| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joomi Lee, Min-Gul Kim, Hyeon-Cheol Jeong, Kwang-Hee Shi. Physiologically-based pharmacokinetic model for clozapine in Korean patients with schizophrenia. Translational and clinical pharmacology. vol 29. issue 1. 2021-04-16. PMID:33854999. |
this study aimed to develop a pbpk m&s of clozapine in korean patients with schizophrenia. |
2021-04-16 |
2023-08-13 |
Not clear |
| Miquel Bioque, Eduard Parellada, Clemente García-Rizo, Sílvia Amoretti, Adriana Fortea, Giovanni Oriolo, Pol Palau, Ester Boix-Quintana, Gemma Safont, Miquel Bernard. Clozapine and paliperidone palmitate antipsychotic combination in treatment-resistant schizophrenia and other psychotic disorders: A retrospective 6-month mirror-image study. European psychiatry : the journal of the Association of European Psychiatrists. vol 63. issue 1. 2021-04-13. PMID:32669145. |
clozapine and paliperidone palmitate antipsychotic combination in treatment-resistant schizophrenia and other psychotic disorders: a retrospective 6-month mirror-image study. |
2021-04-13 |
2023-08-13 |
Not clear |
| Sylwia Łukasiewic. Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D Polymers. vol 13. issue 7. 2021-04-13. PMID:33805130. |
development of a new polymeric nanocarrier dedicated to controlled clozapine delivery at the dopamine d clozapine, the second generation antipsychotic drug, is one of the prominent compounds used for treatment of schizophrenia. |
2021-04-13 |
2023-08-13 |
Not clear |
| Sylwia Łukasiewic. Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D Polymers. vol 13. issue 7. 2021-04-13. PMID:33805130. |
nevertheless, clozapine still remains the first-choice drug for the situation of drug-resistance schizophrenia. |
2021-04-13 |
2023-08-13 |
Not clear |
| Stefania Bonaccorso, Angelo Ricciardi, Sophie Ouabbou, Christos Theleritis, Arabella Ross-Michaelides, Antonio Metastasio, Neil Stewart, Marwa Mohammed, Fabrizio Schifan. Clozapine, neutropenia and Covid-19: should clinicians be concerned? 3 months report. Brain, behavior, & immunity - health. vol 13. 2021-04-06. PMID:33527097. |
clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. |
2021-04-06 |
2023-08-13 |
Not clear |
| Jessica Spokes, Samantha Hollingworth, Karl Winckel, Steve Kisely, Andrea Baker, Peter Cosgrove, Dan Siskin. Metformin reduces 12-month change in body weight among people newly commenced on clozapine: a retrospective naturalistic cohort study. Therapeutic advances in psychopharmacology. vol 11. 2021-04-03. PMID:33796266. |
as clozapine remains the most effective antipsychotic for treatment-resistant schizophrenia (trs), identifying treatments to ameliorate clozapine-induced weight gain (ciwg) is urgently needed to reduce this morality gap. |
2021-04-03 |
2023-08-13 |
Not clear |
| Ádám Menus, Ádám Kiss, Katalin Tóth, Dávid Sirok, Máté Déri, Ferenc Fekete, Gábor Csukly, Katalin Monostor. Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia. Scientific reports. vol 10. issue 1. 2021-03-29. PMID:33277605. |
clozapine is effective in treatment-resistant schizophrenia; however, adverse effects often result in discontinuation of clozapine therapy. |
2021-03-29 |
2023-08-13 |
Not clear |
| Ádám Menus, Ádám Kiss, Katalin Tóth, Dávid Sirok, Máté Déri, Ferenc Fekete, Gábor Csukly, Katalin Monostor. Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia. Scientific reports. vol 10. issue 1. 2021-03-29. PMID:33277605. |
in patients with schizophrenia (n = 96), development of clozapine concentration-dependent metabolic side-effects was found to be associated with pharmacokinetic variability related to cyp3a4 but not to cyp1a2 expression. |
2021-03-29 |
2023-08-13 |
Not clear |
| Dian-Jeng Li, Ching-Hua Lin, Cheng-Chung Che. Factors impeding switching from clozapine to paliperidone among patients with chronic schizophrenia-A retrospective cohort study. Experimental and clinical psychopharmacology. 2021-03-29. PMID:33779196. |
the present study aimed to investigate the predictors for failed switching from clozapine to paliperidone (fscp) among patients with chronic schizophrenia. |
2021-03-29 |
2023-08-13 |
human |
| Dian-Jeng Li, Ching-Hua Lin, Cheng-Chung Che. Factors impeding switching from clozapine to paliperidone among patients with chronic schizophrenia-A retrospective cohort study. Experimental and clinical psychopharmacology. 2021-03-29. PMID:33779196. |
this 9-year (january 2010-december 2018) retrospective study included 78 individuals with schizophrenia who wished to switch from clozapine to paliperidone and resided in a nursing home in taiwan. |
2021-03-29 |
2023-08-13 |
human |
| Rakesh Kumar, Arvind Sharma, Navneet Kaur, Anand Singh, Manik Chhabra, Rishabh Sharm. A case report on clozapine-induced ventricular ectopics: a fatal adverse drug reaction. Journal of basic and clinical physiology and pharmacology. vol 31. issue 3. 2021-03-26. PMID:32304306. |
background clozapine is one of the most efficacious antipsychotic drug used for the treatment-resistant schizophrenia; it is sometimes associated with serious adverse reactions like agranulocytosis, myocarditis, cardiac rhythm disturbances, etc. |
2021-03-26 |
2023-08-13 |
Not clear |
| Katsunori Toyoda, Takeo Hata, Shigeru Yamauchi, Shinya Kinoshita, Masami Nishihara, Kazuhisa Uchiyama, Ken Inada, Tetsufumi Kanazaw. Clozapine Is Better Tolerated in Younger Patients: Risk Factors for Discontinuation from a Nationwide Database in Japan. Psychiatry investigation. vol 18. issue 2. 2021-03-25. PMID:33460532. |
the effectiveness of clozapine is clearly superior to other antipsychotics in the treatment of refractory schizophrenia. |
2021-03-25 |
2023-08-13 |
Not clear |
| Melissa Sussman, Michael Epifania, Derrick Eng, Jae Cho, Richard Stewar. Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis. Case reports in psychiatry. vol 2021. 2021-03-24. PMID:33688445. |
clozapine, the choice atypical antipsychotic for refractory schizophrenia, schizoaffective disorder, and bipolar disorder, has been shown to reduce positive and negative symptoms of schizophrenia. |
2021-03-24 |
2023-08-13 |
Not clear |
| Shayan Amiri, Rana Dizaji, Majid Momeny, Evan Gauvin, Mir-Jamal Hossein. Clozapine attenuates mitochondrial dysfunction, inflammatory gene expression, and behavioral abnormalities in an animal model of schizophrenia. Neuropharmacology. vol 187. 2021-03-23. PMID:33636190. |
clozapine attenuates mitochondrial dysfunction, inflammatory gene expression, and behavioral abnormalities in an animal model of schizophrenia. |
2021-03-23 |
2023-08-13 |
rat |
| Basile Chrétien, Sophie Fedrizzi, Véronique Lelong-Boulouard, Marion Sassier, Joachim Alexandre, Charles Dolladill. Could N-acetylcysteine improve the safety of clozapine? Human psychopharmacology. vol 36. issue 2. 2021-03-22. PMID:33206415. |
clozapine is an atypical antipsychotic indicated in patients with treatment-resistant schizophrenia which remains underused due to safety issues. |
2021-03-22 |
2023-08-13 |
Not clear |
| Basile Chrétien, Sophie Fedrizzi, Véronique Lelong-Boulouard, Marion Sassier, Joachim Alexandre, Charles Dolladill. Could N-acetylcysteine improve the safety of clozapine? Human psychopharmacology. vol 36. issue 2. 2021-03-22. PMID:33206415. |
nac could also secondarily show positive knock-on effects for the patients by improving clinical symptoms of schizophrenia in synergy with clozapine, and by reducing substance abuse and thus by improving the patient's overall condition. |
2021-03-22 |
2023-08-13 |
Not clear |
| Menahem Krakowski, Umit Tural, Pál Czobo. The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol. The American journal of psychiatry. vol 178. issue 3. 2021-03-22. PMID:33472389. |
the importance of conduct disorder in the treatment of violence in schizophrenia: efficacy of clozapine compared with olanzapine and haloperidol. |
2021-03-22 |
2023-08-13 |
Not clear |
| Menahem Krakowski, Umit Tural, Pál Czobo. The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol. The American journal of psychiatry. vol 178. issue 3. 2021-03-22. PMID:33472389. |
this study is a head-to-head comparison of clozapine, olanzapine, and haloperidol in the treatment of violent schizophrenia patients with and without conduct disorder. |
2021-03-22 |
2023-08-13 |
Not clear |
| Jessica L Dawson, Janet K Sluggett, Jennifer L Schumann, Nicholas G Procter, J Simon Bel. Fatal poisonings involving clozapine: A 16-year review of Australian coronial investigations. The Australian and New Zealand journal of psychiatry. 2021-03-19. PMID:33736477. |
concerns about intentional and unintentional poisoning present a barrier to wider use of clozapine in treatment-resistant schizophrenia. |
2021-03-19 |
2023-08-13 |
Not clear |
| Mathias Lundberg, Sophie Curbo, Hannes Bohman, Ingrid Agartz, Sven-Ove Ögren, Cesare Patrone, Shiva Mansour. Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy. Bioscience reports. vol 40. issue 1. 2021-03-16. PMID:31919522. |
if the data are further confirmed in vivo, the results may encourage an expanded use of clozapine to restore impaired neurogenesis in schizophrenia. |
2021-03-16 |
2023-08-13 |
mouse |