| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Zuse, Helge Prinz, Klaus Müller, Peter Schmidt, Eckhard G Günther, Frank Schweizer, Jochen H M Prehn, Marek Lo. 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity. European journal of pharmacology. vol 575. issue 1-3. 2008-03-06. PMID:17707367. |
western blot analysis demonstrated that caspase-3, an apoptosis mediator, was activated in a time-dependent manner after exposure of sh-sy5y cells to drugs 1a and 2. |
2008-03-06 |
2023-08-12 |
Not clear |
| Takashi Sasayama, Kazuhiro Tanaka, Katsu Mizukawa, Atsufumi Kawamura, Takeshi Kondoh, Kohkichi Hosoda, Eiji Kohmur. Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo. Journal of neuro-oncology. vol 85. issue 2. 2008-03-03. PMID:17530176. |
flow cytometric and western blot assay demonstrated that tlbc induced apoptosis independent of changes to the tumor suppressor p53. |
2008-03-03 |
2023-08-12 |
mouse |
| Jinsang Yoo, Yong J Le. Effect of hyperthermia and chemotherapeutic agents on TRAIL-induced cell death in human colon cancer cells. Journal of cellular biochemistry. vol 103. issue 1. 2008-02-29. PMID:17520700. |
interestingly, when analyzed with western blot, we detected little change in the intracellular levels of proteins related to apoptosis. |
2008-02-29 |
2023-08-12 |
human |
| Marc Weinkauf, Maximilian Christopeit, Wolfgang Hiddemann, Martin Dreylin. Proteome- and microarray-based expression analysis of lymphoma cell lines identifies a p53-centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma. Electrophoresis. vol 28. issue 23. 2008-02-20. PMID:17990259. |
expression data were confirmed by western blot analysis of identified proteins and 2-d gel hybridization of proteins with known overexpression (g1/s-specific cyclin-d1, apoptosis regulator bcl-2). |
2008-02-20 |
2023-08-12 |
Not clear |
| Thomas Zuliani, Hélène Obriot, Martine Tual, Nadège Lachman-Weber, Marc Dumas, Pierre Formstecher, Renata Polakowska, Marie-Hélène Ratinau. Variable Bax antigenicity is linked to keratinocyte position within epidermal strata and UV-induced apoptosis. Experimental dermatology. vol 17. issue 2. 2008-02-14. PMID:18177350. |
bax expression was evaluated with three different, western blot pretested, anti-bax antibodies (ab) and correlated with markers of keratinocyte differentiation and apoptosis using anti-beta(1) integrin and anti-active caspase-3 abs respectively. |
2008-02-14 |
2023-08-12 |
human |
| Yuanfei Peng, Minhua Zheng, Bo Feng, Xuehua Chen, Beiqin Yu, Aiguo Lu, Minliang Wang, Jianwen Li, Junjun Ma, Lie X. Hyperthermic CO2 pneumoperitoneum induces apoptosis in human colon cancer cells through Bax-associated mitochondrial pathway. Oncology reports. vol 19. issue 1. 2008-02-12. PMID:18097578. |
further western blot analysis and flow cytometric analysis of mitochondrial membrane potential showed that bax-associated mitochondrial apoptotic pathway played critical role in the induction of apoptosis. |
2008-02-12 |
2023-08-12 |
human |
| Hiroyuki Inaba, Yasuo Nagaoka, Yukihiro Kushima, Ayako Kumagai, Yoshinori Matsumoto, Minoru Sakaguchi, Kimiye Baba, Shinichi Uesat. Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells. Biological & pharmaceutical bulletin. vol 31. issue 1. 2008-02-06. PMID:18175946. |
cell cycle analyses, dna fragmentation assays, and tunel assays as well as western blot assays suggested that these catechins inhibited cell growth through mitogen-activated protein kinase (mapk)-mediated apoptosis rather than cell cycle regulation. |
2008-02-06 |
2023-08-12 |
human |
| Lihua Li, Yi Qu, Jinhui Li, Ying Xiong, Meng Mao, Dezhi M. Relationship between HIF-1alpha expression and neuronal apoptosis in neonatal rats with hypoxia-ischemia brain injury. Brain research. vol 1180. 2008-02-05. PMID:17920049. |
rat brains from hypoxia, hi, and sham controls were collected to detect hif-1alpha expression and cellular apoptosis using immunohistochemistry, western blot analysis, and tdt-mediated dutp-biotin nick end labeling (tunel). |
2008-02-05 |
2023-08-12 |
rat |
| Venkateswaran Subramaniam, Helena Gardner, Serge Joth. Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells. Experimental and molecular pathology. vol 83. issue 3. 2008-02-04. PMID:17945213. |
western blot analyses were negative for cleaved parp in lysates from cd44(sol) cells, suggesting resistance to apoptosis. |
2008-02-04 |
2023-08-12 |
human |
| Steffen Zopf, Daniel Neureiter, Steve Bouralexis, Tobias Abt, Keith B Glaser, Kinya Okamoto, Marion Ganslmayer, Eckhart G Hahn, Christoph Herold, Matthias Ocke. Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo. International journal of oncology. vol 31. issue 6. 2008-01-15. PMID:17982666. |
hct116 cell lines were incubated with a-423378.0 at different concentrations for 3-120 h. cell viability, proliferation and apoptosis rates were determined and verified by western blot, detection of mitochondrial membrane potential breakdown deltapsi(m), activation of caspases-3, -8 and cytokeratin 18 cleavage. |
2008-01-15 |
2023-08-12 |
mouse |
| Pengxia Zhang, Hongmei Li, Dong Chen, Juhua Ni, Yuming Kang, Shuqiu Wan. Oleanolic acid induces apoptosis in human leukemia cells through caspase activation and poly(ADP-ribose) polymerase cleavage. Acta biochimica et biophysica Sinica. vol 39. issue 10. 2008-01-02. PMID:17928930. |
western blot analysis showed that caspase-9 and caspase-3 were activated, accompanied by the cleavage of poly(adp-ribose) polymerase (parp) in the target cells during fll- or oa-induced apoptosis. |
2008-01-02 |
2023-08-12 |
human |
| Qun Li, Jun Re. Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. Aging cell. vol 6. issue 6. 2007-12-31. PMID:17973971. |
pro- and anti-apoptotic proteins including bax, p53, pp53, bcl2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc) and x-linked inhibitor of apoptosis protein (xiap) were assessed by western blot. |
2007-12-31 |
2023-08-12 |
mouse |
| Hannele Hasala, Xianzhi Zhang, Seppo Saarelainen, Eeva Moilanen, Hannu Kankaanrant. c-Jun N-terminal kinase mediates constitutive human eosinophil apoptosis. Pulmonary pharmacology & therapeutics. vol 20. issue 5. 2007-12-27. PMID:16934508. |
slow activation of jnk in constitutive apoptosis as well as a similar tendency in dexamethasone-induced eosinophil apoptosis could be observed by western blot analyses. |
2007-12-27 |
2023-08-12 |
human |
| B Baisden, S Sonne, R M Joshi, V Ganapathy, P S Shekhawa. Antenatal dexamethasone treatment leads to changes in gene expression in a murine late placenta. Placenta. vol 28. issue 10. 2007-12-20. PMID:17559929. |
oligo apoptaq assay and western blot studies showed that dex-treatment increased apoptosis of trophoblast cells. |
2007-12-20 |
2023-08-12 |
mouse |
| Qing Wu, Yan Chen, Xing-Gang Li, Yuan-Yan Tan. [Regulatory effect of curcumin on p300 and HDAC1 in B-NHL cells]. Zhongguo shi yan xue ye xue za zhi. vol 14. issue 2. 2007-12-14. PMID:16638200. |
the in vitro cultured raji cells were treated with curcumin at various concentrations (6.25-50 micromol/l) and at different time points (0, 6, 12, 24 and 48 hours), the inhibitory ratio of cell growth was measured by mtt assay, the cell apoptosis rate was detected by flow cytometry with annexin v-fitc/pi double staining, the changes of p300 and hdac1 mrna expression and protein level in raji cells were determined by rt-pcr and western blot. |
2007-12-14 |
2023-08-12 |
Not clear |
| Jingwei Cheng, David V Yu, Jian-Hua Zhou, David J Shapir. Tamoxifen induction of CCAAT enhancer-binding protein alpha is required for tamoxifen-induced apoptosis. The Journal of biological chemistry. vol 282. issue 42. 2007-12-12. PMID:17716978. |
quantitative reverse transcription-pcr, western blot analysis, and rna interference knockdown suggest that cell cycle arrest resulting from oht-eralpha induction of p21 may facilitate apoptosis. |
2007-12-12 |
2023-08-12 |
Not clear |
| S-K Hwang, H Jin, J T Kwon, S-H Chang, T H Kim, C-S Cho, K H Lee, M R Young, N H Colburn, G R Beck, H-S Yang, M-H Ch. Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Gene therapy. vol 14. issue 18. 2007-12-10. PMID:17611588. |
results obtained by western blot analysis, immunohistochemistry, luciferase assay and deoxynucleotidyl-transferase-mediated nick end labeling study suggest that combined actions such as facilitating apoptosis, controlling cell cycle and suppression of ap-1 activity by pdcd4 may provide useful tool for designing lung tumor prevention and treatment by which pdcd4 functions as a transformation suppressor in the future. |
2007-12-10 |
2023-08-12 |
mouse |
| Yoshiko Inoue, Taketoshi Asanuma, Nataliya Smith, Debra Saunders, Jenny Oblander, Yashige Kotake, Robert A Floyd, Rheal A Towne. Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. Free radical research. vol 41. issue 9. 2007-11-27. PMID:17729114. |
increased apoptosis in cd-treated livers was confirmed by western blot analyses of caspases and cytochrome c. this study was also able to detect differences in apoptotic events following phenyl butyl nitrone (pbn) treatment. |
2007-11-27 |
2023-08-12 |
rat |
| Jing-Pin Lin, Jai-Sing Yang, Nai-Wen Chang, Tsan-Hung Chiu, Chin-Cheng Su, Kung-Wen Lu, Yung-Tsuan Ho, Chin-Chung Yeh, Mei-Dueyang, Hui-Ju Lin, Jing-Gung Chun. GADD153 mediates berberine-induced apoptosis in human cervical cancer Ca ski cells. Anticancer research. vol 27. issue 5A. 2007-11-27. PMID:17970084. |
western blot also showed that berberine induced the expression of gadd153, a transcription factor involved in apoptosis. |
2007-11-27 |
2023-08-12 |
human |
| Anna Sebestyén, Melinda Hajdu, Lilla Kis, Gábor Barna, László Koppe. Smad4-independent, PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells. Experimental cell research. vol 313. issue 15. 2007-11-21. PMID:17643425. |
gene expression and apoptosis were detected by rt-pcr, western blot analysis and flow cytometry. |
2007-11-21 |
2023-08-12 |
Not clear |