| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Almonte-Becerril, F Navarro-Garcia, A Gonzalez-Robles, M A Vega-Lopez, C Lavalle, J B Kour. Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model. Apoptosis : an international journal on programmed cell death. vol 15. issue 5. 2010-06-18. PMID:20091349. |
to identify the mechanisms, as well as the chronology by which chondrocytes are eliminated during oa pathogenesis, we decided to evaluate apoptosis (by active caspase 3 and tunel signal) and autophagy (by lc3ii molecule and cytoplasmic vacuolization) using immunohistochemistry and western blot techniques in an animal oa model. |
2010-06-18 |
2023-08-12 |
Not clear |
| Nina Habermann, Adrienne Schön, Elizabeth K Lund, Michael Gle. Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. Apoptosis : an international journal on programmed cell death. vol 15. issue 5. 2010-06-18. PMID:20107900. |
lt97 human colon adenoma and ht29 human colon adenocarcinoma cells were used to investigate modulation of apoptosis by epa, dha or linoleic acid (la) using a set of endpoints, namely phosphatidylserine staining with annexin-v (flow cytometry), bcl-2 expression (real-time rt-pcr), and bid, caspase 3, 8 and 9 expression as well as parp cleavage (western blot). |
2010-06-18 |
2023-08-12 |
human |
| Jia-Jun Liu, Yong Zhang, Wei-Bin Guang, Hong-Zhi Yang, Dong-Jun Lin, Ruo-Zhi Xia. Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. International journal of molecular sciences. vol 9. issue 11. 2010-06-17. PMID:19330074. |
marked morphological changes of cell apoptosis were observed clearly after the cells were treated with ponicidin for 48 approximately 72 h. rt-pcr and western blot analysis demonstrated that both survivin and bcl-2 expressions were down-regulated remarkably while bax expression remained constant before and after apoptosis occurred. |
2010-06-17 |
2023-08-12 |
Not clear |
| Qingning Liang, Yuchen Sheng, Lili Ji, Yang Min, Yuye Xia, Zhengtao Wan. Acetaminophen-induced cytotoxicity on human normal liver L-02 cells and the protection of antioxidants. Toxicology mechanisms and methods. vol 20. issue 5. 2010-06-17. PMID:20465405. |
further results showed that 10 mm ap caused cell apoptosis after 48 h treatment based on the dna fragmentation assay and western blot of caspase-3 activation, respectively. |
2010-06-17 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Shabnam Ahmed, Alex Dayton, M Lakshmi Kuppusamy, Mia Tazi, Anna Bratasz, Liyue Tong, Brian K Rivera, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells. Free radical biology & medicine. vol 48. issue 9. 2010-06-16. PMID:20156552. |
western blot analysis showed that the dap-induced growth arrest and apoptosis in cancer cells were mediated by inhibition of stat3 phosphorylation at the tyr705 and ser727 residues and induction of apoptotic markers of cleaved caspase-3 and parp. |
2010-06-16 |
2023-08-12 |
human |
| Ayad M Al-Katib, Yuan Sun, Anton Scott Goustin, Asfar Sohail Azmi, Ben Chen, Amro Aboukameel, Ramzi M Mohamma. SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status. Journal of hematology & oncology. vol 2. 2010-06-15. PMID:19220884. |
multiple cytochemical and molecular approaches such as acridine orange/ethidium bromide assay for apoptosis, co-immunoprecipitation of complexes and western blot analysis, caspase luminescent activity assay and apoptotic dna fragmentation assay were used to demonstrate the effect of tw-37 on different b-cell lines, patient derived samples, as well as in animal xenograft models. |
2010-06-15 |
2023-08-12 |
mouse |
| Tanveer Sharif, Cyril Auger, Mahmoud Alhosin, Claudine Ebel, Mayada Achour, Nelly Etienne-Selloum, Guy Fuhrmann, Christian Bronner, Valérie B Schini-Kert. Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1. European journal of cancer (Oxford, England : 1990). vol 46. issue 5. 2010-06-14. PMID:20074931. |
cell cycle analysis, apoptosis activity and oxidative stress levels were assessed by flow cytometry, and the expression of p73, uhrf1 and active caspase-3 by western blot analysis. |
2010-06-14 |
2023-08-12 |
human |
| T Narasaraju, H H Ng, M C Phoon, Vincent T K Cho. MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis. American journal of respiratory cell and molecular biology. vol 42. issue 6. 2010-06-10. PMID:19617401. |
this study revealed that blocking macrophage recruitment into the lungs in a mouse model of influenza pneumonitis resulted in enhanced alveolar epithelial damage and apoptosis, as evaluated by histopathology, immunohistochemistry, western blot, rt-pcr, and tunel assays. |
2010-06-10 |
2023-08-12 |
mouse |
| Wanjing Ding, Tianyu Cai, Hong Zhu, Rui Wu, Chongxing Tu, Liuqing Yang, Wei Lu, Qiaojun He, Bo Yan. Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo. Cancer letters. vol 293. issue 2. 2010-05-24. PMID:20137855. |
western blot experiments indicated that trail and sunitinib synergistically enhanced apoptosis by simultaneously activating the extrinsic and intrinsic pathways. |
2010-05-24 |
2023-08-12 |
mouse |
| Ming Hua Bi, Juliane Ott, Tobias Fischer, Matthias Hecker, Hartmut Dietrich, Martina Barbara Schaefer, Philip Markart, Bao En Wang, Werner Seeger, Konstantin Maye. Induction of lymphocyte apoptosis in a murine model of acute lung injury--modulation by lipid emulsions. Shock (Augusta, Ga.). vol 33. issue 2. 2010-05-19. PMID:19487975. |
after lps challenge and infusion of lipid emulsions, apoptosis of lymphocytes and lung injury were assessed by flow cytometry, western blot, and histology. |
2010-05-19 |
2023-08-12 |
mouse |
| Shuang Wang, Yali Wang, Jing Jiang, Ruifang Wang, Lisa Li, Zhaoping Qiu, Hong Wu, Daling Zh. 15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway. Prostaglandins & other lipid mediators. vol 91. issue 1-2. 2010-05-19. PMID:20060487. |
to test this hypothesis, we studied the effect of 15-hete on cell survival and apoptosis using western blot, cell viability measurement, nuclear morphology determination, tunel assay and mitochondrial potential analysis. |
2010-05-19 |
2023-08-12 |
rat |
| Tereza Cristina da Silva, Bruno Cogliati, Ana Paula da Silva, Heidge Fukumasu, Gokithi Akisue, Márcia Kazumi Nagamine, Patrícia Matsuzaki, Mitsue Haraguchi, Silvana Lima Górniak, Maria Lúcia Zaidan Dagl. Pfaffia paniculata (Brazilian ginseng) roots decrease proliferation and increase apoptosis but do not affect cell communication in murine hepatocarcinogenesis. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 2. 2010-05-11. PMID:19427770. |
cellular proliferation was evaluated by immunohistochemistry for pcna, apoptosis was evaluated by apoptotic bodies count and alkaline comet technique, and intercellular communication by diffusion of lucifer yellow dye, immunofluorescence, western blot and real-time pcr for connexins 26 and 32. |
2010-05-11 |
2023-08-12 |
mouse |
| Shu Yu, Yuntian Shen, Jie Liu, Fei Din. Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:19787459. |
according to western blot analysis, pretreatment with salidroside transiently caused the activation of erk1/2 pathway; a selective inhibitor of the mitogen-activated protein kinase kinase (mapkk, mek) blocked salidroside-activated erk pathway and thus attenuated the influences of salidroside on h(2)o(2)-induced increase in the level of cleaved caspase-3, a chief executant of apoptosis cascades. |
2010-05-07 |
2023-08-12 |
Not clear |
| Daniel Iglesias-Serret, Maria Piqué, Montserrat Barragán, Ana M Cosialls, Antonio F Santidrián, Diana M González-Gironès, Llorenç Coll-Mulet, Mercè de Frias, Gabriel Pons, Joan Gi. Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis : an international journal on programmed cell death. vol 15. issue 2. 2010-05-03. PMID:19936928. |
furthermore, we studied the changes induced by aspirin in some genes involved in the control of apoptosis at mrna level, by performing reverse transcriptase multiplex ligation-dependent probe amplification (rt-mlpa), and at protein level by western blot. |
2010-05-03 |
2023-08-12 |
human |
| Weidong Cao, Xiaoliang Yang, Jie Zhou, Zenghui Teng, Lei Cao, Xiang Zhang, Zhou Fe. Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice. Apoptosis : an international journal on programmed cell death. vol 15. issue 2. 2010-05-03. PMID:20033782. |
furthermore, rt-pcr and western blot assay further substantiated that difopein had strong effects to induce glioma cell apoptosis through down-regulating bcl-2, up-regulating bax and activating caspase-9 and caspase-3. |
2010-05-03 |
2023-08-12 |
mouse |
| Xue-ying Zhou, Feng-hua Fu, Zhen Li, Qiu-ju Dong, Jie He, Chang-hai Wan. Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma. Planta medica. vol 75. issue 15. 2010-04-23. PMID:19579181. |
the results of pulse-field gel electrophoresis and western blot analysis show the induction of caspase-independent apoptosis by escin. |
2010-04-23 |
2023-08-12 |
mouse |
| G Vinothini, C Balachandran, S Nagin. Evaluation of molecular markers in canine mammary tumors: correlation with histological grading. Oncology research. vol 18. issue 5-6. 2010-04-20. PMID:20225757. |
we analyzed changes in the expression of markers of hormone and receptor status (estradiol, estrogen receptor; er and her-2/neu), hormone metabolism (cyp1a1 and cyp1b1), cell proliferation and survival [proliferating cell nuclear antigen (pcna), glutathione s-transferase-p (gst-p), nuclear factor-kappab (nf-kappab-p50, nf-kappab-p65), phosphorylated-inhibitor of kappab-alpha (p-ikappab-alpha) and ikappab], apoptosis (bcl-2, bax, caspases, apaf-1, cytochrome-c, and parp), invasion [matrix metalloproteinases-2 and -9 (mmp-2, mmp-9), tissue inhibitor of matrix metalloproteinase-2 (timp-2), and reversion-inducing cysteine-rich protein with kazal motifs (reck)], angiogenesis [vascular endothelial growth factor (vegf)], and epigenetics [dna methyltransferase (dnmt-1), histone deacetylase (hdac-1)] by immunohistochemical localization and western blot analysis and correlated these with histological grade. |
2010-04-20 |
2023-08-12 |
human |
| Mizuki Sudo, Yutaka Kan. Myofiber apoptosis occurs in the inflammation and regeneration phase following eccentric contractions in rats. The journal of physiological sciences : JPS. vol 59. issue 6. 2010-04-16. PMID:19636670. |
the expression of proteins related to apoptosis (bcl-2 and bax) was examined by western blot assay. |
2010-04-16 |
2023-08-12 |
rat |
| Wei-Jan Huang, Chia-Li Wu, Chia-Wei Lin, Li-Ling Chi, Pen-Yuan Chen, Chun-Jung Chiu, Chung-Yang Huang, Chia-Nan Che. Marchantin A, a cyclic bis(bibenzyl ether), isolated from the liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells. Cancer letters. vol 291. issue 1. 2010-04-16. PMID:19913353. |
fluorescence microscopy and a western blot analysis indicated that marchantin a actively induced apoptosis of mcf-7 cells. |
2010-04-16 |
2023-08-12 |
human |
| Olga Grzybowska-Izydorczyk, Barbara Cebula, Tadeusz Robak, Piotr Smolewsk. Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia. European journal of cancer (Oxford, England : 1990). vol 46. issue 4. 2010-04-09. PMID:20045309. |
in this study, expression of inhibitor of apoptosis proteins, iaps (ciap1, ciap2, xiap and survivin), and their antagonists (smac/diablo and htra2/omi) was comprehensively analysed in 100 untreated cll patients, using flow cytometry and western blot techniques. |
2010-04-09 |
2023-08-12 |
Not clear |