| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaofeng Han, Peng Zhang, Rong Jiang, Fei Xia, Meiling Li, Feng-Jin Gu. Explore on the effect of ATF6 on cell growth and apoptosis in cartilage development. Histochemistry and cell biology. vol 142. issue 5. 2015-10-13. PMID:24934104. |
besides, ad-atf6 can activate, whereas knockdown atf6 by an sirna-silencing approach inhibited, er stress-mediated apoptosis in chondrogenesis induced by bmp2, as assayed by cleaved caspase3, chop, p-jnk expression in the course of chondrocyte differentiation. |
2015-10-13 |
2023-08-13 |
Not clear |
| Xiaofeng Han, Peng Zhang, Rong Jiang, Fei Xia, Meiling Li, Feng-Jin Gu. Explore on the effect of ATF6 on cell growth and apoptosis in cartilage development. Histochemistry and cell biology. vol 142. issue 5. 2015-10-13. PMID:24934104. |
collectively, these findings reveal a novel critical role of atf6 in regulating er stress-mediated apoptosis in chondrocyte differentiation and the molecular mechanisms involved. |
2015-10-13 |
2023-08-13 |
Not clear |
| Chongshan Dai, Jichang Li, Shusheng Tang, Jian Li, Xilong Xia. Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways. Antimicrobial agents and chemotherapy. vol 58. issue 7. 2015-09-10. PMID:24798292. |
it was evident that colistin-induced apoptosis involved the mitochondrial pathway (downregulation of bcl-2 and upregulation of cytochrome c [cytc] and bax), death receptor pathway (upregulation of fas, fasl, and fas-associated death domain [fadd]), and endoplasmic reticulum pathway (upregulation of grp78/bip, atf6, gadd153/chop, and caspase-12). |
2015-09-10 |
2023-08-13 |
mouse |
| Bo Yu, Lili Wen, Bing Xiao, Fang Han, Yuxiu Sh. Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons. BMC neuroscience. vol 15. 2015-07-08. PMID:25331812. |
the aim of this study was to investigate whether endoplasmic reticulum-related pathway is involved in single-prolonged stress (sps) induced apoptosis in the mpfc of ptsd rats by examining the expression levels of atf6 alpha (atf6α), two important downstream molecular chaperones of atf6α in the er stress: glucose-regulated protein (grp) 78 and erp57, and apoptotic factors caspase 12, caspase 9, and caspase 3. |
2015-07-08 |
2023-08-13 |
rat |
| Lisa Fredriksson, Steven Wink, Bram Herpers, Giulia Benedetti, Mackenzie Hadi, Hans de Bont, Geny Groothuis, Mirjam Luijten, Erik Danen, Marjo de Graauw, John Meerman, Bob van de Wate. Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 140. issue 1. 2015-02-19. PMID:24752500. |
targeted rna interference studies revealed that whereas er stress signaling through inositol-requiring enzyme 1α (ire1α) and activating transcription factor 6 (atf6) acted cytoprotective, activation of the er stress protein kinase perk and subsequent expression of chop was pivotal for the onset of drug/tnfα-induced apoptosis. |
2015-02-19 |
2023-08-13 |
human |
| Padmaja Gade, Srikanta B Manjegowda, Shreeram C Nallar, Uday B Maachani, Alan S Cross, Dhananjaya V Kalvakolan. Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1. Molecular and cellular biology. vol 34. issue 21. 2014-11-24. PMID:25135476. |
regulation of the death-associated protein kinase 1 expression and autophagy via atf6 requires apoptosis signal-regulating kinase 1. |
2014-11-24 |
2023-08-13 |
mouse |
| Yonju Ha, Arul K Shanmugam, Shanu Markand, Eric Zorrilla, Vadivel Ganapathy, Sylvia B Smit. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell and tissue research. vol 356. issue 1. 2014-11-18. PMID:24469320. |
we therefore used σr1(-/-) mice to investigate the expression of er stress genes (bip/grp78, atf6, atf4, ire1α) and proteins involved in apoptosis (bcl2, bax) and to examine the retinal transcriptome at young ages. |
2014-11-18 |
2023-08-12 |
mouse |
| Irina Hirsch, Matthias Weiwad, Erik Prell, David Michael Ferrar. ERp29 deficiency affects sensitivity to apoptosis via impairment of the ATF6-CHOP pathway of stress response. Apoptosis : an international journal on programmed cell death. vol 19. issue 5. 2014-11-12. PMID:24370996. |
as a result of impaired atf6 activation, dermal fibroblasts and adult thyrocytes from erp29(-/-) mice display significantly lower apoptosis sensitivities when treated with tunicamycin and hydrogen peroxide. |
2014-11-12 |
2023-08-12 |
mouse |
| Allison Kupsco, Daniel Schlen. Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese medaka (Oryzias latipes). Environmental science & technology. vol 48. issue 12. 2014-10-24. PMID:24856650. |
although significant changes in apoptosis were not observed, we witnessed up to 100 fold increases in transcripts of the endoplasmic reticulum (er) chaperone, immunoglobulin binding protein (bip) and trends toward increasing downstream signals, activating transcription factor 4 (atf4) and atf6 indicating potential contributions of the unfolded protein response to the effects of semet and hypersaline conditions. |
2014-10-24 |
2023-08-13 |
Not clear |
| Wei Wang, Haicheng Yan, Changwu Dou, Youle S. Human leptin triggers proliferation of A549 cells via blocking endoplasmic reticulum stress-related apoptosis. Biochemistry. Biokhimiia. vol 78. issue 12. 2014-09-22. PMID:24460967. |
er stress unfolded protein response (upr) proteins, perk and atf6, were involved in leptin-triggered apoptosis. |
2014-09-22 |
2023-08-12 |
human |
| Zhi-Cheng Wang, Jian-Feng Wang, Yan-Bo Li, Cai-Xia Guo, Yang Liu, Fang Fang, Shou-Liang Gon. Involvement of endoplasmic reticulum stress in apoptosis of testicular cells induced by low-dose radiation. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 33. issue 4. 2014-09-09. PMID:23904376. |
the study examined the role of endoplasmic reticulum stress (ers) and signaling pathways of inositol-requiring enzyme-1 (ire1), rna-activated protein kinase-like er kinase (perk) and activating transcription factor-6 (atf6) in apoptosis of mouse testicular cells treated with low-dose radiation (ldr). |
2014-09-09 |
2023-08-12 |
mouse |
| Zhi-Cheng Wang, Jian-Feng Wang, Yan-Bo Li, Cai-Xia Guo, Yang Liu, Fang Fang, Shou-Liang Gon. Involvement of endoplasmic reticulum stress in apoptosis of testicular cells induced by low-dose radiation. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 33. issue 4. 2014-09-09. PMID:23904376. |
it was concluded that the ers, regulated by ire1, perk and atf6 pathways, is involved in the apoptosis of testicular cells in ldr mice, which is associated with ers-apoptotic signaling molecules of jnk, caspase-12 and chop. |
2014-09-09 |
2023-08-12 |
mouse |
| Kwang Hong Tay, Qi Luan, Amanda Croft, Chen Chen Jiang, Lei Jin, Xu Dong Zhang, Hsin-Yi Tsen. Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24240056. |
apoptosis triggered by endoplasmic reticulum (er) stress is associated with rapid attenuation of the ire1α and atf6 pathways but persistent activation of the perk branch of the unfolded protein response (upr) in cells. |
2014-08-18 |
2023-08-12 |
Not clear |
| Kwang Hong Tay, Qi Luan, Amanda Croft, Chen Chen Jiang, Lei Jin, Xu Dong Zhang, Hsin-Yi Tsen. Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24240056. |
in contrast to an initial increase followed by rapid reduction in activation of ire1α and atf6 signaling in control cells that were relatively sensitive to er stress-induced apoptosis, activation of ire1α and atf6 by the pharmacological er stress inducer tunicamycin (tm) or thapsigargin (tg) persisted in melanoma cells. |
2014-08-18 |
2023-08-12 |
Not clear |
| Kwang Hong Tay, Qi Luan, Amanda Croft, Chen Chen Jiang, Lei Jin, Xu Dong Zhang, Hsin-Yi Tsen. Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24240056. |
sustained activation of ire1α and atf6 signaling played an important role in protecting melanoma cells from er stress-induced apoptosis, as interruption of ire1α or atf6 rendered melanoma cells sensitive to apoptosis induced by tm or tg. |
2014-08-18 |
2023-08-12 |
Not clear |
| Kwang Hong Tay, Qi Luan, Amanda Croft, Chen Chen Jiang, Lei Jin, Xu Dong Zhang, Hsin-Yi Tsen. Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24240056. |
taken together, these results identify sustained activation of the ire1α and atf6 pathways of the upr driven by the mek/erk pathway as an important protective mechanism against er stress-induced apoptosis in melanoma cells. |
2014-08-18 |
2023-08-12 |
Not clear |
| Feng-Jin Guo, Zhangyuan Xiong, Xiaojie Lu, Mengliang Ye, Xiaofeng Han, Rong Jian. ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269637. |
atf6 upregulates xbp1s and inhibits er stress-mediated apoptosis in osteoarthritis cartilage. |
2014-08-18 |
2023-08-12 |
Not clear |
| Feng-Jin Guo, Zhangyuan Xiong, Xiaojie Lu, Mengliang Ye, Xiaofeng Han, Rong Jian. ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269637. |
the purpose of this study was to determine (1) whether xbp1s influences er stress-mediated apoptosis in osteoarthritis (oa); (2) whether atf6 regulates ire1/xbp1 signal pathway in oa cartilage; (3) what are the associated molecules affecting apoptosis in osteoarthritis and the molecular events underlying this process. |
2014-08-18 |
2023-08-12 |
Not clear |
| Shanshan Zhou, Xia Yin, Yang Zheng, Xiao Miao, Wenke Feng, Jun Cai, Lu Ca. Metallothionein prevents intermittent hypoxia-induced cardiac endoplasmic reticulum stress and cell death likely via activation of Akt signaling pathway in mice. Toxicology letters. vol 227. issue 2. 2014-06-27. PMID:24680926. |
ih exposures for 3 days to 4 weeks significantly increased cardiac er stress and apoptosis, shown by the increased expression of grp78, atf6 and chop, the activation of caspase-12 and capase-3, and the decreased bcl2/bax expression ratio, predominantly in the 3rd week of ih exposures. |
2014-06-27 |
2023-08-12 |
mouse |
| Amin Afrazi, Maria F Branca, Chhinder P Sodhi, Misty Good, Yukihiro Yamaguchi, Charlotte E Egan, Peng Lu, Hongpeng Jia, Shahab Shaffiey, Joyce Lin, Congrong Ma, Garrett Vincent, Thomas Prindle, Samantha Weyandt, Matthew D Neal, John A Ozolek, John Wiersch, Markus Tschurtschenthaler, Chiyo Shiota, George K Gittes, Timothy R Billiar, Kevin Mollen, Arthur Kaser, Richard Blumberg, David J Hacka. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. The Journal of biological chemistry. vol 289. issue 14. 2014-05-30. PMID:24519940. |
tlr4-mediated er stress and apoptosis of iscs required perk (protein kinase-related pkr-like er kinase), chop (c/ebp homologous protein), and myd88 (myeloid differentiation primary response gene 88), but not atf6 (activating transcription factor 6) or xbp1 (x-box-binding protein 1). |
2014-05-30 |
2023-08-12 |
mouse |