| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongjie Xiong, Huatao Chen, Pengfei Lin, Aihua Wang, Lei Wang, Yaping Ji. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. American journal of physiology. Cell physiology. vol 312. issue 3. 2017-06-06. PMID:28100484. |
atf6 knockdown decreases apoptosis, arrests the s phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. |
2017-06-06 |
2023-08-13 |
mouse |
| Yongjie Xiong, Huatao Chen, Pengfei Lin, Aihua Wang, Lei Wang, Yaping Ji. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. American journal of physiology. Cell physiology. vol 312. issue 3. 2017-06-06. PMID:28100484. |
the aim of this study was to assess the role of atf6 in mouse granulosa cells with respect to apoptosis, the cell cycle, and steroid hormone production, as well as several key genes related to follicular development, via rna interference, immunohistochemical staining, real-time quantitative pcr, western blotting, flow cytometry, terminal deoxynucleotidyltransferase-mediated deoxy-utp nick end labeling (tunel) assay, and elisa. |
2017-06-06 |
2023-08-13 |
mouse |
| Yongjie Xiong, Huatao Chen, Pengfei Lin, Aihua Wang, Lei Wang, Yaping Ji. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. American journal of physiology. Cell physiology. vol 312. issue 3. 2017-06-06. PMID:28100484. |
flow cytometry and tunel assay analysis indicated that atf6 depletion decreased apoptosis and arrested the s phase of the cell cycle in mouse granulosa cells. |
2017-06-06 |
2023-08-13 |
mouse |
| Angelica M Merlot, Nurul H Shafie, Yu Yu, Vera Richardson, Patric J Jansson, Sumit Sahni, Darius J R Lane, Zaklina Kovacevic, Danuta S Kalinowski, Des R Richardso. Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase. Biochemical pharmacology. vol 109. 2017-04-26. PMID:27059255. |
our results demonstrate that the cytotoxic chelator, dp44mt, which forms redox-active metal complexes, significantly: (1) increased er stress-associated pro-apoptotic signaling molecules (i.e., p-eif2α, atf4, chop); (2) increased ire1α phosphorylation (p-ire1α) and xbp1 mrna splicing; (3) reduced expression of er stress-associated cell survival signaling molecules (e.g., xbp1s and p58(ipk)); (4) increased cleavage of the transcription factor, atf6, which enhances expression of its downstream targets (i.e., chop and bip); and (5) increased phosphorylation of camkii that induces apoptosis. |
2017-04-26 |
2023-08-13 |
Not clear |
| Lili Wen, Fang Han, Yuxiu Shi, Xiaoyan L. Role of the Endoplasmic Reticulum Pathway in the Medial Prefrontal Cortex in Post-Traumatic Stress Disorder Model Rats. Journal of molecular neuroscience : MN. vol 59. issue 4. 2017-03-09. PMID:27112439. |
three signalling pathways [protein kinase rna-like endoplasmic reticulum kinase (perk), activating transcription factor 6 (atf6), and inositol-requiring enzyme 1 (ire1)] in the endoplasmic reticulum (er) play a critical role in resisting apoptosis. |
2017-03-09 |
2023-08-13 |
rat |
| Min-Jung Park, Ki-Seok Oh, Jong-Hyun Nho, Gye-Yeop Kim, Dong-Il Ki. Asymmetric dimethylarginine (ADMA) treatment induces apoptosis in cultured rat mesangial cells via endoplasmic reticulum stress activation. Cell biology international. vol 40. issue 6. 2017-02-21. PMID:26992443. |
adma treatment increased caspase-3 activity and activated three branches of er stress signaling (perk, ire1, and atf6) that induce mesangial cell apoptosis. |
2017-02-21 |
2023-08-13 |
rat |
| Hao-Hao Zhang, Xiao-Jun Ma, Li-Na Wu, Yan-Yan Zhao, Peng-Yu Zhang, Ying-Hui Zhang, Ming-Wei Shao, Fei Liu, Fei Li, Gui-Jun Qi. Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction. Molecular and cellular biochemistry. vol 420. issue 1-2. 2017-02-06. PMID:27449933. |
sirt3 knockdown effectively enhanced the upregulation of phospho-extracellular regulated protein kinases (perk), inositol-requiring enzyme-1 (ire1), activating transcription factor 6 (atf6), and c/ebp homologous protein (chop) induced by palmitate, and promoted palmitate-induced β-cell apoptosis and dysfunction. |
2017-02-06 |
2023-08-13 |
rat |
| Jia-You Tang, Ping Jin, Qing He, Lin-He Lu, Ji-Peng Ma, Wei-Lun Gao, He-Ping Bai, Jian Yan. Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation. Molecular and cellular biochemistry. vol 424. issue 1-2. 2017-02-06. PMID:27785700. |
naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in h9c2 myocardial cells: involvement in atf6, ire1α and perk signaling activation. |
2017-02-06 |
2023-08-13 |
Not clear |
| Jia-You Tang, Ping Jin, Qing He, Lin-He Lu, Ji-Peng Ma, Wei-Lun Gao, He-Ping Bai, Jian Yan. Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation. Molecular and cellular biochemistry. vol 424. issue 1-2. 2017-02-06. PMID:27785700. |
finally, we found that atf6 sirna, perk sirna or ire1α sirna abolished h/r-induced cytotoxicity and apoptosis in h9c2 cells. |
2017-02-06 |
2023-08-13 |
Not clear |
| Jia-You Tang, Ping Jin, Qing He, Lin-He Lu, Ji-Peng Ma, Wei-Lun Gao, He-Ping Bai, Jian Yan. Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation. Molecular and cellular biochemistry. vol 424. issue 1-2. 2017-02-06. PMID:27785700. |
in conclusion, these results confirmed that er stress-mediated apoptosis contributes to the protection effects of naringenin against h/r injury, which is potentially involved in atf6, ire1α and perk signaling activation. |
2017-02-06 |
2023-08-13 |
Not clear |
| Yachao Wang, Li Jiang, Yuanfeng Li, Xuegang Luo, Jian H. Excessive Selenium Supplementation Induced Oxidative Stress and Endoplasmic Reticulum Stress in Chicken Spleen. Biological trace element research. vol 172. issue 2. 2017-02-03. PMID:26740217. |
in addition, the er stress genes grp78 and atf6 were highly expressed (p < 0.05), and the apoptosis genes caspase 3 and caspase 12 were increased, but bcl 2 was decreased by se treatment (p < 0.05). |
2017-02-03 |
2023-08-13 |
chicken |
| Yongyong Cui, Deming Zhao, Paul Andrew Barrow, Xiangmei Zho. The endoplasmic reticulum stress response: A link with tuberculosis? Tuberculosis (Edinburgh, Scotland). vol 97. 2016-12-20. PMID:26980496. |
prolonged or uncontrolled ers leads to the activation of three signaling pathways (ire1, perk and atf6) which directs the cell towards apoptosis. |
2016-12-20 |
2023-08-13 |
Not clear |
| Chun-Lei Liu, Xin Li, Lu Gan, Yun-Yun He, Li-Li Wang, Kun-Lun H. High-content screening identifies inhibitors of the nuclear translocation of ATF6. International journal of molecular medicine. vol 37. issue 2. 2016-10-27. PMID:26707144. |
as unfolded protein levels arise in the er, the er cytoplasmic domain of atf6 moves to the nucleus, where it activates the transcription of a range of genes, including those involved in apoptosis. |
2016-10-27 |
2023-08-13 |
Not clear |
| Linlin Fan, Hongji Li, Yongwu Niu, Qihe Che. Characterization and Inducing Melanoma Cell Apoptosis Activity of Mannosylerythritol Lipids-A Produced from Pseudozyma aphidis. PloS one. vol 11. issue 2. 2016-07-19. PMID:26828792. |
combined with the up regulation of signaling ire1 and atf6, it can be speculated that mel-a-induced b16 melanoma cell apoptosis was associated with the endoplasmic reticulum stress (ers). |
2016-07-19 |
2023-08-13 |
Not clear |
| Xuefeng Bu, Yinghai Zhao, Zhijian Zhang, Mubin Wang, Mi Li, Yulan Ya. Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress. American journal of cancer research. vol 6. issue 5. 2016-06-13. PMID:27293989. |
collectively, the results suggest that rl-rvg increased er stress in three branch pathways (atf6, inositol-requiring enzyme 1 (ire1), and pkr-like er protein kinase (perk)) that are upstream regulators of autophagy and apoptosis. |
2016-06-13 |
2023-08-13 |
Not clear |
| Lili Liu, Bingyou Yang, Yupeng Cheng, Hongjin Li. Ameliorative Effects of Selenium on Cadmium-Induced Oxidative Stress and Endoplasmic Reticulum Stress in the Chicken Kidney. Biological trace element research. vol 167. issue 2. 2016-06-03. PMID:25805271. |
cd administration significantly increased the accumulation of cd, the malondialdehyde (mda) content, no production, inos activity, inos expression levels, expression levels of er stress-related genes (grp78, grp94, atf4, atf6, and ire) and the pro-apoptosis gene caspase 3, and the rate of apoptosis. |
2016-06-03 |
2023-08-13 |
human |
| Luran Liu, Chang Liu, Yuting Lu, Lina Liu, Yan Jian. ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-31. PMID:26261584. |
er stress related factor atf6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. |
2016-05-31 |
2023-08-13 |
Not clear |
| Luran Liu, Chang Liu, Yuting Lu, Lina Liu, Yan Jian. ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-31. PMID:26261584. |
in conclusion, apoptosis is served as an important factor that triggers the hie brain injury through cleaving the atf6 and caspase-12 er stress-related protein. |
2016-05-31 |
2023-08-13 |
Not clear |
| Guang Rong, Xun Tang, Tingting Guo, Na Duan, Yue Wang, Lei Yang, Jun Zhang, Xiujie Lian. Advanced oxidation protein products induce apoptosis in podocytes through induction of endoplasmic reticulum stress. Journal of physiology and biochemistry. vol 71. issue 3. 2016-05-27. PMID:26197866. |
collectively, our results indicate for the first time that aopps trigger podocyte apoptosis through induction of er stress, which might be regulated by nadph oxidase-dependent ros through rage, and that this apoptosis is mediated by three unfolded protein response pathways, the perk, atf6, and ire1 pathways, and the mediators, chop and caspase-12. |
2016-05-27 |
2023-08-13 |
Not clear |
| Jiqian Xu, Houxiang Hu, Bin Chen, Rongchuan Yue, Zhou Zhou, Yin Liu, Shuang Zhang, Lei Xu, Huan Wang, Zhengping Y. Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291709. |
we observed that lycopene alleviated the h/r injury as revealed by improving cell viability and reducing apoptosis, suppressed reactive oxygen species (ros) generation and improved the phosphorylated ampk expression, attenuated er stress as evidenced by decreasing the expression of grp78, atf6 mrna, sxbp-1 mrna, eif2α mrna and eif2α phosphorylation, alleviated er stress-induced apoptosis as manifested by reducing chop/gadd153 expression, the ratio of bax/bcl-2, caspase-12 and caspase-3 activity in h/r-treated cardiomyocytes. |
2016-05-13 |
2023-08-13 |
mouse |