| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kwang Hong Tay, Qi Luan, Amanda Croft, Chen Chen Jiang, Lei Jin, Xu Dong Zhang, Hsin-Yi Tsen. Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24240056. |
taken together, these results identify sustained activation of the ire1α and atf6 pathways of the upr driven by the mek/erk pathway as an important protective mechanism against er stress-induced apoptosis in melanoma cells. |
2014-08-18 |
2023-08-12 |
Not clear |
| Feng-Jin Guo, Zhangyuan Xiong, Xiaojie Lu, Mengliang Ye, Xiaofeng Han, Rong Jian. ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269637. |
atf6 upregulates xbp1s and inhibits er stress-mediated apoptosis in osteoarthritis cartilage. |
2014-08-18 |
2023-08-12 |
Not clear |
| Feng-Jin Guo, Zhangyuan Xiong, Xiaojie Lu, Mengliang Ye, Xiaofeng Han, Rong Jian. ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269637. |
the purpose of this study was to determine (1) whether xbp1s influences er stress-mediated apoptosis in osteoarthritis (oa); (2) whether atf6 regulates ire1/xbp1 signal pathway in oa cartilage; (3) what are the associated molecules affecting apoptosis in osteoarthritis and the molecular events underlying this process. |
2014-08-18 |
2023-08-12 |
Not clear |
| Shanshan Zhou, Xia Yin, Yang Zheng, Xiao Miao, Wenke Feng, Jun Cai, Lu Ca. Metallothionein prevents intermittent hypoxia-induced cardiac endoplasmic reticulum stress and cell death likely via activation of Akt signaling pathway in mice. Toxicology letters. vol 227. issue 2. 2014-06-27. PMID:24680926. |
ih exposures for 3 days to 4 weeks significantly increased cardiac er stress and apoptosis, shown by the increased expression of grp78, atf6 and chop, the activation of caspase-12 and capase-3, and the decreased bcl2/bax expression ratio, predominantly in the 3rd week of ih exposures. |
2014-06-27 |
2023-08-12 |
mouse |
| Amin Afrazi, Maria F Branca, Chhinder P Sodhi, Misty Good, Yukihiro Yamaguchi, Charlotte E Egan, Peng Lu, Hongpeng Jia, Shahab Shaffiey, Joyce Lin, Congrong Ma, Garrett Vincent, Thomas Prindle, Samantha Weyandt, Matthew D Neal, John A Ozolek, John Wiersch, Markus Tschurtschenthaler, Chiyo Shiota, George K Gittes, Timothy R Billiar, Kevin Mollen, Arthur Kaser, Richard Blumberg, David J Hacka. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. The Journal of biological chemistry. vol 289. issue 14. 2014-05-30. PMID:24519940. |
tlr4-mediated er stress and apoptosis of iscs required perk (protein kinase-related pkr-like er kinase), chop (c/ebp homologous protein), and myd88 (myeloid differentiation primary response gene 88), but not atf6 (activating transcription factor 6) or xbp1 (x-box-binding protein 1). |
2014-05-30 |
2023-08-12 |
mouse |
| Nina Weiß, Agatha Stegemann, Marwa A T Elsayed, Karin U Schallreuter, Thomas A Luger, Karin Loser, Dieter Metze, Carsten Weishaupt, Markus Böh. Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells. The Journal of investigative dermatology. vol 134. issue 1. 2014-03-04. PMID:23884247. |
mechanistic studies revealed that dec-rrll-cmk induces classical apoptosis of melanoma cells in vitro and affects expression of several ski-1 target genes including activating transcription factor 6 (atf6). |
2014-03-04 |
2023-08-12 |
mouse |
| Nina Weiß, Agatha Stegemann, Marwa A T Elsayed, Karin U Schallreuter, Thomas A Luger, Karin Loser, Dieter Metze, Carsten Weishaupt, Markus Böh. Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells. The Journal of investigative dermatology. vol 134. issue 1. 2014-03-04. PMID:23884247. |
however, atf6 gene silencing does not result in apoptosis of melanoma cells, suggesting that dec-rrll-cmk induces cell death in an atf6-independent manner. |
2014-03-04 |
2023-08-12 |
mouse |
| Wei-Guang Zhang, Lin Chen, Qin Dong, Juan He, Han-Dong Zhao, Feng-Lan Li, Hui L. Mmu-miR-702 functions as an anti-apoptotic mirtron by mediating ATF6 inhibition in mice. Gene. vol 531. issue 2. 2013-12-23. PMID:24035931. |
according to over-expression experiments, mmu-mir-702 inhibited apoptosis as well as the expression levels of a subset of apoptosis-related genes including activating transcription factor 6 (atf6). |
2013-12-23 |
2023-08-12 |
mouse |
| Sun-Ji Park, Tae-Shin Kim, Choon-Keun Park, Sang-Hee Lee, Jin-Man Kim, Kyu-Sun Lee, In-Kyu Lee, Jeen-Woo Park, Mark A Lawson, Dong-Seok Le. hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. Journal of molecular endocrinology. vol 50. issue 2. 2013-08-08. PMID:23256993. |
these findings suggest that hcg-induced er stress plays important roles in steroidogenic enzyme expression via modulation of the atf6 pathway as well as er stress-mediated apoptosis in leydig cells. |
2013-08-08 |
2023-08-12 |
mouse |
| Shutong Yao, Chuanlong Zong, Ying Zhang, Hui Sang, Mingfeng Yang, Peng Jiao, Yongqi Fang, Nana Yang, Guohua Song, Shucun Qi. Activating transcription factor 6 mediates oxidized LDL-induced cholesterol accumulation and apoptosis in macrophages by up-regulating CHOP expression. Journal of atherosclerosis and thrombosis. vol 20. issue 1. 2013-07-10. PMID:23037953. |
this study was to explore whether activating transcription factor 6 (atf6), an important sensor to endoplasmic reticulum (er) stress, would mediate oxidized low-density lipoprotein (ox-ldl)- induced cholesterol accumulation and apoptosis in cultured macrophages and the underlying molecular mechanisms. |
2013-07-10 |
2023-08-12 |
Not clear |
| Payam Mohammad Gharibani, Jigar Modi, Chunliu Pan, Janet Menzie, Zhiyuan Ma, Po-Chih Chen, Rui Tao, Howard Prentice, Jang-Yen W. The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture. Advances in experimental medicine and biology. vol 776. 2013-06-12. PMID:23392887. |
our results show not only taurine elicits neuroprotection through the activation of the atf6 and the ire1 pathways, but also it can reduce apoptosis in these models. |
2013-06-12 |
2023-08-12 |
rat |
| Pengfei Lin, YanZhou Yang, Xiao Li, Fenglei Chen, ChenChen Cui, Linyong Hu, Qian Li, Wei Liu, YaPing Ji. Endoplasmic reticulum stress is involved in granulosa cell apoptosis during follicular atresia in goat ovaries. Molecular reproduction and development. vol 79. issue 6. 2012-11-08. PMID:22532439. |
activating transcription factor-6 (atf6) and atf4 mrnas were significantly increased during granulosa cell apoptosis in vivo; in contrast to atf6, atf4 mrna was attenuated after 16 hr of culture despite the persistence of er stress. |
2012-11-08 |
2023-08-12 |
Not clear |
| Pengfei Lin, YanZhou Yang, Xiao Li, Fenglei Chen, ChenChen Cui, Linyong Hu, Qian Li, Wei Liu, YaPing Ji. Endoplasmic reticulum stress is involved in granulosa cell apoptosis during follicular atresia in goat ovaries. Molecular reproduction and development. vol 79. issue 6. 2012-11-08. PMID:22532439. |
serum deprivation could also increase apoptosis of cultured granulosa cells through the er stress pathway as both atf6 and perk/eif2α/atf4 signaling have been implicated in the granulosa cell apoptosis of atretic follicles. |
2012-11-08 |
2023-08-12 |
Not clear |
| I Galindo, B Hernáez, R Muñoz-Moreno, M A Cuesta-Geijo, I Dalmau-Mena, C Alons. The ATF6 branch of unfolded protein response and apoptosis are activated to promote African swine fever virus infection. Cell death & disease. vol 3. 2012-11-08. PMID:22764100. |
the atf6 branch of unfolded protein response and apoptosis are activated to promote african swine fever virus infection. |
2012-11-08 |
2023-08-12 |
Not clear |
| Kinnosuke Yahiro, Hiroyasu Tsutsuki, Kohei Ogura, Sayaka Nagasawa, Joel Moss, Masatoshi Nod. Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells. Infection and immunity. vol 80. issue 5. 2012-06-12. PMID:22354021. |
here, we show that an early event in subab-induced apoptosis in hela cells is mediated by rna-dependent protein kinase (pkr)-like er kinase (perk), not activating transcription factor 6 (atf6) or inositol-requiring enzyme 1(ire1), two other er stress sensors. |
2012-06-12 |
2023-08-12 |
Not clear |
| Sandrine Lépine, Jeremy C Allegood, Yvette Edmonds, Sheldon Milstien, Sarah Spiege. Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22052905. |
moreover, silencing atg5 or the three sensors of the unfolded protein response, ire1α, atf6, and pkr-like eif2α kinase (perk), significantly decreased both autophagy and apoptosis. |
2012-02-27 |
2023-08-12 |
Not clear |
| Can E Senkal, Suriyan Ponnusamy, Yefim Manevich, Marisa Meyers-Needham, Sahar A Saddoughi, Archana Mukhopadyay, Paul Dent, Jacek Bielawski, Besim Ogretme. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. The Journal of biological chemistry. vol 286. issue 49. 2012-02-21. PMID:22013072. |
overall, these data suggest a novel mechanism of how cers6/c(16)-ceramide alteration activates atf6 and induces er-stress-mediated apoptosis in squamous cell carcinomas. |
2012-02-21 |
2023-08-12 |
mouse |
| Palaniyandi Ravanan, Renata Sano, Priti Talwar, Satoshi Ogasawara, Shu-ichi Matsuzawa, Michael Cuddy, Sanjay K Singh, G S R Subba Rao, Paturu Kondaiah, John C Ree. Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines. Molecular cancer therapeutics. vol 10. issue 9. 2012-01-23. PMID:21746806. |
similar to other proapoptotic synthetic triterpenoid compounds, cemb-induced apoptosis involved endoplasmic reticulum stress, as shown by partial rescue of tumor cells by sirna-mediated knockdown of expression of genes involved in the unfolded protein response such as ire1α, perk, and atf6. |
2012-01-23 |
2023-08-12 |
Not clear |
| Nobuhiro Morishima, Keiko Nakanishi, Akihiko Nakan. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. The Journal of biological chemistry. vol 286. issue 40. 2011-12-09. PMID:21841196. |
activating transcription factor-6 (atf6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (mcl-1) protein via induction of ww domain binding protein 1. |
2011-12-09 |
2023-08-12 |
Not clear |
| Nobuhiro Morishima, Keiko Nakanishi, Akihiko Nakan. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. The Journal of biological chemistry. vol 286. issue 40. 2011-12-09. PMID:21841196. |
this implies that active atf6 has the ability to mediate apoptosis. |
2011-12-09 |
2023-08-12 |
Not clear |