| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Emel Sahin, Mehmet Sahin, Ahter Dilsad Sanlio\\xc4\\x9flu, Saadet G\\xc3\\xbcm\\xc3\\xbcsl\\xc3\\xb. KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. vol 27. issue 1. 2011-04-22. PMID:21204621.' |
apoptosis was detected by flow cytometric annexin v binding assay and by western blot analysis of procaspase-3 and cleaved poly (adp-ribose) polymerase levels. |
2011-04-22 |
2023-08-12 |
Not clear |
| Hong-Zin Lee, Da-Tian Bau, Chao-Lin Kuo, Ru-Yin Tsai, Yu-Chang Chen, Yu-Hao Chan. Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa. The American journal of Chinese medicine. vol 39. issue 1. 2011-04-15. PMID:21213409. |
according to trypan blue exclusion assay and western blot analysis, h. diffusa had a significant inhibition of cell growth and induction of cell apoptosis in colo 205 (colon cancer), hep 3b (hepatocellular carcinoma) and h460 (lung cancer) cell lines. |
2011-04-15 |
2023-08-12 |
Not clear |
| Aimin Zhang, Yi Liu, Yizheng Shen, Youhe Xu, Xiangtie L. Osteopontin silencing by small interfering RNA induces apoptosis and suppresses invasion in human renal carcinoma Caki-1 cells. Medical oncology (Northwood, London, England). vol 27. issue 4. 2011-04-08. PMID:19921477. |
western blot demonstrated that the effects of opn silence were significantly accompanied by the activation of mitochondria-related apoptosis pathway involving cytochrome c, apaf-1, cleaved caspase-3 and bcl-2/bax, and the downregulation of invasion-related proteins of mmp-2 and upa expression. |
2011-04-08 |
2023-08-12 |
human |
| M Salhab, L Tosca, C Cabau, P Papillier, C Perreau, J Dupont, P Mermillod, S Uzbekov. Kinetics of gene expression and signaling in bovine cumulus cells throughout IVM in different mediums in relation to oocyte developmental competence, cumulus apoptosis and progesterone secretion. Theriogenology. vol 75. issue 1. 2011-04-08. PMID:20961603. |
based on transcriptomic data, we studied by using real-time rt-pcr and western blot in bovine cumulus cells, the kinetics of expression of several candidate genes involved in oxidative stress response, apoptosis, steroid metabolism and signal transmission throughout ivm. |
2011-04-08 |
2023-08-12 |
cattle |
| Aifeng Zhai, Yi Zhang, Xiaonan Zhu, Jinting Liang, Xuelan Wang, Yongcheng Lin, Ruzhu Che. Secalonic acid A reduced colchicine cytotoxicity through suppression of JNK, p38 MAPKs and calcium influx. Neurochemistry international. vol 58. issue 1. 2011-03-31. PMID:21073911. |
further studies from western blot and confocal microscopy experiments showed that the activation of jnk, p38 mapks and caspase-3 during neuron apoptosis triggered by 1 μm colchicine could be obviously suppressed by saa; on the other hand, an increase in the intracellular free ca(2+) by 1 μm colchicine in the cortical neuron was blocked evidently by saa. |
2011-03-31 |
2023-08-12 |
rat |
| Cheng Chang, Youqing Zhu, Xiaoyan Tang, Wenhui Ta. The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture. Molecular biology reports. vol 38. issue 1. 2011-03-21. PMID:20333548. |
by western blot analysis, we found the level of bcl-2 were down-regulated, whereas, the level of bcl-2 up-regulated.so we suggest that up-regulation of mitochondrial bax expression and down-regulation of bcl-2 expression participated in the apoptosis induced by nctd. |
2011-03-21 |
2023-08-12 |
human |
| Cheng-Chung Liu, Shih-Ming Jung, Augusto Orlandi, Ta-Sen Yeh, Yu-Shen Lin, Tzu-Fang Shiu, Hsueh-Hua Wu, Jaw-Ji Chu, Pyng-Jing Lin, Pao-Hsien Ch. The Fas-mediated apoptotic pathway in cardiac myxoma. International journal of surgical pathology. vol 18. issue 6. 2011-03-17. PMID:21081533. |
apoptosis signal transduction was determined by assessing dna fragmentation, fas ligand (fasl), fas, tumor necrosis factor-α (tnf-α), caspase-3, and terminal deoxynucleotidyl transferase nick-end labeling (tunel) assay through immunohistochemical stain, quantitative reverse transcriptase- polymerase chain reaction (rt-pcr), and western blot analysis. |
2011-03-17 |
2023-08-12 |
Not clear |
| Cheng-Chung Liu, Shih-Ming Jung, Augusto Orlandi, Ta-Sen Yeh, Yu-Shen Lin, Tzu-Fang Shiu, Hsueh-Hua Wu, Jaw-Ji Chu, Pyng-Jing Lin, Pao-Hsien Ch. The Fas-mediated apoptotic pathway in cardiac myxoma. International journal of surgical pathology. vol 18. issue 6. 2011-03-17. PMID:21081533. |
the rt-pcr and western blot analysis (fas/fasl, tnf-α, caspase-3, and apoptosis) of the cardiac myxoma and cultured cardiac myxoma cells confirmed the immunochemical results. |
2011-03-17 |
2023-08-12 |
Not clear |
| Kalimuthu Senthilkumar, Perumal Elumalai, Ramachandran Arunkumar, Sivanantham Banudevi, Nandagopal Dharmalingam Gunadharini, Govindaraj Sharmila, Kandaswamy Selvakumar, Jagadeesan Arunakara. Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Molecular and cellular biochemistry. vol 344. issue 1-2. 2011-03-10. PMID:20658310. |
to investigate the effect of quercetin on insulin-like growth factor signaling and apoptosis in androgen independent prostate cancer cells (pc-3), igf-ir, pi-3k, p-akt, akt, cyclin d1, bad, cytochrome c, parp, caspases-9 and 10 protein levels were assessed by western blot analysis. |
2011-03-10 |
2023-08-12 |
Not clear |
| Minjian Kong, Junqiang Fan, Aiqiang Dong, Haifeng Cheng, Rongzhen X. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta biochimica et biophysica Sinica. vol 42. issue 11. 2011-03-10. PMID:20978038. |
cell proliferation and apoptosis were measured by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay, flow cytometry, western blot analysis, and dna ladder. |
2011-03-10 |
2023-08-12 |
mouse |
| Li Wang, Wensha Yang, Paul Read, James Larner, Ke Shen. Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy. Nanotechnology. vol 21. issue 47. 2011-03-03. PMID:21030759. |
induction of apoptosis was measured by the tunel assay and western blot analysis of the cleaved caspase-3. |
2011-03-03 |
2023-08-12 |
Not clear |
| X Cao, Z Huo, M Lu, D Mao, Q Zhao, C Xu, C Wang, B Zen. Purification of lectin from larvae of the fly, Musca domestica, and in vitro anti-tumor activity in MCF-7 cells. Journal of insect science (Online). vol 10. 2011-02-22. PMID:21067415. |
western blot revealed that mll-2 induced apoptosis in mcf-7 cells was associated with typical apoptosis proteins in the mitochondrial pathway. |
2011-02-22 |
2023-08-12 |
human |
| Hongbin Zou, Hao Wu, Xiangnan Zhang, Yu Zhao, Joachim Stöckigt, Yijia Lou, Yongping Y. Synthesis, biological evaluation, and structure-activity relationship study of novel cytotoxic aza-caffeic acid derivatives. Bioorganic & medicinal chemistry. vol 18. issue 17. 2011-02-08. PMID:20673727. |
flow cytometric and western blot analysis indicate that compound 80 plays a role in mitochondria-dependent apoptosis activity by suppressing k562 cell proliferation in a concentration- and time-dependent manner. |
2011-02-08 |
2023-08-12 |
human |
| Hua Wei, Zongwei Li, Shengshou Hu, Xi Chen, Xiangfeng Con. Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. Journal of cellular biochemistry. vol 111. issue 4. 2011-02-07. PMID:20665666. |
signaling pathways involved in h(2)o(2) induced apoptosis were analyzed with western blot. |
2011-02-07 |
2023-08-12 |
Not clear |
| Kui Dong Kang, Aman Shah Abdul Majid, Kyung-A Kim, Kyungsu Kang, Hong Ryul Ahn, Chu Won Nho, Sang Hoon Jun. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochemical research. vol 35. issue 11. 2011-02-03. PMID:20809085. |
cell viability assays, apoptosis assay, reactive oxygen species analysis, western blot analysis, flow cytometric analysis, glutathione (gsh) and glutathione-s-transferase (gst) measurement) were used to demonstrate the effect of sulbutiamine. |
2011-02-03 |
2023-08-12 |
Not clear |
| Yu Zhao, Jie Hui, Dan Wang, Li Zhu, Jing-Huai Fang, Xiao-Dong Zha. Synthesis, cytotoxicity and pro-apoptosis of novel benzoisoindolin hydrazones as anticancer agents. Chemical & pharmaceutical bulletin. vol 58. issue 10. 2011-02-02. PMID:20930398. |
western blot analysis disclosed that compound 4 induced apoptosis via the mitochondrial pathway accompanied by an increased expression of bax and a decreased expression of bcl-2. |
2011-02-02 |
2023-08-12 |
Not clear |
| Wenjian Zhang, Jun Ju, Gloria Gronowic. Odontoblast-targeted Bcl-2 overexpression impairs dentin formation. Journal of cellular biochemistry. vol 111. issue 2. 2011-01-25. PMID:20518070. |
odontoblast apoptosis was evaluated by tunel and western blot detection of cleaved caspase-3. |
2011-01-25 |
2023-08-12 |
mouse |
| Bharat Bhusan Patnaik, Atish Roy, Soumik Agarwal, Shelley Bhattachary. Induction of oxidative stress by non-lethal dose of mercury in rat liver: possible relationships between apoptosis and necrosis. Journal of environmental biology. vol 31. issue 4. 2011-01-20. PMID:21186712. |
western blot analysis indicated upregulation of caspase-9 and upsurge in effect or caspase-3 activity leading to apoptosis. |
2011-01-20 |
2023-08-12 |
rat |
| Su Yeon Kim, Jung Su Ryu, Hailan Li, Woo-Jae Park, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Uy Dong Sohn, Dong-Seok Ki. UVB-activated indole-3-acetic acid induces apoptosis of PC-3 prostate cancer cells. Anticancer research. vol 30. issue 11. 2011-01-18. PMID:21115913. |
it was also found through western blot analysis that the cytotoxic effect of iaa(uvb) resulted from apoptosis. |
2011-01-18 |
2023-08-12 |
Not clear |
| Jun-Kuan Wang, Li-Na Yu, Feng-Jiang Zhang, Mei-Juan Yang, Jing Yu, Min Yan, Gao Che. Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathway. Brain research. vol 1357. 2011-01-14. PMID:20705063. |
apoptosis and apoptosis-related proteins were studied by tunel, immunohistochemistry and western blot. |
2011-01-14 |
2023-08-12 |
rat |