| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Najma Farahani, Mina Alimohammadi, Mehdi Raei, Noushin Nabavi, Amir Reza Aref, Kiavash Hushmandi, Salman Daneshi, Alireza Razzaghi, Afshin Taheriazam, Mehrdad Hashem. Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions. Journal of cell communication and signaling. vol 18. issue 4. 2024-12-18. PMID:39691874. |
key regulators, including perk, ire1α, and atf6, are discussed for their roles in upregulating chop levels and triggering apoptosis. |
2024-12-18 |
2024-12-21 |
Not clear |
| Pingshu Zhang, Wen Li, Ya Ou, Qi Yan, Qi Wu, Xiaodong Yua. The relationship between endoplasmic reticulum stress and apoptosis in the process of adipose-derived stromal cells differentiating into astrocytes. Cell adhesion & migration. vol 18. issue 1. 2024-11-20. PMID:39563165. |
in this study, the expression of protein factors related to endoplasmic reticulum stress (ers) and apoptosis, including grp78, atf6, perk, chop, caspase12, and caspase3, was detected in cells. |
2024-11-20 |
2024-11-23 |
Not clear |
| Haonan Meng, Heng Ai, Danting Li, Xiaochun Jiang, Hualing Zhang, Jiaping Xu, Shoujun Huan. Bombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BmBIP. International journal of biological macromolecules. 2024-11-17. PMID:39551318. |
mechanistically, apoptosis and atf6 signaling are involved in bmufbp1-regulated bmbip expression and bmnpv proliferation. |
2024-11-17 |
2024-11-22 |
Not clear |
| Linh Thi Truc Pham, Supachoke Mangmool, Warisara Parichatikanon. Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Guardians against Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Heart Diseases. ACS pharmacology & translational science. vol 7. issue 11. 2024-11-14. PMID:39539254. |
such consequences are achieved by enhancing adenosine triphosphate (atp) production, preserving mitochondrial membrane potential, improving the activity of electron transport chain complexes, maintaining mitochondrial dynamics, mitigating oxidative stress and apoptosis, influencing cellular calcium and sodium handling, and targeting the unfolded protein response (upr) through three signaling pathways including inositol requiring enzyme 1α (ire1α), protein kinase r like endoplasmic reticulum kinase (perk), and activating transcription factor 6 (atf6). |
2024-11-14 |
2024-11-17 |
Not clear |
| Yanan Li, Tianwen Ma, Xiaoping Lv, Zongsheng Qiu, Shuxin Li, Jingjing Qi, Chengwei We. Fluoride stimulates the MAPK pathway to regulate endoplasmic reticulum stress and heat shock proteins to induce duodenal toxicity in chickens. Poultry science. vol 103. issue 12. 2024-11-03. PMID:39490130. |
fluorosis activates ers through ire1, perk and atf6 pathways, increases the expression of hsp60, hsp70 and hsp90, and causes apoptosis and oxidative damage in duodenal tissue. |
2024-11-03 |
2024-11-06 |
human |
| Amira Abdalla Abdelshafy Mohamed, Seham Samir Soliman, Ahmed S H Soliman, Ahmed Hanafy, Yaping Ji. Endoplasmic reticulum stress is involved in mycotoxin zearalenone induced inflammatory response, proliferation, and apoptosis in goat endometrial stromal cells. Reproductive biology. vol 24. issue 4. 2024-09-04. PMID:39232304. |
these results suggest that the ire1 pathway can reduce apoptosis protein markers, down activate ire1, and unfolded protein response branches such as atf6 and lc3 in escs. |
2024-09-04 |
2024-09-08 |
Not clear |
| Siqi Wang, Fang Ji, Xiaoli Gao, Zhiyi Li, Si Lv, Juan Zhang, Jiarui Luo, Dan Li, Jie Yan, Huayang Zhang, Kaicheng Fang, Lin Wu, Miaoling L. Tyrosine Kinase Inhibitor Lenvatinib Causes Cardiotoxicity by Inducing Endoplasmic Reticulum Stress and Apoptosis through Activating ATF6, IRE1α and PERK Signaling Pathways. Recent patents on anti-cancer drug discovery. 2024-07-12. PMID:38994620. |
tyrosine kinase inhibitor lenvatinib causes cardiotoxicity by inducing endoplasmic reticulum stress and apoptosis through activating atf6, ire1α and perk signaling pathways. |
2024-07-12 |
2024-07-14 |
Not clear |
| Yu-Chen Liu, Xue Bai, Bing Liao, Xu-Bo Chen, Li-Hua Li, Yue-Hui Liu, Hai-Jun Hu, Kai X. Activating transcription factor 6 contributes to cisplatin‑induced ototoxicity via regulating the unfolded proteins response. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-28. PMID:38941893. |
in this study, we observed that cisplatin exposure induced apoptosis of mouse auditory oc-1 cells, accompanied by a significant increase in the expression of atf6 and c/ebp homologous protein (chop). |
2024-06-28 |
2024-07-01 |
mouse |
| Yu-Chen Liu, Xue Bai, Bing Liao, Xu-Bo Chen, Li-Hua Li, Yue-Hui Liu, Hai-Jun Hu, Kai X. Activating transcription factor 6 contributes to cisplatin‑induced ototoxicity via regulating the unfolded proteins response. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-28. PMID:38941893. |
collectively, our results revealed the underlying mechanism by which activation of atf6 significantly improved cisplatin-induced hair cell apoptosis, at least in part by inhibiting apoptosis signal-regulating kinase 1 expression, and demonstrated that pharmacological activation of atf6-mediated unfolded protein response is a potential treatment for cisplatin-induced ototoxicity. |
2024-06-28 |
2024-07-01 |
mouse |
| Jiajie Gan, Haoming Ma, Yeyun Ma, Mengyuan Zhou, Ying Li, Weiping Yan, Zibo Don. Silybin prevented avermectin-induced cardiotoxicity in carp by modulating oxidative stress, inflammation, endoplasmic reticulum stress, mitochondrial apoptosis, and autophagy. Fish & shellfish immunology. 2024-05-13. PMID:38740228. |
silybin exerted anti-inflammatory effects through the nuclear factor kappa b (nf-κb) pathway, antioxidant effects through the nuclear factor erythroid 2-related factor 2 (nrf2) - kelch-like ech-associated protein 1 (keap1) pathway, alleviated cardiac er stress through the glucose-regulated protein 78 (grp78)/activating transcription factor 6 (atf6)/c/ebp homologous protein (chop) axis, suppressed apoptosis through the mitochondrial pathway, and inhibited excessive autophagy initiation through the pten-induced putative kinase 1 (pink1)/ parkin rbr e3 ubiquitin protein ligase (parkin) signaling pathway. |
2024-05-13 |
2024-05-27 |
Not clear |
| Kezia Rachellea Mustakim, Mi Young Eo, Mi Hyun Seo, Hyeong-Cheol Yang, Min-Keun Kim, Hoon Myoung, Soung Min Ki. Ultrastructural and immunohistochemical evaluation of hyperplastic soft tissues surrounding dental implants in fibular jaws. Scientific reports. vol 14. issue 1. 2024-05-10. PMID:38730018. |
in immunohistochemical analysis, unfolded protein-response markers atf6, perk, xbp1, inflammatory marker nfκb, necroptosis marker mlkl, apoptosis marker gadd153, autophagy marker lc3, epithelial-mesenchymal transition, and angiogenesis markers were expressed variably in hyperplastic tissue surrounding fff implants, peri-implantitis, and fbg tissues. |
2024-05-10 |
2024-05-27 |
Not clear |
| Huimin Liu, Ye Zheng, Shaoning Kan, Ming Hao, Huan Jiang, Shuangji Li, Rong Li, Yinyu Wang, Dongxu Wang, Weiwei Li. Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration. Heliyon. vol 10. issue 8. 2024-04-22. PMID:38644851. |
mt also promoted the expression of atf4, atf6, bip, bap31 and chop in crl-1623 cells leading to endoplasmic reticulum stress, and induced autophagy and apoptosis in crl-1623 cells. |
2024-04-22 |
2024-04-24 |
Not clear |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Doyoung Kwon, Hyeji Seo, Sou Hyun Kim, Ki Wung Chung, Jaewon Lee, Young-Suk Jun. Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-03-31. PMID:38556155. |
diclofenac-promoted hepatic oxidative stress (oxidized proteins, 4-hydroxynonenal, and malondialdehyde), endoplasmic reticulum (er) stress (bip, atf6, and chop), and apoptosis (cleaved caspase-3 and cleaved parp) were enhanced by fasting. |
2024-03-31 |
2024-04-03 |
mouse |
| Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. |
in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. |
2024-03-26 |
2024-03-28 |
human |
| Fusen Yue, Jinsheng Xu, Linyi Meng, Qi Wang, Mingtao Tan, Aoying Zhang, Shanchun Yan, Dun Jian. A new insight into Cd exposure-induced hemocyte reduction in Lymantria dispar larvae: Involvement of the ROS-ATF6-ER stress-apoptosis pathway. Journal of hazardous materials. vol 469. 2024-03-20. PMID:38508113. |
studies using inhibitors confirmed that apoptosis mediated the decrease in hemocyte count, er stress mediated apoptosis, atf6 pathway mediated er stress, and ros or oxidative stress mediated er stress through the activation of the atf6 pathway. |
2024-03-20 |
2024-03-23 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Zhao Dai, Tian Hu, Junwen Wei, Xue Wang, Chuipu Cai, Yong Gu, Yunhui Hu, Wenjia Wang, Qihui Wu, Jiansong Fan. Network-based identification and mechanism exploration of active ingredients against Alzheimer's disease via targeting endoplasmic reticulum stress from traditional chinese medicine. Computational and structural biotechnology journal. vol 23. 2024-01-23. PMID:38261917. |
experimental results showed that echinacoside and danthron were able to effectively reduce er stress-mediated neuronal apoptosis by inhibiting the expression levels of bip, p-perk, atf6, and chop in app-sh-sy5y cells. |
2024-01-23 |
2024-01-26 |
Not clear |
| Jinuk Seo, Doyoung Kwon, Sou Hyun Kim, Mi Ran Byun, Yun-Hee Lee, Young-Suk Jun. Role of autophagy in betaine-promoted hepatoprotection against non-alcoholic fatty liver disease in mice. Current research in food science. vol 8. 2024-01-15. PMID:38222825. |
in addition, it reduced the cdahfd-induced er stress (bip, atf6, and chop) and apoptosis (bax, cleaved caspase-3, and cleaved parp); however, it induced autophagy (lc3ii/i and p62) which was downregulated by cdahfd. |
2024-01-15 |
2024-01-17 |
mouse |
| Chang Liu, Rong J. Potential Role of Endoplasmic Reticulum Stress in Modulating Protein Homeostasis in Oligodendrocytes to Improve White Matter Injury in Preterm Infants. Molecular neurobiology. 2024-01-05. PMID:38180617. |
3) ire1 and atf6 pathways enhanced various gene transcription associated with protein folding, secreting, eard, and erqc to prompt cell protein homeostasis micro-environment; however, sustained ire1 and/or atf6 activity could prompt cell survival toward apoptosis via the pro-apoptotic pathway, inflammation, and other patterns. |
2024-01-05 |
2024-01-07 |
Not clear |