| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madeleine S A Tan, Faraz Honarparvar, James R Falconer, Harendra S Parekh, Preeti Pandey, Dan J Siskin. A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions. Psychopharmacology. vol 238. issue 3. 2021-03-16. PMID:33410989. |
clozapine is the most effective antipsychotic for treatment-refractory schizophrenia for reducing positive psychotic symptoms. |
2021-03-16 |
2023-08-13 |
Not clear |
| Dorothea Lesche, Sam Mostafa, Ian Everall, Christos Pantelis, Chad A Bousma. Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity. The pharmacogenomics journal. vol 20. issue 2. 2021-03-12. PMID:31616047. |
among 66 adult schizophrenia patients treated with clozapine-based combination therapies, we explored the impact of genotype-predicted cyp1a2, cyp2d6, and cyp2c19 activity on dose-adjusted clozapine concentrations and symptom severity, with and without correction for inhibitors and inducers of these enzymes. |
2021-03-12 |
2023-08-13 |
Not clear |
| M Nystazaki, M Karanikola, V Gartzoni, A Georgou, St Tolia, Chr Liapis, M Psomiadi, G Alevizopoulo. [Development and implementation of clozapine protocol in patients with schizophrenia in Greece]. Psychiatrike = Psychiatriki. vol 31. issue 1. 2021-03-01. PMID:32544078. |
[development and implementation of clozapine protocol in patients with schizophrenia in greece]. |
2021-03-01 |
2023-08-13 |
Not clear |
| M Nystazaki, M Karanikola, V Gartzoni, A Georgou, St Tolia, Chr Liapis, M Psomiadi, G Alevizopoulo. [Development and implementation of clozapine protocol in patients with schizophrenia in Greece]. Psychiatrike = Psychiatriki. vol 31. issue 1. 2021-03-01. PMID:32544078. |
clozapine efficacy is well established in people diagnosed with schizophrenia via reducing both positive and negative symptoms. |
2021-03-01 |
2023-08-13 |
Not clear |
| In Won Chung, Hye Sung Kim, Jung Hyun Kim, Jin Hyeok Jang, Yong Sik Ki. Resolution of Persistent Auditory Verbal Hallucinations after Long-term Electroconvulsive Therapy Maintenance: A Case Report of a Patient with Clozapine-resistant Schizophrenia. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 19. issue 1. 2021-02-28. PMID:33508802. |
a 32-year-old woman with schizophrenia and persistent auditory verbal hallucinations (avhs), which caused continuous suicidal thoughts and depression, was treated with electroconvulsive therapy (ect) of an acute course followed by maintenance ect (m-ect) augmented onto clozapine for 7 years. |
2021-02-28 |
2023-08-13 |
Not clear |
| Anna Dietrich-Muszalska, Joanna Kolodziejczyk-Czepas, Pawel Nowa. Comparative Study of the Effects of Atypical Antipsychotic Drugs on Plasma and Urine Biomarkers of Oxidative Stress in Schizophrenic Patients. Neuropsychiatric disease and treatment. vol 17. 2021-02-26. PMID:33628026. |
therefore, in the present study, we assessed the ability of six atypical ads (clozapine, olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone) used in schizophrenia treatment to modulate oxidative damage to different biomolecules such as lipids and proteins. |
2021-02-26 |
2023-08-13 |
Not clear |
| Motohiro Okada, Kouji Fukuyama, Takashi Shiroyama, Masahiko Murat. A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43. International journal of molecular sciences. vol 21. issue 19. 2021-02-25. PMID:32987640. |
clozapine (clz) is an approved antipsychotic agent for the medication of treatment-resistant schizophrenia but is also well known as one of the most toxic antipsychotics. |
2021-02-25 |
2023-08-13 |
Not clear |
| M Z van der Horst, F van Houwelingen, J J Luyk. Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report. BMC psychiatry. vol 20. issue 1. 2021-02-22. PMID:33246443. |
clozapine is an atypical antipsychotic proven to be superior in the treatment of treatment-resistant schizophrenia. |
2021-02-22 |
2023-08-13 |
Not clear |
| Albert T Higgins-Chen, Marco P Boks, Christiaan H Vinkers, René S Kahn, Morgan E Levin. Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects. Biological psychiatry. vol 88. issue 3. 2021-02-18. PMID:32199607. |
schizophrenia and epigenetic aging biomarkers: increased mortality, reduced cancer risk, and unique clozapine effects. |
2021-02-18 |
2023-08-13 |
Not clear |
| Chieh-Hsin Lin, Yu-Ming Chen, Hsien-Yuan Lan. Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant. Current drug targets. vol 21. issue 6. 2021-02-17. PMID:31660823. |
clozapine has been regarded as the last-line antipsychotic agent for patients with refractory schizophrenia. |
2021-02-17 |
2023-08-13 |
Not clear |
| Chieh-Hsin Lin, Yu-Ming Chen, Hsien-Yuan Lan. Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant. Current drug targets. vol 21. issue 6. 2021-02-17. PMID:31660823. |
earlier, the inhibition of d-amino acid oxidase (daao) that may metabolize d-amino acids and activate nmdar has been reported to be beneficial for patients with schizophrenia receiving antipsychotics except for clozapine. |
2021-02-17 |
2023-08-13 |
Not clear |
| b' Nikola Gligorijevi\\xc4\\x87, Tamara Vasovi\\xc4\\x87, Steva Levi\\xc4\\x87, \\xc4\\x8cedo Miljevi\\xc4\\x87, Olgica Nedi\\xc4\\x87, Milan Nikoli\\xc4\\x8. Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. International journal of biological macromolecules. vol 154. 2021-02-15. PMID:32184141.' |
clozapine is an atypical antipsychotic used for the treatment of schizophrenia. |
2021-02-15 |
2023-08-13 |
Not clear |
| Joana Viana, Nick Wildman, Eilis Hannon, Audrey Farbos, Paul O' Neill, Karen Moore, Ronny van Aerle, Greg Paull, Eduarda Santos, Jonathan Mil. Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. vol 6. issue 1. 2021-02-13. PMID:32015324. |
clozapine is an atypical antipsychotic medication that is used to treat schizophrenia patients who are resistant to other antipsychotic drugs. |
2021-02-13 |
2023-08-13 |
zebrafish |
| Joana Viana, Nick Wildman, Eilis Hannon, Audrey Farbos, Paul O' Neill, Karen Moore, Ronny van Aerle, Greg Paull, Eduarda Santos, Jonathan Mil. Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. vol 6. issue 1. 2021-02-13. PMID:32015324. |
network analysis identified co-expression modules characterised by striking changes in module connectivity in response to clozapine, and these were enriched for regulatory pathways relevant to the etiology of schizophrenia. |
2021-02-13 |
2023-08-13 |
zebrafish |
| Lennart Kyllesø, Robert Løvsletten Smith, Øystein Karlstad, Ole A Andreassen, Espen Molde. Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. NPJ schizophrenia. vol 6. issue 1. 2021-02-13. PMID:32681055. |
adequate antipsychotic treatment intensity is required for defining treatment-resistant schizophrenia (trs) and justifying clozapine treatment. |
2021-02-13 |
2023-08-13 |
Not clear |
| Siamak Sabou. Clozapine screening in people taking clozapine: Understanding diagnostic accuracy in schizophrenia. Schizophrenia research. vol 222. 2021-02-10. PMID:32565153. |
clozapine screening in people taking clozapine: understanding diagnostic accuracy in schizophrenia. |
2021-02-10 |
2023-08-13 |
Not clear |
| Ching-Hua Lin, Hung-Yu Chan, Chun-Chi Hsu, Feng-Chua Che. Temporal trends in clozapine use at time of discharge among people with schizophrenia at two public psychiatric hospitals in Taiwan, 2006-2017. Scientific reports. vol 10. issue 1. 2021-02-10. PMID:33093511. |
temporal trends in clozapine use at time of discharge among people with schizophrenia at two public psychiatric hospitals in taiwan, 2006-2017. |
2021-02-10 |
2023-08-13 |
Not clear |
| Ching-Hua Lin, Hung-Yu Chan, Chun-Chi Hsu, Feng-Chua Che. Temporal trends in clozapine use at time of discharge among people with schizophrenia at two public psychiatric hospitals in Taiwan, 2006-2017. Scientific reports. vol 10. issue 1. 2021-02-10. PMID:33093511. |
clozapine treatment remains the gold standard for treatment-resistant schizophrenia. |
2021-02-10 |
2023-08-13 |
Not clear |
| Ching-Hua Lin, Hung-Yu Chan, Chun-Chi Hsu, Feng-Chua Che. Temporal trends in clozapine use at time of discharge among people with schizophrenia at two public psychiatric hospitals in Taiwan, 2006-2017. Scientific reports. vol 10. issue 1. 2021-02-10. PMID:33093511. |
this study aimed to describe temporal trends in clozapine use at discharge among patients with schizophrenia at two of the largest public psychiatric hospitals in taiwan over a twelve-year period. |
2021-02-10 |
2023-08-13 |
Not clear |
| Cynthia Yi-An Chen, Kah Kheng Goh, Chun-Hsin Chen, Mong-Liang L. The Role of Adiponectin in the Pathogenesis of Metabolic Disturbances in Patients With Schizophrenia. Frontiers in psychiatry. vol 11. 2021-02-10. PMID:33551872. |
we propose that olanzapine and clozapine might have a time-dependent biphasic effect on blood adiponectin levels in patients with schizophrenia. |
2021-02-10 |
2023-08-13 |
Not clear |