| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melissa Sussman, Michael Epifania, Derrick Eng, Jae Cho, Richard Stewar. Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis. Case reports in psychiatry. vol 2021. 2021-03-24. PMID:33688445. |
clozapine, the choice atypical antipsychotic for refractory schizophrenia, schizoaffective disorder, and bipolar disorder, has been shown to reduce positive and negative symptoms of schizophrenia. |
2021-03-24 |
2023-08-13 |
Not clear |
| Shayan Amiri, Rana Dizaji, Majid Momeny, Evan Gauvin, Mir-Jamal Hossein. Clozapine attenuates mitochondrial dysfunction, inflammatory gene expression, and behavioral abnormalities in an animal model of schizophrenia. Neuropharmacology. vol 187. 2021-03-23. PMID:33636190. |
clozapine attenuates mitochondrial dysfunction, inflammatory gene expression, and behavioral abnormalities in an animal model of schizophrenia. |
2021-03-23 |
2023-08-13 |
rat |
| Basile Chrétien, Sophie Fedrizzi, Véronique Lelong-Boulouard, Marion Sassier, Joachim Alexandre, Charles Dolladill. Could N-acetylcysteine improve the safety of clozapine? Human psychopharmacology. vol 36. issue 2. 2021-03-22. PMID:33206415. |
clozapine is an atypical antipsychotic indicated in patients with treatment-resistant schizophrenia which remains underused due to safety issues. |
2021-03-22 |
2023-08-13 |
Not clear |
| Basile Chrétien, Sophie Fedrizzi, Véronique Lelong-Boulouard, Marion Sassier, Joachim Alexandre, Charles Dolladill. Could N-acetylcysteine improve the safety of clozapine? Human psychopharmacology. vol 36. issue 2. 2021-03-22. PMID:33206415. |
nac could also secondarily show positive knock-on effects for the patients by improving clinical symptoms of schizophrenia in synergy with clozapine, and by reducing substance abuse and thus by improving the patient's overall condition. |
2021-03-22 |
2023-08-13 |
Not clear |
| Menahem Krakowski, Umit Tural, Pál Czobo. The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol. The American journal of psychiatry. vol 178. issue 3. 2021-03-22. PMID:33472389. |
the importance of conduct disorder in the treatment of violence in schizophrenia: efficacy of clozapine compared with olanzapine and haloperidol. |
2021-03-22 |
2023-08-13 |
Not clear |
| Menahem Krakowski, Umit Tural, Pál Czobo. The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol. The American journal of psychiatry. vol 178. issue 3. 2021-03-22. PMID:33472389. |
this study is a head-to-head comparison of clozapine, olanzapine, and haloperidol in the treatment of violent schizophrenia patients with and without conduct disorder. |
2021-03-22 |
2023-08-13 |
Not clear |
| Jessica L Dawson, Janet K Sluggett, Jennifer L Schumann, Nicholas G Procter, J Simon Bel. Fatal poisonings involving clozapine: A 16-year review of Australian coronial investigations. The Australian and New Zealand journal of psychiatry. 2021-03-19. PMID:33736477. |
concerns about intentional and unintentional poisoning present a barrier to wider use of clozapine in treatment-resistant schizophrenia. |
2021-03-19 |
2023-08-13 |
Not clear |
| Mathias Lundberg, Sophie Curbo, Hannes Bohman, Ingrid Agartz, Sven-Ove Ögren, Cesare Patrone, Shiva Mansour. Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy. Bioscience reports. vol 40. issue 1. 2021-03-16. PMID:31919522. |
if the data are further confirmed in vivo, the results may encourage an expanded use of clozapine to restore impaired neurogenesis in schizophrenia. |
2021-03-16 |
2023-08-13 |
mouse |
| Madeleine S A Tan, Faraz Honarparvar, James R Falconer, Harendra S Parekh, Preeti Pandey, Dan J Siskin. A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions. Psychopharmacology. vol 238. issue 3. 2021-03-16. PMID:33410989. |
clozapine is the most effective antipsychotic for treatment-refractory schizophrenia for reducing positive psychotic symptoms. |
2021-03-16 |
2023-08-13 |
Not clear |
| Dorothea Lesche, Sam Mostafa, Ian Everall, Christos Pantelis, Chad A Bousma. Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity. The pharmacogenomics journal. vol 20. issue 2. 2021-03-12. PMID:31616047. |
among 66 adult schizophrenia patients treated with clozapine-based combination therapies, we explored the impact of genotype-predicted cyp1a2, cyp2d6, and cyp2c19 activity on dose-adjusted clozapine concentrations and symptom severity, with and without correction for inhibitors and inducers of these enzymes. |
2021-03-12 |
2023-08-13 |
Not clear |
| M Nystazaki, M Karanikola, V Gartzoni, A Georgou, St Tolia, Chr Liapis, M Psomiadi, G Alevizopoulo. [Development and implementation of clozapine protocol in patients with schizophrenia in Greece]. Psychiatrike = Psychiatriki. vol 31. issue 1. 2021-03-01. PMID:32544078. |
[development and implementation of clozapine protocol in patients with schizophrenia in greece]. |
2021-03-01 |
2023-08-13 |
Not clear |
| M Nystazaki, M Karanikola, V Gartzoni, A Georgou, St Tolia, Chr Liapis, M Psomiadi, G Alevizopoulo. [Development and implementation of clozapine protocol in patients with schizophrenia in Greece]. Psychiatrike = Psychiatriki. vol 31. issue 1. 2021-03-01. PMID:32544078. |
clozapine efficacy is well established in people diagnosed with schizophrenia via reducing both positive and negative symptoms. |
2021-03-01 |
2023-08-13 |
Not clear |
| In Won Chung, Hye Sung Kim, Jung Hyun Kim, Jin Hyeok Jang, Yong Sik Ki. Resolution of Persistent Auditory Verbal Hallucinations after Long-term Electroconvulsive Therapy Maintenance: A Case Report of a Patient with Clozapine-resistant Schizophrenia. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 19. issue 1. 2021-02-28. PMID:33508802. |
a 32-year-old woman with schizophrenia and persistent auditory verbal hallucinations (avhs), which caused continuous suicidal thoughts and depression, was treated with electroconvulsive therapy (ect) of an acute course followed by maintenance ect (m-ect) augmented onto clozapine for 7 years. |
2021-02-28 |
2023-08-13 |
Not clear |
| Anna Dietrich-Muszalska, Joanna Kolodziejczyk-Czepas, Pawel Nowa. Comparative Study of the Effects of Atypical Antipsychotic Drugs on Plasma and Urine Biomarkers of Oxidative Stress in Schizophrenic Patients. Neuropsychiatric disease and treatment. vol 17. 2021-02-26. PMID:33628026. |
therefore, in the present study, we assessed the ability of six atypical ads (clozapine, olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone) used in schizophrenia treatment to modulate oxidative damage to different biomolecules such as lipids and proteins. |
2021-02-26 |
2023-08-13 |
Not clear |
| Motohiro Okada, Kouji Fukuyama, Takashi Shiroyama, Masahiko Murat. A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43. International journal of molecular sciences. vol 21. issue 19. 2021-02-25. PMID:32987640. |
clozapine (clz) is an approved antipsychotic agent for the medication of treatment-resistant schizophrenia but is also well known as one of the most toxic antipsychotics. |
2021-02-25 |
2023-08-13 |
Not clear |
| M Z van der Horst, F van Houwelingen, J J Luyk. Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report. BMC psychiatry. vol 20. issue 1. 2021-02-22. PMID:33246443. |
clozapine is an atypical antipsychotic proven to be superior in the treatment of treatment-resistant schizophrenia. |
2021-02-22 |
2023-08-13 |
Not clear |
| Albert T Higgins-Chen, Marco P Boks, Christiaan H Vinkers, René S Kahn, Morgan E Levin. Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects. Biological psychiatry. vol 88. issue 3. 2021-02-18. PMID:32199607. |
schizophrenia and epigenetic aging biomarkers: increased mortality, reduced cancer risk, and unique clozapine effects. |
2021-02-18 |
2023-08-13 |
Not clear |
| Chieh-Hsin Lin, Yu-Ming Chen, Hsien-Yuan Lan. Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant. Current drug targets. vol 21. issue 6. 2021-02-17. PMID:31660823. |
clozapine has been regarded as the last-line antipsychotic agent for patients with refractory schizophrenia. |
2021-02-17 |
2023-08-13 |
Not clear |
| Chieh-Hsin Lin, Yu-Ming Chen, Hsien-Yuan Lan. Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant. Current drug targets. vol 21. issue 6. 2021-02-17. PMID:31660823. |
earlier, the inhibition of d-amino acid oxidase (daao) that may metabolize d-amino acids and activate nmdar has been reported to be beneficial for patients with schizophrenia receiving antipsychotics except for clozapine. |
2021-02-17 |
2023-08-13 |
Not clear |
| b' Nikola Gligorijevi\\xc4\\x87, Tamara Vasovi\\xc4\\x87, Steva Levi\\xc4\\x87, \\xc4\\x8cedo Miljevi\\xc4\\x87, Olgica Nedi\\xc4\\x87, Milan Nikoli\\xc4\\x8. Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. International journal of biological macromolecules. vol 154. 2021-02-15. PMID:32184141.' |
clozapine is an atypical antipsychotic used for the treatment of schizophrenia. |
2021-02-15 |
2023-08-13 |
Not clear |