| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hetal P Patel, Priyanka S Chaudhari, Priyanshi A Gandhi, Bhargavi V Desai, Ditixa T Desai, Praful P Dedhiya, Bhavin A Vyas, Furqan A Maulv. Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: Optimization and in vivo pharmacokinetic studies. International journal of pharmaceutics. vol 600. 2021-06-17. PMID:33737093. |
clozapine is widely used to treat schizophrenia as an atypical antipsychotic. |
2021-06-17 |
2023-08-13 |
Not clear |
| Virginie Moulier, Mohamed Wassim Krir, Marine Dalmont, Olivier Guillin, Maud Rothärme. A prospective multicenter assessor-blinded randomized controlled study to compare the efficacy of short versus long protocols of electroconvulsive therapy as an augmentation strategy to clozapine in patients with ultra-resistant schizophrenia (SURECT study). Trials. vol 22. issue 1. 2021-06-17. PMID:33858488. |
a prospective multicenter assessor-blinded randomized controlled study to compare the efficacy of short versus long protocols of electroconvulsive therapy as an augmentation strategy to clozapine in patients with ultra-resistant schizophrenia (surect study). |
2021-06-17 |
2023-08-13 |
Not clear |
| Virginie Moulier, Mohamed Wassim Krir, Marine Dalmont, Olivier Guillin, Maud Rothärme. A prospective multicenter assessor-blinded randomized controlled study to compare the efficacy of short versus long protocols of electroconvulsive therapy as an augmentation strategy to clozapine in patients with ultra-resistant schizophrenia (SURECT study). Trials. vol 22. issue 1. 2021-06-17. PMID:33858488. |
our objective is to compare the efficacy and tolerance between two protocols of combined ect and clozapine treatment in patients with ultra-resistant schizophrenia (urs): a 6-month protocol (short protocol with 20 ect sessions) and a 12-month protocol (long protocol with 40 ect sessions). |
2021-06-17 |
2023-08-13 |
Not clear |
| Rikinkumar S Patel, Nikhila Veluri, Alex Suchorab, Kaushal Shah, Geetika Verm. Clozapine-Induced Constipation: A Case Report and Review of Current Management Guidelines. Cureus. vol 13. issue 5. 2021-06-15. PMID:34123610. |
clozapine is a second-generation antipsychotic recommended after the failure of two or more antipsychotics for treatment-resistant schizophrenia. |
2021-06-15 |
2023-08-13 |
Not clear |
| Dragana Ignjatovic Ristic, Dan Cohen, Ivan Risti. Prescription attitudes and practices regarding clozapine among Serbian psychiatrists: results of a nationwide survey. Therapeutic advances in psychopharmacology. vol 11. 2021-06-11. PMID:34104415. |
despite clozapine being the most effective treatment for treatment-resistant schizophrenia (trs), a clear explanation as to why it is underutilized and why its initiation is delayed remains unclear. |
2021-06-11 |
2023-08-13 |
Not clear |
| Michelle Iris Jakobsen, H Grønborg, H V Hansen, A Fink-Jense. Clozapine-associated neutropenia following augmentation with sodium valproate. SAGE open medical case reports. vol 9. 2021-06-11. PMID:34104448. |
clozapine is gold standard for the management of treatment-resistant schizophrenia. |
2021-06-11 |
2023-08-13 |
Not clear |
| Atsuhiro Miyazawa, Nobuhisa Kanahara, Yusuke Nakata, Satoshi Kodama, Hiroshi Kimura, Atsushi Kimura, Yasunori Oda, Hiroyuki Watanabe, Masaomi Iy. Clozapine Prolongs Cortical Silent Period in Patients with Treatment-Resistant Schizophrenia. Psychopharmacology bulletin. vol 51. issue 2. 2021-06-08. PMID:34092820. |
clozapine prolongs cortical silent period in patients with treatment-resistant schizophrenia. |
2021-06-08 |
2023-08-13 |
Not clear |
| Atsuhiro Miyazawa, Nobuhisa Kanahara, Yusuke Nakata, Satoshi Kodama, Hiroshi Kimura, Atsushi Kimura, Yasunori Oda, Hiroyuki Watanabe, Masaomi Iy. Clozapine Prolongs Cortical Silent Period in Patients with Treatment-Resistant Schizophrenia. Psychopharmacology bulletin. vol 51. issue 2. 2021-06-08. PMID:34092820. |
although clozapine exhibited high efficacy for treating the symptoms of patients with treatment-resistant schizophrenia (trs), its precise action mechanisms have not been fully understood. |
2021-06-08 |
2023-08-13 |
Not clear |
| Rachel Grimminck, Oloruntoba Oluboka, Manvir Sihota, Donna L Rutherford, Helen Yeun. Combination of Clozapine With Long-Acting Injectable Antipsychotics in Treatment-Resistant Schizophrenia: Preliminary Evidence From Health Care Utilization Indices. The primary care companion for CNS disorders. vol 22. issue 4. 2021-06-07. PMID:32678523. |
combination of clozapine with long-acting injectable antipsychotics in treatment-resistant schizophrenia: preliminary evidence from health care utilization indices. |
2021-06-07 |
2023-08-13 |
Not clear |
| Rachel Grimminck, Oloruntoba Oluboka, Manvir Sihota, Donna L Rutherford, Helen Yeun. Combination of Clozapine With Long-Acting Injectable Antipsychotics in Treatment-Resistant Schizophrenia: Preliminary Evidence From Health Care Utilization Indices. The primary care companion for CNS disorders. vol 22. issue 4. 2021-06-07. PMID:32678523. |
clozapine is indicated for treatment-resistant schizophrenia (trs), but only 30%-60% of patients will respond. |
2021-06-07 |
2023-08-13 |
Not clear |
| Basel A Abdel-Wahab, Safaa Yousef Salem, Hala Mostafa Mohammed, Nashwa Ahmed Mohammed, Helal F Hett. The role of vimentin, Connexin-43 proteins, and oxidative stress in the protective effect of propranolol against clozapine-induced myocarditis and apoptosis in rats. European journal of pharmacology. vol 890. 2021-06-07. PMID:33098837. |
clozapine (clz) represents an effective treatment for resistant schizophrenia. |
2021-06-07 |
2023-08-13 |
rat |
| Shinwon Kang, Hyun Jong Noh, Soo Hyeon Bae, Yong-Seok Kim, Hogun Lew, Jisoo Lim, Se Joo Kim, Kyung Sue Hong, Jong-Cheol Rah, Chul Hoon Ki. Clozapine generates obsessive compulsive disorder-like behavior in mice. Molecular brain. vol 13. issue 1. 2021-06-04. PMID:32471517. |
however, because ocs are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate ocs de novo. |
2021-06-04 |
2023-08-13 |
mouse |
| Shinwon Kang, Hyun Jong Noh, Soo Hyeon Bae, Yong-Seok Kim, Hogun Lew, Jisoo Lim, Se Joo Kim, Kyung Sue Hong, Jong-Cheol Rah, Chul Hoon Ki. Clozapine generates obsessive compulsive disorder-like behavior in mice. Molecular brain. vol 13. issue 1. 2021-06-04. PMID:32471517. |
these data demonstrate that chronic clozapine treatment can generate ocd-like behavior in mice and support the hypothesis that clozapine produces de novo ocs regardless of schizophrenia status. |
2021-06-04 |
2023-08-13 |
mouse |
| Nobuyuki Nomura, Kohei Kitagawa, Ryuhei So, Fuminari Misawa, Masafumi Kodama, Hiroyoshi Takeuchi, Robert Bies, Thomas Straubinger, Christopher Banker, Yuya Mizuno, Masaru Mimura, Hiroyuki Uchid. Comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study. Therapeutic advances in psychopharmacology. vol 11. 2021-05-30. PMID:34046160. |
comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study. |
2021-05-30 |
2023-08-13 |
Not clear |
| Nobuyuki Nomura, Kohei Kitagawa, Ryuhei So, Fuminari Misawa, Masafumi Kodama, Hiroyoshi Takeuchi, Robert Bies, Thomas Straubinger, Christopher Banker, Yuya Mizuno, Masaru Mimura, Hiroyuki Uchid. Comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study. Therapeutic advances in psychopharmacology. vol 11. 2021-05-30. PMID:34046160. |
there have been scarce data on the distribution of clozapine concentrations in comparison with the recommended range (350-600 ng/ml) or their relationship with side effects among patients with treatment-resistant schizophrenia. |
2021-05-30 |
2023-08-13 |
Not clear |
| Satish Suhas, Vijay Kumar, Dinakaran Damodharan, Priyamvada Sharma, Naren P Rao, Shivarama Varambally, Ganesan Venkatasubramanian, Pratima Murthy, Bangalore N Gangadha. Do Indian patients with schizophrenia need half the recommended clozapine dose to achieve therapeutic serum level? An exploratory study. Schizophrenia research. vol 222. 2021-05-18. PMID:32518001. |
do indian patients with schizophrenia need half the recommended clozapine dose to achieve therapeutic serum level? |
2021-05-18 |
2023-08-13 |
human |
| Satish Suhas, Vijay Kumar, Dinakaran Damodharan, Priyamvada Sharma, Naren P Rao, Shivarama Varambally, Ganesan Venkatasubramanian, Pratima Murthy, Bangalore N Gangadha. Do Indian patients with schizophrenia need half the recommended clozapine dose to achieve therapeutic serum level? An exploratory study. Schizophrenia research. vol 222. 2021-05-18. PMID:32518001. |
we measured the serum clozapine levels in 142 patients with schizophrenia and related disorders at a tertiary care psychiatric institute in india. |
2021-05-18 |
2023-08-13 |
human |
| Tiffany Brazile, Amr F Barakat, Syed Bukhari, Erik B Schelbert, Prem Soma. A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance. The American journal of case reports. vol 22. 2021-05-18. PMID:33990535. |
background clozapine, a second-generation antipsychotic, is often prescribed for refractory schizophrenia; however, it can cause life-threatening adverse events including agranulocytosis and myocarditis. |
2021-05-18 |
2023-08-13 |
Not clear |
| Tiffany Brazile, Amr F Barakat, Syed Bukhari, Erik B Schelbert, Prem Soma. A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance. The American journal of case reports. vol 22. 2021-05-18. PMID:33990535. |
case report a 25-year-old man with refractory schizophrenia was admitted with severe psychotic symptoms and started on a rapid titration of clozapine. |
2021-05-18 |
2023-08-13 |
Not clear |
| Tiffany Brazile, Amr F Barakat, Syed Bukhari, Erik B Schelbert, Prem Soma. A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance. The American journal of case reports. vol 22. 2021-05-18. PMID:33990535. |
this report highlights that myocarditis can be associated with clozapine pharmacotherapy in patients with schizophrenia and demonstrates the value of diagnosis using non-invasive cmr. |
2021-05-18 |
2023-08-13 |
Not clear |