| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhangxiao Peng, Yan Wang, Jianhui Fan, Xuejing Lin, Chunying Liu, Yang Xu, Weidan Ji, Chao Yan, Changqing S. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. Scientific reports. vol 7. 2018-10-29. PMID:28117370. |
the findings indicated that vosl and cd could induce breast cancer cell cycle arrest and apoptosis through c-myc/p53 and akt/14-3-3 signaling pathways and may be novel effective candidates for breast cancer treatment. |
2018-10-29 |
2023-08-13 |
Not clear |
| Anthony Bertucci, Fabien Pierron, Julien Thébault, Christophe Klopp, Julie Bellec, Patrice Gonzalez, Magalie Baudrimon. Transcriptomic responses of the endangered freshwater mussel Margaritifera margaritifera to trace metal contamination in the Dronne River, France. Environmental science and pollution research international. vol 24. issue 35. 2018-10-18. PMID:28963680. |
amongst the studied metals, cr, zn, cd, and ni were the main factors correlated with transcription levels, with effects on translation, apoptosis, immune response, response to stimulus, and transport pathways. |
2018-10-18 |
2023-08-13 |
Not clear |
| Liugen Gu, Zhenming Ge, Yamin Wang, Meiqin Shen, Ping Zha. Activating transcription factor 3 promotes intestinal epithelial cell apoptosis in Crohn's disease. Pathology, research and practice. vol 214. issue 6. 2018-09-28. PMID:29716766. |
intestinal epithelial cell (iec) apoptosis plays a vital role in the pathogenesis of crohn's disease (cd), which is an inflammatory bowel disease (ibd). |
2018-09-28 |
2023-08-13 |
mouse |
| Liugen Gu, Zhenming Ge, Yamin Wang, Meiqin Shen, Ping Zha. Activating transcription factor 3 promotes intestinal epithelial cell apoptosis in Crohn's disease. Pathology, research and practice. vol 214. issue 6. 2018-09-28. PMID:29716766. |
in summary, these data indicated that atf3 might promote iec apoptosis in cd via up-regulating the stability and transcription activity of p53, implying a novel molecular target for cd therapy. |
2018-09-28 |
2023-08-13 |
mouse |
| Rong-Kun Bao, Shu-Fang Zheng, Xin-Yue Wan. Selenium protects against cadmium-induced kidney apoptosis in chickens by activating the PI3K/AKT/Bcl-2 signaling pathway. Environmental science and pollution research international. vol 24. issue 25. 2018-09-24. PMID:28707237. |
cadmium (cd) is a toxic heavy metal that can induce apoptosis. |
2018-09-24 |
2023-08-13 |
chicken |
| Gang Liu, Yan Yuan, Mengfei Long, Tongwang Luo, Jianchun Bian, Xuezhong Liu, Jianhong Gu, Hui Zou, Ruilong Song, Yi Wang, Lin Wang, Zongping Li. Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture. Scientific reports. vol 7. issue 1. 2018-09-05. PMID:28428545. |
here we demonstrated that cadmium (cd) activated the fas/fasl apoptosis pathway in rat proximal tubular (rpt) cells; this was accompanied by simultaneous activation of autophagy resulted in reduced apoptosis. |
2018-09-05 |
2023-08-13 |
rat |
| Maria Dobre, Teodora Ecaterina Mănuc, Elena Milanesi, Iancu Emil Pleşea, Eugen Nicolae Ţieranu, Caterina Popa, Mircea Mănuc, Carmen Monica Preda, Ioana Ţieranu, Mihai Mircea Diculescu, Elena Mirela Ionescu, Gabriel Bechean. Mucosal CCR1 gene expression as a marker of molecular activity in Crohn's disease: preliminary data. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 58. issue 4. 2018-09-05. PMID:29556615. |
a series of mechanisms of immune response, inflammation and apoptosis have been demonstrated to contribute to the appearance and evolution of crohn's disease (cd) through the overexpression of several cytokines and chemokines in a susceptible host. |
2018-09-05 |
2023-08-13 |
Not clear |
| Liugen Gu, Juan Zhao, Shiqing Zhang, Weisong Xu, Runzhou Ni, Xiaojuan Li. Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn's disease. Pathology, research and practice. vol 214. issue 2. 2018-08-30. PMID:29129496. |
apoptosis in intestinal epithelial cells (iecs) prevents the development of crohn's disease (cd), a type of inflammatory bowel disease (ibd). |
2018-08-30 |
2023-08-13 |
mouse |
| Liugen Gu, Juan Zhao, Shiqing Zhang, Weisong Xu, Runzhou Ni, Xiaojuan Li. Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn's disease. Pathology, research and practice. vol 214. issue 2. 2018-08-30. PMID:29129496. |
in conclusion, our data indicated that runx2 might protect iecs from apoptosis in cd, thus revealing a novel molecular target for treating cd. |
2018-08-30 |
2023-08-13 |
mouse |
| Silvia Martina Ferrari, Guido Bocci, Teresa Di Desidero, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Anna Fioravanti, Paola Orlandi, Sabrina Rosaria Paparo, Armando Patrizio, Simona Piaggi, Concettina La Motta, Salvatore Ulisse, Enke Baldini, Gabriele Materazzi, Paolo Miccoli, Alessandro Antonelli, Poupak Fallah. Vandetanib has antineoplastic activity in anaplastic thyroid cancer, in vitro and in vivo. Oncology reports. vol 39. issue 5. 2018-08-29. PMID:29517106. |
vandetanib (1 and 100 nm; 1, 10, 25 and 50 µm) was tested by wst‑1, apoptosis, migration and invasion assays: in primary atc cells, in the 8305c continuous cell line, and in af cells; and in 8305c cells in cd nu/nu mice. |
2018-08-29 |
2023-08-13 |
mouse |
| Xiaocui Chen, Yinghua Xu, Zuowang Cheng, Hong Su, Xiu Liu, Dongmei Xu, Carolyn Kapron, Ju Li. Low-dose cadmium activates the JNK signaling pathway in human renal podocytes. International journal of molecular medicine. vol 41. issue 4. 2018-08-23. PMID:29393374. |
however, proliferation, viability, apoptosis and alignment of the f‑actin cytoskeleton in hrps were not significantly affected by cd treatment, with or without sp600125 pretreatment. |
2018-08-23 |
2023-08-13 |
human |
| Youyang Qu, Yu Liu, Li Chen, Yanmei Zhu, Xingjun Xiao, Di Wang, Yulan Zh. Nobiletin prevents cadmium-induced neuronal apoptosis by inhibiting reactive oxygen species and modulating JNK/ERK1/2 and Akt/mTOR networks in rats. Neurological research. vol 40. issue 3. 2018-08-20. PMID:29334873. |
nobiletin reduced neuronal apoptosis induced by cd and raised cleaved caspase-3 levels. |
2018-08-20 |
2023-08-13 |
rat |
| Su Yang, Yue Zhang, Yi-ran Zhang, Dong Cui, Ran-lu Liu, Yan-ming Wan. [Apoptosis induced by transferring cytosine deaminase suicide gene into kinds of cancer cells with novel polyamidoamine dendrimers]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 2. 2018-08-06. PMID:29856585. |
this study demonstrates efficacy of a novel polyamidoamine dendrimers(pamam dendrimers) with pentaerythritol derivatives as the core(g5 pd dendrimer) in deliver of the cytosine deaminase(cd) gene and egfp gene fusion plasmid into different tumor cell lines to induce apoptosis. |
2018-08-06 |
2023-08-13 |
Not clear |
| Wenjing Liu, Ming Ge, Xuequan Hu, Ai Lv, Dexing Ma, Xiaodan Huang, Ruili Zhan. The Effects of Agaricus blazei Murill Polysaccharides on Cadmium-Induced Apoptosis and the TLR4 Signaling Pathway of Peripheral Blood Lymphocytes in Chicken. Biological trace element research. vol 180. issue 1. 2018-07-30. PMID:28283953. |
in this study, we investigated the effects of agaricus blazei murill polysaccharides (abp) on cadmium (cd)-induced apoptosis and the tlr4 signaling pathway of chicken peripheral blood lymphocytes (pbls). |
2018-07-30 |
2023-08-13 |
chicken |
| Mariana Morozesk, Lidiane S Franqui, Adrislaine S Mansano, Diego Stéfani T Martinez, Marisa N Fernande. Interactions of oxidized multiwalled carbon nanotube with cadmium on zebrafish cell line: The influence of two co-exposure protocols on in vitro toxicity tests. Aquatic toxicology (Amsterdam, Netherlands). vol 200. 2018-07-25. PMID:29751160. |
the ox-mwcnt increased cd toxicity at low concentration probably by a "trojan horse" and/or synergistic effect, and induced apoptosis and necrosis in zfl cells. |
2018-07-25 |
2023-08-13 |
cattle |
| Zheng-Guo Cui, Yu-Jie Jin, Lu Sun, Shahbaz Ahmad Zakki, Meng-Ling Li, Qian-Wen Feng, Takashi Kondo, Ryohei Ogawa, Hidekuni Inader. Potential hazards of fenvalerate in massive pollution influence the apoptosis sensitivity. Journal of applied toxicology : JAT. vol 38. issue 2. 2018-07-23. PMID:28949029. |
in the present study, the effects of fen on cadmium (cd)-induced apoptosis and the associated molecular mechanisms were investigated in human myeloid leukemia u937 cells. |
2018-07-23 |
2023-08-13 |
human |
| Limin Cai, Haiyan Li, Cui Chen, Xue Cheng, Yu Wang, Jing Liu, Yongchen Wang, Lijun Ha. Role of inhibitor of growth 4 in the suppression of human melanoma cells through the Fas/FasL-mediated apoptosis pathway. International journal of molecular medicine. vol 41. issue 2. 2018-07-17. PMID:29207034. |
first, the effect of overexpressing or downregulating ing4 on the apoptosis of the transfected melanoma cells and cluster of differentiation (cd)3+ t cells was investigated. |
2018-07-17 |
2023-08-13 |
human |
| Jeeyoung Kim, Haengseok Song, Hye-Ryeon Heo, Jung Woon Kim, Hye-Ryun Kim, Yoonki Hong, Se-Ran Yang, Seon-Sook Han, Seung-Joon Lee, Woo Jin Kim, Seok-Ho Hon. Cadmium-induced ER stress and inflammation are mediated through C/EBP-DDIT3 signaling in human bronchial epithelial cells. Experimental & molecular medicine. vol 49. issue 9. 2018-05-21. PMID:28860664. |
cd treatment led to marked upregulation and downregulation of genes associated with the cell cycle, apoptosis, oxidative stress and inflammation as well as various signal transduction pathways. |
2018-05-21 |
2023-08-13 |
human |
| Wanqiu Xie, Ming Ge, Guangxing Li, Linan Zhang, Zequn Tang, Ruyue Li, Ruili Zhan. Astragalus Polysaccharide Protect against Cadmium-Induced Cytotoxicity through the MDA5/NF-κB Pathway in Chicken Peripheral Blood Lymphocytes. Molecules (Basel, Switzerland). vol 22. issue 10. 2018-05-21. PMID:28946702. |
cadmium (cd) is a known environmental pollutant that is associated with inflammation, oxidative stress, and cell apoptosis. |
2018-05-21 |
2023-08-13 |
chicken |
| Cong Zhang, Jia Lin, Jing Ge, Li-Li Wang, Nan Li, Xue-Tong Sun, Hua-Bin Cao, Jin-Long L. Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 44. 2018-05-09. PMID:28765097. |
these results indicated that se ameliorated the cytotoxicity of cd by recovering hepatocyte morphology and function, inhibiting reactive oxygen species (ros) and malondialdehyde (mda) production, reducing intracellular ldh release, autophagy and apoptosis, and increasing the major antioxidative activities (total antioxidant capacity (t-aoc) and superoxide dismutase (sod). |
2018-05-09 |
2023-08-13 |
chicken |