| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsiao Chi Wang, Jen-Hung Yang, Shu-Chen Hsieh, Lee-Yan Shee. Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. Journal of agricultural and food chemistry. vol 58. issue 11. 2010-08-27. PMID:20459099. |
western blot results showed the concordance for the expression of molecules involved in g(2)/m arrest and apoptosis observed by cell cycle and cell viability analysis. |
2010-08-27 |
2023-08-12 |
human |
| Gamal Badr, Heba Saad, Hanan Waly, Khadega Hassan, Hanem Abdel-Tawab, Ibrahim M Alhazza, Emad A Ahme. Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL). Cellular immunology. vol 263. issue 1. 2010-08-25. PMID:20231019. |
using flow cytometry and western blot analysis, we have found that type 1 ifns (ifn-alpha/beta) protect human b cells in culture from spontaneous apoptosis and from apoptosis mediated by anti-cd95 agonist, in a dose- and time-dependant manner. |
2010-08-25 |
2023-08-12 |
mouse |
| Hsu-Feng Lu, Yu-Jie Chie, Ming-Sung Yang, Ching-Sung Lee, Jene-John Fu, Jai-Sing Yang, Tzu-Wei Tan, Shin-Hwar Wu, Yi-Shih Ma, Siu-Wan Ip, Jing-Gung Chun. Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway. International journal of oncology. vol 36. issue 6. 2010-08-20. PMID:20428772. |
western blot analysis was used to determined the levels of bax and bcl-2 and apoptosis associated proteins, and confocal laser microscope for examining the translocation of associated protein after exposed to apigenin. |
2010-08-20 |
2023-08-12 |
human |
| Yi Tang, Wenli Liu, Jianfeng Zhou, Qinglei Gao, Jianhong W. Apoptotic sensitivity to irradiation increased after transfection of chk1 antisense chain to HL-60 cell line. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 25. issue 5. 2010-08-19. PMID:16463660. |
twenty-four h after irradiation, the changes in the chk1 protein expression was assayed by western blot, and the cell cycles and apoptosis rate detected by fcm. |
2010-08-19 |
2023-08-12 |
Not clear |
| M F Ziauddin, Z S Guo, M E O'Malley, F Austin, P J Popovic, M A Kavanagh, J Li, M Sathaiah, P Thirunavukarasu, B Fang, Y J Lee, D L Bartlet. TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer. Gene therapy. vol 17. issue 4. 2010-08-18. PMID:20182517. |
western blot analyses were consistent with the notion that trail induced cancer cell death mainly through apoptosis, whereas ox and vjs6 induced cell death more through non-apoptotic death pathways. |
2010-08-18 |
2023-08-12 |
mouse |
| Makoto Naoi, Wakako Maruyama, Hong Yi, Yuriko Yamaoka, Masayo Shamoto-Nagai, Yukihiro Akao, Manfred Gerlach, Masashi Tanaka, Peter Riedere. Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18399961. |
western blot analysis for protein-bound gsh demonstrated that only nm reduced s-glutathionylated proteins in mitochondria and dissociated macromolecular structure of complex i. reactive oxygen and nitrogen species were required for the deglutathionylation by nm, which antioxidants reduced significantly with prevention of apoptosis. |
2010-08-13 |
2023-08-12 |
Not clear |
| David Yu Greenblatt, Mary Ndiaye, Herbert Chen, Muthusamy Kunnimalaiyaa. Lithium inhibits carcinoid cell growth in vitro. American journal of translational research. vol 2. issue 3. 2010-08-12. PMID:20589165. |
western blot analysis revealed increased expression of cleaved poly (adp-ribose) polymerase (parp), indicating the induction of apoptosis. |
2010-08-12 |
2023-08-12 |
Not clear |
| Li Quan, Zhang Jian, Zou Ping, Li Weimin. Proteinase-activated receptor-1 mediates allogeneic CD8(+) T cell-induced apoptosis of vascular endothelial cells. Medical oncology (Northwood, London, England). vol 26. issue 4. 2010-08-10. PMID:19082770. |
to ascertain the mechanism of endothelial apoptosis, we determined that allogeneic cd8(+) t cell, sfllrn enhanced cleavage of caspase-3 and led to p38mapk activation as assessed by western blot. |
2010-08-10 |
2023-08-12 |
human |
| Chang-Qing Zhao, Yue-Hui Zhang, Sheng-Dan Jiang, Lei-Sheng Jiang, Li-Yang Da. Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age (Dordrecht, Netherlands). vol 32. issue 2. 2010-08-09. PMID:19960285. |
after sodium nitroprusside treatment, annular cell apoptosis was observed morphologically and quantified by flow cytometry; the expression of biomarkers of er stress and mitochondrial dysfunction were analyzed by reverse transcriptase pcr (rt-pcr), fluorescence double labeling, and western blot; and mitochondrial membrane potential was detected by 5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbo cyanine iodide (jc-1) staining. |
2010-08-09 |
2023-08-12 |
rat |
| Heike Boisvert, Margaret J Dunca. Translocation of Porphyromonas gingivalis gingipain adhesin peptide A44 to host mitochondria prevents apoptosis. Infection and immunity. vol 78. issue 8. 2010-08-06. PMID:20547744. |
cell viability assays and quantitative real-time pcr showed that the peptide interacted with the cell death machinery by triggering upregulation of antiapoptotic factors bcl-2 and bcl-xl and prevented staurosporine-induced apoptosis for up to 12 h. we confirmed these findings with western blot analyses of caspase-9 activation in time course experiments with staurosporine. |
2010-08-06 |
2023-08-12 |
Not clear |
| Chuandong Fan, Hua Su, Jing Zhao, Baoxiang Zhao, Shangli Zhang, Junying Mia. A novel copper complex of salicylaldehyde pyrazole hydrazone induces apoptosis through up-regulating integrin beta4 in H322 lung carcinoma cells. European journal of medicinal chemistry. vol 45. issue 4. 2010-08-02. PMID:20089331. |
immunofluorescence and western blot analyses showed an elevated protein level of integrin beta4 upon cu-16 treatment, and knockdown of integrin beta4 significantly inhibited cu-16 induced apoptosis in h322 cells. |
2010-08-02 |
2023-08-12 |
Not clear |
| Qin Hu, Ruile Pan, Liwei Wang, Bo Peng, Jingtian Tang, Xinmin Li. Platycodon grandiflorum induces apoptosis in SKOV3 human ovarian cancer cells through mitochondrial-dependent pathway. The American journal of Chinese medicine. vol 38. issue 2. 2010-07-29. PMID:20387232. |
3-(4,5- dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (mtt) assay was used to monitor cell numbers, annexin-v/propidium iodide (pi) staining, rt-pcr and western blot were used to examine cell apoptosis, caspases activation. |
2010-07-29 |
2023-08-12 |
human |
| Roberto E Favoni, Alessandra Pattarozzi, Michele Lo Casto, Federica Barbieri, Monica Gatti, Laura Paleari, Adriana Bajetto, Carola Porcile, Giovanni Gaudino, Luciano Mutti, Giorgio Corte, Tullio Flori. Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. Current cancer drug targets. vol 10. issue 2. 2010-07-22. PMID:20088784. |
cell proliferation, dna synthesis and apoptosis were measured by mtt, thymidine incorporation and facs analysis; egfr, erk1/2 and akt expression and phosphorylation by western blot, whereas receptor sites were analyzed by binding studies. |
2010-07-22 |
2023-08-12 |
human |
| Xiaobao Jin, Hanfang Mei, Xiaobo Li, Yan Ma, Ai-hua Zeng, Yan Wang, Xuemei Lu, Fujiang Chu, Qiang Wu, Jiayong Zh. Apoptosis-inducing activity of the antimicrobial peptide cecropin of Musca domestica in human hepatocellular carcinoma cell line BEL-7402 and the possible mechanism. Acta biochimica et biophysica Sinica. vol 42. issue 4. 2010-07-21. PMID:20383464. |
western blot analysis and rt-pcr were used to determine the expression levels of proteins involved in apoptosis, such as fas, fas-l, caspase-8, and caspase-3. |
2010-07-21 |
2023-08-12 |
human |
| Ewa Jablonska, Marzena Garle. TLRs and Bcl-2 family proteins in neutrophils of oral cavity cancer patients. Folia histochemica et cytobiologica. vol 47. issue 4. 2010-07-20. PMID:20430729. |
the expression of these proteins in neutrophils and autologous peripheral blood mononuclear cells (pbmcs) was analyzed by western blot, the intensity of apoptosis was estimated by flow cytometry, caspase-9 activity by colorimetric assay, and the cytochrome c concentration by elisa. |
2010-07-20 |
2023-08-12 |
human |
| Liping Wei, Dongdong Sun, Zhiyong Yin, Yuan Yuan, Andrew Hwang, Yingmei Zhang, Rui Si, Rongqing Zhang, Wenyi Guo, Feng Cao, Haichang Wan. A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats. Apoptosis : an international journal on programmed cell death. vol 15. issue 4. 2010-07-19. PMID:20044781. |
apoptosis index of cmecs was detected by tunel assay and phosphor-limk2 protein expression was examined by western blot analysis. |
2010-07-19 |
2023-08-12 |
rat |
| Khawar Chaudhry, Ryan Rogers, Miao Guo, Qin Lai, Gunjan Goel, Brandon Liebelt, Xunming Ji, Alecia Curry, Aaron Carranza, David F Jimenez, Yuchuan Din. Matrix metalloproteinase-9 (MMP-9) expression and extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation in exercise-reduced neuronal apoptosis after stroke. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20298757. |
apoptotic protein caspase-3 and neuronal apoptosis in cortex and striatum was determined by western blot at 24h reperfusion and tunel staining at 48h reperfusion in 5 i/r injury groups: no treatment, mmp-9 inhibitor (doxycycline), pre-ischemic exercise, exercised animals undergone erk1/2 inhibition (u0126), and dual inhibition of erk1/2 and mmp-9 in exercised ischemic rats. |
2010-07-08 |
2023-08-12 |
rat |
| Tongsen Zheng, Jiabei Wang, Xi Chen, Xianzhi Meng, Xuan Song, Zhaoyang Lu, Hongchi Jiang, Lianxin Li. Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 31. issue 4. 2010-07-08. PMID:20422343. |
cell proliferation assay, apoptosis assay, western blot, coimmunoprecipitation, and small interfering rna (sirna) experiments were analyzed in hucct1 cells. |
2010-07-08 |
2023-08-12 |
Not clear |
| Yunlan Li, Jinjie Liu, Qingshan L. Mechanisms by which the antitumor compound di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) induces apoptosis and the mitochondrial-mediated signaling pathway in human cancer SGC-7901 cells. Molecular carcinogenesis. vol 49. issue 6. 2010-06-29. PMID:20336762. |
inhibition of proliferation of four cancer cell lines compared with normal human hepatic l-o2 cells, cancer cell apoptosis, and expression of related mrna and protein were detected using the methyl thiazolyl tetrazolium (mtt), flow cytometry, reverse transcription polymerase chain reaction (rt-pcr), western blot, and dna ladder assays, and electron microscopy and immunocytochemistry. |
2010-06-29 |
2023-08-12 |
human |
| Yiyi Ye, Jianwen Liu, Jianhe Xu, Lijuan Sun, Mingcang Chen, Minbo La. Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 3. 2010-06-22. PMID:20060462. |
furthermore, apoptosis related proteins such as p53, bax and bcl-2 were analyzed by using western blot analysis. |
2010-06-22 |
2023-08-12 |
human |