| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miao He, Lin Zhao, Min-Jie Wei, Wei-Fan Yao, Hai-Shan Zhao, Fu-Jun Che. Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose. Biological & pharmaceutical bulletin. vol 32. issue 1. 2009-04-15. PMID:19122281. |
tdt-mediated dutp-biotin nick end labeling (tunel) staining method was used to detect neuronal apoptosis, and the activation and expression of proapoptotic protein caspase-3 in the hippocampus were observed and analyzed using immunohistochemical staining and the western blot method to evaluate apoptosis in the brain. |
2009-04-15 |
2023-08-12 |
mouse |
| Sanchita P Ghosh, Michael W Perkins, Kevin Hieber, Shilpa Kulkarni, Tzu-Cheg Kao, E Premkumar Reddy, M V Ramana Reddy, Manoj Maniar, Thomas Seed, K Sree Kuma. Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms. Radiation research. vol 171. issue 2. 2009-04-07. PMID:19267542. |
western blot analyses indicated that the radiation protection provided by ex-rad resulted in reduced levels of pro-apoptosis proteins such as p53 as well as its downstream regulators p21, bax, c-abl and p73, indicating that ex-rad could rescue cells from ionizing radiation-induced p53-dependent apoptosis. |
2009-04-07 |
2023-08-12 |
mouse |
| H Kanemitsu, H Yamauchi, M Komatsu, S Yamamoto, S Okazaki, H Nakayam. Time-course changes in neural cell apoptosis in the rat fetal brain from dams treated with 6-mercaptopurine (6-MP). Histology and histopathology. vol 24. issue 3. 2009-04-06. PMID:19130401. |
moreover, pyknotic cells were immunohistochemically positive for cleaved caspase-3, one of the key executioners of apoptosis, and the increased expression of the protein from 30 to 48 h was confirmed by using western blot analysis. |
2009-04-06 |
2023-08-12 |
rat |
| Jianxiong He, Canhua Huang, Aiping Tong, Bin Chen, Zhi Zeng, Peng Zhang, Chunting Wang, Yuquan We. Proteomic analysis of cervical cancer cells treated with suberonylanilide hydroxamic acid. Journal of biosciences. vol 33. issue 5. 2009-04-02. PMID:19179759. |
moreover,pgam1 has been proven to be downregulated in another cervical cancer cell line (caski) by western blot analysis.together,using proteomic tools,we identified several differentially expressed proteins that underwent saha-induced apoptosis. |
2009-04-02 |
2023-08-12 |
human |
| Ling Wang, Da Jin Li, Wen Jun Wang, Ying Zh. [DHEA inhibits apoptosis of murine OB through MAPK signaling pathways independent of either ARs or ERs]. Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology. vol 39. issue 4. 2009-03-27. PMID:16955795. |
western blot showed that neither receptor antagonist ici 182,780 nor flutamide could block the dhea-induced erks phosphorylation in obs,which was similar to the apoptosis. |
2009-03-27 |
2023-08-12 |
Not clear |
| Ye-Hong Kuang, Xiang Chen, Juan Su, Li-Sha Wu, Li-Qiu Liao, Dai Li, Zhe-Sheng Chen, Takuro Kanekur. RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer letters. vol 276. issue 2. 2009-03-20. PMID:19097686. |
data presented herein showed that mdr derivative scc kb/v cell line expressed significantly higher cd147 and x-linked inhibitor of apoptosis (xiap) than its sensitive counterpart kb cells by rt-pcr and western blot analysis. |
2009-03-20 |
2023-08-12 |
human |
| Yu Rong Yan, Yu Rong Fu, Zong Yin Qi. [Quantitative analysis of nuclear proteome in apoptosis hepatoma cells induced by hydroxycamptothecin]. Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology. vol 41. issue 2. 2009-03-17. PMID:18567502. |
the apoptosis was induced by hydroxycamptothecin in hepatoma cells, the nucleus of cells were isolated and verified with western blot. |
2009-03-17 |
2023-08-12 |
Not clear |
| Huanchen Sha, Qingyong Ma, Rajiv Kumar Jha, Fuguo Xu, Liancai Wang, Zheng Wang, Yan Zhao, Fenling Fa. Resveratrol ameliorates hepatic injury via the mitochondrial pathway in rats with severe acute pancreatitis. European journal of pharmacology. vol 601. issue 1-3. 2009-03-03. PMID:18977215. |
we investigated cytochrome c released from mitochondria and used the rt-pcr (reverse transcription pcr), western blot technique to evaluate bax, bcl-2, and caspase-3 expression levels in hepatic tissue over the time course of apoptosis. |
2009-03-03 |
2023-08-12 |
rat |
| Jadranka Dujic, Stefan Kippenberger, Ana Ramirez-Bosca, Joaquin Diaz-Alperi, Jürgen Bereiter-Hahn, Roland Kaufmann, August Bernd, Matthias Hofman. Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model. International journal of cancer. vol 124. issue 6. 2009-02-23. PMID:19035461. |
the effect on apoptosis was further confirmed by western blot analysis showing enhanced activation of caspases-9. |
2009-02-23 |
2023-08-12 |
mouse |
| Shufeng Li, Mingyan E, Bo Y. Adriamycin induces myocardium apoptosis through activation of nuclear factor kappaB in rat. Molecular biology reports. vol 35. issue 4. 2009-02-09. PMID:17577680. |
myocardial apoptosis was detected by dna fragmentation assay and tunel assay; location and distribution of p-ikappab alpha was observed by immunohistochemical assay; myocardial expression of p-ikappab alpha protein was assessed by western blot analysis; activity of nf-kappab was evaluated by electrophoretic mobility shift assay. |
2009-02-09 |
2023-08-12 |
rat |
| S Kumar, H P Reusch, Y Ladilo. Acidic pre-conditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia. Journal of cellular and molecular medicine. vol 12. issue 5A. 2009-02-04. PMID:18053090. |
western blot analysis exploring the under lying mechanism leading to this protection revealed suppression of the endoplasmic reticulum- (reduced cleavage of caspase-12) and mitochondria-mediated (reduced cytochrome c release) pathways of apoptosis. |
2009-02-04 |
2023-08-12 |
Not clear |
| Emilie Arnault, Lucie Tosca, Anne-Marie Courtot, Mireille Doussau, Arlette Pesty, Catherine Finaz, Isabelle Allemand, Brigitte Lefèvr. Caspase-2(L), caspase-9, and caspase-3 during in vitro maturation and fragmentation of the mouse oocyte. Developmental dynamics : an official publication of the American Association of Anatomists. vol 237. issue 12. 2009-02-04. PMID:19035350. |
surprisingly, western blot analysis revealed that the three cleaved caspases were present in similar amounts in healthy and fragmented oocytes and caspase inhibition did not prevent doxorubicin-induced apoptosis. |
2009-02-04 |
2023-08-12 |
mouse |
| Hangping Yao, Xiajing Tang, Xueting Shao, Lei Feng, Nanping Wu, Ke Ya. Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9. Cell research. vol 17. issue 6. 2009-01-21. PMID:17339884. |
to study apoptosis, the cells were assessed by morphologic examination and annexin v-propidium iodide double staining flow cytometry; to investigate the underlying molecular mechanisms, the expression of caspase-3 and caspase-9 were assayed by western blot and quantitative rt-pcr, and the activities of caspase-3 and caspase-9 were measured by a chemicon caspase colorimetric activity assay kit. |
2009-01-21 |
2023-08-12 |
human |
| Arabinda Das, Amogh Belagodu, Russel J Reiter, Swapan K Ray, Naren L Bani. Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. Journal of pineal research. vol 45. issue 2. 2009-01-14. PMID:18373557. |
western blot analyses showed alterations in bax and bcl-2 expression resulting in increased bax:bcl-2 ratio during apoptosis. |
2009-01-14 |
2023-08-12 |
rat |
| Fausto Bogazzi, Dania Russo, Francesco Raggi, Federica Ultimieri, Claudio Urbani, Maurizio Gasperi, Luigi Bartalena, Enio Martin. Transgenic mice overexpressing growth hormone (GH) have reduced or increased cardiac apoptosis through activation of multiple GH-dependent or -independent cell death pathways. Endocrinology. vol 149. issue 11. 2009-01-06. PMID:18617616. |
cardiomyocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase assay and annexin v; expression of pro- or antiapoptotic proteins was assessed by western blot. |
2009-01-06 |
2023-08-12 |
mouse |
| Noriyuki Kamochi, Masahiro Nakashima, Shigehisa Aoki, Kazuyoshi Uchihashi, Hajime Sugihara, Shuji Toda, Sho Kud. Irradiated fibroblast-induced bystander effects on invasive growth of squamous cell carcinoma under cancer-stromal cell interaction. Cancer science. vol 99. issue 12. 2009-01-06. PMID:19018771. |
the present study shows that irradiated fibroblasts promoted the invasive growth of t3m-1 scc cells, but not their apoptosis, more greatly than non-irradiated fibroblasts, using collagen gel invasion assay, immunohistochemistry and western blot. |
2009-01-06 |
2023-08-12 |
human |
| Zongjian Zhu, Weiqin Jiang, Jennifer L Sells, Elizabeth S Neil, John N McGinley, Henry J Thompso. Effect of nonmotorized wheel running on mammary carcinogenesis: circulating biomarkers, cellular processes, and molecular mechanisms in rats. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 17. issue 8. 2008-12-16. PMID:18708381. |
western blot analyses of mammary carcinomas revealed that proteins involved in cell proliferation were reduced (p < 0.001) and those involved in apoptosis via the mitochondrial pathway were elevated (p < 0.001) by physical activity. |
2008-12-16 |
2023-08-12 |
rat |
| Wen-Juan Wang, Qing-Quan Li, Jing-Da Xu, Xi-Xi Cao, Hai-Xia Li, Feng Tang, Qi Chen, Jin-Ming Yang, Zu-De Xu, Xiu-Ping Li. Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells. International journal of oncology. vol 33. issue 5. 2008-12-16. PMID:18949367. |
using 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (mtt) assay, western blot, hoechst 33258 staining assay and flow cytometry, we found that over-expression of uch-l1 in mcf7 cells induced apoptosis. |
2008-12-16 |
2023-08-12 |
mouse |
| Tingyan Liu, Meixia Zhang, Hongliang Zhang, Chunyan Sun, Yihui Den. Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 265. issue 10. 2008-12-02. PMID:18309509. |
measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by western blot analysis showed that the effect of cucurbitacin b was due to suppression of the expression of p-stat3, bcl-2, and cyclin b1. |
2008-12-02 |
2023-08-12 |
mouse |
| Xiaobei Wang, Lihua H. Protein expression of BLM gene and its apoptosis sensitivity in hematopoietic tumor cell strains. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 28. issue 1. 2008-11-17. PMID:18278455. |
in order to investigate the differential expression of blm protein in hematopoietic tumor cell strains and study the effects of blm gene on ultraviolet (uv)-or hydroxyurea (hu)-induced apoptosis, western blot was used to detect the expression of blm protein in normal human bone marrow mononuclear cells and 4 kinds of hematopoietic tumor cell strains. |
2008-11-17 |
2023-08-12 |
human |