| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuhiro Morishima, Keiko Nakanishi, Akihiko Nakan. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. The Journal of biological chemistry. vol 286. issue 40. 2011-12-09. PMID:21841196. |
here, we demonstrate that overexpression of active atf6 induced apoptosis in myoblast cells. |
2011-12-09 |
2023-08-12 |
Not clear |
| Nobuhiro Morishima, Keiko Nakanishi, Akihiko Nakan. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. The Journal of biological chemistry. vol 286. issue 40. 2011-12-09. PMID:21841196. |
moreover, coexpression of a dominant negative form of atf6 suppressed apoptosis. |
2011-12-09 |
2023-08-12 |
Not clear |
| Nobuhiro Morishima, Keiko Nakanishi, Akihiko Nakan. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. The Journal of biological chemistry. vol 286. issue 40. 2011-12-09. PMID:21841196. |
neither bcl-2 nor bcl-x(l) were reduced upon apoptosis induction in c2c12 cells that overexpressed atf6 or wbp1. |
2011-12-09 |
2023-08-12 |
Not clear |
| Nobuhiro Morishima, Keiko Nakanishi, Akihiko Nakan. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. The Journal of biological chemistry. vol 286. issue 40. 2011-12-09. PMID:21841196. |
these results suggested that mcl-1 is a determinant of cell fate, and atf6 mediates apoptosis via specific suppression of mcl-1 through up-regulation of wbp1. |
2011-12-09 |
2023-08-12 |
Not clear |
| Gordon P Meares, Marjelo A Mines, Eléonore Beurel, Tae-Yeon Eom, Ling Song, Anna A Zmijewska, Richard S Jop. Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells. Experimental cell research. vol 317. issue 11. 2011-08-09. PMID:21356208. |
apoptosis following upr activation can be mediated by activation of two transcription factors, atf4 and atf6, that activate expression of the death-inducing transcription factor c/ebp homologous protein (chop/gadd153) following er stress. |
2011-08-09 |
2023-08-12 |
Not clear |
| X-Q Zhang, Z Yang, W F Benedic. Direct gene transfer of adenoviral-mediated interferon α into human bladder cancer cells but not the bystander factors produced induces endoplasmic reticulum stress-related cytotoxicity. Cancer gene therapy. vol 18. issue 4. 2011-07-22. PMID:21183949. |
after 24 h of ad-ifnα infection, the ku7 cancer cells produced spliced x-box binding protein 1 and activating transcription factor 6 protein (atf6), evoking an er stress response that could contribute to ad-ifnα induced apoptosis in these cancer cells. |
2011-07-22 |
2023-08-12 |
human |
| Min Guan, Kristen Fousek, Chunling Jiang, Song Guo, Tim Synold, Bixin Xi, Chu-Chih Shih, Warren A Cho. Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 7. 2011-07-21. PMID:21355074. |
nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of srebp-1 and atf6. |
2011-07-21 |
2023-08-12 |
Not clear |
| Dae Young Kwon, Young Sup Kim, Il Sung Ahn, Da Sol Kim, Suna Kang, Snag Mee Hong, Sunmin Par. Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats. Journal of pharmacological sciences. vol 111. issue 4. 2010-02-19. PMID:20019445. |
exendin-4 enhanced beta-cell proliferation and neogenesis in stz-treated and -untreated px rats and reduced beta-cell apoptosis partly by attenuating the expression of endoplasmic reticulum stress-response genes such as x-box-binding protein-1, activating transcription factor (atf)-4, atf6, and c/ebp-homologous protein. |
2010-02-19 |
2023-08-12 |
rat |
| Dongyin Guan, Yingying Xu, Min Yang, Hao Wang, Xiaoming Wang, Zonghou She. N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway. Molecular carcinogenesis. vol 49. issue 1. 2010-02-01. PMID:19722195. |
additionally, both the activating transcription factor 6 (atf6) protein and x box-binding protein 1 (xbp1) mrna were processed, which facilitates the expression of c/ebp homologous protein (chop), a key-signaling component of er stress-induced apoptosis. |
2010-02-01 |
2023-08-12 |
human |
| Atsuko Tanimura, Toshiaki Yujiri, Yoshinori Tanaka, Masayuki Hatanaka, Noriyuki Mitani, Yukinori Nakamura, Kazutoshi Mori, Yukio Tanizaw. The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells. Leukemia research. vol 33. issue 7. 2009-05-28. PMID:19237191. |
upr inhibition using inositol-requiring enzyme 1alpha (ire1alpha) or activating transcription factor 6 (atf6) dominant-negative mutants diminished the ability of bcr-abl to protect the cells from etoposide- and imatinib-induced apoptosis. |
2009-05-28 |
2023-08-12 |
Not clear |
| Daniel A Cunha, Paul Hekerman, Laurence Ladrière, Angie Bazarra-Castro, Fernanda Ortis, Marion C Wakeham, Fabrice Moore, Joanne Rasschaert, Alessandra K Cardozo, Elisa Bellomo, Lutgart Overbergh, Chantal Mathieu, Roberto Lupi, Tsonwin Hai, Andre Herchuelz, Piero Marchetti, Guy A Rutter, Décio L Eizirik, Miriam Cno. Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. Journal of cell science. vol 121. issue Pt 14. 2008-10-07. PMID:18559892. |
palmitate induced more apoptosis and markedly activated the ire1, perk and atf6 pathways, owing to a sustained depletion of er ca(2+) stores, whereas the unsaturated ffa oleate led to milder perk and ire1 activation and comparable atf6 signaling. |
2008-10-07 |
2023-08-12 |
human |
| Marianne Kraus, Elke Malenke, Jeannette Gogel, Holger Müller, Thomas Rückrich, Herman Overkleeft, Huib Ovaa, Ewa Koscielniak, Jörg Thomas Hartmann, Christoph Driesse. Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis. Molecular cancer therapeutics. vol 7. issue 7. 2008-09-08. PMID:18645004. |
whereas neither bortezomib nor ritonavir monotherapy translated into significant apoptosis at therapeutic drug levels, the combination strongly increased the level of er stress and activated perk, ire1, and atf6, synergistically induced chop, jnk, caspase-4, and caspase-9, and resulted in >90% apoptosis. |
2008-09-08 |
2023-08-12 |
Not clear |
| Jiahao Liu, Weike Mao, Chikao Iwai, Shuji Fukuoka, Raju Vulapalli, Huanlei Huang, Tingchung Wang, Virendra K Sharma, Shey-Shing Sheu, Michael Fu, Chang-Seng Lian. Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress. Journal of molecular and cellular cardiology. vol 44. issue 2. 2008-04-03. PMID:18155231. |
this was associated with increase in heart weight, myocyte apoptosis, activation of caspase-3, -9 and -12, and increased er stress as evidenced by upregulation of grp78 and chop and cleavage of atf6. |
2008-04-03 |
2023-08-12 |
mouse |
| M Yokouchi, N Hiramatsu, K Hayakawa, A Kasai, Y Takano, J Yao, M Kitamur. Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. Cell death and differentiation. vol 14. issue 8. 2007-12-20. PMID:17464326. |
the atf6 and ire1 pathways cooperatively caused apoptosis via induction of chop, activation of xbp1 and phosphorylation of jnk, and the perk-eif2alpha pathway counteracted the proapoptotic processes. |
2007-12-20 |
2023-08-12 |
Not clear |
| Satoshi Endo, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Ayumi Kasai, Yasuhiro Tagawa, Norifumi Sawada, Jian Yao, Masanori Kitamur. Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70. Molecular pharmacology. vol 72. issue 5. 2007-12-13. PMID:17702888. |
blockade of atf6 by 4-(2-aminoethyl) benzenesulfonyl fluoride enhanced apoptosis by gga, and it was correlated with attenuated induction of both grp78 and chop. |
2007-12-13 |
2023-08-12 |
Not clear |
| Weike Mao, Shuji Fukuoka, Chikao Iwai, Jiahao Liu, Virendra K Sharma, Shey-Shing Sheu, Michael Fu, Chang-seng Lian. Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. American journal of physiology. Heart and circulatory physiology. vol 293. issue 3. 2007-10-19. PMID:17545481. |
myocyte apoptosis was determined by terminal deoxytransferase-mediated dutp nick-end labeling and caspase-3 activity, whereas camkii, mapk family (jnk, p38, erk), and er stress signals (atf6, grp78, chop, caspase-12) were measured by western blot, immunohistochemistry, and kinase activity assay. |
2007-10-19 |
2023-08-12 |
Not clear |
| Farook Thameem, Vidya S Farook, Clifton Bogardus, Michal Prochazk. Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. Diabetes. vol 55. issue 3. 2006-04-19. PMID:16505252. |
activating transcription factor 6 (atf6) is important for protective cell response to accumulation of unfolded and misfolded proteins in endoplasmic reticulum, and disturbances of this process can contribute to beta-cell apoptosis. |
2006-04-19 |
2023-08-12 |
human |
| Keiko Nakanishi, Tatsuhiko Sudo, Nobuhiro Morishim. Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development. The Journal of cell biology. vol 169. issue 4. 2005-08-08. PMID:15897261. |
endoplasmic reticulum stress signaling transmitted by atf6 mediates apoptosis during muscle development. |
2005-08-08 |
2023-08-12 |
mouse |
| Keiko Nakanishi, Tatsuhiko Sudo, Nobuhiro Morishim. Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development. The Journal of cell biology. vol 169. issue 4. 2005-08-08. PMID:15897261. |
atf6, but not other er stress sensors, was specifically activated during apoptosis in myoblasts, suggesting that partial but selective activation of er stress signaling was sufficient for induction of apoptosis. |
2005-08-08 |
2023-08-12 |
mouse |
| Keiko Nakanishi, Tatsuhiko Sudo, Nobuhiro Morishim. Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development. The Journal of cell biology. vol 169. issue 4. 2005-08-08. PMID:15897261. |
these results suggest that specific er stress signaling transmitted by atf6 leads to naturally occurring apoptosis during muscle development. |
2005-08-08 |
2023-08-12 |
mouse |