| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Kliem, B Berisha, H H D Meyer, D Scham. Regulatory changes of apoptotic factors in the bovine corpus luteum after induced luteolysis. Molecular reproduction and development. vol 76. issue 3. 2009-08-07. PMID:18563705. |
the western blot revealed an increasing level of an 89 kda fragment of parp-1 from 12 to 24 hr, which is specific for apoptosis. |
2009-08-07 |
2023-08-12 |
cattle |
| Dasa Zupancic, Gaj Vidmar, Kristijan Jezerni. Melatonin prevents the development of hyperplastic urothelium induced by repeated doses of cyclophosphamide. Virchows Archiv : an international journal of pathology. vol 454. issue 6. 2009-08-04. PMID:19381685. |
transmission and scanning electron microscopy, immunohistochemistry and western blot analysis were used to study the ultrastructure, apoptosis, proliferation and differentiation of urothelial cells. |
2009-08-04 |
2023-08-12 |
mouse |
| Limin Cai, Xiaomei Li, Shuyun Zheng, Yanhua Wang, Yandong Wang, Haiyan Li, Jing Yang, Jianfang Su. Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14. Melanoma research. vol 19. issue 1. 2009-07-30. PMID:19430401. |
the detection of the expression of cell cycle or apoptosis regulators in transfected m14 cells was carried out by western blot analysis. |
2009-07-30 |
2023-08-12 |
human |
| Manjari Chaudhari, R Jayaraj, A S B Bhaskar, P V Lakshmana Ra. Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology. vol 262. issue 2. 2009-07-28. PMID:19524637. |
western blot analysis showed increase in levels of mitochondrial apoptogenic factors bax, bcl-2, cytochrome-c followed by activation of caspases-9, -3 and -7 leading to dna fragmentation and apoptosis. |
2009-07-28 |
2023-08-12 |
human |
| Gum-Yong Kang, Eung-Ryoung Lee, Jung-Hyun Kim, Jin Woo Jung, Jun Lim, Sang Kyung Kim, Ssang-Goo Cho, Kwang Pyo Ki. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. European journal of pharmacology. vol 611. issue 1-3. 2009-07-23. PMID:19356725. |
western blot analysis showed cleavage of poly (adp-ribose) polymerase (parp), caspase-7, bax, and caspase-9 indicating that the intracellular pathway of apoptosis was involved. |
2009-07-23 |
2023-08-12 |
human |
| Huahong Xie, Liucun Gao, Na Chai, Jiugang Song, Jun Wang, Zhenshun Song, Caiping Chen, Yanglin Pan, Lina Zhao, Shiren Sun, Kaichun Wu, Mark A Feitelson, Jie Liu, Daiming Fa. Potent cell growth inhibitory effects in hepatitis B virus X protein positive hepatocellular carcinoma cells by the selective cyclooxygenase-2 inhibitor celecoxib. Molecular carcinogenesis. vol 48. issue 1. 2009-07-15. PMID:18506760. |
rt-pcr and western blot were used to identify the molecules involved in celecoxib induced cell apoptosis. |
2009-07-15 |
2023-08-12 |
Not clear |
| S Rasul, R Balasubramanian, A Filipović, M J Slade, E Yagüe, R C Coombe. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. British journal of cancer. vol 100. issue 12. 2009-07-02. PMID:19513078. |
flow cytometric and western blot analyses indicated that gsi1 induces a g2/m arrest leading to apoptosis, through downregulation of bcl-2, bax and bcl-xl. |
2009-07-02 |
2023-08-12 |
Not clear |
| Jun Ren, Sara A Babcock, Qun Li, Anna F Huff, Shi-Yan Li, Thomas A Dose. Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. Toxicology letters. vol 187. issue 3. 2009-06-25. PMID:19429258. |
western blot was performed to examine expression (or its activation) of aldh2, the pro- and anti-apoptotic proteins caspase-8, bax, bcl-2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc), flice-like inhibitory protein (flip), x-linked inhibitor of apoptosis protein (xiap), akt, glycogen synthase kinase-3beta (gsk-3beta), p38, c-jun n-terminal kinase (jnk) and extracellular signal-regulated kinase (erk). |
2009-06-25 |
2023-08-12 |
mouse |
| Sergio Huerta, Guillermina Baay-Guzman, Cesar R Gonzalez-Bonilla, Edward H Livingston, Sara Huerta-Yepez, Benjamin Bonavid. In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF. Nitric oxide : biology and chemistry. vol 20. issue 3. 2009-06-15. PMID:19105980. |
several lines of evidence suggest the involvement of aif expression level in the sensitivity of sw620 to cddp-induced apoptosis: (1) sensitization of sw620 by the no donor detanonoate to cddp-induced apoptosis correlated with the induction of aif as assessed by rt-pcr and western blot analysis, (2) treatment of sw620 cells with sirna aif, but not with control sirnas, inhibited detanonoate-induced sensitization to cddp apoptosis, (3) sensitization by detanonoate observed in vitro was corroborated in vivo in nude mice bearing sw620 tumor xenografts and treated with the combination of detanonoate and cddp, and (4) tumor tissues derived from the sw620 xenografts revealed significant upregulation of aif and increased apoptosis by detanonoate and cddp combination treatment. |
2009-06-15 |
2023-08-12 |
mouse |
| X Song, B Kong, D Li, Q Yan. The inhibitory effect of human embryonic germ cells on ovarian cancer. Neoplasma. vol 56. issue 1. 2009-06-09. PMID:19152240. |
we examined the efficacy of hegcs through coculturing skov3 with hegcs, detecting tunel apoptosis and caspase-9 activity by immunocytochemistry, and measuring the expression of akt by real-time pcr and western blot. |
2009-06-09 |
2023-08-12 |
mouse |
| Javier Megías, María Isabel Guillén, Victoria Clérigues, Ana I Rojo, Antonio Cuadrado, Miguel Angel Castejón, Francisco Gomar, María José Alcara. Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes. Biochemical pharmacology. vol 77. issue 12. 2009-06-02. PMID:19428335. |
gene expression was assessed by quantitative real-time pcr, protein levels by elisa and western blot, apoptosis by laser scanning cytometry using annexin v-fitc and tunel assays, and oxidative stress by lsc with dihydrorhodamine 123. |
2009-06-02 |
2023-08-12 |
Not clear |
| Yu-Rong Fu, Zheng-Jun Yi, Yu-Rong Yan, Zong-Yin Qi. Hydroxycamptothecin-induced apoptosis in hepatoma SMMC-7721 cells and the role of mitochondrial pathway. Mitochondrion. vol 6. issue 4. 2009-05-11. PMID:16926123. |
western blot analysis was used to evaluate the release of mitochondrial cytochrome c and aif; on the other hand, translocation of cytochrome c and aif from mitochondria to cytosol during apoptosis were confirmed by confocal microscopy. |
2009-05-11 |
2023-08-12 |
human |
| Yu-Ching Li, Hui-Ju Lin, Jen-Hung Yang, Jai-Sing Yang, Heng-Chien Ho, Shu-Jen Chang, Te-Chun Hsai, Hsu-Feng Lu, An-Cheng Huang, Jing-Gung Chun. Baicalein-induced apoptosis via endoplasmic reticulum stress through elevations of reactive oxygen species and mitochondria dependent pathway in mouse-rat hybrid retina ganglion cells (N18). Neurochemical research. vol 34. issue 3. 2009-05-11. PMID:18661233. |
we also demonstrated a release of the cytochrome c from mitochondria into cytosol and an activation of caspase-3, which led to the occurrence of apoptosis in n18 cells treated with baicalein by western blot. |
2009-05-11 |
2023-08-12 |
Not clear |
| Yong Chun Jin, Wooyeol Kim, Yu Mi Ha, Il Woo Shin, Ju Tae Sohn, Hye Jung Kim, Han Geuk Seo, Jea Heun Lee, Ki Churl Chan. Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo. Vascular pharmacology. vol 50. issue 1-2. 2009-04-27. PMID:18996224. |
apoptosis was evaluated by western blot analysis (bcl-2, bax expression), dna strand breaks, tunel analysis and measuring myocardial caspase-3 activity. |
2009-04-27 |
2023-08-12 |
rat |
| Jun Jiang, Jianan Wang, Changling Li, Shan Ping Yu, Ling We. Dual roles of tumor necrosis factor-alpha receptor-1 in a mouse model of hindlimb ischemia. Vascular medicine (London, England). vol 14. issue 1. 2009-04-23. PMID:19144778. |
western blot analysis revealed less expression of pro-apoptotic markers bax and cleaved caspase-3 in tnfr-1-/- mice 1 day after ischemia, supporting the hypothesis that the absence of tnfr-1 results in a reduction of apoptosis. |
2009-04-23 |
2023-08-12 |
mouse |
| Zongjian Zhu, Weiqin Jiang, John N McGinley, Henry J Thompso. Energetics and mammary carcinogenesis: effects of moderate-intensity running and energy intake on cellular processes and molecular mechanisms in rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 106. issue 3. 2009-04-15. PMID:19095749. |
compared with sc, mammary carcinogenesis was inhibited by re or pa. cancer incidence, 92.6%, 77.8%, and 66.7% (p = 0.06), and cancer multiplicity, 3.44, 2.11, and 1.62 cancers/rat (p = 0.006), in sc, re, and pa, respectively, were reduced to a similar extent by re and pa. histological and western blot analyses of mammary carcinomas provided evidence that re and pa induced apoptosis via the mitochondrial pathway, that cell cycle progression was suppressed at the g(1)/s transition, and that intratumoral blood vessel density was reduced, although it remains to be determined whether pa and re exert these effects via the same mechanisms. |
2009-04-15 |
2023-08-12 |
rat |
| Miao He, Lin Zhao, Min-Jie Wei, Wei-Fan Yao, Hai-Shan Zhao, Fu-Jun Che. Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose. Biological & pharmaceutical bulletin. vol 32. issue 1. 2009-04-15. PMID:19122281. |
tdt-mediated dutp-biotin nick end labeling (tunel) staining method was used to detect neuronal apoptosis, and the activation and expression of proapoptotic protein caspase-3 in the hippocampus were observed and analyzed using immunohistochemical staining and the western blot method to evaluate apoptosis in the brain. |
2009-04-15 |
2023-08-12 |
mouse |
| Sanchita P Ghosh, Michael W Perkins, Kevin Hieber, Shilpa Kulkarni, Tzu-Cheg Kao, E Premkumar Reddy, M V Ramana Reddy, Manoj Maniar, Thomas Seed, K Sree Kuma. Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms. Radiation research. vol 171. issue 2. 2009-04-07. PMID:19267542. |
western blot analyses indicated that the radiation protection provided by ex-rad resulted in reduced levels of pro-apoptosis proteins such as p53 as well as its downstream regulators p21, bax, c-abl and p73, indicating that ex-rad could rescue cells from ionizing radiation-induced p53-dependent apoptosis. |
2009-04-07 |
2023-08-12 |
mouse |
| H Kanemitsu, H Yamauchi, M Komatsu, S Yamamoto, S Okazaki, H Nakayam. Time-course changes in neural cell apoptosis in the rat fetal brain from dams treated with 6-mercaptopurine (6-MP). Histology and histopathology. vol 24. issue 3. 2009-04-06. PMID:19130401. |
moreover, pyknotic cells were immunohistochemically positive for cleaved caspase-3, one of the key executioners of apoptosis, and the increased expression of the protein from 30 to 48 h was confirmed by using western blot analysis. |
2009-04-06 |
2023-08-12 |
rat |
| Jianxiong He, Canhua Huang, Aiping Tong, Bin Chen, Zhi Zeng, Peng Zhang, Chunting Wang, Yuquan We. Proteomic analysis of cervical cancer cells treated with suberonylanilide hydroxamic acid. Journal of biosciences. vol 33. issue 5. 2009-04-02. PMID:19179759. |
moreover,pgam1 has been proven to be downregulated in another cervical cancer cell line (caski) by western blot analysis.together,using proteomic tools,we identified several differentially expressed proteins that underwent saha-induced apoptosis. |
2009-04-02 |
2023-08-12 |
human |