987. |
moreover, knockdown of birc3 not only triggered cell toxicity and apoptosis but also strengthened cd toxicity in hk-2 cells. |
2019-07-24 |
2023-08-13 |
human |
| Jin-Yong Lee, Maki Tokumoto, Gi-Wook Hwang, Moo-Yeol Lee, Masahiko Sato. Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity. Scientific reports. vol 7. issue 1. 2019-07-24. PMID:29229987. |
these results suggest that cd induces apoptosis through the inhibition of arnt-regulated birc3 in human proximal tubular cells. |
2019-07-24 |
2023-08-13 |
human |
| Matías F F Pérez Díaz, Maria G Plateo Pignatari, Verónica P Filippa, Fabián H Mohamed, Eduardo J Marchevsky, María S Gimenez, Dario C Ramire. A soybean-based diet modulates cadmium-induced vascular apoptosis. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 52. 2019-06-24. PMID:30732889. |
compared to cbd-co, inflammatory and apoptosis markers increased in the aorta with the concentration of cd in the drinking water. |
2019-06-24 |
2023-08-13 |
rat |
| Ding Zhang, Ting Zhang, Jingying Liu, Jianshan Chen, Ying Li, Guanbao Ning, Nairui Huo, Wenxia Tian, Haili M. Zn Supplement-Antagonized Cadmium-Induced Cytotoxicity in Macrophages In Vitro: Involvement of Cadmium Bioaccumulation and Metallothioneins Regulation. Journal of agricultural and food chemistry. vol 67. issue 16. 2019-06-17. PMID:30942077. |
zn supplement significantly inhibited cd cytotoxicity in raw 264.7 or hd-11 macrophages by mitigating cell apoptosis, excessive ros output, and mitochondrial membrane depolarization. |
2019-06-17 |
2023-08-13 |
Not clear |
| Lingmin Zhang, Qingqing Xia, Yingying Zhou, Jie L. Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells. Toxicology letters. vol 311. 2019-06-10. PMID:31054874. |
our current study demonstrated that cd induced apoptosis in a human rpe cell line arpe-19 cells, as it dose-dependently caused cell viability loss and activated caspase-3. |
2019-06-10 |
2023-08-13 |
human |
| Ting Xu, Yan Yang, Li Zhao, Dan-Dan Zhou, Yan Zhan. [Prediction Value of TWEAK/Fn14 in Crohn's Disease with Intestinal Fibrosis]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 48. issue 5. 2019-05-30. PMID:29130664. |
to investigate the expression of tumor necrosis factor-like weak inducer of apoptosis (tweak)/ fibroblast growth factorinducible 14 (fn14) in the serum and colon tissue of crohn's disease (cd) and to elucidate whether the expression of tweak/fn14 can be used as an indicator for intestinal fibrosis. |
2019-05-30 |
2023-08-13 |
Not clear |
| Huilin Yang, Yuande Peng, Yixue Shi, Jianxiang Tian, Juan Wang, Qisheng Song, Zhiyue Lv, Chunliang Xie, Zhi Wan. Transcriptome analysis provides insights into the immunity function of venom glands in Pardosa pseudoannulata in responses to cadmium toxicity. Environmental science and pollution research international. vol 25. issue 24. 2019-05-29. PMID:29881962. |
expression profile analysis demonstrated that immunity-related genes involved in bacterial invasion of epithelial cells, leukocyte transendothelial migration, platelet activation, apoptosis, phagosome, and rap1 signaling pathway were upregulated by cd exposure, except the genes involved in ppar signaling pathway were downregulated. |
2019-05-29 |
2023-08-13 |
spider |
| Yingjie Yang, Qian Yang, Jian Yang, Yiqiong Ma, Guohua Din. Angiotensin II induces cholesterol accumulation and injury in podocytes. Scientific reports. vol 7. issue 1. 2019-05-20. PMID:28878222. |
pretreating podocytes with methyl-β-cyclodextrin (cd), which induces cholesterol efflux, decreased ang ii-mediated cholesterol accumulation and ang ii-induced podocyte apoptosis and maintained the podocyte cytoskeleton and spreading. |
2019-05-20 |
2023-08-13 |
Not clear |
| Chao Ma, Ke Du, Ying Zhao, Linkui Zhang, Baichun Hu, Maosheng Chen. Pyrrolo[2,1-c][1,4] benzodiazepine-3,11-diones protect SHSY-5Y cells from Cd-induced apoptosis involving suppression of endoplasmic reticulum stress. Bioorganic & medicinal chemistry. vol 26. issue 18. 2019-04-22. PMID:30243792. |
cadmium (cd) is a potent toxic heavy metal, some studies showed that cd-induced apoptosis is through er stress pathway. |
2019-04-22 |
2023-08-13 |
Not clear |