| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinwon Kang, Hyun Jong Noh, Soo Hyeon Bae, Yong-Seok Kim, Hogun Lew, Jisoo Lim, Se Joo Kim, Kyung Sue Hong, Jong-Cheol Rah, Chul Hoon Ki. Clozapine generates obsessive compulsive disorder-like behavior in mice. Molecular brain. vol 13. issue 1. 2021-06-04. PMID:32471517. |
these data demonstrate that chronic clozapine treatment can generate ocd-like behavior in mice and support the hypothesis that clozapine produces de novo ocs regardless of schizophrenia status. |
2021-06-04 |
2023-08-13 |
mouse |
| Nobuyuki Nomura, Kohei Kitagawa, Ryuhei So, Fuminari Misawa, Masafumi Kodama, Hiroyoshi Takeuchi, Robert Bies, Thomas Straubinger, Christopher Banker, Yuya Mizuno, Masaru Mimura, Hiroyuki Uchid. Comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study. Therapeutic advances in psychopharmacology. vol 11. 2021-05-30. PMID:34046160. |
comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study. |
2021-05-30 |
2023-08-13 |
Not clear |
| Nobuyuki Nomura, Kohei Kitagawa, Ryuhei So, Fuminari Misawa, Masafumi Kodama, Hiroyoshi Takeuchi, Robert Bies, Thomas Straubinger, Christopher Banker, Yuya Mizuno, Masaru Mimura, Hiroyuki Uchid. Comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study. Therapeutic advances in psychopharmacology. vol 11. 2021-05-30. PMID:34046160. |
there have been scarce data on the distribution of clozapine concentrations in comparison with the recommended range (350-600 ng/ml) or their relationship with side effects among patients with treatment-resistant schizophrenia. |
2021-05-30 |
2023-08-13 |
Not clear |
| Satish Suhas, Vijay Kumar, Dinakaran Damodharan, Priyamvada Sharma, Naren P Rao, Shivarama Varambally, Ganesan Venkatasubramanian, Pratima Murthy, Bangalore N Gangadha. Do Indian patients with schizophrenia need half the recommended clozapine dose to achieve therapeutic serum level? An exploratory study. Schizophrenia research. vol 222. 2021-05-18. PMID:32518001. |
do indian patients with schizophrenia need half the recommended clozapine dose to achieve therapeutic serum level? |
2021-05-18 |
2023-08-13 |
human |
| Satish Suhas, Vijay Kumar, Dinakaran Damodharan, Priyamvada Sharma, Naren P Rao, Shivarama Varambally, Ganesan Venkatasubramanian, Pratima Murthy, Bangalore N Gangadha. Do Indian patients with schizophrenia need half the recommended clozapine dose to achieve therapeutic serum level? An exploratory study. Schizophrenia research. vol 222. 2021-05-18. PMID:32518001. |
we measured the serum clozapine levels in 142 patients with schizophrenia and related disorders at a tertiary care psychiatric institute in india. |
2021-05-18 |
2023-08-13 |
human |
| Tiffany Brazile, Amr F Barakat, Syed Bukhari, Erik B Schelbert, Prem Soma. A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance. The American journal of case reports. vol 22. 2021-05-18. PMID:33990535. |
background clozapine, a second-generation antipsychotic, is often prescribed for refractory schizophrenia; however, it can cause life-threatening adverse events including agranulocytosis and myocarditis. |
2021-05-18 |
2023-08-13 |
Not clear |
| Tiffany Brazile, Amr F Barakat, Syed Bukhari, Erik B Schelbert, Prem Soma. A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance. The American journal of case reports. vol 22. 2021-05-18. PMID:33990535. |
case report a 25-year-old man with refractory schizophrenia was admitted with severe psychotic symptoms and started on a rapid titration of clozapine. |
2021-05-18 |
2023-08-13 |
Not clear |
| Tiffany Brazile, Amr F Barakat, Syed Bukhari, Erik B Schelbert, Prem Soma. A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance. The American journal of case reports. vol 22. 2021-05-18. PMID:33990535. |
this report highlights that myocarditis can be associated with clozapine pharmacotherapy in patients with schizophrenia and demonstrates the value of diagnosis using non-invasive cmr. |
2021-05-18 |
2023-08-13 |
Not clear |
| Parita Shah, Eric Plitman, Yusuke Iwata, Julia Kim, Shinichiro Nakajima, Nathan Chan, Eric E Brown, Fernando Caravaggio, Edgardo Torres, Margaret Hahn, M Mallar Chakravarty, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrer. Glutamatergic neurometabolites and cortical thickness in treatment-resistant schizophrenia: Implications for glutamate-mediated excitotoxicity. Journal of psychiatric research. vol 124. 2021-05-14. PMID:32169688. |
the present study had two main aims: (1) to explore differences in cortical thickness between patients with treatment-resistant schizophrenia non-responsive to clozapine (ultra-treatment-resistant schizophrenia, utrs), patients with treatment-resistant schizophrenia responsive to clozapine (cloz-resp), patients responsive to first-line non-clozapine antipsychotics (fl-resp), and healthy controls (hcs); and (2) to test our hypothesis of structural compromise as a manifestation of neurotoxic effects from elevated glutamate (glu) (i.e. |
2021-05-14 |
2023-08-13 |
Not clear |
| Pramod C Nair, Ross A McKinnon, John O Miners, Tarun Bastiampilla. Binding of clozapine to the GABA Molecular psychiatry. vol 25. issue 9. 2021-05-14. PMID:32203158. |
binding of clozapine to the gaba clozapine is the gold-standard agent for treatment resistant schizophrenia but its mechanism of action remains unclear. |
2021-05-14 |
2023-08-13 |
Not clear |
| Takeo Hata, Tetsufumi Kanazawa, Takeshi Hamada, Masami Nishihara, Hiroshi Yoneda, Miki Nakajima, Takahiro Katsumat. The 12-year trend report of antipsychotic usage in a nationwide claims database derived from four million people in Japan. Journal of psychiatric research. vol 127. 2021-05-14. PMID:32450360. |
although the use of antipsychotics for schizophrenia in japan mostly corresponds to various clinical guidelines, limited use of clozapine and lais was identified. |
2021-05-14 |
2023-08-13 |
Not clear |
| Seyed Alireza Hosseini, Brianna Skrzypcak, Rama Yasaei, Sara Abdijadid, Fowrooz Joolhar, Theingi Tiffany Win, Leila Moosav. Successful Clozapine Re-Challenge After Suspected Clozapine-Induced Myocarditis. The American journal of case reports. vol 21. 2021-05-14. PMID:33137026. |
background clozapine plays a unique role in the management of treatment-resistant schizophrenia (trs). |
2021-05-14 |
2023-08-13 |
Not clear |
| Seyed Alireza Hosseini, Brianna Skrzypcak, Rama Yasaei, Sara Abdijadid, Fowrooz Joolhar, Theingi Tiffany Win, Leila Moosav. Successful Clozapine Re-Challenge After Suspected Clozapine-Induced Myocarditis. The American journal of case reports. vol 21. 2021-05-14. PMID:33137026. |
case report we present the case of a 22-year-old hispanic man with treatment-resistant schizophrenia and polysubstance use disorder (methamphetamine, cannabis, and alcohol) initiated on aggressive clozapine titration after lack of response to several other therapies. |
2021-05-14 |
2023-08-13 |
Not clear |
| Amjad Daaboul, Daniel Sedding, Sebastian Nuding, Artjom Schot. Successful Treatment of an Acute High-Dose Clozapine Poisoning without Detoxication. The American journal of case reports. vol 22. 2021-05-14. PMID:33591960. |
background clozapine is a well-proven atypical antipsychotic drug used for therapy of treatment-resistant schizophrenia. |
2021-05-14 |
2023-08-13 |
Not clear |
| Amjad Daaboul, Daniel Sedding, Sebastian Nuding, Artjom Schot. Successful Treatment of an Acute High-Dose Clozapine Poisoning without Detoxication. The American journal of case reports. vol 22. 2021-05-14. PMID:33591960. |
case report we report the case of a 28-year-old man with prior diagnosed schizophrenia who presumably ingested 8 g (regular maximum daily dose 900 mg/d) of clozapine with uncertain intent. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yusuke Iwata, Shinichiro Nakajima, Eric Plitman, Peter Truong, Ali Bani-Fatemi, Fernando Caravaggio, Julia Kim, Parita Shah, Wanna Mar, Sofia Chavez, Gary Remington, Philip Gerretsen, Vincenzo De Luca, Napapon Sailasuta, Ariel Graff-Guerrer. Glutathione Levels and Glutathione-Glutamate Correlation in Patients With Treatment-Resistant Schizophrenia. Schizophrenia bulletin open. vol 2. issue 1. 2021-05-13. PMID:33969302. |
patients with schizophrenia were categorized into 3 groups with respect to their antipsychotic response: (1) clozapine (clz) nonresponders, (2) clz responders, and (3) first-line responders (flr). |
2021-05-13 |
2023-08-13 |
Not clear |
| Aleksandar Todorovic, Sweta Lal, Frances Dark, Veronica De Monte, Steve Kisely, Dan Siskin. CBTp for people with treatment refractory schizophrenia on clozapine: a systematic review and meta-analysis. Journal of mental health (Abingdon, England). 2021-05-08. PMID:33076721. |
cbtp for people with treatment refractory schizophrenia on clozapine: a systematic review and meta-analysis. |
2021-05-08 |
2023-08-13 |
Not clear |
| Aleksandar Todorovic, Sweta Lal, Frances Dark, Veronica De Monte, Steve Kisely, Dan Siskin. CBTp for people with treatment refractory schizophrenia on clozapine: a systematic review and meta-analysis. Journal of mental health (Abingdon, England). 2021-05-08. PMID:33076721. |
cognitive behavioural therapy for psychosis (cbtp), an effective treatment for people with schizophrenia, may have a role in clozapine refractory schizophrenia. |
2021-05-08 |
2023-08-13 |
Not clear |
| Isabella R Willcocks, Sophie E Legge, Mariana Nalmpanti, Lucy Mazzeo, Adrian King, John Jansen, Marinka Helthuis, Michael J Owen, Michael C O'Donovan, James T R Walters, Antonio F Pardiña. Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959025. |
clozapine metabolism is associated with absolute neutrophil count in individuals with treatment-resistant schizophrenia. |
2021-05-08 |
2023-08-13 |
Not clear |
| Isabella R Willcocks, Sophie E Legge, Mariana Nalmpanti, Lucy Mazzeo, Adrian King, John Jansen, Marinka Helthuis, Michael J Owen, Michael C O'Donovan, James T R Walters, Antonio F Pardiña. Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959025. |
up to one-third of those with schizophrenia fail to respond to standard antipsychotics and are considered to have treatment-resistant schizophrenia, a condition for which clozapine is the only evidence-based medication. |
2021-05-08 |
2023-08-13 |
Not clear |