| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie-Xiang Zhang, Wei-Chen Yuan, Cheng-Gang Li, Hai-Yan Zhang, Shu-Yan Han, Xiao-Hong L. A review on the mechanisms underlying the antitumor effects of natural products by targeting the endoplasmic reticulum stress apoptosis pathway. Frontiers in pharmacology. vol 14. 2023-12-04. PMID:38044941. |
when ers is under- or overexpressed, it activates the protein kinase r (pkr)-like endoplasmic reticulum kinase (perk)-, inositol-requiring enzyme 1 (ire1)- and activating transcription factor 6 (atf6)-related apoptotic pathways to induce apoptosis. |
2023-12-04 |
2023-12-10 |
human |
| Lulu Ding, Huali Zhu, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Bianhua Zhou, Hongwei Wang, Zijun Yang, Zongping Liu, Jicang Wan. Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway. Environmental science and pollution research international. 2023-11-24. PMID:38001299. |
the mrna and protein expression levels of ers and apoptosis related factors such as grp78, ire1α, xbp1, atf6, caspase-12, caspase-3 and bax in the cells were significantly increased (p < 0.01), while the mrna and protein expression levels of bcl-2 were significantly reduced (p < 0.01). |
2023-11-24 |
2023-11-28 |
rat |
| Meina Huang, Jinhui Wang, Meili Zhai, Jiqiang Liu, Yongjie Zhu, Yang Zhang, Jing Zhao, Huiquan Wang, Jinglai Sun, Hui Yu, Chong Li. Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-15. PMID:37714499. |
subsequently, according to the dynamic changes of apoptosis in lung specimens, and the expression changes in sig-1r-regulated er stress pathway proteins (sig-1r, grp78, p-perk, atf6, ire1, caspase-12, atf4, chop, caspase-3 and p-jnk), it was confirmed that the sig-1r-regulated er stress signaling pathway was involved in the occurrence of hali. |
2023-09-15 |
2023-10-07 |
Not clear |
| Biswadeep Das, Sagnika Samal, Hamida Hamdi, Aditi Pal, Arpita Biswas, Jyotika Behera, Gyanraj Singh, Chinmay Kumar Behera, Debee Prasad Sahoo, Sanghamitra Pat. Role of endoplasmic reticulum stress-related unfolded protein response and its implications in dengue virus infection for biomarker development. Life sciences. 2023-07-30. PMID:37517582. |
this could be attributed to the uncontrolled activation of the key upr signaling pathways: inositol-requiring transmembrane kinase/endoribonuclease 1 (ire1), protein kinase r (pkr)-like endoplasmic reticulum kinase (perk), and activating transcription factor-6 (atf6), which promote cell autophagy under normal and diseased conditions through the downstream regulation of apoptosis promoting factors such as x-box binding protein (xbp1), gadd34, and atf-6. |
2023-07-30 |
2023-08-14 |
Not clear |
| Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Zhi Chen, Xiang-Shun Cu. ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. Zoological research. vol 44. issue 5. 2023-07-28. PMID:37501400. |
atf6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. |
2023-07-28 |
2023-08-14 |
Not clear |
| Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Zhi Chen, Xiang-Shun Cu. ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. Zoological research. vol 44. issue 5. 2023-07-28. PMID:37501400. |
activating transcription factor 6 (atf6), one of the three sensor proteins in the endoplasmic reticulum (er), is an important regulator of er stress-induced apoptosis. |
2023-07-28 |
2023-08-14 |
Not clear |
| Nurhan Akaras, Mustafa Ileriturk, Cihan Gur, Sefa Kucukler, Mehmet Oz, Fatih Mehmet Kandemi. The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach. Environmental science and pollution research international. 2023-07-15. PMID:37453011. |
moreover chr down-regulated cd-induced er stress markers (perk, ire1, atf6, chop, and grp78) and apoptosis markers (caspase-3, bax) lung tissue. |
2023-07-15 |
2023-08-14 |
rat |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |
| Xiaogang Huang, Xiongzhi He, Rongxian Qiu, Xuemei Xie, Fengfeng Zheng, Feihua Chen, Zhenting H. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333449. |
the expression levels of bmi1, kat2b, and proteins related to upr (p-eif2α, eif2α, atf4, and atf6), nf-κb (p65 and p-p65), apoptosis (cleaved caspase-3, bcl-2, and bax) and necroptosis (p-mlkl and mlkl) were determined by western blot. |
2023-06-19 |
2023-08-14 |
Not clear |
| Sung Woo Lee, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong-Seok Le. ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2023-06-01. PMID:37261864. |
atf6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes. |
2023-06-01 |
2023-08-14 |
mouse |
| Sung Woo Lee, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong-Seok Le. ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2023-06-01. PMID:37261864. |
the er stress and apoptosis response to cadmium were most strongly stimulated through the activating transcription factor 6 (atf6) pathway; in contrast, sirna-induced inhibition of protein expression could reduce apoptosis under stressful conditions. |
2023-06-01 |
2023-08-14 |
mouse |
| Boxin Li, Hui Yang, Haipeng Wu, Huanhuan Wang, Zhongming Ye, Yao Wu, Yuting Chen, Huanwen Tan. Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environmental toxicology. 2023-05-06. PMID:37148176. |
knockdown of atf6 enhanced autophagy and apoptosis levels and further inhibited mtor activation; activation of atf6 by aa147 enhanced cellular activity, suggesting that atf6 may affect cellular autophagy and apoptosis through mtor. |
2023-05-06 |
2023-08-14 |
human |
| Shima Poorghobadi, Kazem Baesi, Safoora Gharibzadeh, Reza Shirzad, Mohammad S Khosravy, Maryam Fazeli, Farzaneh Sheikholeslam. Autophagy and unfolded protein response induction: a crosstalk between street rabies virus and the host. Cell stress & chaperones. 2023-05-03. PMID:37133695. |
the expression of hypoxanthine-guanine phosphoribosyltransferase (hprt), ccaat/enhancer binding protein homologous protein (chop), apoptosis signal-regulating kinase 1 (ask1), activating transcription factor 6 (atf6), and caspase 3 (casp3) genes was also investigated. |
2023-05-03 |
2023-08-14 |
mouse |
| Xiaocheng Huang, Shanghong Ji, Chenchen Bian, Jian Sun, Hong J. The endoplasmic reticulum stress - Bcl-2-related ovarian killer (BOK) pathway participates in docosahexaenoic acid-induced adipocyte apoptosis in grass carp (Ctenopharyngodon Idella). Journal of animal science. 2023-04-17. PMID:37067261. |
two upr branches, the inositol-requiring enzyme 1 (ire1α) and activating transcription factor 6 (atf6) signaling pathways, are possibly important in dha-induced adipocyte apoptosis, unlike protein kinase rna-activated-like er kinase (perk). |
2023-04-17 |
2023-08-14 |
Not clear |
| Ting Yang, Yuhong Zhang, Lixuan Chen, Elizabeth Rosalind Thomas, Wenjing Yu, Bo Cheng, Xiang L. The potential roles of ATF family in the treatment of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 161. 2023-03-19. PMID:36934558. |
atf5 is presumed to regulate apoptosis, and atf6 is involved in the regulation of endoplasmic reticulum stress (ers). |
2023-03-19 |
2023-08-14 |
Not clear |
| Elif Ayazoglu Demir, Selim Demir, Ilke Onur Kazaz, Hatice Kucuk, Nihal Turkmen Alemdar, Ali Buyuk, Ahmet Mentese, Yuksel Aliyaziciogl. Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress. Tissue & cell. vol 82. 2023-03-15. PMID:36921493. |
the levels of dna damage [8-hydroxy-2'-deoxyguanosine (8-ohdg)], antioxidant system [superoxide dismutase (sod) and catalase (cat)], pro-inflammatory cytokines [high mobility group box 1 (hmgb1), nuclear factor kappa b protein 65 (nf-κb p65), tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6) and myeloperoxidase (mpo)], er stress [78-kda glucose-regulated protein (grp78), activating transcription factor 6 (atf6) and ccaat-enhancer-binding protein homologous protein (chop)] and apoptosis (caspase-3) markers in testicular tissues were determined using commercial enzyme-linked immunosorbent assay (elisa) kits. |
2023-03-15 |
2023-08-14 |
rat |
| Zhisheng Li, Xinzhu Liu, Kun Zhang, Hongqing Zhao, Peng Luo, Dawei Li, Zhaoxing Liu, Huageng Yuan, Bohan Zhang, Xiaoye Xie, Chuan'an She. Role and mechanism of endoplasmic reticulum stress in mice pancreatic islet dysfunction after severe burns. Journal of burn care & research : official publication of the American Burn Association. 2023-03-04. PMID:36869805. |
the er stress-related pathway markers bip, xbp1, p-perk, p-eif2α, chop, atf6, apoptosis-related protein cleaved-caspase 3, and islet cell apoptosis were measured. |
2023-03-04 |
2023-08-14 |
mouse |
| Zhisheng Li, Xinzhu Liu, Kun Zhang, Hongqing Zhao, Peng Luo, Dawei Li, Zhaoxing Liu, Huageng Yuan, Bohan Zhang, Xiaoye Xie, Chuan'an She. Role and mechanism of endoplasmic reticulum stress in mice pancreatic islet dysfunction after severe burns. Journal of burn care & research : official publication of the American Burn Association. 2023-03-04. PMID:36869805. |
the expression of bip, xbp1, p-perk, p-eif2α, chop, atf6, cleaved-caspase 3, and islet cell apoptosis were increased significantly after severe burns. |
2023-03-04 |
2023-08-14 |
mouse |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Mohammad Keyvaloo Shahrestanaki, Abdollah Mirjani, Mustafa Ghanadian, Mahmoud Aghae. Cycloartane triterpenoid from Euphorbia macrostegia modulates ER stress signaling pathways to induce apoptosis in MDA-MB231 and MCF-7 breast cancer cell lines. Naunyn-Schmiedeberg's archives of pharmacology. 2023-02-24. PMID:36826495. |
cycloart-e25 potently induces protein aggregation and upregulated chop, perk, atf6, bip, and xbp1 factors in both mda-mb-231 mb-231 and mcf-7 cell lines, indicating the involvement of ers in cycloart-e25-mediated apoptosis. |
2023-02-24 |
2023-08-14 |
Not clear |