| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiyuan Chen, Yaling Liu, Li Yang, Peng Liu, Yu Zhang, Xiangyang Wan. MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway. Immunology letters. vol 222. 2021-05-19. PMID:32194141. |
mir-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting atf6 pathway. |
2021-05-19 |
2023-08-13 |
mouse |
| Zhiyuan Chen, Yaling Liu, Li Yang, Peng Liu, Yu Zhang, Xiangyang Wan. MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway. Immunology letters. vol 222. 2021-05-19. PMID:32194141. |
mir-149 alleviates ers-induced inflammation and apoptosis by down-regulating the atf6 signaling pathway, thus inhibiting the progression of nafld. |
2021-05-19 |
2023-08-13 |
mouse |
| Guoqin Wang, Qiuwen Ye, Shujuan Ning, Zhuangqing Yang, Yunlan Chen, Lijuan Zhang, Youguang Huang, Fujia Xie, Xi Cheng, Junlin Chi, Yi Lei, Rong Guo, Jiangqiong Ha. LncRNA MEG3 promotes endoplasmic reticulum stress and suppresses proliferation and invasion of colorectal carcinoma cells through the MEG3/miR-103a-3p/PDHB ceRNA pathway. Neoplasma. vol 68. issue 2. 2021-05-14. PMID:33118833. |
restoring meg3 suppressed cell viability, colony formation ability, and invasion, arrested cell cycle, and induced apoptosis rate in sw620 and hct116 cells, as well as promoted expression of er stress-related proteins (grp78, atf6, chop, caspase-3, and caspase-9). |
2021-05-14 |
2023-08-13 |
human |
| Jie-Hui Tan, Rong-Chang Cao, Lei Zhou, Zhi-Tao Zhou, Huo-Ji Chen, Jia Xu, Xue-Mei Chen, Yang-Chen Jin, Jia-Yu Lin, Jun-Ling Zeng, Shu-Ji Li, Min Luo, Guo-Dong Hu, Xiao-Bing Yang, Jin Jin, Guo-Wei Zhan. ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis. Theranostics. vol 10. issue 18. 2021-05-05. PMID:32724472. |
atf6 aggravates acinar cell apoptosis and injury by regulating p53/aifm2 transcription in severe acute pancreatitis. |
2021-05-05 |
2023-08-13 |
Not clear |
| Min-Young Kwon, Narae Hwang, Sung Hoon Back, Seon-Jin Lee, Mark A Perrella, Su Wol Chun. Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions. The FEBS journal. vol 287. issue 10. 2021-04-22. PMID:32167239. |
nod2 interacted with an er stress sensor molecule, atf6, and acted as a negative regulator for atf6 activation and its downstream target molecule, chop, that regulates er stress-induced apoptosis. |
2021-04-22 |
2023-08-13 |
mouse |
| Chengcheng Zhang, Jiashu Hu, Xiuling Wang, Yuyang Wang, Mengjiao Guo, Xiaorong Zhang, Yantao W. Avian reovirus infection activate the cellular unfold protein response and induced apoptosis via ATF6-dependent mechanism. Virus research. vol 297. 2021-04-12. PMID:33741393. |
protein kinase rna-like endoplasmic reticulum kinase (perk), inositol-requiring enzyme 1 (ire1) and activating transcription factor 6 (atf6) are core molecules in unfold protein response (upr) and play critical role in er stress related apoptosis, as well as downstream regulation factors, as caspase-12 and c/ebp homologous protein (chop). |
2021-04-12 |
2023-08-13 |
Not clear |
| Chengcheng Zhang, Jiashu Hu, Xiuling Wang, Yuyang Wang, Mengjiao Guo, Xiaorong Zhang, Yantao W. Avian reovirus infection activate the cellular unfold protein response and induced apoptosis via ATF6-dependent mechanism. Virus research. vol 297. 2021-04-12. PMID:33741393. |
further study revealed that when inhibit the upr effect by 4pba pretreated or knockdown of atf6 by lentivirus mediated shrna abolished the activation effect of upr, caspase-12, cleaved-caspase-3 activation, as well as the apoptosis induction by arv infection. |
2021-04-12 |
2023-08-13 |
Not clear |
| Chengcheng Zhang, Jiashu Hu, Xiuling Wang, Yuyang Wang, Mengjiao Guo, Xiaorong Zhang, Yantao W. Avian reovirus infection activate the cellular unfold protein response and induced apoptosis via ATF6-dependent mechanism. Virus research. vol 297. 2021-04-12. PMID:33741393. |
the present study provides mechanistic insights into that upr particular atf6 played critical roles and works upstream of caspase in the process of cellular apoptosis induced by arv infection. |
2021-04-12 |
2023-08-13 |
Not clear |
| Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Min-Hee Kang, Jin-Hoi Ki. Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer. International journal of molecular sciences. vol 21. issue 18. 2021-02-26. PMID:32947930. |
endoplasmic reticulum-mediated stress and apoptosis were confirmed by upregulation of protein kinase rna-like endoplasmic reticulum kinase (perk), inositol-requiring enzyme 1 (ire1), activating transcription factor 6 (atf6), activating transcription factor 4 (atf4), p53, bax, and caspase-3 and down regulation of b-cell lymphoma 2 (bcl-2). |
2021-02-26 |
2023-08-13 |
human |
| Yingying He, John Bosco Ruganzu, Chengheng Lin, Bo Ding, Quzhao Zheng, Xiangyuan Wu, Ruiyang Ma, Qian Liu, Yang Wang, Hui Jin, Yihua Qian, Xiaoqian Peng, Shengfeng Ji, Liangliang Zhang, Weina Yang, Xiaomei Le. Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Neurochemistry international. vol 133. 2021-02-23. PMID:31778727. |
furthermore, tan iia significantly reduced the deposition of aβ plaques and neuronal apoptosis, and markedly prevented abnormal expression of glucose regulated protein 78 (grp78), initiation factor 2α (eif2α), inositol-requiring enzyme 1α (ire1α), activating transcription factor 6 (atf6), as well as suppressed the activation of c/ebp homologous protein (chop) and c-jun n-terminal kinase (jnk) pathways in the parietal cortex and hippocampus. |
2021-02-23 |
2023-08-13 |
mouse |
| Yeon Sook Kim, Dae Won Kim, Seong-Gon Kim, Suk Keun Le. 4-hexylresorcinol-induced protein expression changes in human umbilical cord vein endothelial cells as determined by immunoprecipitation high-performance liquid chromatography. PloS one. vol 15. issue 12. 2021-02-15. PMID:33320912. |
4hr-treated huvecs tended to increase the er stress mediators by upregulating eif2ak3, atf4, atf6, lysozyme, and lc3 and downregulating eif2α and gadd153 (chop), resulting in parp-1/aif-mediated apoptosis. |
2021-02-15 |
2023-08-13 |
human |
| Junjian Wang, Rui Hu, Chunyan Yin, Yanfeng Xia. Tanshinone IIA reduces palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells. Fundamental & clinical pharmacology. vol 34. issue 2. 2020-11-25. PMID:31520549. |
palmitate led to cytotoxicity, tg accumulation, and apoptosis in hepg2 cells and also strongly induced er stress indicated by increased grp78, phosphorylation of eif2α, atf6, and chop. |
2020-11-25 |
2023-08-13 |
Not clear |
| Aditya Upadhyay, Rohit A Sinha, Alok Kumar, Madan M Godbol. Time-restricted feeding ameliorates maternal high-fat diet-induced fetal lung injury. Experimental and molecular pathology. vol 114. 2020-10-27. PMID:32151561. |
our results showed that trf considerably prevented maternal hfd-induced apoptosis in fetal lung tissue that corroborated with a reduction in caspase activation and increased levels of anti-apoptotic bcl2 family proteins together with a lower level of er-stress and autophagy markers including atf6, chop and lc3-ii. |
2020-10-27 |
2023-08-13 |
rat |
| Yuko Yoshikawa, Kei Sugimoto, Yoshitsugu Ochiai, Norio Ohash. Intracellular proliferation of Anaplasma phagocytophilum is promoted via modulation of endoplasmic reticulum stress signaling in host cells. Microbiology and immunology. vol 64. issue 4. 2020-10-19. PMID:31909489. |
moreover, perk and atf6 partially mediated a. phagocytophilum-induced apoptosis by promoting the expression of ccaat/enhancer-binding protein homologous protein, which induces the transcription of several proapoptotic genes. |
2020-10-19 |
2023-08-13 |
Not clear |
| Kwon Jeong, Kiyoon Kim, Hunsung Kim, Yoojung Oh, Seong-Jin Kim, Yunhee Jo, Wonchae Cho. Hypoxia induces cyclophilin B through the activation of transcription factor 6 in gastric adenocarcinoma cells. Oncology letters. vol 9. issue 6. 2020-10-01. PMID:26137159. |
collectively, these results demonstrate that atf6 positively regulates the expression of cypb by binding to an atf6-responsive region in the promoter, which may play an important role in the attenuation of apoptosis in the adaption to hypoxia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhihui Jiao, Xiaoning Liu, Yajun Ma, Yansong Ge, Qianzhen Zhang, Boyang Liu, Hongbin Wan. Adipose-Derived Stem Cells Protect Ischemia-Reperfusion and Partial Hepatectomy by Attenuating Endoplasmic Reticulum Stress. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32266259. |
mechanistically, the adscs significantly downregulated ers-related proteins, including grp78, p-eif2α, atf6 and xbp1s, as well as the proteins involved in ers-induced apoptosis like p-jnk, atf4 and chop. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
in our study, firstly, l02 cells were treated with different concentrations of rfp for different time intervals, and the apoptosis, survival rate and endoplasmic reticulum stress gene and protein expressions of glucose-regulated protein 78 (grp 78), pkr-like er kinase (perk), activating transcription factor (atf)4, c/ebp-homologus protein (chop), atf6, arginine-rich, mutated in early stage tumors (armet), p-inositol-requiring enzyme 1 (ire1) and x-box binding protein 1 (xbp-1) were measured. |
2020-09-23 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that rfp increased apoptosis of l02 cells, decreased cell survival, and increased the gene and protein expression levels of grp78, perk, atf4, chop, atf6, armet, p-ire1 and xbp-1, suggesting that rfp could induce hepatocyte injury, and the degree of injury was positively correlated with the dose and time of rfp. |
2020-09-23 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that schizandrin b increased cell survival rate in dose-dependent and time-dependent manner, decreased cell apoptosis rate, and reduced protein and gene expression levels of grp78, perk, atf4, chop, atf6, armet and xbp-1. |
2020-09-23 |
2023-08-13 |
Not clear |
| Yanrong Li, Weiyu Jiang, Qiaona Niu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Chan Din. eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus. Cell death & disease. vol 10. issue 12. 2020-08-31. PMID:31767828. |
we found that ndv infection activated all three branches of the upr signaling (perk-eif2α, atf6, and ire1α) and triggered apoptosis, in avian cells (df-1 and cef) and in various human cancer cell types (hela, cal27, hn13, a549, h1299, huh7, and hepg2). |
2020-08-31 |
2023-08-13 |
human |