| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingyong Huang, Li Wan, Heping Lu, Xiaoqiang L. High expression of active ATF6 aggravates endoplasmic reticulum stress‑induced vascular endothelial cell apoptosis through the mitochondrial apoptotic pathway. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29512699. |
the results demonstrated that high expression of activated atf6 aggravates er stress‑induced vec apoptosis through the mitochondrial apoptotic pathway. |
2018-09-13 |
2023-08-13 |
Not clear |
| Pan-Pan Kang, Shu-Tong Yao, Tian-Tian Guo, Zhi-Chao Wang, Hua Tian, Peng Jiao, Jian Zhou, Shu-Cun Qi. [Activating transcription factor 6-C/EBP homologous protein pathway mediates advanced glycated albumin-induced macrophage apoptosis]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 6. 2018-08-29. PMID:29270592. |
the purpose of this study was to investigate whether activating transcription factor 6 (atf6), a sensor to endoplasmic reticulum stress (ers), would mediate advanced glycated albumin (age-alb)-induced macrophage apoptosis and to elucidate the possible molecular mechanisms. |
2018-08-29 |
2023-08-13 |
Not clear |
| Pan-Pan Kang, Shu-Tong Yao, Tian-Tian Guo, Zhi-Chao Wang, Hua Tian, Peng Jiao, Jian Zhou, Shu-Cun Qi. [Activating transcription factor 6-C/EBP homologous protein pathway mediates advanced glycated albumin-induced macrophage apoptosis]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 6. 2018-08-29. PMID:29270592. |
sirna-mediated knockdown of atf6 significantly inhibited age-alb-induced macrophage injury, as indicated by the increased cell viability and the decreased ldh release, apoptosis and caspase-3 activation. |
2018-08-29 |
2023-08-13 |
Not clear |
| Pan-Pan Kang, Shu-Tong Yao, Tian-Tian Guo, Zhi-Chao Wang, Hua Tian, Peng Jiao, Jian Zhou, Shu-Cun Qi. [Activating transcription factor 6-C/EBP homologous protein pathway mediates advanced glycated albumin-induced macrophage apoptosis]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 6. 2018-08-29. PMID:29270592. |
these results suggest that atf6 and its downstream molecule chop are involved in age-alb-induced macrophage apoptosis. |
2018-08-29 |
2023-08-13 |
Not clear |
| Janet M Menzie-Suderam, Payam Mohammad-Gharibani, Jigar Modi, Zea Ma, Rui Tao, Howard Prentice, Jang-Yen W. Granulocyte-colony stimulating factor protects against endoplasmic reticulum stress in an experimental model of stroke. Brain research. vol 1682. 2018-08-03. PMID:29277709. |
g-csf treatment significantly (p < .05) attenuated the expression of proteins involved in er stress apoptosis pathway; atf4, atf6, p-p38mapk, pjnk and chop. |
2018-08-03 |
2023-08-13 |
rat |
| Wei Zhang, Zhiqing Sun, Fanhua Men. Schisandrin B Ameliorates Myocardial Ischemia/Reperfusion Injury Through Attenuation of Endoplasmic Reticulum Stress-Induced Apoptosis. Inflammation. vol 40. issue 6. 2018-07-10. PMID:28748322. |
collectively, these results revealed that sch b exerts protection role on myocardial i/r injury through decreasing oxidative reaction, suppressing atf6 and perk pathway, and attenuating er stress-induced apoptosis. |
2018-07-10 |
2023-08-13 |
rat |
| Dong Han, Xiang Li, Shuang Li, Tao Su, Li Fan, Wen-Si Fan, Hong-Yu Qiao, Jiang-Wei Chen, Miao-Miao Fan, Xiu-Juan Li, Ya-Bin Wang, Sai Ma, Ya Qiu, Zu-Hong Tian, Feng Ca. Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist. Free radical biology & medicine. vol 113. 2018-07-05. PMID:28993270. |
furthermore, the levels of myocardial inflammatory cytokines (tnf-α, il-6, il-1β, mcp-1, mpo and hmgb1), oxidative stress (ros generation, mda), endoplasmic-reticulum (er) stress (protein levels of chop, grp78, grp94, ire1α, and atf6), and cardiac apoptosis following clp were inhibited by t0901317 treatment in wild-type mice but not in sirt1-/- mice. |
2018-07-05 |
2023-08-13 |
mouse |
| Ying Liu, Zi-Yu Jiang, Yuan-Li Zhou, Hui-Hui Qiu, Gang Wang, Yi Luo, Jing-Bing Liu, Xiong-Wei Liu, Wei-Quan Bu, Jie Song, Li Cui, Xiao-Bin Jia, Liang Fen. β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-30. PMID:28672279. |
more importantly, ers inhibitor 4-pba, ire1α inhibitor stf-083010, atf6 inhibitor anti-atf6 and perk inhibitor gsk2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of β-elemene. |
2018-04-30 |
2023-08-13 |
mouse |
| Yang Zhou, Wei-Kun Jia, Zhao Jian, Liang Zhao, Chen-Cheng Liu, Yong Wang, Ying-Bin Xia. Downregulation of microRNA‑199a‑5p protects cardiomyocytes in cyanotic congenital heart disease by attenuating endoplasmic reticulum stress. Molecular medicine reports. vol 16. issue 3. 2018-04-16. PMID:28713984. |
in addition, the mir‑199a‑5p mimic and inhibitor were evidently able to change grp78 and atf6 gene expression and er stress‑associated apoptosis in hypoxia‑treated cardiomyocytes. |
2018-04-16 |
2023-08-13 |
human |
| Fenghua Li, Yang Yang, Lili Yang, Kai Wang, Xing Zhang, Yunlong Zong, Yixin Ding, Changhong Wang, Li Zhang, Guang J. Resveratrol alleviates FFA and CCl4 induced apoptosis in HepG2 cells via restoring endoplasmic reticulum stress. Oncotarget. vol 8. issue 27. 2018-03-29. PMID:28415630. |
the expression of molecules related to apoptosis (caspases, bcl-2/bax) and er stress (grp78, ire1, atf6, perk, et al.) |
2018-03-29 |
2023-08-13 |
Not clear |
| Xiu-Mei Li, Jing Liu, Fang-Fang Pan, Dong-Dong Shi, Zhi-Guo Wen, Pei-Long Yan. Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway. PloS one. vol 13. issue 1. 2018-02-23. PMID:29324796. |
it is concluded based on our result that qa induces apoptosis and er stress just as qa-induced er stress pathway may mediate apoptosis by upregulating mrna expression levels of eif2α, atf4, ire1, xbp1, atf6, perk and chop in the hela cells. |
2018-02-23 |
2023-08-13 |
human |
| Cheng Zhan. Roles of Grp78 in Female Mammalian Reproduction. Advances in anatomy, embryology, and cell biology. vol 222. 2017-09-26. PMID:28389754. |
grp78 as a central regulator of er stress (ers) plays many important roles in cell survival and apoptosis through controlling the activation of transmembrane ers sensors: pkr-like er-associated kinase (perk), inositol requiring kinase 1 (ire1), and activating transcription factor 6 (atf6). |
2017-09-26 |
2023-08-13 |
Not clear |
| Shuling Song, Jin Tan, Yuyang Miao, Mengmeng Li, Qiang Zhan. Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress. Journal of cellular physiology. vol 232. issue 11. 2017-09-18. PMID:28067409. |
there are common upstream signaling pathways between autophagy and apoptosis induced by er stress, including perk/atf4, ire1α, atf6, and ca |
2017-09-18 |
2023-08-13 |
Not clear |
| Ling He, Jing Yuan, Qingyun Xu, Ruixue Chen, Liguo Chen, Meixia Fan. miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. PloS one. vol 11. issue 8. 2017-07-24. PMID:27537404. |
three ers pathways exist:protein kinase rna-like er kinase (perk), activating transcription factor 6 (atf6) and inositol-requiring enzyme-1 (ire-1)-induced apoptosis. |
2017-07-24 |
2023-08-13 |
mouse |
| Hang Nguyen, Bruce D Uha. The unfolded protein response controls ER stress-induced apoptosis of lung epithelial cells through angiotensin generation. American journal of physiology. Lung cellular and molecular physiology. vol 311. issue 5. 2017-06-12. PMID:27638906. |
the results showed that either mg132 or g100s sp-c mutation activated all three canonical pathways of the upr (ire1/xbp1, atf6, and perk/eif2α), which led to a significant increase in cathepsin d or in tace (an ace-2 ectodomain shedding enzyme) and eventually caused aec apoptosis. |
2017-06-12 |
2023-08-13 |
human |
| Yongjie Xiong, Huatao Chen, Pengfei Lin, Aihua Wang, Lei Wang, Yaping Ji. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. American journal of physiology. Cell physiology. vol 312. issue 3. 2017-06-06. PMID:28100484. |
atf6 knockdown decreases apoptosis, arrests the s phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. |
2017-06-06 |
2023-08-13 |
mouse |
| Yongjie Xiong, Huatao Chen, Pengfei Lin, Aihua Wang, Lei Wang, Yaping Ji. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. American journal of physiology. Cell physiology. vol 312. issue 3. 2017-06-06. PMID:28100484. |
the aim of this study was to assess the role of atf6 in mouse granulosa cells with respect to apoptosis, the cell cycle, and steroid hormone production, as well as several key genes related to follicular development, via rna interference, immunohistochemical staining, real-time quantitative pcr, western blotting, flow cytometry, terminal deoxynucleotidyltransferase-mediated deoxy-utp nick end labeling (tunel) assay, and elisa. |
2017-06-06 |
2023-08-13 |
mouse |
| Yongjie Xiong, Huatao Chen, Pengfei Lin, Aihua Wang, Lei Wang, Yaping Ji. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. American journal of physiology. Cell physiology. vol 312. issue 3. 2017-06-06. PMID:28100484. |
flow cytometry and tunel assay analysis indicated that atf6 depletion decreased apoptosis and arrested the s phase of the cell cycle in mouse granulosa cells. |
2017-06-06 |
2023-08-13 |
mouse |
| Angelica M Merlot, Nurul H Shafie, Yu Yu, Vera Richardson, Patric J Jansson, Sumit Sahni, Darius J R Lane, Zaklina Kovacevic, Danuta S Kalinowski, Des R Richardso. Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase. Biochemical pharmacology. vol 109. 2017-04-26. PMID:27059255. |
our results demonstrate that the cytotoxic chelator, dp44mt, which forms redox-active metal complexes, significantly: (1) increased er stress-associated pro-apoptotic signaling molecules (i.e., p-eif2α, atf4, chop); (2) increased ire1α phosphorylation (p-ire1α) and xbp1 mrna splicing; (3) reduced expression of er stress-associated cell survival signaling molecules (e.g., xbp1s and p58(ipk)); (4) increased cleavage of the transcription factor, atf6, which enhances expression of its downstream targets (i.e., chop and bip); and (5) increased phosphorylation of camkii that induces apoptosis. |
2017-04-26 |
2023-08-13 |
Not clear |
| Lili Wen, Fang Han, Yuxiu Shi, Xiaoyan L. Role of the Endoplasmic Reticulum Pathway in the Medial Prefrontal Cortex in Post-Traumatic Stress Disorder Model Rats. Journal of molecular neuroscience : MN. vol 59. issue 4. 2017-03-09. PMID:27112439. |
three signalling pathways [protein kinase rna-like endoplasmic reticulum kinase (perk), activating transcription factor 6 (atf6), and inositol-requiring enzyme 1 (ire1)] in the endoplasmic reticulum (er) play a critical role in resisting apoptosis. |
2017-03-09 |
2023-08-13 |
rat |