| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yen-Tze Liu, Ming-Ju Hsieh, Jen-Tsun Lin, Gene Chen, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Yi-Ting Hsi, Mu-Kuan Chen, Ming-Chih Cho. Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway. Environmental toxicology. vol 34. issue 4. 2019-04-22. PMID:30623577. |
moreover, the rate of apoptosis of cells treated with cd plus jnk inhibitors was decreased compared to cd-treated cells. |
2019-04-22 |
2023-08-13 |
human |
| Yen-Tze Liu, Ming-Ju Hsieh, Jen-Tsun Lin, Gene Chen, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Yi-Ting Hsi, Mu-Kuan Chen, Ming-Chih Cho. Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway. Environmental toxicology. vol 34. issue 4. 2019-04-22. PMID:30623577. |
this is the first study to demonstrate that cd induces apoptosis in human oral cancer cells and can be expected to be a promising anticancer agent for oral cancer treatment. |
2019-04-22 |
2023-08-13 |
human |
| Shihao Chen, Gang Liu, Mengfei Long, Hui Zou, Hengmi Cu. Alpha lipoic acid attenuates cadmium-induced nephrotoxicity via the mitochondrial apoptotic pathways in rat. Journal of inorganic biochemistry. vol 184. 2019-04-08. PMID:29654931. |
treatment with 50 mg/l cd also damaged renal cell mitochondria and nuclei, and activated the mitochondrial apoptosis pathway, indicated by increased gene and protein expression/activation of caspase-9, caspase-3, poly adp-ribose polymerase (parp) and bcl-2 adenovirus e1a nineteen kilodalton interacting protein 3 (bnip3), and translocation of cytochrome c (cyt c), apoptosis-inducing factor (aif), and endonuclease g (endo g). |
2019-04-08 |
2023-08-13 |
rat |
| Shihao Chen, Gang Liu, Mengfei Long, Hui Zou, Hengmi Cu. Alpha lipoic acid attenuates cadmium-induced nephrotoxicity via the mitochondrial apoptotic pathways in rat. Journal of inorganic biochemistry. vol 184. 2019-04-08. PMID:29654931. |
however, simultaneous supplementation with α-la (50 mg/kg·bw) protected kidney cells from cd-induced cytotoxicity by reducing mda levels and cd content, restoring endogenous enzyme activities, renewing mitochondrial function, and preventing activation of the mitochondria apoptosis pathway. |
2019-04-08 |
2023-08-13 |
rat |
| Yi Sun, Jing Zhou, Ya-Jing Guo, Liu Chen, Tao Li, Yan-Ling Gao, Yu-Ning Wang, Ji-Meng Zhao, Huan-Gan Wu, Yin Sh. [Herbal cake-partitioned moxibustion improves intestinal epithelial barrier dysfunction by suppressing TNF-α-mediated apoptosis pathway of intestinal epithelium in rats with Crohn's disease]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 1. 2019-04-05. PMID:30773854. |
to observe the effect of herbal cake-partitioned moxibustion (moxi) on tumor necrosis factor (tnf)-α/ tnf receptor 1 (tnfr1)-associated death domain (tradd) / fas-associated death domain (fadd) pathway-mediated apoptosis of intestinal epithelial cells in crohn's disease (cd) rats, so as to explore its underlying mechanisms in the treatment of cd. |
2019-04-05 |
2023-08-13 |
rat |
| S Vincent, R Sumit, S Bavithra, V Victoria, N Akhila, J Prabh. Metallothionein Induced Time Dependent Histomorphometric Analysis of Clarias gariepinus Exposed to Cadmium. Bulletin of environmental contamination and toxicology. vol 102. issue 1. 2019-03-26. PMID:30406814. |
our results revealed that fish exposed to cd induced apoptosis in fish tissues via induction of caspases and in contrast the metallothionein was also increased consistently with different doses of cd exposure. |
2019-03-26 |
2023-08-13 |
human |
| Katarzyna Neubauer, Barbara Woźniak-Stolarska, Małgorzata Krzystek-Korpack. Peripheral Lymphocytes of Patients with Inflammatory Bowel Disease Have Altered Concentrations of Key Apoptosis Players: Preliminary Results. BioMed research international. vol 2018. 2019-03-19. PMID:30515402. |
observed abnormalities in intrinsic pathway of apoptosis are more pronounced in cd. |
2019-03-19 |
2023-08-13 |
Not clear |
| Gunnar F Kwakye, Jessica A Jiménez, Morgan G Thomas, Brett A Kingsley, Matthew McIIvin, Mak A Saito, Edmund M Korle. Heterozygous huntingtin promotes cadmium neurotoxicity and neurodegeneration in striatal cells via altered metal transport and protein kinase C delta dependent oxidative stress and apoptosis signaling mechanisms. Neurotoxicology. vol 70. 2019-03-18. PMID:30399392. |
heterozygous htt coupled with cd exposure caused increased expression of protein kinase c δ (pkcδ) and other key oxidative stress proteins levels, enhanced the activation of caspase-9 and caspase-3 mediated apoptosis, and blocked the overexpression of extracellular signal-regulated kinase (erk). |
2019-03-18 |
2023-08-13 |
mouse |
| Gunnar F Kwakye, Jessica A Jiménez, Morgan G Thomas, Brett A Kingsley, Matthew McIIvin, Mak A Saito, Edmund M Korle. Heterozygous huntingtin promotes cadmium neurotoxicity and neurodegeneration in striatal cells via altered metal transport and protein kinase C delta dependent oxidative stress and apoptosis signaling mechanisms. Neurotoxicology. vol 70. 2019-03-18. PMID:30399392. |
collectively, these results demonstrate that heterozygous htt exhibits greater neurotoxic properties when coupled with cd exposure to cause cell death via caspase mediated apoptosis, altered metal transport, and modulation of erk and pkcδ dependent oxidative signaling mechanisms. |
2019-03-18 |
2023-08-13 |
mouse |
| Xiaotong Wang, Xiaopeng Cui, Chuanwu Zhu, Ming Li, Juan Zhao, Zhongyi Shen, Xiaohang Shan, Liang Wang, Han Wu, Yanting Shen, You Ni, Dongmei Zhang, Guoxiong Zho. FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Molecular medicine reports. vol 18. issue 5. 2019-01-25. PMID:30221722. |
in conclusion, these results suggest that the upr protein fkbp11 may protect iecs against ifn‑γ/tnf‑α induced apoptosis by inhibiting the er stress‑associated jnk/caspase apoptotic pathway in cd. |
2019-01-25 |
2023-08-13 |
mouse |
| Haijuan Zhang, Baoxin Zhang, Cuixia Di, Mohammad Chand Ali, Jia Chen, Zhan Li, Jing Si, Hong Zhang, Hongdeng Qi. Label-free fluorescence imaging of cytochrome c in living systems and anti-cancer drug screening with nitrogen doped carbon quantum dots. Nanoscale. vol 10. issue 11. 2019-01-08. PMID:29509193. |
here, we designed a novel label-free n-doped carbon dot (n-doped cd)-based nanosensor that enables fluorescence activation imaging of cyt c release in cell apoptosis. |
2019-01-08 |
2023-08-13 |
zebrafish |
| Paola Bonaventura, Guillaume Courbon, Aline Lamboux, Fabien Lavocat, Hubert Marotte, Francis Albarède, Pierre Miosse. Protective effect of low dose intra-articular cadmium on inflammation and joint destruction in arthritis. Scientific reports. vol 7. issue 1. 2018-12-18. PMID:28546541. |
cell death through apoptosis was highly induced by cd in inflammatory synoviocytes (80% reduction of cell viability, p < 0.01). |
2018-12-18 |
2023-08-13 |
rat |
| Ruiwen Cao, Yongliang Liu, Qing Wang, Qianqian Zhang, Dinglong Yang, Hui Liu, Yi Qu, Jianmin Zha. The impact of ocean acidification and cadmium on the immune responses of Pacific oyster, Crassostrea gigas. Fish & shellfish immunology. vol 81. 2018-12-11. PMID:30064018. |
however, inhibited phagocytosis rate, combined with increased dna damage, apoptosis rate and ros production of hemocytes were observed in oysters under exposure to cd exposure alone or combined with oa. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jie Gu, Shuya Dai, Yanmin Liu, Haitao Liu, Yao Zhang, Xingqi Ji, Feng Yu, Yang Zhou, Liang Chen, William Ka Fai Tse, Chris Kong Chu Wong, Binghai Chen, Haifeng Sh. Activation of Ca Scientific reports. vol 8. issue 1. 2018-11-27. PMID:29348484. |
previous studies have proved that cd impact on renal cell proliferation, autophagy and apoptosis, but the detoxification drugs and the functional mechanism are still in study. |
2018-11-27 |
2023-08-13 |
mouse |
| Tongwang Luo, Huiyan Zhang, Qi Yu, Gang Liu, Mengfei Long, Kanglei Zhang, Wei Liu, Ruilong Song, Jianchun Bian, Jianhong Gu, Hui Zou, Xuezhong Liu, Yan Yuan, Zongping Li. ERK1/2 MAPK promotes autophagy to suppress ER stress-mediated apoptosis induced by cadmium in rat proximal tubular cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 52. 2018-11-26. PMID:29870746. |
the goal of the present study was to investigate the toxic mechanism of cd on rpt cells, and to elucidate the role of erk1/2 signaling pathway in mediating the relationship between apoptosis and autophagy. |
2018-11-26 |
2023-08-13 |
rat |
| Tongwang Luo, Huiyan Zhang, Qi Yu, Gang Liu, Mengfei Long, Kanglei Zhang, Wei Liu, Ruilong Song, Jianchun Bian, Jianhong Gu, Hui Zou, Xuezhong Liu, Yan Yuan, Zongping Li. ERK1/2 MAPK promotes autophagy to suppress ER stress-mediated apoptosis induced by cadmium in rat proximal tubular cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 52. 2018-11-26. PMID:29870746. |
we observed that increased cd concentration disrupted cell morphology, increased apoptosis and induced autophagy. |
2018-11-26 |
2023-08-13 |
rat |
| Tongwang Luo, Huiyan Zhang, Qi Yu, Gang Liu, Mengfei Long, Kanglei Zhang, Wei Liu, Ruilong Song, Jianchun Bian, Jianhong Gu, Hui Zou, Xuezhong Liu, Yan Yuan, Zongping Li. ERK1/2 MAPK promotes autophagy to suppress ER stress-mediated apoptosis induced by cadmium in rat proximal tubular cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 52. 2018-11-26. PMID:29870746. |
our results indicated that cd exposure damages cells also induces apoptosis and autophagy, meanwhile demonstrate that the erk1/2 signaling pathway plays an important role in this process. |
2018-11-26 |
2023-08-13 |
rat |
| Shu-Hua Yang, Li-Hui Yu, Lin Li, Yang Guo, Yi Zhang, Miao Long, Peng Li, Jian-Bin H. Protective Mechanism of Sulforaphane on Cadmium-Induced Sertoli Cell Injury in Mice Testis via Nrf2/ARE Signaling Pathway. Molecules (Basel, Switzerland). vol 23. issue 7. 2018-10-31. PMID:30029485. |
our results also showed that sfn reduced the apoptosis rate, increased the activity of t-sod, inhibited the increase of the mda content caused by cd. |
2018-10-31 |
2023-08-13 |
mouse |
| Zhangxiao Peng, Yan Wang, Jianhui Fan, Xuejing Lin, Chunying Liu, Yang Xu, Weidan Ji, Chao Yan, Changqing S. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. Scientific reports. vol 7. 2018-10-29. PMID:28117370. |
ingenuity pathways analysis (ipa) results based on the differentially expressed proteins revealed that both vosl and cd affect the 14-3-3-mediated signaling, c-myc mediated apoptosis signaling and protein kinase a (pka) signaling. |
2018-10-29 |
2023-08-13 |
Not clear |
| Zhangxiao Peng, Yan Wang, Jianhui Fan, Xuejing Lin, Chunying Liu, Yang Xu, Weidan Ji, Chao Yan, Changqing S. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. Scientific reports. vol 7. 2018-10-29. PMID:28117370. |
cell cycle arrest and apoptosis were induced in a dose-dependent manner, and the expressions of p53 and p-14-3-3 were significantly up-regulated, whereas the expressions of c-myc, p-akt, p-bid were significantly down-regulated, furthermore, the ratio of bax/bcl-2 were significantly increased in breast cancer cells after cd and vosl treatment. |
2018-10-29 |
2023-08-13 |
Not clear |