| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song Xiang, Yihua Wang, Dengliang Lei, Yunhai Luo, Dadi Peng, Kezhen Zong, Yanyao Liu, Zuotian Huang, Shaojiang Mo, Xingyu Pu, Jinli Zheng, Zhongjun W. Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m Clinical immunology (Orlando, Fla.). 2023-04-08. PMID:37030526. |
mechanistically, western blot and immunohistochemical showed that mettl3 inhibited apoptosis via upregulating ho-1. |
2023-04-08 |
2023-08-14 |
rat |
| Nil Kilic, Mohammadreza Dastouri, Irfan Kandemir, Erkan Yilma. The effects of KIR2DL4 stimulated NK-92 cells on the apoptotic pathways of HER2 + /HER-breast cancer cells. Medical oncology (Northwood, London, England). vol 40. issue 5. 2023-04-07. PMID:37027073. |
the most effective cell cytotoxicity ratio (1:10) was used in the immunostaining and western blot assays to evaluate apoptosis pathway proteins. |
2023-04-07 |
2023-08-14 |
Not clear |
| Lijuan He, Wei Zhou, Lamei Wang, Na Tang, Yongjia Wang, Hua Zhong, Yan Tang, Dongmei Xi, Fang H. Murine Cytomegalovirus Infection Induced miR-1929-3p Down-Regulation Promotes the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Mice by Targeting Endothelin A Receptor and Downstream NLRP3 Activation Pathway. Molecular biotechnology. 2023-04-06. PMID:37022597. |
western blot detected proteins of cell proliferation, apoptosis, and the nlrp3 inflammasome. |
2023-04-06 |
2023-08-14 |
mouse |
| WenBin Liu, ZhengWei Tan, YueChao Zhao, YanNa Zhao, XiaoLing Yu, BoLin Wang, FengLin Shen, Ai Mi, JinJian Lan, RuiLan Ga. Panaxadiol saponin ameliorates ferroptosis in iron-overload aplastic anemia mice and Meg-01 cells by activating Nrf2/HO-1 and PI3K/AKT/mTOR signaling pathway. International immunopharmacology. vol 118. 2023-04-06. PMID:37023700. |
the effects of pnd or combined with deferasirox (dfs) on iron deposition, labile iron pool (lip), several ferroptosis events, apoptosis, mitochondrial structure, as well as ferroptosis-, nrf2/ho-1-, and pi3k/akt/mtor pathway-related markers in iron-induced meg-01 cells were examined by prussian-blue staining, flow cytometer, elisa, hoechst 33342 staining, transmission electron microscope, and western blot assays, respectively. |
2023-04-06 |
2023-08-14 |
mouse |
| Liudmila Kulik, Brandon Renner, Jennifer Laskowski, Joshua M Thurman, V Michael Holer. Highly pathogenic natural monoclonal antibody B4-IgM recognizes a post-translational modification comprised of acetylated N-terminal methionine followed by aspartic or glutamic acid. Molecular immunology. vol 157. 2023-04-05. PMID:37018938. |
however, the b4-igm antibody epitope was detected by western blot of unknown human proteins and by flow cytometry on all studied human cell lines undergoing apoptosis and on a minor subset of healthy cells. |
2023-04-05 |
2023-08-14 |
mouse |
| Xiaobing Yang, Jiahui Zhao, Dechao Wei, Tao Feng, Pengju Guo, Qiankun Li, Yongxing Wang, Yili Han, Mingchuan Li, Yongguang Jiang, Yong Lu. Enzalutamide combination with Arsenic trioxide suppresses the progression of castration-resistant prostate cancer. Journal of chemotherapy (Florence, Italy). 2023-04-03. PMID:37011019. |
western blot was employed to assess the expression levels of protein-related angiogenesis, apoptosis, dna repair, and the screened genes. |
2023-04-03 |
2023-08-14 |
Not clear |
| Jing Wang, Xuan Wang, Mingying Cao, Lingli Zhang, Jingna Li. CircUSP39/miR-362-3p/TRAF3 Axis Mediates Hypoxia/Reoxygenation-Induced Cardiomyocyte Oxidative Stress, Inflammation, and Apoptosis. International heart journal. vol 64. issue 2. 2023-04-02. PMID:37005320. |
cell counting kit-8, enzyme-linked immunosorbent assay, flow cytometry, and western blot (wb) assay were used to determine cell viability, oxidative stress, inflammatory factor levels, and cell apoptosis. |
2023-04-02 |
2023-08-14 |
Not clear |
| Tingting Wang, Qionghua Long, Yang Hu, Yongli Yang, Xingguo Li, Huan We. miR-181c-5p suppresses neuronal pyroptosis via NLRP1 in Alzheimer's disease. Behavioural brain research. 2023-04-01. PMID:37003492. |
to further study the effects of nlrp1-induced pyroptosis on ad, mir-181c-5p, which could targeted bind to nlrp1, was knocked down or overexpression in ht22 cells to detect cell apoptosis with tunel assay, the expression of inflammasome-related proteins with western blot and the content of inflammatory factors with elisa. |
2023-04-01 |
2023-08-14 |
mouse |
| Guiying Xiao, Fang Yuan, Yang Deng, Debiao Xiang, Liguang Xiong, Xin Li, Yuan L. Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response. Journal of biochemical and molecular toxicology. 2023-03-30. PMID:36992629. |
finally, the expressions of genes and proteins (bax, bcl-2, caspase-3, caspase-9) related to apoptosis were evaluated through quantitative polymerase chain reaction and western blot assay. |
2023-03-30 |
2023-08-14 |
mouse |
| Rivak Punchoo, Greta Dreyer, Tahir S Pilla. 25-Hydroxycholecalciferol Inhibits Cell Growth and Induces Apoptosis in SiHa Cervical Cells via Autocrine Vitamin D Metabolism. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979850. |
we evaluated cell health parameters (cell count, viability, and cell cycle), cell death modes (apoptosis, autophagic-dependent death, and necrosis by flow cytometry and transmission electron microscopy), and autocrine vdms gene and protein expression by qpcr and western blot, respectively. |
2023-03-29 |
2023-08-14 |
Not clear |
| Dadi Li, Shuxian Zhao, Bin Zhu, Wanmin Zhao, Ya Ding, Xuejun Li, Donglin Fu, Haiyang Yu, Baogui Wang, Tan Pa. Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival. Drug development research. 2023-03-29. PMID:36988113. |
terminal deoxynucleotidyl transferase dutp nick end labeling staining and western blot analysis were used to assess neural cell apoptosis. |
2023-03-29 |
2023-08-14 |
rat |
| Der-An Tsao, Yu-Chien Wang, Shang-Tao Chien, Shih-Yi Lin, Huoy-Rou Chan. Fucoidan enhances the effect of chemotherapeutic drug against drug-resistant lung cancer cells. Pakistan journal of pharmaceutical sciences. vol 36. issue 1. 2023-03-27. PMID:36967501. |
cell culture, mtt assay, wound healing assay, gelatin zymography assay, dna fragmentation assay, apoptosis assay, reverse transcription polymerase chain reaction (rt-pcr) western blot analysis was adopted. |
2023-03-27 |
2023-08-14 |
Not clear |
| Xiaojing Xing, Xuguang Wang, Meichen Liu, Qianxue Guo, Hongyue Wan. Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells. Cancer biology & therapy. vol 24. issue 1. 2023-03-27. PMID:36967521. |
cck-8, flow cytometry, western blot, and transwell assays demonstrated that silence of rasip1 inhibited proliferation, cell cycle transition, and invasion and induced significant apoptosis in dlbcl cells, and ectopic expression of rasip1 played opposite roles. |
2023-03-27 |
2023-08-14 |
Not clear |
| Fangting You, Cheng Li, Shicheng Zhang, Qiaoshan Zhang, Zhiyuan Hu, Yuhui Wang, Tong Zhang, Qingming Meng, Rutong Yu, Shangfeng Ga. Sitagliptin inhibits the survival, stemness and autophagy of glioma cells, and enhances temozolomide cytotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-03-26. PMID:36966667. |
we used cck-8, edu, colony formation, tunel and flow cytometry assays to assess cell proliferation and apoptosis; sphere formation and limiting dilution assays to measure self-renewal and stemness of glioma stem cells (gscs); western blot, qrt-pcr or immunohistochemical analysis to measure the expression of proliferation or stem cell markers; western blot/fluorescent analysis of lc3 and other molecules to evaluate autophagy formation and degradation in glioma cells. |
2023-03-26 |
2023-08-14 |
mouse |
| Zi Liu, Chenlu Xia, Nina Wang, Jianguo Cao, Guozheng Huang, Liang M. Synthesis and evaluation of piperazine-tethered derivatives of alepterolic acid as anti-cancer agents. Chemistry & biodiversity. 2023-03-24. PMID:36960853. |
hoechst staining, flow cytometry and western blot analysis revealed that compound 3n induced caspase-dependent apoptosis in mda-mb-231 cells. |
2023-03-24 |
2023-08-14 |
Not clear |
| Wesam F Farrash, Akhmed Aslam, Riyad Almaimani, Faisal Minshawi, Hussain Almasmoum, Aiman Alsaegh, Mohammad S Iqbal, Aisha Tabassum, Mohamed E Elzubier, Mahmoud Z El-Readi, Amani A Mahbub, Shakir Idris, Bassem Refaa. Metformin and thymoquinone co-treatment enhance 5-fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer cells. BioFactors (Oxford, England). 2023-03-17. PMID:36929658. |
the gene and protein expression of apoptosis (pcna/survivin/bax/cytochrome-c/caspase-3) and cell cycle (ccnd1/ccnd3/p21/p27) molecules, the pi3k/mtor/hif1α oncogenic pathway, and glycolysis regulatory enzymes were measured by quantitative-pcr and western blot. |
2023-03-17 |
2023-08-14 |
Not clear |
| Yang Liu, Hao Yu, Peng Yu, Peng Peng, Chao Li, Zhenyang Xiang, Dexiang Ba. Gelatin methacryloyl hydrogel scaffold loaded with activated Schwann cells attenuates apoptosis and promotes functional recovery following spinal cord injury. Experimental and therapeutic medicine. vol 25. issue 4. 2023-03-13. PMID:36911380. |
cell apoptosis was evaluated using tunel staining and immunochemistry, and apoptosis-related protein expression was detected using western blot analysis. |
2023-03-13 |
2023-08-14 |
rat |
| Pedro Barrios-Bernal, José Lucio-Lozada, Maritza Ramos-Ramírez, Norma Hernández-Pedro, Oscar Arriet. A Novel Combination of Sotorasib and Metformin Enhances Cytotoxicity and Apoptosis in KRAS-Mutated Non-Small Cell Lung Cancer Cell Lines through MAPK and P70S6K Inhibition. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901764. |
cellular cytotoxicity was evaluated by an mtt assay, apoptosis induction through flow cytometry, and mapk and mtor pathways were assessed by western blot. |
2023-03-11 |
2023-08-14 |
Not clear |
| Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
the expressions of pink1, parkin, p62, lc3b, nlrp3 inflammasome proteins, and apoptosis proteins in nasal tissues and hnepcs were measured by western blot. |
2023-03-11 |
2023-08-14 |
mouse |
| Ke Liu, Lei Chai, Taotao Zhao, Shaosan Zhang, Jixiang Wang, Yanghuan Yu, Ruiyan Niu, Zilong Su. Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice. Biological trace element research. 2023-03-08. PMID:36884125. |
the results of qrt-pcr and western blot displayed naf- induced apoptosis via tumor necrosis factor recpter 1 (tnfr1) signaling pathway, while treadmill exercise could restore the molecular changes caused by excessive naf exposure. |
2023-03-08 |
2023-08-14 |
mouse |